AR061627A1 - Formas de dosificacion solidas de valsartan, amlodipina, e hidroclorotiazida, y metodo para elaborarlas - Google Patents
Formas de dosificacion solidas de valsartan, amlodipina, e hidroclorotiazida, y metodo para elaborarlasInfo
- Publication number
- AR061627A1 AR061627A1 ARP070102798A ARP070102798A AR061627A1 AR 061627 A1 AR061627 A1 AR 061627A1 AR P070102798 A ARP070102798 A AR P070102798A AR P070102798 A ARP070102798 A AR P070102798A AR 061627 A1 AR061627 A1 AR 061627A1
- Authority
- AR
- Argentina
- Prior art keywords
- solid dosage
- valsartan
- mixed
- dosage forms
- hydroclorotiazida
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Reivindicacion 1: Una forma de dosificacion solida, la cual comprende: valsartan; amlodipina; hidroclorotiazida; y aditivos farmacéuticamente aceptables adecuados para la preparacion de las formas de dosificacion solidas de valsartan. Reivindicacion 14: Un método para la elaboracion de una forma de dosificacion solida, el cual comprende los pasos de: (a) mezclar valsartan, amlodipina, hidroclorotiazida, y aditivos farmacéuticamente aceptables, para formar un material mezclado; (b) tamizar el material mezclado para formar un material tamizado; (c) mezclar el material tamizado para formar un material mezclado/tamizado; (d) compactar el material mezclado/tamizado para formar un material compactado; (e) moler el material compactado para formar un material molido; (f) mezclar el material molido para formar un material mezclado/molido; y (g) comprimir el material mezclado/molido para formar una forma de dosificacion solida en una sola capa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80588306P | 2006-06-27 | 2006-06-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061627A1 true AR061627A1 (es) | 2008-09-10 |
Family
ID=38662673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102798A AR061627A1 (es) | 2006-06-27 | 2007-06-25 | Formas de dosificacion solidas de valsartan, amlodipina, e hidroclorotiazida, y metodo para elaborarlas |
Country Status (23)
Country | Link |
---|---|
US (2) | US20100003321A1 (es) |
EP (1) | EP2037893A2 (es) |
JP (1) | JP2009542709A (es) |
KR (1) | KR20090021191A (es) |
CN (2) | CN101478956B (es) |
AR (1) | AR061627A1 (es) |
AU (1) | AU2007265138A1 (es) |
BR (1) | BRPI0713785A2 (es) |
CA (1) | CA2654986A1 (es) |
CL (1) | CL2007001870A1 (es) |
EC (1) | ECSP088987A (es) |
HK (1) | HK1133818A1 (es) |
IL (1) | IL195797A0 (es) |
MA (1) | MA30529B1 (es) |
MX (1) | MX2008016532A (es) |
NO (1) | NO20090314L (es) |
NZ (1) | NZ573295A (es) |
PE (2) | PE20080991A1 (es) |
RU (1) | RU2449786C2 (es) |
TN (1) | TNSN08538A1 (es) |
TW (1) | TW200808379A (es) |
WO (1) | WO2008002905A2 (es) |
ZA (1) | ZA200810053B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3239B1 (ar) | 2008-09-22 | 2018-03-08 | Novartis Ag | تركيبات جالينية من مركبات عضوية |
WO2011001440A1 (en) * | 2009-07-03 | 2011-01-06 | Hetero Research Foundation | Pharmaceutical compositions of valsartan |
WO2011039108A2 (en) | 2009-09-30 | 2011-04-07 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives |
US10610489B2 (en) | 2009-10-02 | 2020-04-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof |
CN102091069A (zh) * | 2009-12-11 | 2011-06-15 | 浙江华海药业股份有限公司 | 缬沙坦和氨氯地平的复方制剂及其制备方法 |
CN101897675B (zh) * | 2010-02-10 | 2012-11-21 | 温士顿医药股份有限公司 | 含有凡尔沙坦或其药学上可接受的盐的固体剂型口服医药组成物 |
CN101829111B (zh) * | 2010-05-23 | 2014-12-17 | 浙江华海药业股份有限公司 | 含有缬沙坦的固体制剂及其制备方法 |
CN102716132B (zh) * | 2011-03-29 | 2015-09-30 | 石药集团中奇制药技术(石家庄)有限公司 | 复方氨氯地平/缬沙坦/氢氯噻嗪片及其制备方法 |
AU2012360935A1 (en) * | 2011-12-26 | 2014-07-17 | Novartis Ag | Tablets and dry-coated agents |
US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
CN102614190A (zh) * | 2012-04-17 | 2012-08-01 | 北京哈三联科技股份有限公司 | 含有缬沙坦、氨氯地平和氢氯噻嗪的片剂及其制备方法 |
JP6018420B2 (ja) * | 2012-06-05 | 2016-11-02 | ニプロ株式会社 | アンジオテンシンii受容体拮抗薬およびサイアザイド系利尿薬を含む医薬組成物 |
MX358211B (es) | 2012-07-23 | 2018-08-10 | Landsteiner Scient S A De C V | Una composición farmacéutica de liberación comprendiendo hidroclorotiazida, losartán y basilato de amlodipino. |
CN103655580B (zh) * | 2012-08-28 | 2017-12-01 | 海南中济医药科技有限公司 | 一种含有缬沙坦、苯磺酸氨氯地平和氢氯噻嗪的药物组合物及其制备方法 |
WO2014058047A1 (ja) * | 2012-10-12 | 2014-04-17 | 味の素株式会社 | カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤の製造方法 |
CN102846625A (zh) * | 2012-10-18 | 2013-01-02 | 海口华仕联医药科技有限公司 | 一种稳定的缬沙坦、氨氯地平和氢氯噻嗪的药物组合及其制备方法 |
US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US20140303098A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
AU2014255727B2 (en) | 2013-04-18 | 2019-07-25 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
CZ2013783A3 (cs) | 2013-10-08 | 2015-04-15 | Zentiva, K. S | Stabilní farmaceutická kompozice obsahující amlodipin a valsartan |
CN105106962A (zh) * | 2015-08-29 | 2015-12-02 | 西安力邦肇新生物科技有限公司 | 一种复方降压制剂及其应用 |
JP6411662B2 (ja) * | 2016-05-30 | 2018-10-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 固定容量配合剤 |
WO2018153513A1 (en) | 2017-02-27 | 2018-08-30 | Idorsia Pharmaceuticals Ltd | Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases |
US11382866B2 (en) * | 2017-07-06 | 2022-07-12 | Mankind Pharma Ltd. | Fixed dose pharmaceutical composition of valsartan and sacubitril |
WO2022132067A1 (en) * | 2020-12-18 | 2022-06-23 | Santa Farma Ilac Sanayii A.S. | Stable bilayer tablet compositions |
CN113171352A (zh) * | 2021-04-15 | 2021-07-27 | 海南锦瑞制药有限公司 | 一种沙坦类降压复方制剂的制备方法 |
GR1010320B (el) * | 2021-08-04 | 2022-10-11 | Win Medica Φαρμακευτικη Ανωνυμη Εταιρεια, | Στερεες φαρμακοτεχνικες μορφες ιρβεσαρτανης, υδροχλωροθειαζιδης και αμλοδιπινης |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057344A (en) * | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
EP0795327A1 (en) * | 1996-03-13 | 1997-09-17 | Pfizer Inc. | Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin |
RU2188636C2 (ru) * | 1998-03-26 | 2002-09-10 | Др. Редди'С Лабораторис Лтд. | Стабильный фармацевтический препарат, содержащий амлодипина безилат и атенолол |
EP1353727A2 (en) * | 2000-12-01 | 2003-10-22 | Novartis AG | Combinations of an angiotensin receptor antagonist and an anti-hypertensive drugor a statin, for the treatment of sexual dysfunction |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
UA78273C2 (en) * | 2002-01-16 | 2007-03-15 | Boehringer Ingelheim Pharma | Bilayer pharmaceutical tablet containing telmisartan and hydrochlorothiazide and method for producing thereof |
US6869970B2 (en) | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
AUPS236902A0 (en) * | 2002-05-16 | 2002-06-13 | Northern Sydney Area Health Service | Composition and method for treating hypertension |
EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
KR100580168B1 (ko) | 2003-03-21 | 2006-05-16 | 삼성전자주식회사 | 다중 홈 에이전트 제어장치 및 방법 |
WO2005070463A2 (en) | 2004-01-12 | 2005-08-04 | Sepracor, Inc. | Compositions comprising (s)-amlodipine malate and an angiotensin receptor blocker and methods of their use |
US7879352B2 (en) | 2004-05-21 | 2011-02-01 | Accu-Break Technologies, Inc. | Scored pharmaceutical tablets comprising a plurality of segments |
DK1814527T4 (da) * | 2004-11-05 | 2020-12-07 | Boehringer Ingelheim Int | Dobbeltlagstablet omfattende telmisartan og amlodipin |
CN100389830C (zh) * | 2005-05-08 | 2008-05-28 | 广州市施柏医药科技有限公司 | 一种治疗高血压的药物组合物 |
-
2007
- 2007-06-25 PE PE2007000810A patent/PE20080991A1/es not_active Application Discontinuation
- 2007-06-25 PE PE2011001722A patent/PE20120542A1/es not_active Application Discontinuation
- 2007-06-25 AR ARP070102798A patent/AR061627A1/es not_active Application Discontinuation
- 2007-06-26 MX MX2008016532A patent/MX2008016532A/es not_active Application Discontinuation
- 2007-06-26 CN CN200780024142XA patent/CN101478956B/zh active Active
- 2007-06-26 KR KR1020087031581A patent/KR20090021191A/ko not_active Application Discontinuation
- 2007-06-26 NZ NZ573295A patent/NZ573295A/en not_active IP Right Cessation
- 2007-06-26 AU AU2007265138A patent/AU2007265138A1/en not_active Abandoned
- 2007-06-26 WO PCT/US2007/072097 patent/WO2008002905A2/en active Application Filing
- 2007-06-26 TW TW096123057A patent/TW200808379A/zh unknown
- 2007-06-26 JP JP2009518503A patent/JP2009542709A/ja active Pending
- 2007-06-26 RU RU2009102273/15A patent/RU2449786C2/ru not_active IP Right Cessation
- 2007-06-26 US US11/915,096 patent/US20100003321A1/en not_active Abandoned
- 2007-06-26 EP EP07799032A patent/EP2037893A2/en not_active Ceased
- 2007-06-26 CN CN2013100435988A patent/CN103169711A/zh active Pending
- 2007-06-26 CA CA002654986A patent/CA2654986A1/en not_active Abandoned
- 2007-06-26 BR BRPI0713785-0A patent/BRPI0713785A2/pt not_active IP Right Cessation
- 2007-06-26 CL CL200701870A patent/CL2007001870A1/es unknown
-
2008
- 2008-11-26 ZA ZA200810053A patent/ZA200810053B/xx unknown
- 2008-12-08 IL IL195797A patent/IL195797A0/en unknown
- 2008-12-18 EC EC2008008987A patent/ECSP088987A/es unknown
- 2008-12-24 MA MA31506A patent/MA30529B1/fr unknown
- 2008-12-26 TN TNP2008000538A patent/TNSN08538A1/en unknown
-
2009
- 2009-01-20 NO NO20090314A patent/NO20090314L/no not_active Application Discontinuation
- 2009-11-11 HK HK09110531.6A patent/HK1133818A1/xx not_active IP Right Cessation
-
2012
- 2012-01-03 US US13/342,533 patent/US8475839B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2008002905A3 (en) | 2008-12-11 |
HK1133818A1 (en) | 2010-04-09 |
KR20090021191A (ko) | 2009-02-27 |
MX2008016532A (es) | 2009-01-19 |
US8475839B2 (en) | 2013-07-02 |
AU2007265138A1 (en) | 2008-01-03 |
WO2008002905A2 (en) | 2008-01-03 |
IL195797A0 (en) | 2009-09-01 |
CN103169711A (zh) | 2013-06-26 |
CN101478956A (zh) | 2009-07-08 |
ZA200810053B (en) | 2009-11-25 |
TNSN08538A1 (en) | 2010-04-14 |
US20100003321A1 (en) | 2010-01-07 |
US20120164218A1 (en) | 2012-06-28 |
EP2037893A2 (en) | 2009-03-25 |
RU2009102273A (ru) | 2010-08-10 |
RU2449786C2 (ru) | 2012-05-10 |
CA2654986A1 (en) | 2008-01-03 |
BRPI0713785A2 (pt) | 2012-10-30 |
MA30529B1 (fr) | 2009-06-01 |
CN101478956B (zh) | 2013-03-20 |
NO20090314L (no) | 2009-01-26 |
NZ573295A (en) | 2012-01-12 |
TW200808379A (en) | 2008-02-16 |
ECSP088987A (es) | 2009-01-30 |
JP2009542709A (ja) | 2009-12-03 |
PE20080991A1 (es) | 2008-09-05 |
CL2007001870A1 (es) | 2008-06-13 |
PE20120542A1 (es) | 2012-05-14 |
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