AR059055A1 - Imidazoles sustituidos y sus usos como pesticidas - Google Patents
Imidazoles sustituidos y sus usos como pesticidasInfo
- Publication number
- AR059055A1 AR059055A1 ARP070100202A ARP070100202A AR059055A1 AR 059055 A1 AR059055 A1 AR 059055A1 AR P070100202 A ARP070100202 A AR P070100202A AR P070100202 A ARP070100202 A AR P070100202A AR 059055 A1 AR059055 A1 AR 059055A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylene
- alkoxy
- haloalkyl
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se refiere a una gama de compuestos de imidazol 2-bencil sustituido alfa sustituido y las sales y los solvatos farmacéuticamente aceptables de los mismos, a composiciones que comprenden tales compuestos, procedimientos para sus síntesis y su uso como parasiticidas. Reivindicacion 1: Un compuesto de formula (1) en la que R1, R2, R3, R4, R5 se seleccionan independientemente entre el grupo constituido por hidrogeno, ciano, nitro, halo, hidroxi, alquilo C1-4 opcionalmente sustituido con uno o más grupos hidroxi, cicloalquilo C3-6 opcionalmente sustituido con uno o más grupos alquilo C1-4 o halo, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, fenilo, amino, NRXRY, y S(O)nR10; R6 se selecciona entre el grupo constituido por hidrogeno, - alquilen-C0-2-R7, -alquilen C1-2-OR7, -alquilen C0-2-C(O)R7, - alquilen C1-2-OC(O)R7, -alquilen C1-2-OC(O)OR7, -alquilen C0-2-C(O)OR7, - alquilen C1-2-N(H)C(O)R7, -alquilen C1-2-N(R7)C(O)R7, -alquilen C0-2-C(O)NHR7, -alquilen C0-2-C(O)NR15R16, - alquilen C1-2-NHC(O)NR15R16, -alquilen C1-2-NR7C(O)NR15R16, -alquilen C1-2-OC(O)NHR7, -alquilen C1-2- OC(O)NR15R16, alquilen C0-2- CH=N(R7), -alquilen C1-2-P(=O)(NR15R16)(NR15R16), -alquilen C0-2-Si(R7)3, y -alquilen C0-2-S(O)nR10, en los que el alquileno C0-2 o alquileno C1-2 de R6 puede, cuando sea químicamente posible, opcionalmente estar sustituido con uno o más sustituyentes seleccionados entre el grupo constituido por alquilo C1-6, cicloalquilo C3-6, alquilen C1-4-(cicloalquilo C3- 6), alquilen C0-6-fenilo, dicho sustituyente alquilen C0-2 o alquilen C1-2 puede a su vez estar opcionalmente sustituido adicionalmente, cuando químicamente sea posible, con uno o más sustituyentes seleccionados entre el grupo constituido por hidrogeno, ciano, nitro, halo, formilo, oxo, hidroxi, C(O)OH, alquilo C1-4, alquilen C1-4- cicloalquilo C3-6, alcoxi C1-4, alquilen C1-4-alcoxi C1-4, -C(O)O alquilo C1-4, haloalquilo C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, dialquilamino C1- 4, y S(O)nR10; en los que cada R7, R15 y R16, cuando sea químicamente posible, se selecciona independientemente entre el grupo constituido por hidrogeno, alquilo C1-8, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3 -8, alquilen C1-4-(cicloalquilo C3-6), alquilen C1-4-alcoxi C1-4, haloalquilo C1-6, alquilen C0-6-fenilo, alquilen C0-6-naftilo, alquilen C0-6-(tetrahidronaftilo) y alquilen C0-2-(Het), donde Het se selecciona entre oxetanilo, tetrahidropiranilo, piperidinilo, morfolinilo, furilo, piridilo, benzofuranilo, benzotiazolilo, indolilo, 2,3- benzodioxolilo, 2,3-dihidro-1,4-benzodioxinilo, indolilo y 1,5-naftiridinilo; o R15 y R16 junto con el nitrogeno al que están unidos pueden formar un anillo heterocíclico saturado o no saturado de tres a siete miembros que contiene opcionalmente uno o más átomos adicionales de N, O o S o grupos SO2 en los que cada uno de los grupos anteriores R7, R15 o R16 pueden independientemente incluir uno o más sustituyentes opcionales cuando sea químicamente posible, seleccionados entre hidrogeno, ciano, nitro, halo, formilo, oxo, hidroxi, C(O)OH, alquilo C1-4-alquenilo C2-4, alquinilo C2 -4, cicloalquilo C3-6, alquilen C1-4-cicloalquilo C3-6, alcoxi C1-4, alquilen C1-4- alcoxi C1-4, alcoxi C1-4-alcoxi C1-4, alcanoilo C1-4, -C(O)O alquilo C1-4, haloalquilo C1-4, halocicloalquilo C3-6, haloalcoxi C1-4, haloalcanoilo C1-4, - C(O)O haloalquilo C1-4, fenilo, 4-halofenilo, 4-alcoxifenilo, 2-cianofenilo, fenoxi, 4-halofenoxi, benciloxi, 4-halobenciloxi, benzoilo, pirazolilo, triazolilo, 2-halo-4- pirimidinilo, 2-feniletilo, amino, alquilamino C1-4, dialquilamino C1-4, C(O)N(alquilo C1-4)2, N(alquilen C1-4)C(O)(alquilo C1-4) y S(O)nR10, R8 y R9 se seleccionan independientemente entre el grupo constituido por hidrogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4 y alquilen C0-4-fenilo pero con la condicion de que R8 y R9 no sean ambos hidrogeno; en los que cada uno de R8 y R9 pueden independientemente incluir uno o más sustituyentes opcionales cuando sea químicamente posible seleccionados entre hidrogeno, ciano, halo, hidroxi, alquilo C1-4, cicloalquilo C3-6, alcoxi C1-4, -C(O)O-alquilo C1-4, haloalquilo C1-4, haloalcoxi C1-4, y S(O)nR10; o R8 y R9 junto con el carbono al que están unidos pueden formar un anillo carbocíclico, saturado de tres a seis miembros, dicho anillo está opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo constituido por halo, alquilo C1-2, alcoxi C1-2, haloalquilo C1-2, haloalcoxi C1-2; R11 y R12 se seleccionan independientemente entre el grupo constituido por hidrogeno, halo, ciano, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, y haloalcoxi C1-4; en los que Rx y Ry se seleccionan independientemente entre hidrogeno, alquilo C1-4, haloalquilo C1-4, y S(O)nR10; cada n es independientemente 0, 1 o 2; y cada R10 es independientemente hidrogeno, hidroxi, alquilo C1-4, haloalquilo C1-4, 4-halofenilo, amino, alquilamino C1-6 y di alquilamino C1-6; o una sal o profármaco farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76076506P | 2006-01-19 | 2006-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059055A1 true AR059055A1 (es) | 2008-03-12 |
Family
ID=38038547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100202A AR059055A1 (es) | 2006-01-19 | 2007-01-17 | Imidazoles sustituidos y sus usos como pesticidas |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US7592362B2 (es) |
| EP (2) | EP1981853B1 (es) |
| JP (1) | JP4463317B2 (es) |
| KR (1) | KR101044494B1 (es) |
| CN (1) | CN101370786B (es) |
| AR (1) | AR059055A1 (es) |
| AT (1) | ATE505461T1 (es) |
| AU (1) | AU2007206698B2 (es) |
| BR (1) | BRPI0707185B8 (es) |
| CA (1) | CA2632771C (es) |
| CY (1) | CY1111473T1 (es) |
| DE (1) | DE602007013869D1 (es) |
| DK (1) | DK1981853T3 (es) |
| EA (1) | EA015738B1 (es) |
| ES (1) | ES2362935T3 (es) |
| HK (1) | HK1127919A1 (es) |
| IL (1) | IL192063A0 (es) |
| MA (1) | MA30166B1 (es) |
| ME (2) | ME00044B (es) |
| MY (1) | MY145812A (es) |
| NO (1) | NO341141B1 (es) |
| NZ (1) | NZ569209A (es) |
| PL (1) | PL1981853T3 (es) |
| PT (1) | PT1981853E (es) |
| RS (1) | RS53512B1 (es) |
| SI (1) | SI1981853T1 (es) |
| TN (1) | TNSN08306A1 (es) |
| TW (1) | TWI337998B (es) |
| UA (1) | UA93696C2 (es) |
| UY (1) | UY30096A1 (es) |
| WO (1) | WO2007083207A1 (es) |
| ZA (1) | ZA200805565B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1159320B1 (en) | 1998-11-02 | 2011-01-12 | Dow Global Technologies Inc. | Shear thinning ethylene/alpha-olefin/diene interpolymers and their preparation |
| US7592362B2 (en) * | 2006-01-19 | 2009-09-22 | Pfizer Limited | Substituted imidazoles |
| US20100041712A1 (en) * | 2008-08-18 | 2010-02-18 | Pfizer Inc. | Substituted imidazole combinations |
| CA2748249C (en) | 2008-12-24 | 2013-07-02 | Daiichi Sankyo Company, Limited | Cyclic amine compounds |
| CA2748250A1 (en) | 2008-12-24 | 2010-07-01 | Daiichi Sankyo Company, Limited | Indanyl compounds |
| EP2398318B1 (en) | 2009-02-23 | 2012-12-05 | Wyeth LLC | Improved-scent ectoparasiticidal formulation |
| EP3214066B8 (en) * | 2009-07-16 | 2024-03-27 | Specialty Operations France | Process for the preparation of fluoroalkyl fluoroformates |
| AU2010339691B2 (en) * | 2010-01-07 | 2015-04-02 | Alkermes Pharma Ireland Limited | Prodrugs of heteraromatic compounds |
| AU2011210267A1 (en) | 2010-01-29 | 2012-09-20 | Pfizer Inc. | Topical antiparasitic formulations |
| CN102127066B (zh) * | 2010-12-10 | 2013-08-14 | 邵阳学院 | 4-(7-甲氧基-2,2-二甲基-2,3-二氢苯并呋喃-5-基)-2-(3,4-二甲苯氨基)噻唑手性晶体 |
| WO2012139010A1 (en) * | 2011-04-08 | 2012-10-11 | University Of Kansas | Grp94 inhibitors |
| US9295623B2 (en) * | 2011-10-03 | 2016-03-29 | Eq Ag Solutions | Methods of preventing the transmission of communicable diseases in livestock |
| CA2855954C (en) | 2011-11-17 | 2020-09-01 | Merial Limited | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof. |
| DK2802325T3 (en) | 2012-01-13 | 2017-03-13 | Massachusetts Gen Hospital | ANESTHETIC RELATIONS AND RELATED APPLICATIONS THEREOF |
| CN102987824A (zh) * | 2012-11-29 | 2013-03-27 | 张敏 | 一种防螨虫被 |
| CN104844459B (zh) * | 2014-02-18 | 2016-08-24 | 扬州三友合成化工有限公司 | 一种氯甲基异丙基碳酸酯的制备方法 |
| CN108349953B (zh) * | 2015-11-18 | 2022-06-17 | 孟山都技术公司 | 杀虫组合物和方法 |
| DK3455212T3 (da) * | 2016-05-12 | 2022-03-28 | Heptares Therapeutics Ltd | Hæmmere af protease-aktiveret receptor-2 |
| WO2019089631A1 (en) * | 2017-10-30 | 2019-05-09 | University Of North Texas Health Science Center At Fort Worth | Deterrents for arthropods and marine organisms |
| CN115073298A (zh) * | 2022-05-31 | 2022-09-20 | 湖南华腾制药有限公司 | 连续流微反应器合成2-甲基-3-三氟甲基苯胺的方法 |
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2007
- 2007-01-04 US US11/619,735 patent/US7592362B2/en active Active
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