AR070520A1 - Derivados de azuleno nitrogenados,composiciones farmaceuticas que los contienen,proceso de preparacion y usos de los mismos para tratar trastornos metabolicos y digestivos,entre otros. - Google Patents
Derivados de azuleno nitrogenados,composiciones farmaceuticas que los contienen,proceso de preparacion y usos de los mismos para tratar trastornos metabolicos y digestivos,entre otros.Info
- Publication number
- AR070520A1 AR070520A1 ARP090100236A ARP090100236A AR070520A1 AR 070520 A1 AR070520 A1 AR 070520A1 AR P090100236 A ARP090100236 A AR P090100236A AR P090100236 A ARP090100236 A AR P090100236A AR 070520 A1 AR070520 A1 AR 070520A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently selected
- substituted
- optionally
- heteroaryl
- cycloalkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- XYHCUTXPTZLWTM-UHFFFAOYSA-N [N].C1=CC=C2C=CC=CC=C12 Chemical class [N].C1=CC=C2C=CC=CC=C12 XYHCUTXPTZLWTM-UHFFFAOYSA-N 0.000 title 1
- 230000001079 digestive effect Effects 0.000 title 1
- 230000002503 metabolic effect Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 22
- 229910003827 NRaRb Inorganic materials 0.000 abstract 18
- 125000001072 heteroaryl group Chemical group 0.000 abstract 17
- 125000000623 heterocyclic group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 15
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 10
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 10
- 229910052757 nitrogen Inorganic materials 0.000 abstract 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 9
- 125000003342 alkenyl group Chemical group 0.000 abstract 9
- 125000000304 alkynyl group Chemical group 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 9
- 229910052760 oxygen Inorganic materials 0.000 abstract 9
- 229910052717 sulfur Inorganic materials 0.000 abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 8
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 8
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 7
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 7
- 125000004643 (C1-C12) haloalkoxy group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910006069 SO3H Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 2
- 125000002576 diazepinyl group Chemical group N1N=C(C=CC=C1)* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- -1 -OR9 Chemical group 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/06—Antianaemics
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Virology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202DE2008 | 2008-01-24 | ||
| IN688DE2008 | 2008-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070520A1 true AR070520A1 (es) | 2010-04-14 |
Family
ID=40474786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100236A AR070520A1 (es) | 2008-01-24 | 2009-01-26 | Derivados de azuleno nitrogenados,composiciones farmaceuticas que los contienen,proceso de preparacion y usos de los mismos para tratar trastornos metabolicos y digestivos,entre otros. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8455479B2 (https=) |
| EP (1) | EP2250157B1 (https=) |
| JP (1) | JP5640208B2 (https=) |
| KR (1) | KR20100113122A (https=) |
| CN (1) | CN101925586B (https=) |
| AP (1) | AP2010005364A0 (https=) |
| AR (1) | AR070520A1 (https=) |
| AU (1) | AU2009207297B2 (https=) |
| BR (1) | BRPI0906705A2 (https=) |
| CA (1) | CA2712685A1 (https=) |
| CL (1) | CL2009000135A1 (https=) |
| EA (1) | EA018612B1 (https=) |
| PE (1) | PE20091353A1 (https=) |
| WO (1) | WO2009093269A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2012035549A2 (en) | 2010-09-13 | 2012-03-22 | Panacea Biotec Ltd | An improved process for the synthesis of beta amino acid derivatives |
| CN102617566B (zh) * | 2011-01-30 | 2015-03-04 | 山东轩竹医药科技有限公司 | 吡啶并咪唑烷衍生物 |
| CN104230935A (zh) * | 2011-04-26 | 2014-12-24 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| CN102241678B (zh) * | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| KR20160028241A (ko) | 2014-09-03 | 2016-03-11 | 김형도 | 목욕탕용 순환배관 슬러지 제거방법 |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| EP3416969B1 (en) | 2016-02-15 | 2021-05-05 | The Regents of The University of Michigan | Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors |
| CN106883152A (zh) * | 2017-04-07 | 2017-06-23 | 上海应用技术大学 | 一种β‑氨基酮的制备方法 |
| CN108084187A (zh) * | 2017-12-15 | 2018-05-29 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类氢化物 |
| WO2022099011A1 (en) * | 2020-11-06 | 2022-05-12 | Cytokinetics, Inc. | Bicyclic 1,4-diazepanones and therapeutic uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US7208498B2 (en) | 2002-07-15 | 2007-04-24 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
| ATE370141T1 (de) | 2002-10-07 | 2007-09-15 | Merck & Co Inc | Antidiabetische heterocyclische beta- aminoverbindungen als inhibitoren von dipeptidylpeptidase |
| KR20050067418A (ko) * | 2002-10-18 | 2005-07-01 | 머크 앤드 캄파니 인코포레이티드 | 당뇨병을 치료 또는 예방하기 위한 베타-아미노헤테로사이클릭 디펩티딜 펩티다제 억제제 |
| WO2004058266A1 (en) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| WO2004103276A2 (en) * | 2003-05-14 | 2004-12-02 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| AU2004261186A1 (en) * | 2003-07-31 | 2005-02-10 | Merck & Co., Inc. | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| US20090156465A1 (en) * | 2005-12-30 | 2009-06-18 | Sattigeri Jitendra A | Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors |
-
2009
- 2009-01-23 EA EA201070864A patent/EA018612B1/ru not_active IP Right Cessation
- 2009-01-23 US US12/863,016 patent/US8455479B2/en not_active Expired - Fee Related
- 2009-01-23 WO PCT/IN2009/000061 patent/WO2009093269A1/en not_active Ceased
- 2009-01-23 BR BRPI0906705-1A patent/BRPI0906705A2/pt not_active IP Right Cessation
- 2009-01-23 CA CA2712685A patent/CA2712685A1/en not_active Abandoned
- 2009-01-23 CN CN200980103148.5A patent/CN101925586B/zh not_active Expired - Fee Related
- 2009-01-23 PE PE2009000101A patent/PE20091353A1/es not_active Application Discontinuation
- 2009-01-23 EP EP09703708.9A patent/EP2250157B1/en not_active Not-in-force
- 2009-01-23 KR KR1020107018056A patent/KR20100113122A/ko not_active Withdrawn
- 2009-01-23 CL CL2009000135A patent/CL2009000135A1/es unknown
- 2009-01-23 AP AP2010005364A patent/AP2010005364A0/en unknown
- 2009-01-23 AU AU2009207297A patent/AU2009207297B2/en not_active Ceased
- 2009-01-23 JP JP2010543630A patent/JP5640208B2/ja not_active Expired - Fee Related
- 2009-01-26 AR ARP090100236A patent/AR070520A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011510068A (ja) | 2011-03-31 |
| EP2250157A1 (en) | 2010-11-17 |
| AU2009207297B2 (en) | 2011-11-10 |
| CN101925586A (zh) | 2010-12-22 |
| CL2009000135A1 (es) | 2009-10-09 |
| EP2250157B1 (en) | 2014-11-05 |
| JP5640208B2 (ja) | 2014-12-17 |
| AU2009207297A1 (en) | 2009-07-30 |
| EA018612B1 (ru) | 2013-09-30 |
| KR20100113122A (ko) | 2010-10-20 |
| CN101925586B (zh) | 2014-05-07 |
| WO2009093269A9 (en) | 2009-10-15 |
| WO2009093269A1 (en) | 2009-07-30 |
| CA2712685A1 (en) | 2009-07-30 |
| US8455479B2 (en) | 2013-06-04 |
| EA201070864A1 (ru) | 2011-02-28 |
| BRPI0906705A2 (pt) | 2015-06-30 |
| US20100311732A1 (en) | 2010-12-09 |
| AP2010005364A0 (en) | 2010-08-31 |
| PE20091353A1 (es) | 2009-09-05 |
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