PE20110206A1 - Derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Info

Publication number
PE20110206A1
PE20110206A1 PE2010000465A PE2010000465A PE20110206A1 PE 20110206 A1 PE20110206 A1 PE 20110206A1 PE 2010000465 A PE2010000465 A PE 2010000465A PE 2010000465 A PE2010000465 A PE 2010000465A PE 20110206 A1 PE20110206 A1 PE 20110206A1
Authority
PE
Peru
Prior art keywords
diona
indol
dihydro
oxo
atoms
Prior art date
Application number
PE2010000465A
Other languages
English (en)
Inventor
Jean-Claude Ortuno
Jean-Michel Lacoste
Michael Burbridge
Alain Pierre
Alexis Cordi
Imre Fejes
John Hickman
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PE20110206A1 publication Critical patent/PE20110206A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Storage Device Security (AREA)
  • Computer And Data Communications (AREA)

Abstract

REFERIDA A UN DERIVADO DE DIHIDROINDOLONA DE FORMULA (I), DONDE m Y n SON 1 O 2; A ES PIRROLILO NO SUSTITUIDO O SUSTITUIDO POR 1 A 3 ALQUILO C1-C6 LINEALES O RAMIFICADOS; X ES C(O), S(O) O SO2; R1 Y R2 SON ALQUILO C1-C6 O JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO MONO O BICICLICO DE 5 A 8 ATOMOS CON HETEROATOMOS TALES COMO N, O Y S; R3 Y R4 FORMAN JUNTO CON LOS ATOMOS A LOS QUE ESTAN UNIDOS UN HETEROCICLO MONO O BICICLICO DE 5 A 8 ATOMOS CON HETEROATOMOS TALES COMO N, O Y S; R5 ES H O ALQUILO C1-C6 LINEAL O RAMIFICADO; R6 ES H O HALOGENO. SON COMPUESTOS PREFERIDOS: 3-[(3-{[4-(4-MORFOLINILMETIL)-1H-PIRROL-2-IL]METILEN}-2-OXO-2,3-DIHIDRO-1H-INDOL-5-IL)METIL]-1,3-TIAZOLIDIN-2,4-DIONA, 3-[((3Z)-3-{[4-(4-MORFOLINILMETIL)-1H-PIRROL-2-IL]METILEN}-2-OXO-2,3-DIHIDRO-1H-INDOL-5-IL)METIL]-1,3-TIAZOLIDIN-2,4-DIONA, 3-[3-(4-MORFOLIN-4-ILMETIL-1H-PIRROL-2-ILMETILEN)-2-OXO-2,3-DIHIDRO-1H-INDOL-5-ILMETIL]-OXAZOLIDIN-2,4-DIONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA MIGRACION DE CELULAS CANCEROSAS Y SON UTILES EN EL TRATAMIENTO DEL CANCER, PRINCIPALMENTE, EN TUMORES SOLIDOS METASTASICOS
PE2010000465A 2009-08-04 2010-07-21 Derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen PE20110206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903839A FR2948940B1 (fr) 2009-08-04 2009-08-04 Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
PE20110206A1 true PE20110206A1 (es) 2011-04-09

Family

ID=41796204

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2010000465A PE20110206A1 (es) 2009-08-04 2010-07-21 Derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (43)

Country Link
US (3) US8133889B2 (es)
EP (1) EP2281822B1 (es)
JP (2) JP5475588B2 (es)
KR (1) KR101309101B1 (es)
CN (1) CN101987848B (es)
AP (1) AP2756A (es)
AR (1) AR077510A1 (es)
AU (1) AU2010203305B2 (es)
BR (1) BRPI1003241A2 (es)
CA (1) CA2710224C (es)
CL (1) CL2010000804A1 (es)
CO (1) CO6320143A1 (es)
CU (1) CU23921B1 (es)
CY (1) CY1113914T1 (es)
DK (1) DK2281822T3 (es)
EA (1) EA019481B1 (es)
EC (1) ECSP10010380A (es)
ES (1) ES2403227T3 (es)
FR (1) FR2948940B1 (es)
GE (1) GEP20125548B (es)
HK (1) HK1155742A1 (es)
HN (1) HN2010001537A (es)
HR (1) HRP20130327T1 (es)
IL (1) IL207183A (es)
JO (1) JO2808B1 (es)
MA (1) MA32184B1 (es)
ME (1) ME01491B (es)
MX (1) MX2010008557A (es)
MY (1) MY183326A (es)
NI (1) NI201000134A (es)
NZ (1) NZ586993A (es)
PE (1) PE20110206A1 (es)
PL (1) PL2281822T3 (es)
PT (1) PT2281822E (es)
RS (1) RS52701B (es)
SA (1) SA110310634B1 (es)
SG (1) SG168499A1 (es)
SI (1) SI2281822T1 (es)
TW (1) TWI408138B (es)
UA (1) UA105357C2 (es)
UY (1) UY32801A (es)
WO (1) WO2011015728A1 (es)
ZA (1) ZA201005424B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008411B1 (fr) * 2013-07-12 2015-07-03 Servier Lab Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent
US10245270B2 (en) * 2013-07-12 2019-04-02 Les Laboratoires Servier Salt of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, its preparation, and formulations containing it
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
FR3039401B1 (fr) * 2015-07-31 2018-07-13 Les Laboratoires Servier Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr
US10343991B2 (en) * 2016-11-02 2019-07-09 Council Of Scientific & Industrial Research C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof
JOP20200024A1 (ar) * 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
CA3071795A1 (en) 2017-08-04 2019-02-07 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
CN113845524B (zh) * 2021-10-29 2023-11-07 四川农业大学 一种螺吡咯吲哚酮类化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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JPH0892248A (ja) * 1994-09-26 1996-04-09 Yamanouchi Pharmaceut Co Ltd インドリノン誘導体
CA2383623A1 (en) * 1998-08-04 2000-02-17 Sugen, Inc. 3-methylidenyl-2-indolinone modulators of protein kinase
BR9916327A (pt) * 1998-12-17 2001-09-18 Hoffmann La Roche Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
EP1194539A2 (en) 1999-06-25 2002-04-10 Universität Zürich Hetero-associating coiled-coil peptides and screening method therefor
AU2001239770B2 (en) * 2000-02-15 2006-01-05 Pharmacia & Upjohn Company Pyrrole substituted 2-indolinone protein kinase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2003057690A1 (en) * 2001-12-27 2003-07-17 Theravance, Inc. Indolinone derivatives useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
MXPA06004438A (es) * 2003-10-24 2006-06-20 Schering Ag Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer.
US7378530B2 (en) 2005-02-22 2008-05-27 Nereus Pharmaceuticals, Inc. Anti-cancer and anti-microbial 5-membered heterocyclic compounds
EP1971333A4 (en) * 2005-12-29 2009-05-20 Scripps Research Inst AMINO ACID DERIVATIVES OF PROTEIN KINASE INHIBITORS ON INDOLINONE BASE
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
JO2808B1 (en) 2014-09-15
US20130331380A1 (en) 2013-12-12
PL2281822T3 (pl) 2013-06-28
US20110034460A1 (en) 2011-02-10
SG168499A1 (en) 2011-02-28
ZA201005424B (en) 2011-04-28
SA110310634B1 (ar) 2013-11-10
MA32184B1 (fr) 2011-04-01
CA2710224A1 (fr) 2011-02-04
JP2011037848A (ja) 2011-02-24
CU20100157A7 (es) 2012-03-15
HK1155742A1 (en) 2012-05-25
US8541412B2 (en) 2013-09-24
AU2010203305A1 (en) 2011-02-24
NI201000134A (es) 2014-02-11
IL207183A (en) 2014-01-30
EP2281822A1 (fr) 2011-02-09
ME01491B (me) 2014-04-20
JP2013116908A (ja) 2013-06-13
US8653073B2 (en) 2014-02-18
ECSP10010380A (es) 2011-03-31
NZ586993A (en) 2012-01-12
KR20110014116A (ko) 2011-02-10
US8133889B2 (en) 2012-03-13
CN101987848B (zh) 2014-06-18
AU2010203305B2 (en) 2015-02-05
EP2281822B1 (fr) 2013-01-16
MY183326A (en) 2021-02-18
KR101309101B1 (ko) 2013-09-16
MX2010008557A (es) 2011-02-03
CL2010000804A1 (es) 2011-08-26
WO2011015728A1 (fr) 2011-02-10
CN101987848A (zh) 2011-03-23
HRP20130327T1 (hr) 2013-05-31
RS52701B (en) 2013-08-30
SI2281822T1 (sl) 2013-04-30
DK2281822T3 (da) 2013-04-22
CY1113914T1 (el) 2016-07-27
PT2281822E (pt) 2013-02-27
FR2948940A1 (fr) 2011-02-11
AR077510A1 (es) 2011-08-31
TW201118092A (en) 2011-06-01
JP5538580B2 (ja) 2014-07-02
AP2010005343A0 (en) 2010-08-31
UA105357C2 (uk) 2014-05-12
CO6320143A1 (es) 2011-09-20
EA201001087A1 (ru) 2011-04-29
EA019481B1 (ru) 2014-04-30
TWI408138B (zh) 2013-09-11
HN2010001537A (es) 2013-05-06
AP2756A (en) 2013-09-30
ES2403227T3 (es) 2013-05-16
UY32801A (es) 2011-01-31
BRPI1003241A2 (pt) 2012-04-10
IL207183A0 (en) 2010-12-30
CA2710224C (fr) 2013-01-08
JP5475588B2 (ja) 2014-04-16
FR2948940B1 (fr) 2011-07-22
CU23921B1 (es) 2013-07-31
GEP20125548B (en) 2012-05-25
US20120046287A1 (en) 2012-02-23

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