AR059604A1 - Anticuerpos contra il- 22 humana y usos para los mismos - Google Patents
Anticuerpos contra il- 22 humana y usos para los mismosInfo
- Publication number
- AR059604A1 AR059604A1 ARP070100742A ARP070100742A AR059604A1 AR 059604 A1 AR059604 A1 AR 059604A1 AR P070100742 A ARP070100742 A AR P070100742A AR P070100742 A ARP070100742 A AR P070100742A AR 059604 A1 AR059604 A1 AR 059604A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino acid
- antigen
- disorders
- acid sequence
- bind
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente proporciona anticuerpos humanos y fragmentos de los mismo que se aglutinan con antígeno que se aglutinan específicamente con interleucina-22 (IL - 22). Los anticuerpos pueden actuar como antagonistas de la actividad de IL- 22, modulando así las respuestas inmunes en general y aquellas mediadas por IL - 22 en particular. Las composiciones y métodos divulgados podrán ser utilizados, por ejemplo, en el diagnostico, tratamiento o prevencion de trastornos inflamatorios, enfermedades autoinmunes, alergías, choque séptico, trastornos infecciosos, rechazo de transplante, cáncer y otros trastornos del sistema inmune. Reivindicacion 1: Un anticuerpo aislado o fragmentado aglutinante con antígeno del mismo, que específicamente se aglutina con IL - 22, donde el anticuerpo o su fragmento aglutinante con antígeno, comprende una secuencia de aminoácido que es por lo menos el 95% idéntica a la secuencia de aminoácido mostrada menos el 95% idéntica a la secuencia de aminoácido mostrada en la SEQ ID NO: 5, 6, 7, 23, 24, 25, 41, 42, 43, 59, 60, 61, 77, 78, 79, 95, 96, 97, 113, 114, 115, 131, 132, 133, 149, 150, 151, 167, 168, 169, 185, 186, 187, 203, 204, 205, 221, 222, 223, 239, 240, 241, 257, 258, 259, 275, 276, 277, 293, 294, 295, 311, 312, 313, 329, 330, 331, 347, 348, 349, 365, 366, 367, 383, 384, 385, 401, 402, 403, 419, 420, 421, 437, 438, 439, 455, 456, 457, 473, 474, 475, 491, 492, 493, 509, 510, 511, 527, 528, 529, 545, 546, 547, 563, 564, 565, 581, 582, 583, 599, 600, 601, 617, 618, 619.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77459606P | 2006-02-21 | 2006-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059604A1 true AR059604A1 (es) | 2008-04-16 |
Family
ID=38236225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100742A AR059604A1 (es) | 2006-02-21 | 2007-02-22 | Anticuerpos contra il- 22 humana y usos para los mismos |
Country Status (32)
Country | Link |
---|---|
US (4) | US7901684B2 (es) |
EP (3) | EP3020729B1 (es) |
JP (1) | JP5150516B2 (es) |
KR (2) | KR20080113214A (es) |
CN (1) | CN101426816B (es) |
AR (1) | AR059604A1 (es) |
AT (1) | ATE538137T1 (es) |
AU (1) | AU2007217751B2 (es) |
BR (1) | BRPI0708101B8 (es) |
CA (1) | CA2643226C (es) |
CR (1) | CR10237A (es) |
DK (2) | DK1991584T3 (es) |
EC (1) | ECSP088751A (es) |
ES (2) | ES2377463T3 (es) |
HK (1) | HK1120813A1 (es) |
HN (1) | HN2008001292A (es) |
HU (1) | HUE044595T2 (es) |
IL (1) | IL193605A (es) |
MX (2) | MX337778B (es) |
MY (1) | MY146664A (es) |
NO (1) | NO20083715L (es) |
NZ (1) | NZ570878A (es) |
PE (1) | PE20080111A1 (es) |
PL (2) | PL3020729T3 (es) |
PT (2) | PT1991584E (es) |
RU (1) | RU2467016C2 (es) |
SA (1) | SA07280062B1 (es) |
SG (1) | SG172628A1 (es) |
SI (2) | SI1991584T1 (es) |
TW (1) | TWI417301B (es) |
WO (1) | WO2007098170A1 (es) |
ZA (1) | ZA200807278B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2357193B1 (en) * | 1999-04-28 | 2015-11-04 | Genetics Institute, LLC | Human GIL-19/AE289 proteins and polynucleotides encoding same |
AU2006342792A1 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to IL-22 and IL-22R |
TWI417301B (zh) * | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-22(il-22)之抗體及其用途 |
AU2009285585A1 (en) * | 2008-08-28 | 2010-03-04 | Wyeth Llc | Uses of IL-22, IL-17, and IL-1 family cytokines in autoimmune diseases |
WO2011022093A2 (en) | 2009-04-13 | 2011-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for detecting the presence of an analyte in a sample |
CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
CN106198715B (zh) | 2010-03-12 | 2020-01-10 | 小利兰·斯坦福大学托管委员会 | 基于磁性传感器的定量结合动力学分析 |
US20120114652A1 (en) * | 2010-05-03 | 2012-05-10 | Abbott Laboratories | Anti-pai-1 antibodies and methods of use thereof |
CN103382223B (zh) * | 2012-04-01 | 2015-06-10 | 上海益杰生物技术有限公司 | 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽 |
WO2014015133A1 (en) * | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
WO2014033252A1 (en) * | 2012-08-31 | 2014-03-06 | arGEN-X BV | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
EP3385277A1 (en) | 2013-03-15 | 2018-10-10 | F. Hoffmann-La Roche AG | Il-22 polypeptides and il-22 fc fusion proteins and methods of use |
CN105139918B (zh) * | 2015-06-26 | 2017-04-12 | 哈尔滨工业大学 | 一种柔板印刷用低银高性能导电浆料及其制备方法 |
CN105601739B (zh) * | 2016-02-22 | 2019-01-18 | 王晨辉 | 一种人源化抗白介素22基因工程抗体及其应用 |
WO2018039107A1 (en) * | 2016-08-22 | 2018-03-01 | Medimmune, Llc | Binding molecules specific for notch4 and uses thereof |
JP2020513574A (ja) * | 2016-11-24 | 2020-05-14 | ヒュベット バイオ, インコーポレイテッドHuvet Bio, Inc. | 疾患の診断用組成物 |
TWI797097B (zh) | 2016-11-28 | 2023-04-01 | 日商中外製藥股份有限公司 | 包含抗原結合域與運送部分的多胜肽 |
KR102536314B1 (ko) * | 2018-05-23 | 2023-05-25 | 주식회사 휴벳바이오 | 질환의 진단용 조성물 |
US11834472B2 (en) | 2018-06-05 | 2023-12-05 | Bioatla, Inc. | Anti-IL-22 antibodies, antibody fragments, their immunoconjugates and uses thereof |
JP7323608B2 (ja) * | 2018-10-11 | 2023-08-08 | アリヴィオ セラピューティクス, インコーポレイテッド | スマート放出のための非注射用ヒドロゲル製剤 |
KR102226826B1 (ko) * | 2020-08-06 | 2021-03-11 | 주식회사 휴벳바이오 | 버피 코트 시료에 사용하기 위한 췌장암 진단용 조성물 |
IL303295A (en) | 2020-12-07 | 2023-07-01 | UCB Biopharma SRL | Multispecific antibodies and antibody combinations |
IL303294A (en) | 2020-12-07 | 2023-07-01 | UCB Biopharma SRL | Antibodies against interleukin-22 |
MX2023010238A (es) | 2021-03-02 | 2023-12-05 | Dana Farber Cancer Inst Inc | Métodos para tratar trastornos de glóbulos rojos. |
WO2023110942A1 (en) | 2021-12-14 | 2023-06-22 | Charité-Universitätsmedizin Berlin | Prevention of impaired fracture healing |
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