WO2008022962A3 - Verfahren zur herstellung von n-piperidinyl-benzodiazepinen mit cgrp-antagonistischen eigenschaften - Google Patents

Verfahren zur herstellung von n-piperidinyl-benzodiazepinen mit cgrp-antagonistischen eigenschaften Download PDF

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Publication number
WO2008022962A3
WO2008022962A3 PCT/EP2007/058526 EP2007058526W WO2008022962A3 WO 2008022962 A3 WO2008022962 A3 WO 2008022962A3 EP 2007058526 W EP2007058526 W EP 2007058526W WO 2008022962 A3 WO2008022962 A3 WO 2008022962A3
Authority
WO
WIPO (PCT)
Prior art keywords
cgrp
benzodiazepines
piperidinyl
producing
antagonistic properties
Prior art date
Application number
PCT/EP2007/058526
Other languages
English (en)
French (fr)
Other versions
WO2008022962A2 (de
Inventor
Guenther Huchler
Werner Rall
Uwe Ries
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Guenther Huchler
Werner Rall
Uwe Ries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Guenther Huchler, Werner Rall, Uwe Ries filed Critical Boehringer Ingelheim Int
Priority to EP07802657A priority Critical patent/EP2057142A2/de
Priority to AU2007287584A priority patent/AU2007287584A1/en
Priority to BRPI0715822-0A priority patent/BRPI0715822A2/pt
Priority to MX2009001168A priority patent/MX2009001168A/es
Priority to JP2009525031A priority patent/JP2010501517A/ja
Priority to CA002661778A priority patent/CA2661778A1/en
Publication of WO2008022962A2 publication Critical patent/WO2008022962A2/de
Priority to IL197022A priority patent/IL197022A0/en
Publication of WO2008022962A3 publication Critical patent/WO2008022962A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Herstellung von Verbindungen der allgemeinen Formel (I), in der R1 und R2 wie in Anspruch 1 definiert sind, deren pharmazeutisch verträglichen Salze und den Solvaten davon, die ausgehend von Verbindungen der allgemeinen Formel (II), in der R1 wie in Anspruch 1 definiert ist, hergestellt werden können.
PCT/EP2007/058526 2006-08-19 2007-08-16 Verfahren zur herstellung von n-piperidinyl-benzodiazepinen mit cgrp-antagonistischen eigenschaften WO2008022962A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP07802657A EP2057142A2 (de) 2006-08-19 2007-08-16 Verfahren zur herstellung von n-piperidinyl-benzodiazepinen mit cgrp-antagonistischen eigenschaften
AU2007287584A AU2007287584A1 (en) 2006-08-19 2007-08-16 Method for producing N-piperidinyl-benzodiazepines having CGRP-antagonistic properties
BRPI0715822-0A BRPI0715822A2 (pt) 2006-08-19 2007-08-16 processo de preparaÇço
MX2009001168A MX2009001168A (es) 2006-08-19 2007-08-16 Nuevo procedimiento de preparacion.
JP2009525031A JP2010501517A (ja) 2006-08-19 2007-08-16 新規製造方法
CA002661778A CA2661778A1 (en) 2006-08-19 2007-08-16 New production method
IL197022A IL197022A0 (en) 2006-08-19 2009-02-12 Novel preparation method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006039038A DE102006039038A1 (de) 2006-08-19 2006-08-19 Neues Herstellungsverfahren
DE102006039038.5 2006-08-19

Publications (2)

Publication Number Publication Date
WO2008022962A2 WO2008022962A2 (de) 2008-02-28
WO2008022962A3 true WO2008022962A3 (de) 2009-03-05

Family

ID=38954945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/058526 WO2008022962A2 (de) 2006-08-19 2007-08-16 Verfahren zur herstellung von n-piperidinyl-benzodiazepinen mit cgrp-antagonistischen eigenschaften

Country Status (17)

Country Link
US (3) US7696346B2 (de)
EP (1) EP2057142A2 (de)
JP (2) JP2010501517A (de)
KR (1) KR20090055004A (de)
CN (1) CN101600705A (de)
AR (1) AR063692A1 (de)
AU (1) AU2007287584A1 (de)
BR (1) BRPI0715822A2 (de)
CA (1) CA2661778A1 (de)
CL (1) CL2007002408A1 (de)
DE (1) DE102006039038A1 (de)
IL (1) IL197022A0 (de)
MX (1) MX2009001168A (de)
RU (1) RU2009109745A (de)
TW (1) TW200817344A (de)
WO (1) WO2008022962A2 (de)
ZA (1) ZA200810783B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048138A1 (en) * 2008-10-21 2010-04-29 Boehringer Ingelheim International Gmbh Synthesis of intermediates useful for the production of certain cgrp inhibitors and intermediates used in such synthesis
JP7140347B2 (ja) * 2016-06-09 2022-09-21 有機合成薬品工業株式会社 ４－（ピペリジン－４－イル）モルホリンの製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310488A1 (de) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
WO2005092880A1 (de) * 2004-03-29 2005-10-06 Boehringer Ingelheim International Gmbh Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
EP1770087A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2008060568A2 (en) * 2006-11-15 2008-05-22 Neurogen Corporation Amide-substituted aryl piperidines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082847A (en) * 1990-07-18 1992-01-21 Syntex (U.S.A.) Inc. Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
CA2555594A1 (en) * 2004-02-10 2005-08-25 Janssen Pharmaceutica N.V. Pyridazinones as antagonists of a4 integrins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310488A1 (de) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Kondensierte bizyklische amidverbindungen und ihre medizinische verwendung
WO2005092880A1 (de) * 2004-03-29 2005-10-06 Boehringer Ingelheim International Gmbh Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
EP1770087A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2008060568A2 (en) * 2006-11-15 2008-05-22 Neurogen Corporation Amide-substituted aryl piperidines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHE DARDONVILLE, ISABEL ROZAS, PILAR GOYA, ROCIO GIRON, CARLOS GOICOECHEA, MA. ISABEL ,MARTINI: "Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2003, pages 1283 - 1291, XP002508636 *
H. A. STAAB, W. ROHR: "Syntheses using Heterocyclic Amides (Azolides)", NEWER METHODS PREP. ORG. CHEM., vol. 5, 1968, pages 61 - 108, XP009095624 *
PAULINE C. TING, JOE F. LEE, JOHN C. ANTHES, NENG-YANG SHIH, JOHN J. PIWINSKI: "Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 491 - 494, XP002508634 *
RICHARD F. BORCH, MARK. D. BERNSTEIN, H. DUPONT DURST: "The cyanohydridoborate anion as a selective reducing agent", J. AM. CHEM. SOC., vol. 93, no. 12, 1971, pages 2897 - 2904, XP002508635 *

Also Published As

Publication number Publication date
RU2009109745A (ru) 2010-09-27
EP2057142A2 (de) 2009-05-13
JP2012232980A (ja) 2012-11-29
US8084634B2 (en) 2011-12-27
CL2007002408A1 (es) 2008-05-16
CA2661778A1 (en) 2008-02-28
US7696346B2 (en) 2010-04-13
MX2009001168A (es) 2009-02-10
BRPI0715822A2 (pt) 2013-07-23
KR20090055004A (ko) 2009-06-01
US8119797B2 (en) 2012-02-21
WO2008022962A2 (de) 2008-02-28
US20100152439A1 (en) 2010-06-17
US20110295000A1 (en) 2011-12-01
DE102006039038A1 (de) 2008-02-21
IL197022A0 (en) 2009-11-18
ZA200810783B (en) 2010-08-25
TW200817344A (en) 2008-04-16
CN101600705A (zh) 2009-12-09
AU2007287584A1 (en) 2008-02-28
AR063692A1 (es) 2009-02-11
JP2010501517A (ja) 2010-01-21
US20080045705A1 (en) 2008-02-21

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