DE69719360D1 - Zusammensetzungen und methoden zur steigerung der darmfunktion - Google Patents
Zusammensetzungen und methoden zur steigerung der darmfunktionInfo
- Publication number
- DE69719360D1 DE69719360D1 DE69719360T DE69719360T DE69719360D1 DE 69719360 D1 DE69719360 D1 DE 69719360D1 DE 69719360 T DE69719360 T DE 69719360T DE 69719360 T DE69719360 T DE 69719360T DE 69719360 D1 DE69719360 D1 DE 69719360D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- increasing
- glp
- compositions
- bowel function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003871 intestinal function Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 abstract 3
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 3
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 abstract 3
- 239000000813 peptide hormone Substances 0.000 abstract 3
- 210000002429 large intestine Anatomy 0.000 abstract 2
- 210000000813 small intestine Anatomy 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 208000030212 nutrition disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/763,177 US5952301A (en) | 1996-12-10 | 1996-12-10 | Compositions and methods for enhancing intestinal function |
| PCT/CA1997/000945 WO1998025644A1 (en) | 1996-12-10 | 1997-12-10 | Compositions and methods for enhancing intestinal function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69719360D1 true DE69719360D1 (de) | 2003-04-03 |
| DE69719360T2 DE69719360T2 (de) | 2003-12-04 |
Family
ID=25067085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69719360T Expired - Lifetime DE69719360T2 (de) | 1996-12-10 | 1997-12-10 | Zusammensetzungen und methoden zur steigerung der darmfunktion |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5952301A (de) |
| EP (1) | EP0944396B1 (de) |
| AT (1) | ATE233096T1 (de) |
| AU (1) | AU5220098A (de) |
| CA (1) | CA2274596C (de) |
| DE (1) | DE69719360T2 (de) |
| DK (1) | DK0944396T3 (de) |
| ES (1) | ES2193406T3 (de) |
| PT (1) | PT944396E (de) |
| WO (1) | WO1998025644A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| CA2236519C (en) | 1997-05-02 | 2011-09-13 | 1149336 Ontario Inc. | Methods of enhancing functioning of the large intestine |
| AU746633B2 (en) * | 1997-05-16 | 2002-05-02 | 1149336 Ontario Inc. | Methods of enhancing functioning of the upper gastrointestinal tract |
| EP2433623A1 (de) * | 1998-02-02 | 2012-03-28 | Trustees Of Tufts College | Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus |
| AU7421598A (en) * | 1998-05-11 | 1999-11-29 | 1149336 Ontario Inc. | Methods of enhancing functioning of the large intestine |
| EP1104293A1 (de) * | 1998-08-21 | 2001-06-06 | Point Therapeutics, Inc. | Regulierung von substrat aktivität |
| US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| GB9906715D0 (en) | 1999-03-23 | 1999-05-19 | Ferring Bv | Compositions for promoting growth |
| GB9906714D0 (en) | 1999-03-23 | 1999-05-19 | Ferring Bv | Compositions for improving fertility |
| CA2373643A1 (en) * | 1999-05-25 | 2000-11-30 | Point Therapeutics, Inc. | Anti-tumor comprising boroproline compounds |
| EP1806138A1 (de) * | 1999-05-25 | 2007-07-11 | Point Therapeutics, Inc. | Anti-tumor präparate enthaltend boroprolin verbindungen |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| EP1229927B1 (de) * | 1999-11-03 | 2007-12-19 | Novo Nordisk A/S | Verwendung eines wachstumshormons oder eines wachstumshormon-sekretion fördernden mittels zur appetit-unterdrückung bzw. sättigungsinduktion |
| US6599882B1 (en) | 1999-11-05 | 2003-07-29 | Joseph A. Rogoff | Secretin and secretin pharmaceuticals for treating lactose intolerance |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| US7371721B2 (en) * | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
| US20070135345A1 (en) * | 2000-09-18 | 2007-06-14 | Henriksen Dennis B | Use of GLP-2 for the treatment or prevention, of bone-related disorders |
| US6770620B2 (en) | 2000-09-18 | 2004-08-03 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
| US20080249016A1 (en) * | 2000-09-18 | 2008-10-09 | Sanos Bioscience A/S | Use of GLP-2 in a combination treatment for bone-related disorders |
| DE60226702D1 (de) * | 2001-02-16 | 2008-07-03 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| CA2466870A1 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
| EP2316470A3 (de) | 2001-11-26 | 2011-08-24 | Trustees Of Tufts College | Peptidomimetikuminhibitoren von post-Prolin-spaltenden Enzymen |
| US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
| WO2004035624A2 (en) * | 2002-10-14 | 2004-04-29 | Novo Nordisk A/S | Glucagon - like peptide - 2 variants |
| US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| US20050026859A1 (en) * | 2002-11-12 | 2005-02-03 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| US7576121B2 (en) * | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| HRP20141155T1 (hr) * | 2003-11-12 | 2015-01-16 | Sino-Med International Alliance, Inc. | Heterocikliäśki spojevi borne kiseline |
| US7317109B2 (en) * | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) * | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| BRPI0513384A (pt) * | 2004-07-14 | 2008-05-06 | Novartis Ag | combinação de inibidores de dpp-iv e compostos que modulam receptores de 5-ht3 e/ou 5-ht4 |
| PL1877435T5 (pl) | 2005-05-04 | 2021-09-27 | Zealand Pharma A/S | Analogi peptydu glukagonopodobnego 2 (GLP-2) |
| US7825139B2 (en) * | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| CA2669806C (en) | 2006-11-08 | 2018-10-02 | Zealand Pharma A/S | Selective glucagon-like-peptide-2 (glp-2) analogues |
| US20110295151A1 (en) * | 2010-05-26 | 2011-12-01 | Bakos Gregory J | Enteroendocrine Manipulation for Metabolic Effect |
| AU2013255752B2 (en) | 2012-05-03 | 2017-11-09 | Zealand Pharma A/S | Glucagon-like-peptide-2 (GLP-2) analogues |
| EP4219534A3 (de) | 2013-07-08 | 2023-09-27 | The University of Utah Research Foundation | Verfahren zur behandlung von und vorbeugung gegen entzündliche erkrankungen |
| US20180200301A1 (en) * | 2015-05-21 | 2018-07-19 | Shanghai Institutes For Biological Sciences Chinese Academy Of Sciences | Low-Oxygen-Treated Mesenchymal Stem Cell and Use Thereof |
| CN106589110B (zh) * | 2015-10-15 | 2020-01-17 | 上海迈迹生物医药科技有限公司 | 包含聚合物和glp-2衍生物的缀合物 |
| SG10201911851VA (en) | 2016-12-09 | 2020-02-27 | Zealand Pharma As | Acylated glp-1/glp-2 dual agonists |
| PE20200678A1 (es) | 2017-06-16 | 2020-06-11 | Zealand Pharma As | Posologias para la administracion de analogos de peptido de tipo glucagon-2 (glp-2) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2174838T3 (es) * | 1991-10-07 | 2002-11-16 | Brigham & Womens Hospital | Metodo para aumentar la absorcion del intestino. |
| NZ243071A (en) * | 1992-06-08 | 1994-09-27 | Kabi Pharmacia Ab | Igf-2 (or analogue) compositions for pharmaceutical uses |
| US5990077A (en) * | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| EP1231219B1 (de) * | 1996-04-12 | 2010-08-25 | 1149336 Ontario Inc. | Dem Glukagon ähnliches Peptid-2 |
-
1996
- 1996-12-10 US US08/763,177 patent/US5952301A/en not_active Expired - Lifetime
-
1997
- 1997-12-10 PT PT97946986T patent/PT944396E/pt unknown
- 1997-12-10 AU AU52200/98A patent/AU5220098A/en not_active Abandoned
- 1997-12-10 DK DK97946986T patent/DK0944396T3/da active
- 1997-12-10 AT AT97946986T patent/ATE233096T1/de active
- 1997-12-10 CA CA002274596A patent/CA2274596C/en not_active Expired - Fee Related
- 1997-12-10 EP EP97946986A patent/EP0944396B1/de not_active Expired - Lifetime
- 1997-12-10 DE DE69719360T patent/DE69719360T2/de not_active Expired - Lifetime
- 1997-12-10 ES ES97946986T patent/ES2193406T3/es not_active Expired - Lifetime
- 1997-12-10 WO PCT/CA1997/000945 patent/WO1998025644A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2274596C (en) | 2004-11-09 |
| AU5220098A (en) | 1998-07-03 |
| ES2193406T3 (es) | 2003-11-01 |
| DK0944396T3 (da) | 2003-06-23 |
| PT944396E (pt) | 2003-07-31 |
| EP0944396A1 (de) | 1999-09-29 |
| ATE233096T1 (de) | 2003-03-15 |
| US5952301A (en) | 1999-09-14 |
| EP0944396B1 (de) | 2003-02-26 |
| CA2274596A1 (en) | 1998-06-18 |
| WO1998025644A1 (en) | 1998-06-18 |
| DE69719360T2 (de) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |