CO6220928A2 - Combinaciones que comprenden n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)-etil]-amino]metil]fenil]-2e-2-propenamida; y uno omas agentes farmaceuticamente activos; composiciones que los contienen y procesos para fabricar dichas combinaciones - Google Patents

Combinaciones que comprenden n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)-etil]-amino]metil]fenil]-2e-2-propenamida; y uno omas agentes farmaceuticamente activos; composiciones que los contienen y procesos para fabricar dichas combinaciones

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Publication number
CO6220928A2
CO6220928A2 CO09085032A CO09085032A CO6220928A2 CO 6220928 A2 CO6220928 A2 CO 6220928A2 CO 09085032 A CO09085032 A CO 09085032A CO 09085032 A CO09085032 A CO 09085032A CO 6220928 A2 CO6220928 A2 CO 6220928A2
Authority
CO
Colombia
Prior art keywords
inhibitor
methyl
combinations
kinase inhibitor
compound
Prior art date
Application number
CO09085032A
Other languages
English (en)
Inventor
Peter Wisdom Atadja
Wenlin Shao
Kapil N Bhalla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6220928A2 publication Critical patent/CO6220928A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/548—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Una combinación de: (a) N-hidroxi-3-[4-[[[2-(2-metil-1H-indol-3-il)-etil]- amino]-metil]-fenil]-2E-2-propenamida; y (b) uno o más agentes farmacéuticamente activos seleccionados a partir del grupo que consiste en: i. Un inhibidor de la enzima convertidora de angiotensina; ii. Un inhibidor de la cinasa de adenosina; iii. Un adyuvante; iv. Un antagonista de la corteza adrenal; v. Un inhibidor de la senda de AKT; vi. Un agente alquilante; vii. Un inhibidor de angiogénesis; viii. Un esteroide angiostático; ix. Un anti-andrógeno; x. Un anti-estrógeno xi. Un agente anti-hipercalcemia; xii. Un compuesto anti-leucémico; xiii. Un anti-metabolito; xiv. Un anticuerpo anti-proliferativo; xv. Un inductor de apoptosis; xvi. Un antagonista del receptor AT1; xvii. Un inhibidor de la cinasa aurora; xviii. Un inhibidor de aromatasa; xix. Un modificador de la respuesta biológica; xx, Un bisfosfonato; xxi. Un inhibidor de la cinasa de tirosina de Bruton (BTK);xxii. Un inhibidor de calcineurina; xxiii. Un inhibidor de la cinasa CaM II; xxiv. Un inhibidor de la fosfatasa de tirosina CD45; xxv. Un inhibidor de la fosfatasa CDC25; xxvi. Un inhibidor de CYP3A4; xxvii. Un inhibidor de la cinasa CHK; xxviii. Un compuesto que dirige/reduce una actividad de cinasa de proteína o de lípido, o una actividad de fosfatasa de proteína o de lípido, un compuesto anti-angiogénico adicional, o un compuesto que induce los procesos de la diferenciación celular; xxix, Un agente de control para regular genisteína, olomucina, y/o tirfostinas; xxx. Un inhibidor de ciclo-oxigenasa; xxxi. Un inhibidor de la cinasa cRAF; xxxii. Un inhibidor de la cinasa dependiente de ciclina; xxxiii. Un inhibidor de la proteasa de cisteína; xxxiv. Un intercalador de ADN; xxxv. Un rompedor de cadena de ADN; xxxvi. Un inhibidor de la ligasa E3; ...
CO09085032A 2007-02-15 2009-08-13 Combinaciones que comprenden n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)-etil]-amino]metil]fenil]-2e-2-propenamida; y uno omas agentes farmaceuticamente activos; composiciones que los contienen y procesos para fabricar dichas combinaciones CO6220928A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89000507P 2007-02-15 2007-02-15

Publications (1)

Publication Number Publication Date
CO6220928A2 true CO6220928A2 (es) 2010-11-19

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ID=39560929

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09085032A CO6220928A2 (es) 2007-02-15 2009-08-13 Combinaciones que comprenden n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)-etil]-amino]metil]fenil]-2e-2-propenamida; y uno omas agentes farmaceuticamente activos; composiciones que los contienen y procesos para fabricar dichas combinaciones

Country Status (21)

Country Link
US (7) US20100069458A1 (es)
EP (3) EP2120900A2 (es)
JP (1) JP2010519209A (es)
KR (1) KR20090110913A (es)
CN (1) CN101626758A (es)
AR (1) AR065335A1 (es)
AU (1) AU2008216327A1 (es)
BR (1) BRPI0807812A2 (es)
CA (1) CA2677651A1 (es)
CL (1) CL2008000470A1 (es)
CO (1) CO6220928A2 (es)
EC (1) ECSP099576A (es)
IL (1) IL200193A0 (es)
MA (1) MA31205B1 (es)
MX (1) MX2009008584A (es)
PE (1) PE20090519A1 (es)
RU (1) RU2009134223A (es)
TN (1) TN2009000344A1 (es)
TW (1) TW200848022A (es)
WO (1) WO2008100985A2 (es)
ZA (1) ZA200905159B (es)

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US20100069458A1 (en) 2010-03-18
US20180071251A1 (en) 2018-03-15
IL200193A0 (en) 2010-04-15
EP2120900A2 (en) 2009-11-25
US20170027909A1 (en) 2017-02-02
MA31205B1 (fr) 2010-02-01
CL2008000470A1 (es) 2008-08-29
CA2677651A1 (en) 2008-08-21
WO2008100985A3 (en) 2008-10-30
ZA200905159B (en) 2010-05-26
PE20090519A1 (es) 2009-05-29
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ECSP099576A (es) 2009-09-29
CN101626758A (zh) 2010-01-13
RU2009134223A (ru) 2011-03-20
EP2491923A3 (en) 2012-12-26
JP2010519209A (ja) 2010-06-03
US20170246147A1 (en) 2017-08-31
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BRPI0807812A2 (pt) 2020-06-23

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