AR063692A1 - Procedimiento de preparacion de compuestos antagonistas de cgrp(peptido relacionado con el gen de la calcitonina) - Google Patents
Procedimiento de preparacion de compuestos antagonistas de cgrp(peptido relacionado con el gen de la calcitonina)Info
- Publication number
- AR063692A1 AR063692A1 ARP070103675A ARP070103675A AR063692A1 AR 063692 A1 AR063692 A1 AR 063692A1 AR P070103675 A ARP070103675 A AR P070103675A AR P070103675 A ARP070103675 A AR P070103675A AR 063692 A1 AR063692 A1 AR 063692A1
- Authority
- AR
- Argentina
- Prior art keywords
- general formula
- group
- benzyl
- compound
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Suspension/Interruption
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicación 1: Procedimiento para preparar compuestos de fórmula general (2) en la cual R1 significa un grupo de fórmula (3) en el cual R1.1 representa H, alquilo C1-3, C(O)-O-bencilo, C(O)-O-terc-butilo o bencilo, que comprende los pasos de: (a) acoplar un compuesto de fórmula general (4) en la cual R1 está definido como se ha indicado antes, y X significa un átomo de hidrógeno o un átomo metálico seleccionado del grupo consistente en litio, sodio y potasio, con un compuesto de fórmula general (5) en la cual R3 representa un radical de imidazol o de triazol, que está unido a través de un átomo de nitrógeno; (b) aislar un compuesto de fórmula general (1) obtenido en el paso (a), preferiblemente mediante cristalización en un disolvente, y (c) eventualmente recristalizar en un disolvente apropiado un sólido obtenido en el paso (b). Reivindicación 5: Procedimiento para preparar compuestos de fórmula general (1), en la cual R1 representa un grupo de fórmula (3), en el cual R1.1 representa H, alquilo C1-3, C(O)-O-bencilo, C(O)-O-terc-butilo o bencilo, y R2 significa una amina secundaria -NR2.1R2.2, pudiendo estar seleccionados R2.1 y R2.2, de manera independiente entre sí, del grupo consistente en alquilo C1-3 y bencilo, o bien pudiendo formar el grupo -NR2.1R2.2 en conjunto una amina cíclica, que puede estar seleccionada del grupo consistente en morfolin-4-ilo, 1-metilpiperazin-4-ilo, 1 -bencilpiperazin-4-ilo, 1-((alquil C1-3)-carbonil)-piperazin-4-ilo, 1- (t-butiloxicarbonil)-piperazin-4-ilo, 1-(benciloxicarbonil)-piperazin-4-ilo, piperidin-1-ilo y pirrolidin-1-ilo, sus sales y solvatos, que comprende los pasos de: (a) acoplar un compuesto de fórmula general (4) en la cual R1 está definido como se ha indicado antes, y X significa un átomo de hidrógeno o un átomo metálico seleccionado del grupo consistente en litio, sodio y potasio, o un hidrato del mismo, con un compuesto de fórmula general (5) en la cual R3 representa un radical de imidazol o de triazol, que está unido a través de un átomo de nitrógeno; (b) hacer reaccionar un producto originado en el paso (a), de fórmula general (2) en la cual R1 está definido como se ha indicado antes, con un compuesto de fórmula general (6) en la cual R2 está definido como se ha indicado antes; y (c) para preparar compuestos de fórmula general (1), en la cual R1.1 significa un átomo de hidrógeno, eventualmente se elimina a continuación un grupo protector presente de un compuesto de fórmula general (1), en la cual R1.1 representa uno de los grupos C(O)-O-bencilo, C(O)-O-terc-butilo o bencilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006039038A DE102006039038A1 (de) | 2006-08-19 | 2006-08-19 | Neues Herstellungsverfahren |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063692A1 true AR063692A1 (es) | 2009-02-11 |
Family
ID=38954945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103675A Suspension/Interruption AR063692A1 (es) | 2006-08-19 | 2007-08-17 | Procedimiento de preparacion de compuestos antagonistas de cgrp(peptido relacionado con el gen de la calcitonina) |
Country Status (17)
Country | Link |
---|---|
US (3) | US7696346B2 (es) |
EP (1) | EP2057142A2 (es) |
JP (2) | JP2010501517A (es) |
KR (1) | KR20090055004A (es) |
CN (1) | CN101600705A (es) |
AR (1) | AR063692A1 (es) |
AU (1) | AU2007287584A1 (es) |
BR (1) | BRPI0715822A2 (es) |
CA (1) | CA2661778A1 (es) |
CL (1) | CL2007002408A1 (es) |
DE (1) | DE102006039038A1 (es) |
IL (1) | IL197022A0 (es) |
MX (1) | MX2009001168A (es) |
RU (1) | RU2009109745A (es) |
TW (1) | TW200817344A (es) |
WO (1) | WO2008022962A2 (es) |
ZA (1) | ZA200810783B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010048138A1 (en) * | 2008-10-21 | 2010-04-29 | Boehringer Ingelheim International Gmbh | Synthesis of intermediates useful for the production of certain cgrp inhibitors and intermediates used in such synthesis |
JP7140347B2 (ja) * | 2016-06-09 | 2022-09-21 | 有機合成薬品工業株式会社 | 4-(ピペリジン-4-イル)モルホリンの製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5082847A (en) * | 1990-07-18 | 1992-01-21 | Syntex (U.S.A.) Inc. | Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility |
US7112594B2 (en) * | 2000-08-09 | 2006-09-26 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
CA2555594A1 (en) * | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica N.V. | Pyridazinones as antagonists of a4 integrins |
DE102004015723A1 (de) * | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
EP1770087A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
WO2008060568A2 (en) * | 2006-11-15 | 2008-05-22 | Neurogen Corporation | Amide-substituted aryl piperidines |
-
2006
- 2006-08-19 DE DE102006039038A patent/DE102006039038A1/de not_active Withdrawn
-
2007
- 2007-08-16 BR BRPI0715822-0A patent/BRPI0715822A2/pt not_active IP Right Cessation
- 2007-08-16 JP JP2009525031A patent/JP2010501517A/ja active Pending
- 2007-08-16 CA CA002661778A patent/CA2661778A1/en not_active Abandoned
- 2007-08-16 MX MX2009001168A patent/MX2009001168A/es unknown
- 2007-08-16 CN CNA2007800301882A patent/CN101600705A/zh active Pending
- 2007-08-16 KR KR1020097005684A patent/KR20090055004A/ko not_active Application Discontinuation
- 2007-08-16 EP EP07802657A patent/EP2057142A2/de not_active Withdrawn
- 2007-08-16 RU RU2009109745/04A patent/RU2009109745A/ru not_active Application Discontinuation
- 2007-08-16 WO PCT/EP2007/058526 patent/WO2008022962A2/de active Application Filing
- 2007-08-16 AU AU2007287584A patent/AU2007287584A1/en not_active Abandoned
- 2007-08-17 AR ARP070103675A patent/AR063692A1/es not_active Suspension/Interruption
- 2007-08-17 CL CL200702408A patent/CL2007002408A1/es unknown
- 2007-08-17 TW TW096130611A patent/TW200817344A/zh unknown
- 2007-08-17 US US11/840,397 patent/US7696346B2/en active Active
-
2008
- 2008-12-22 ZA ZA200810783A patent/ZA200810783B/xx unknown
-
2009
- 2009-02-12 IL IL197022A patent/IL197022A0/en unknown
-
2010
- 2010-02-23 US US12/710,605 patent/US8084634B2/en active Active
-
2011
- 2011-08-08 US US13/204,969 patent/US8119797B2/en active Active
-
2012
- 2012-05-28 JP JP2012121232A patent/JP2012232980A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2009109745A (ru) | 2010-09-27 |
EP2057142A2 (de) | 2009-05-13 |
JP2012232980A (ja) | 2012-11-29 |
US8084634B2 (en) | 2011-12-27 |
CL2007002408A1 (es) | 2008-05-16 |
CA2661778A1 (en) | 2008-02-28 |
WO2008022962A3 (de) | 2009-03-05 |
US7696346B2 (en) | 2010-04-13 |
MX2009001168A (es) | 2009-02-10 |
BRPI0715822A2 (pt) | 2013-07-23 |
KR20090055004A (ko) | 2009-06-01 |
US8119797B2 (en) | 2012-02-21 |
WO2008022962A2 (de) | 2008-02-28 |
US20100152439A1 (en) | 2010-06-17 |
US20110295000A1 (en) | 2011-12-01 |
DE102006039038A1 (de) | 2008-02-21 |
IL197022A0 (en) | 2009-11-18 |
ZA200810783B (en) | 2010-08-25 |
TW200817344A (en) | 2008-04-16 |
CN101600705A (zh) | 2009-12-09 |
AU2007287584A1 (en) | 2008-02-28 |
JP2010501517A (ja) | 2010-01-21 |
US20080045705A1 (en) | 2008-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2411239C2 (ru) | Органические соединения | |
NO331165B1 (no) | Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme for fremstilling av medikamenter | |
NO20091551L (no) | Derivater av 4-(2-amino-1-hydroksyetyl)fenyl som agonister for betta-2 adrenergisk reseptor | |
JP2015534574A5 (es) | ||
EA200970655A1 (ru) | 6-замещенные пиримидины, ингибирующие вич | |
AR007626A1 (es) | N-[4-(heteroaril-metil)fenil]-heteroarilaminas, composicion que las contiene, proceso para preparar dicha composicion y proceso para preparar dichos compuestos | |
JO2652B1 (en) | Compounds 5,4,2,1 Tetra Hydro-H3-benzazepine Method of preparation and pharmaceutical compounds containing | |
JP2015510886A5 (es) | ||
MX2018008131A (es) | Forma cristalina del inhibidor de la btk quinasa y metodo de preparacion de la misma. | |
MX2019012336A (es) | Compuestos inhibidores del transportador vesicular de monoaminas 2 (vmat2) y composiciones de los mismos. | |
NO20071697L (no) | N-2 Adamantanyl-2-fenoksy-acetamidderivater som 11-beta-hydroksysteroid-dehydrogenaseinhibitorer | |
HRP20211031T1 (hr) | Postupak za proizvodnju novog spoja koji sadrži dušik ili njegove soli i proizvodnja njihovog međuprodukta | |
MX2016006685A (es) | Compuestos heterociclicos de n-acilimino. | |
AR063576A1 (es) | Arilsulfonil- pirrolidinas como inhibidores 5-ht6 | |
PA8783601A1 (es) | Derivados de piperidina/piperazina | |
AR074862A1 (es) | Derivados de heterociclo biciclicos y sus metodos de uso | |
AR047531A1 (es) | Derivados 1h-tieno(2,3-c)pirazol utiles como inhibidores de quinasa | |
TW200637539A (en) | CTGF inhibitors | |
MX2012004089A (es) | Inhibidores de hsp90. | |
WO2005070924A8 (en) | Substituted quinolines and their use as mycobacterial inhibitors | |
RS54201B1 (en) | PROCEDURE FOR PREPARATION OF BIFENYL-2-ILCARBAMIC ACID | |
HUP0302770A2 (hu) | Tripeptidil peptidáz inhibitorok, eljárás az előállítására és ezeket tartalmazó gyógyszerkészítmények | |
MX2010001566A (es) | Derivado de aminopirazolamida. | |
AR057461A1 (es) | Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos | |
AR058405A1 (es) | Amidas inhibidoras de leucotrieno a4 hidrolasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |