AR078087A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents
Inmunoglobulinas con dominio variable dual y usos de las mismasInfo
- Publication number
- AR078087A1 AR078087A1 ARP100102767A ARP100102767A AR078087A1 AR 078087 A1 AR078087 A1 AR 078087A1 AR P100102767 A ARP100102767 A AR P100102767A AR P100102767 A ARP100102767 A AR P100102767A AR 078087 A1 AR078087 A1 AR 078087A1
- Authority
- AR
- Argentina
- Prior art keywords
- nkg2d
- variable domain
- immunoglobulins
- same
- heavy chain
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 229940072221 immunoglobulins Drugs 0.000 title 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 abstract 5
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 abstract 5
- 102000023732 binding proteins Human genes 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 abstract 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- G—PHYSICS
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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-
2010
- 2010-07-28 TW TW099124965A patent/TW201109438A/zh unknown
- 2010-07-28 UY UY0001032808A patent/UY32808A/es not_active Application Discontinuation
- 2010-07-29 EP EP10805046.9A patent/EP2459729A4/en not_active Withdrawn
- 2010-07-29 RU RU2012107526/10A patent/RU2012107526A/ru not_active Application Discontinuation
- 2010-07-29 AU AU2010278947A patent/AU2010278947A1/en not_active Abandoned
- 2010-07-29 SG SG2012006243A patent/SG178148A1/en unknown
- 2010-07-29 KR KR1020127005103A patent/KR20120047274A/ko not_active Withdrawn
- 2010-07-29 US US12/846,317 patent/US20110044980A1/en not_active Abandoned
- 2010-07-29 CN CN2010800434689A patent/CN102791875A/zh active Pending
- 2010-07-29 BR BRBR112012002095-1A patent/BR112012002095A2/pt not_active IP Right Cessation
- 2010-07-29 WO PCT/US2010/043716 patent/WO2011014659A2/en not_active Ceased
- 2010-07-29 CA CA2769518A patent/CA2769518A1/en not_active Abandoned
- 2010-07-29 AR ARP100102767A patent/AR078087A1/es not_active Application Discontinuation
- 2010-07-29 MX MX2012001262A patent/MX2012001262A/es not_active Application Discontinuation
- 2010-07-29 JP JP2012523041A patent/JP2013500721A/ja not_active Withdrawn
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2012
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- 2012-01-26 ZA ZA2012/00666A patent/ZA201200666B/en unknown
Also Published As
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|---|---|
| CA2769518A1 (en) | 2011-02-03 |
| BR112012002095A2 (pt) | 2015-09-01 |
| EP2459729A2 (en) | 2012-06-06 |
| WO2011014659A2 (en) | 2011-02-03 |
| WO2011014659A3 (en) | 2011-04-21 |
| SG178148A1 (en) | 2012-03-29 |
| AU2010278947A1 (en) | 2012-03-01 |
| EP2459729A4 (en) | 2013-04-24 |
| IL217718A0 (en) | 2012-03-29 |
| US20110044980A1 (en) | 2011-02-24 |
| JP2013500721A (ja) | 2013-01-10 |
| MX2012001262A (es) | 2012-05-22 |
| RU2012107526A (ru) | 2013-09-10 |
| KR20120047274A (ko) | 2012-05-11 |
| ZA201200666B (en) | 2014-07-30 |
| CN102791875A (zh) | 2012-11-21 |
| UY32808A (es) | 2011-02-28 |
| TW201109438A (en) | 2011-03-16 |
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