AR057213A1 - Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv - Google Patents

Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv

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Publication number
AR057213A1
AR057213A1 ARP060105309A ARP060105309A AR057213A1 AR 057213 A1 AR057213 A1 AR 057213A1 AR P060105309 A ARP060105309 A AR P060105309A AR P060105309 A ARP060105309 A AR P060105309A AR 057213 A1 AR057213 A1 AR 057213A1
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AR
Argentina
Prior art keywords
nucleic acids
sequences
tgev
prrsv
prrsv sequences
Prior art date
Application number
ARP060105309A
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English (en)
Inventor
Sanchez Luis Enjuanes
Lucas Sonia Zuniga
Gurpegui Isabel Sola
Duran Juan Plana
Original Assignee
Consejo Superior Investigacion
Fort Dodge Veterinaria S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Fort Dodge Veterinaria S A filed Critical Consejo Superior Investigacion
Publication of AR057213A1 publication Critical patent/AR057213A1/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/55511—Organic adjuvants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2770/20041—Use of virus, viral particle or viral elements as a vector
    • C12N2770/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Abstract

Ácidos nucleicos que comprenden: a) secuencias de un virus de gastroenteritis transmisible (TGEV) competente para la replicacion, donde las secuencias codifican una replicasa de TGEV bajo el control de secuencias reguladoras de la expresion, donde la replicasa se expresa en una célula huésped e iniciará la replicacion del ácido nucleico, por lo que incrementará la cantidad de ácidos nucleicos en la célula; y b) una secuencia que codifica al menos un epitope neutralizador de ORF5 del virus del síndrome reproductivo y respiratorio porcino (PRRSV), donde la secuencia incluye un residuo formador de puentes disulfuro, y c) una secuencia que codifica al menos otro polipéptido capaz de incrementar una respuesta inmune contra el PRRSV. Además, se describen vectores, partículas virales y células huésped que comprenden estos ácidos nucleicos, y también con su uso para la preparacion de vacunas, específicamente para la preparacion de vacunas.
ARP060105309A 2005-12-01 2006-12-01 Acidos nucleicos que codifican secuencias tgev y prrsv para la expresion mejorada de secuencias prrsv AR057213A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05026255A EP1792996A1 (en) 2005-12-01 2005-12-01 Nucleic acid sequences encoding vaccines against Porcine reproductive and respiratory syndrome virus (PRRSV)

Publications (1)

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AR057213A1 true AR057213A1 (es) 2007-11-21

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US (2) US20120114683A1 (es)
EP (5) EP1792996A1 (es)
AR (1) AR057213A1 (es)
AT (1) ATE485383T1 (es)
CA (1) CA2631382A1 (es)
CL (1) CL2010000883A1 (es)
DE (1) DE602006017725D1 (es)
DK (1) DK1951882T3 (es)
ES (1) ES2353952T3 (es)
PL (1) PL1951882T3 (es)
PT (1) PT1951882E (es)
TW (2) TWI382089B (es)
WO (1) WO2007062851A2 (es)

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EP2457583A1 (en) 2010-11-26 2012-05-30 Consejo Superior De Investigaciones Cientificas Nucleic acids encoding PRRSV GP5-ecto and M protein
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KR101641865B1 (ko) * 2013-12-13 2016-07-22 한남대학교 산학협력단 실시간 중합효소 연쇄반응을 통한 전염성 위장염 바이러스의 정량 검출방법
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CN104745578A (zh) * 2015-04-21 2015-07-01 天津出入境检验检疫局动植物与食品检测中心 尼帕病毒和猪繁殖与呼吸综合症病毒二重荧光rt-pcr检测试剂及其制备方法与用途
CN106929480B (zh) * 2015-12-29 2021-04-27 普莱柯生物工程股份有限公司 猪繁殖与呼吸综合征病毒株及其应用
CN106755576A (zh) * 2016-12-27 2017-05-31 湖南新南方养殖服务有限公司 一种检测仔猪脐带血中猪轮状病毒的实时荧光rt‑pcr试剂盒及其用途
CN107266581B (zh) * 2017-06-13 2021-07-09 四川大学 藏猪il-12重组质粒增强pcv2疫苗免疫佐剂的制备方法及应用
CN109232736B (zh) * 2017-07-10 2021-11-09 洛阳普泰生物技术有限公司 特异性结合猪传染性胃肠炎病毒的单克隆抗体、药物组合物、试剂盒及其应用
CN107880120B (zh) * 2017-11-06 2018-10-12 陕西诺威利华生物科技有限公司 一种猪传染性胃肠炎病毒卵黄抗体及其制备方法
CN110616201A (zh) * 2018-06-19 2019-12-27 中国动物疫病预防控制中心（农业部屠宰技术中心） 一种猪繁殖与呼吸综合征病毒美洲经典株核酸标准物质及其制备方法
CN109735551A (zh) * 2018-12-26 2019-05-10 河南农业大学 一种猪繁殖与呼吸综合症病毒重组质粒及其构建方法
CN110055251B (zh) * 2019-04-25 2022-05-27 山东省农业科学院畜牧兽医研究所 一种调控pcv2病毒增殖的序列及其应用
CN111996213A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒双荧光标记基因重组毒株的构建方法
CN112812177B (zh) * 2020-08-18 2022-12-09 安徽九川生物科技有限公司 一种鼠源性抗猪传染性胃肠炎病毒的单链抗体及其制备方法
CN112089804A (zh) * 2020-09-17 2020-12-18 楚雄彝族自治州动物疫病预防控制中心 一种抗猪繁殖与呼吸综合征感染的药物及其检测方法
CN116445454B (zh) * 2023-05-23 2023-11-17 中农种源(深圳)科技有限公司 一种用于培育抗tgev感染的猪品种的成套系统及其应用

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EP1792996A1 (en) 2007-06-06
TW201124536A (en) 2011-07-16
EP1951882B1 (en) 2010-10-20
EP2327787A1 (en) 2011-06-01
US20120114683A1 (en) 2012-05-10
PL1951882T3 (pl) 2011-05-31
WO2007062851A3 (en) 2007-10-11
TWI382089B (zh) 2013-01-11
EP2316960A1 (en) 2011-05-04
PT1951882E (pt) 2010-12-31
DK1951882T3 (da) 2011-02-07
TW200738880A (en) 2007-10-16
TWI358455B (en) 2012-02-21
CA2631382A1 (en) 2007-06-07
DE602006017725D1 (de) 2010-12-02
EP2275565A3 (en) 2011-04-27
EP2275565A2 (en) 2011-01-19
EP1951882A2 (en) 2008-08-06
ES2353952T3 (es) 2011-03-08
ATE485383T1 (de) 2010-11-15
WO2007062851A2 (en) 2007-06-07
US20090202588A1 (en) 2009-08-13
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