AR060862A1 - Proteinas de fusion rage, formulaciones y metodos de uso de estas - Google Patents
Proteinas de fusion rage, formulaciones y metodos de uso de estasInfo
- Publication number
- AR060862A1 AR060862A1 ARP070101949A ARP070101949A AR060862A1 AR 060862 A1 AR060862 A1 AR 060862A1 AR P070101949 A ARP070101949 A AR P070101949A AR P070101949 A ARP070101949 A AR P070101949A AR 060862 A1 AR060862 A1 AR 060862A1
- Authority
- AR
- Argentina
- Prior art keywords
- rage
- formulations
- fusion
- methods
- fusion protein
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000004927 fusion Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 5
- 108020001507 fusion proteins Proteins 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
Abstract
Se describen proteínas de fusion RAGE (receptor de glucoproductos finales avanzados) que comprenden las secuencias de polipéptido RAGE ligadas a un segundo polipéptido que no es RAGE. La proteína de fusion RAGE puede utilizar un dominio de polipéptido RAGE que comprende el sitio de union al ligando RAGE y un linker de interdominio ligado directamente al N-término de un dominio de inmunoglobulina CH2. Se describen también las formulaciones de la proteína de fusion RAGE y el uso de las proteínas de fusion RAGE y las formulaciones de la proteína de fusion RAGE como terapéuticos para las patologías intermediadas por RAGE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79845506P | 2006-05-05 | 2006-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060862A1 true AR060862A1 (es) | 2008-07-16 |
Family
ID=38521887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101949A AR060862A1 (es) | 2006-05-05 | 2007-05-04 | Proteinas de fusion rage, formulaciones y metodos de uso de estas |
Country Status (21)
Country | Link |
---|---|
US (2) | US7981424B2 (es) |
EP (2) | EP2021474A2 (es) |
JP (1) | JP5558810B2 (es) |
KR (1) | KR20090008459A (es) |
CN (1) | CN101548012A (es) |
AR (1) | AR060862A1 (es) |
AU (1) | AU2007248784B2 (es) |
BR (1) | BRPI0711193A2 (es) |
CA (1) | CA2651348A1 (es) |
DO (1) | DOP2007000089A (es) |
EA (1) | EA017291B1 (es) |
IL (1) | IL194482A0 (es) |
MX (1) | MX2008013863A (es) |
NL (1) | NL2000626A1 (es) |
NZ (1) | NZ571692A (es) |
PE (1) | PE20080397A1 (es) |
SG (1) | SG171670A1 (es) |
TW (1) | TW200801036A (es) |
UY (1) | UY30324A1 (es) |
WO (1) | WO2007130302A2 (es) |
ZA (1) | ZA200809394B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ552842A (en) * | 2004-08-03 | 2010-05-28 | Univ Columbia | Rage fusion proteins and methods of use |
AP2007003869A0 (en) * | 2004-08-03 | 2007-02-28 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
RU2431804C2 (ru) * | 2005-12-23 | 2011-10-20 | ДжиКоудер Системз АБ | Шаблон позиционирования |
NZ569545A (en) * | 2006-02-09 | 2011-11-25 | Transtech Pharma Inc | Rage fusion proteins and methods of use for treating inflammation |
MX2008013863A (es) | 2006-05-05 | 2008-11-14 | Transtech Pharma Inc | Proteinas de fusion de rage y sus metodos de uso. |
EP2123298A4 (en) * | 2007-02-15 | 2011-09-28 | Univ Fukuoka | MEANS FOR SUPPRESSING THE SLIP IN ORGAN TRANSPLANTATIONS WITH ANTI-HMGB-1 ANTIBODIES |
US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
US8470325B2 (en) * | 2007-02-15 | 2013-06-25 | Kagoshima University | Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody |
US20100216977A1 (en) * | 2007-02-15 | 2010-08-26 | Kyushu University, National University Corporation | Therapeutic agent for interstitial pulmonary disease comprising anti-hmgb-1 antibody |
AU2008265983B2 (en) | 2007-06-14 | 2013-06-20 | Galactica Pharmaceuticals, Inc. | RAGE fusion proteins |
CN102803292A (zh) | 2009-04-20 | 2012-11-28 | 辉瑞公司 | 蛋白质糖基化的控制及其相关组合物和方法 |
WO2011102845A1 (en) * | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
WO2013074820A1 (en) | 2011-11-16 | 2013-05-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
HUE043820T2 (hu) * | 2012-11-28 | 2019-09-30 | Nono Inc | Liofilizált TAT-NR2B9c készítmény |
US10251935B2 (en) | 2012-11-28 | 2019-04-09 | Nono Inc. | Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose |
EP3633381A3 (en) | 2013-12-05 | 2020-07-29 | The Broad Institute, Inc. | Compositions and methods for identifying and treating cachexia or pre-cachexia |
CN107404863B (zh) * | 2014-10-01 | 2021-04-02 | 国立研究开发法人农业·食品产业技术综合研究机构 | 使用基因修饰的家蚕生产的生物素化和氧化ldl受体和晚期糖化终末产物受体 |
EP3822291A1 (en) | 2015-06-10 | 2021-05-19 | The Broad Institute Inc. | Antibodies, compounds and screens for identifying and treating cachexia or pre-cachexia |
WO2017106196A1 (en) | 2015-12-14 | 2017-06-22 | The Broad Institute, Inc. | Compositions and methods for treating cardiac dysfunction |
CN112699601B (zh) * | 2020-12-28 | 2022-05-31 | 电子科技大学 | 一种传感器网络数据的空时重构方法 |
US20230246158A1 (en) * | 2022-02-02 | 2023-08-03 | Enevate Corporation | Cycle life in si/li batteries using high temperature deep discharge cycling |
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US20070014791A1 (en) | 2003-09-05 | 2007-01-18 | Schmidt Ann M | Rage-related methods and copositions for treating glomerular injury |
WO2005042032A1 (en) | 2003-10-31 | 2005-05-12 | The Trustees Of Columbia University In The City Of New York | Methods for treating multiple sclerosis |
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US20060040354A1 (en) | 2004-07-20 | 2006-02-23 | O'keefe Theresa L | Novel polyadenylation signal for use in expression vectors |
WO2006012415A2 (en) * | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Rage protein derivatives |
AP2007003869A0 (en) | 2004-08-03 | 2007-02-28 | Transtech Pharma Inc | Rage fusion proteins and methods of use |
NZ552842A (en) | 2004-08-03 | 2010-05-28 | Univ Columbia | Rage fusion proteins and methods of use |
AU2005289594B2 (en) | 2004-09-27 | 2012-02-02 | Centocor, Inc. | Srage mimetibody, compositions, methods and uses |
US20080207499A1 (en) | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
NZ569545A (en) * | 2006-02-09 | 2011-11-25 | Transtech Pharma Inc | Rage fusion proteins and methods of use for treating inflammation |
MX2008013863A (es) | 2006-05-05 | 2008-11-14 | Transtech Pharma Inc | Proteinas de fusion de rage y sus metodos de uso. |
US20080199467A1 (en) | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
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2007
- 2007-04-25 MX MX2008013863A patent/MX2008013863A/es active IP Right Grant
- 2007-04-25 NZ NZ571692A patent/NZ571692A/en not_active IP Right Cessation
- 2007-04-25 CA CA002651348A patent/CA2651348A1/en not_active Abandoned
- 2007-04-25 KR KR1020087029731A patent/KR20090008459A/ko not_active Application Discontinuation
- 2007-04-25 WO PCT/US2007/010125 patent/WO2007130302A2/en active Application Filing
- 2007-04-25 EP EP07794379A patent/EP2021474A2/en not_active Withdrawn
- 2007-04-25 SG SG201103296-8A patent/SG171670A1/en unknown
- 2007-04-25 AU AU2007248784A patent/AU2007248784B2/en not_active Ceased
- 2007-04-25 EA EA200870502A patent/EA017291B1/ru not_active IP Right Cessation
- 2007-04-25 JP JP2009509615A patent/JP5558810B2/ja not_active Expired - Fee Related
- 2007-04-25 CN CNA200780018207XA patent/CN101548012A/zh active Pending
- 2007-04-25 EP EP11167432A patent/EP2380983A3/en not_active Withdrawn
- 2007-04-25 US US11/789,637 patent/US7981424B2/en not_active Expired - Fee Related
- 2007-04-25 BR BRPI0711193-2A patent/BRPI0711193A2/pt not_active IP Right Cessation
- 2007-05-04 TW TW096115905A patent/TW200801036A/zh unknown
- 2007-05-04 DO DO2007000089A patent/DOP2007000089A/es unknown
- 2007-05-04 AR ARP070101949A patent/AR060862A1/es not_active Application Discontinuation
- 2007-05-04 UY UY30324A patent/UY30324A1/es not_active Application Discontinuation
- 2007-05-04 PE PE2007000550A patent/PE20080397A1/es not_active Application Discontinuation
- 2007-05-04 NL NL2000626A patent/NL2000626A1/nl not_active IP Right Cessation
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2008
- 2008-10-02 IL IL194482A patent/IL194482A0/en unknown
- 2008-11-03 ZA ZA200809394A patent/ZA200809394B/xx unknown
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Also Published As
Publication number | Publication date |
---|---|
MX2008013863A (es) | 2008-11-14 |
WO2007130302A2 (en) | 2007-11-15 |
NZ571692A (en) | 2012-01-12 |
NL2000626A1 (nl) | 2007-11-06 |
ZA200809394B (en) | 2009-07-29 |
PE20080397A1 (es) | 2008-04-28 |
WO2007130302A3 (en) | 2008-04-03 |
AU2007248784A1 (en) | 2007-11-15 |
DOP2007000089A (es) | 2007-11-15 |
US20080045455A1 (en) | 2008-02-21 |
EP2380983A2 (en) | 2011-10-26 |
JP2009536201A (ja) | 2009-10-08 |
CA2651348A1 (en) | 2007-11-15 |
US8344120B2 (en) | 2013-01-01 |
EA017291B1 (ru) | 2012-11-30 |
CN101548012A (zh) | 2009-09-30 |
SG171670A1 (en) | 2011-06-29 |
EP2021474A2 (en) | 2009-02-11 |
IL194482A0 (en) | 2011-08-01 |
US20110282035A1 (en) | 2011-11-17 |
US7981424B2 (en) | 2011-07-19 |
EA200870502A1 (ru) | 2009-06-30 |
JP5558810B2 (ja) | 2014-07-23 |
KR20090008459A (ko) | 2009-01-21 |
AU2007248784B2 (en) | 2013-11-21 |
TW200801036A (en) | 2008-01-01 |
BRPI0711193A2 (pt) | 2013-06-18 |
UY30324A1 (es) | 2008-01-02 |
EP2380983A3 (en) | 2012-12-05 |
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