AR079247A1 - Proteinas de enlace que se enlazan a fgfr1c (receptor del factor de crecimiento de fibroblasto) humano beta-klotho humano y a ambos fgfr1c humano y beta-klotho humano - Google Patents

Proteinas de enlace que se enlazan a fgfr1c (receptor del factor de crecimiento de fibroblasto) humano beta-klotho humano y a ambos fgfr1c humano y beta-klotho humano

Info

Publication number
AR079247A1
AR079247A1 ARP100104458A ARP100104458A AR079247A1 AR 079247 A1 AR079247 A1 AR 079247A1 AR P100104458 A ARP100104458 A AR P100104458A AR P100104458 A ARP100104458 A AR P100104458A AR 079247 A1 AR079247 A1 AR 079247A1
Authority
AR
Argentina
Prior art keywords
human
beta
klotho
fgfr1c
link
Prior art date
Application number
ARP100104458A
Other languages
English (en)
Inventor
Yang Li
Peng Li
Amy N Duguay
Richard Smith
Alice Bakker
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AR079247A1 publication Critical patent/AR079247A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se proporcionan proteínas de enlace que se enlazan específicamente a beta-Klotho o porciones del mismo, FGFR1c o porciones del mismo, o a ambos FGFR1c y beta-Klotho, y opcionalmente también otras proteínas. También se proporcionan secuencias de codificacion, métodos de tratamiento y composiciones farmacéuticas. Reivindicacion 1: Una proteína de enlace que enlaza selectivamente beta-Klotho, caracterizada porque la proteína de enlace comprende uno o más de: C[AGP] [APS] [DGN] [EQ] F [QRT] C [GNRS] [GNS] [GT] [GKQS] [-IK] C [ILV] P [LQRV] [AEHP] W [LRV] CDG [DLV] [DN] DCGD [GN] SDE [AEKPS] [GLPS] [-AEV] [-IT]C (SEQ ID Ns: 254); CLPDEFQC [SG] SGRCIPQ [NT] W [VL] CDGLNDCGDGSDE [PS] PA [HT] C (SEQ ID Ns: 597); y C [AGPR] [AP] [DGNS] [EQ] F [QRT] C [GSK] N [GT] [GHR] [R] C [ILV] [PS] [ALQ] [NST] W [LRV] CDG [DEV] DDC [GL] DGSDE [AET] [DNS] [-A] [-T] C (SEQ ID Ns:249) caracterizada porque los aminoácidos en corchetes indican aminoácidos alternativos en una posicion específica y ô-ô indica sin aminoácido en la posicion especificada.
ARP100104458A 2009-12-02 2010-12-02 Proteinas de enlace que se enlazan a fgfr1c (receptor del factor de crecimiento de fibroblasto) humano beta-klotho humano y a ambos fgfr1c humano y beta-klotho humano AR079247A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26606109P 2009-12-02 2009-12-02
US38136410P 2010-09-09 2010-09-09

Publications (1)

Publication Number Publication Date
AR079247A1 true AR079247A1 (es) 2012-01-04

Family

ID=43501450

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104458A AR079247A1 (es) 2009-12-02 2010-12-02 Proteinas de enlace que se enlazan a fgfr1c (receptor del factor de crecimiento de fibroblasto) humano beta-klotho humano y a ambos fgfr1c humano y beta-klotho humano

Country Status (9)

Country Link
US (2) US8372952B2 (es)
EP (2) EP2506861A1 (es)
JP (1) JP2013512672A (es)
AR (1) AR079247A1 (es)
AU (1) AU2010326024A1 (es)
CA (1) CA2782814A1 (es)
MX (1) MX2012006397A (es)
TW (1) TW201129377A (es)
WO (1) WO2011068893A1 (es)

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