AR065335A1 - Combinaciones de agentes terapeuticos para el tratamiento de cancer - Google Patents

Combinaciones de agentes terapeuticos para el tratamiento de cancer

Info

Publication number
AR065335A1
AR065335A1 ARP080100618A ARP080100618A AR065335A1 AR 065335 A1 AR065335 A1 AR 065335A1 AR P080100618 A ARP080100618 A AR P080100618A AR P080100618 A ARP080100618 A AR P080100618A AR 065335 A1 AR065335 A1 AR 065335A1
Authority
AR
Argentina
Prior art keywords
inhibitor
kinase
tyrosine
kinase inhibitor
protein
Prior art date
Application number
ARP080100618A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR065335A1 publication Critical patent/AR065335A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/548—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Combinacion que comprende la N-hidroxi-3-[4-[[[2-(2-metil-1H-indol-3-iI)-etil]-amino]-metil]-fenil]-2E-2-propenamida; y uno o más agentes farmacéuticamente activos; a composiciones farmacéuticas que comprenden esta combinacion; a métodos detratamiento que comprenden esta combinacion; a procesos para elaborar dicha combinacion; y a un paquete comercial que comprende la combinacion mencionada. Reivindicacion 1: Una combinacion de: (a) N-hidroxi-3-[4-[[[2-(2-metil-1H-indol-3-il)-etiI]-amino]-metil]-fenil}-2E-2-propenamida; y (b) uno o más agentes farmacéuticamente activos seleccionados a partir del grupo que consiste en: Un inhibidor de la enzima convertidora de angiotensina, Un inhibidor de la cinasa de adenosina; Un adyuvante;Un antagonista de la corteza adrenal; Un inhibidor de la senda de AKT; Un agente alquilante; Un inhibidor de angiogénesis; Un esteroide angiostático; Un anti-androgeno; Un anti-estrogeno; Un agente anti-hipercalcemia; Un compuesto anti-leucémico; Unanti-metabolito; Un anticuerpo anti-proliferativo; Un inductor de apoptosis; Un antagonista del receptor AT1; Un inhibidor de la cinasa aurora; Un inhibidor de aromatasa; Un modificador de la respuesta biologica; Un bisfosfonato; Un inhibidor de lacinasa de tirosina de Bruton (BTK); Un inhibidor de calcineurina; Un inhibidor de la cinasa CaM II; Un inhibidor de la fosfatasa de tirosina CD45; Un inhibidor de la fosfatasa CDC25; Un inhibidor de CYP3A4; Un inhibidor de la cinasa CHK; Uncompuesto que dirige/reduce una actividad de cinasa de proteína o de lípido, o una actividad de fosfatasa de proteína o de lípido, un compuesto antiangiogénico adicional, o un compuesto que induce los procesos de la diferenciacion celular; Un agentede control para regular genisteína, olomucina, y/o tirfostinas; Un inhibidor de ciclo-oxigenasa; Un inhibidor de la cinasa cRAF; Un inhibidor de la cinasa dependiente de ciclina; Un inhibidor de la proteasa de cisteína; Un intercalador de ADN; Unrompedor de cadena de ADN; Un inhibidor de la ligasa E3; Un enlazador de EDG; Una hormona endocrina; Compuestos que dirigen, reducen, o inhiben la actividad de la familia del factor de crecimiento epidérmico; Un inhibidor de la cinasa de tirosinareceptora del factor de crecimiento epidérmico, y receptora del factor de crecimiento derivado de plaquetas; Un inhibidor de farnesil-transferasa; Un inhibidor de la cinasa Flk-1; Un compuesto que dirige, reduce, o inhibe la actividad de Flt-3; Unagonista de gonadorelina; Un inhibidor de la cinasa de sintasa de glicogeno-3 (GSK3); Un inhibidor de heparanasa; Un agente utilizado en el tratamiento de malignidades hematologicas; Un inhibidor de la desacetilasa de histona (HDAC); Un inhibidor deHSP90; Un implante que contiene corticosteroides; Un inhibidor de la cinasa l-Kappa B-alfa (IKK); Un inhibidor de la cinasa de tirosina receptora de insulina; Un inhibidor de la cinasa de cinasa N-terminal c-Jun (JNK); Un agente de enlace demicrotubulo; Un inhibidor de cinasa de proteína activada por mitogeno (MAP); Un inhibidor de MDM2; Un inhibidor de MEK; Un inhibidor amino-peptidasa de metionina; Un inhibidor del inhibidor de metaloproteinasa de matriz (MMP); Un anticuerpomonoclonal; Un inhibidor de la cinasa de tirosina NGFR; Un inhibidor de la cinasa MAP p38, incluyendo un inhibidor de la cinasa SAPK2/p38; Un inhibidor de la cinasa de tirosina p56; Un inhibidor de la cinasa de tirosina receptora del factor decrecimiento derivado de plaquetas; Un inhibidor de la cinasa de fosfatidil-inositol-3; Un inhibidor de fosfatasa; Terapia fotodinámica; Un agente de platino; Un inhibidor de la fosfata de proteína, incluyendo un inhibidor de PP1 y PP2, y uninhibidor de la fosfatasa de tirosina; Un inhibidor de la cinasa C de proteína, y un inhibidor de la cinasa delta de la cinasa C de proteína; Un inhibidor de la síntesis de poliamina; Un inhibidor de proteasoma; Un inhibidor de PTP1B; Un inhibidorde la cinasa de proteína tirosina, incluyendo un inhibidor de la cinasa de tirosina de la familia SRC; un inhibidor de la cinasa de tirosina Syk; y un inhibidor de la cinasa de tirosina JAK-2 y/o JAK3; Un inhibidor de las isoformas oncogénicas Ras;Un retinoide; Un inhibidor de la reductasa de ribonucleotido; Un inhibidor de elongacion de la polimerasa de ARN II; Un inhibidor de la descarboxilasa de S-adenosil metionina; Un inhibidor de la cinasa de serina/treonina; Un compuesto que dirige,reduce, o inhibe la actividad/funcion de la cinasa mTOR de serina/treonina; Un antagonista del receptor de sornatostatina; Un inhibidor de la biosíntesis de esterol; Un inhibidor de telomerasa; Un inhibidor de topoisomerasa; Planteamientos que dananlas células tumorales; Un anticuerpo monoclonal del factor de crecimiento endotelial vascular o del receptor del factor de crecimiento endotelial vascular; Un inhibidor de la cinasa de tirosina receptora del factor de crecimiento endotelialvascular; y Un inhibidor de RANKL; y una mezcla de los mismos; para su uso simultáneo, concurrente, separado, o en secuencia en la prevencion o el tratamiento de una enfermedad proliferativa.
ARP080100618A 2007-02-15 2008-02-13 Combinaciones de agentes terapeuticos para el tratamiento de cancer AR065335A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89000507P 2007-02-15 2007-02-15

Publications (1)

Publication Number Publication Date
AR065335A1 true AR065335A1 (es) 2009-06-03

Family

ID=39560929

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100618A AR065335A1 (es) 2007-02-15 2008-02-13 Combinaciones de agentes terapeuticos para el tratamiento de cancer

Country Status (21)

Country Link
US (7) US20100069458A1 (es)
EP (3) EP2120900A2 (es)
JP (1) JP2010519209A (es)
KR (1) KR20090110913A (es)
CN (1) CN101626758A (es)
AR (1) AR065335A1 (es)
AU (1) AU2008216327A1 (es)
BR (1) BRPI0807812A2 (es)
CA (1) CA2677651A1 (es)
CL (1) CL2008000470A1 (es)
CO (1) CO6220928A2 (es)
EC (1) ECSP099576A (es)
IL (1) IL200193A0 (es)
MA (1) MA31205B1 (es)
MX (1) MX2009008584A (es)
PE (1) PE20090519A1 (es)
RU (1) RU2009134223A (es)
TN (1) TN2009000344A1 (es)
TW (1) TW200848022A (es)
WO (1) WO2008100985A2 (es)
ZA (1) ZA200905159B (es)

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US20180071251A1 (en) 2018-03-15
MA31205B1 (fr) 2010-02-01
CA2677651A1 (en) 2008-08-21
EP2491923A2 (en) 2012-08-29
US20180289670A1 (en) 2018-10-11
RU2009134223A (ru) 2011-03-20
EP2359818A1 (en) 2011-08-24
ZA200905159B (en) 2010-05-26
CO6220928A2 (es) 2010-11-19
US20150094274A1 (en) 2015-04-02
US20100069458A1 (en) 2010-03-18
US20130029927A1 (en) 2013-01-31
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US20170246147A1 (en) 2017-08-31
KR20090110913A (ko) 2009-10-23
EP2120900A2 (en) 2009-11-25
AU2008216327A1 (en) 2008-08-21
CN101626758A (zh) 2010-01-13
WO2008100985A2 (en) 2008-08-21
IL200193A0 (en) 2010-04-15
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BRPI0807812A2 (pt) 2020-06-23

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