AR065794A1 - Pirimidodiazepinas sustituidas - Google Patents

Pirimidodiazepinas sustituidas

Info

Publication number
AR065794A1
AR065794A1 ARP080101142A ARP080101142A AR065794A1 AR 065794 A1 AR065794 A1 AR 065794A1 AR P080101142 A ARP080101142 A AR P080101142A AR P080101142 A ARP080101142 A AR P080101142A AR 065794 A1 AR065794 A1 AR 065794A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
hydrogen
attached
ring
Prior art date
Application number
ARP080101142A
Other languages
English (en)
Spanish (es)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR065794(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR065794A1 publication Critical patent/AR065794A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP080101142A 2007-03-22 2008-03-19 Pirimidodiazepinas sustituidas AR065794A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22

Publications (1)

Publication Number Publication Date
AR065794A1 true AR065794A1 (es) 2009-07-01

Family

ID=39415299

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101142A AR065794A1 (es) 2007-03-22 2008-03-19 Pirimidodiazepinas sustituidas

Country Status (23)

Country Link
US (1) US7517873B2 (cg-RX-API-DMAC7.html)
EP (1) EP2139892B1 (cg-RX-API-DMAC7.html)
JP (1) JP5087640B2 (cg-RX-API-DMAC7.html)
KR (1) KR101157848B1 (cg-RX-API-DMAC7.html)
CN (2) CN102746175B (cg-RX-API-DMAC7.html)
AR (1) AR065794A1 (cg-RX-API-DMAC7.html)
AT (1) ATE524472T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008228303B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0809088A2 (cg-RX-API-DMAC7.html)
CA (1) CA2680757A1 (cg-RX-API-DMAC7.html)
CL (1) CL2008000785A1 (cg-RX-API-DMAC7.html)
CY (1) CY1112102T1 (cg-RX-API-DMAC7.html)
DK (1) DK2139892T3 (cg-RX-API-DMAC7.html)
ES (1) ES2371832T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20110807T1 (cg-RX-API-DMAC7.html)
IL (1) IL200617A (cg-RX-API-DMAC7.html)
MX (1) MX2009010034A (cg-RX-API-DMAC7.html)
PE (1) PE20120495A1 (cg-RX-API-DMAC7.html)
PL (1) PL2139892T3 (cg-RX-API-DMAC7.html)
PT (1) PT2139892E (cg-RX-API-DMAC7.html)
SI (1) SI2139892T1 (cg-RX-API-DMAC7.html)
TW (1) TWI363629B (cg-RX-API-DMAC7.html)
WO (1) WO2008113711A1 (cg-RX-API-DMAC7.html)

Families Citing this family (35)

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WO2009023269A2 (en) * 2007-08-15 2009-02-19 Vertex Pharmaceuticals Incorporated 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5h-pyrimido [4, 5-b[1, 4] diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases
AU2008304417B2 (en) * 2007-09-25 2013-07-18 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
CA2700979C (en) * 2007-09-28 2017-06-20 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
US20090291938A1 (en) * 2007-11-19 2009-11-26 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
EP2303889A1 (en) * 2008-06-18 2011-04-06 F. Hoffmann-La Roche AG Halo-substituted pyrimidodiazepines as plkl inhibitors
CN103497192B (zh) 2008-12-09 2015-09-23 吉里德科学公司 Toll样受体调节剂
EP3828185B1 (en) 2009-01-06 2024-11-20 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
PL2442809T3 (pl) 2009-06-17 2017-02-28 Vertex Pharmaceuticals Incorporated Inhibitory replikacji wirusów grypy
JP5763077B2 (ja) 2009-09-14 2015-08-12 ギリアード サイエンシーズ， インコーポレイテッド トール様受容体のモジュレーター
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2014145909A2 (en) 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
EP3024327B1 (en) 2013-07-25 2019-09-04 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
EP3421468B1 (en) 2013-11-13 2020-11-04 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
RU2016134947A (ru) 2014-01-31 2018-03-01 Дана-Фарбер Кансер Институт, Инк. Производные диаминопиримидин бензолсульфона и их применение
JP6522732B2 (ja) 2014-07-11 2019-05-29 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを治療するためのトール様受容体の調節因子
WO2016022902A1 (en) 2014-08-08 2016-02-11 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
KR20190125537A (ko) 2014-09-16 2019-11-06 길리애드 사이언시즈, 인코포레이티드 톨-유사 수용체 조정제의 고체 형태
JP6373490B2 (ja) 2014-09-16 2018-08-15 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体モジュレーターを調製する方法
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CR20180199A (es) 2015-09-11 2018-05-25 Dana Farber Cancer Inst Inc Acetamida tienotriazolodiazepinas y usos de las mismas
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
BR112018009798A8 (pt) 2015-11-25 2019-02-26 Dana Farber Cancer Inst Inc inibidores de bromodomínio bivalentes e usos dos mesmos
JP6968819B2 (ja) * 2016-04-07 2021-11-17 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッドDana−Farber Cancer Institute, Inc. ピリミド−ジアゼピノンキナーゼ骨格化合物およびｐｉ３ｋ媒介性障害の治療方法
EP4034132A4 (en) * 2019-09-27 2023-10-11 Dana-Farber Cancer Institute, Inc. Erk5 degraders as therapeutics in cancer and inflammatory diseases
US20230158158A1 (en) * 2020-03-27 2023-05-25 Uppthera Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
WO2023018237A1 (en) * 2021-08-10 2023-02-16 Uppthera, Inc. Novel plk1 degradation inducing compound
GB202313514D0 (en) 2023-09-05 2023-10-18 Cambridge Entpr Ltd Treatment of inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL354241A1 (en) * 1999-09-17 2003-12-29 Abbott Gmbh & Co.Kgabbott Gmbh & Co.Kg Kinase inhibitors as therapeutic agents
WO2003020722A1 (de) * 2001-09-04 2003-03-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
NZ570530A (en) * 2006-02-14 2011-09-30 Vertex Pharma Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives
TW200808325A (en) 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
JP2010521514A (ja) 2010-06-24
EP2139892A1 (en) 2010-01-06
PT2139892E (pt) 2011-11-21
SI2139892T1 (sl) 2011-12-30
ATE524472T1 (de) 2011-09-15
AU2008228303B2 (en) 2012-04-19
EP2139892B1 (en) 2011-09-14
PE20120495A1 (es) 2012-05-12
PL2139892T3 (pl) 2012-03-30
TW200843781A (en) 2008-11-16
DK2139892T3 (da) 2011-12-12
US20080234255A1 (en) 2008-09-25
CY1112102T1 (el) 2015-11-04
CN101636399A (zh) 2010-01-27
IL200617A0 (en) 2010-05-17
BRPI0809088A2 (pt) 2014-09-09
ES2371832T3 (es) 2012-01-10
CN101636399B (zh) 2012-04-18
CA2680757A1 (en) 2008-09-25
JP5087640B2 (ja) 2012-12-05
KR20090119913A (ko) 2009-11-20
KR101157848B1 (ko) 2012-07-11
TWI363629B (en) 2012-05-11
HRP20110807T1 (hr) 2011-12-31
MX2009010034A (es) 2009-10-12
CN102746175B (zh) 2014-01-15
CL2008000785A1 (es) 2009-03-27
HK1139936A1 (en) 2010-09-30
IL200617A (en) 2014-02-27
WO2008113711A1 (en) 2008-09-25
AU2008228303A1 (en) 2008-09-25
US7517873B2 (en) 2009-04-14
CN102746175A (zh) 2012-10-24

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