AR055609A1 - Combinacion de un agente hipnotico y un compuesto de bis arilo y heteroarilo sustituido y aplicacion terapeutica de la misma - Google Patents
Combinacion de un agente hipnotico y un compuesto de bis arilo y heteroarilo sustituido y aplicacion terapeutica de la mismaInfo
- Publication number
- AR055609A1 AR055609A1 ARP060103594A ARP060103594A AR055609A1 AR 055609 A1 AR055609 A1 AR 055609A1 AR P060103594 A ARP060103594 A AR P060103594A AR P060103594 A ARP060103594 A AR P060103594A AR 055609 A1 AR055609 A1 AR 055609A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocycle
- heteroaryl
- integer
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003326 hypnotic agent Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000002619 bicyclic group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 229910005948 SO2Cl Inorganic materials 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- -1 enantiomers Chemical class 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70965505P | 2005-08-19 | 2005-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055609A1 true AR055609A1 (es) | 2007-08-29 |
Family
ID=37772166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103594A AR055609A1 (es) | 2005-08-19 | 2006-08-17 | Combinacion de un agente hipnotico y un compuesto de bis arilo y heteroarilo sustituido y aplicacion terapeutica de la misma |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7618650B2 (enExample) |
| EP (1) | EP1928442B1 (enExample) |
| JP (1) | JP2009504761A (enExample) |
| KR (1) | KR20080038416A (enExample) |
| CN (1) | CN101242819A (enExample) |
| AR (1) | AR055609A1 (enExample) |
| AT (1) | ATE447400T1 (enExample) |
| AU (1) | AU2006283703A1 (enExample) |
| BR (1) | BRPI0614943A2 (enExample) |
| CA (1) | CA2617980A1 (enExample) |
| DE (1) | DE602006010219D1 (enExample) |
| ES (1) | ES2336142T3 (enExample) |
| MX (1) | MX2008001778A (enExample) |
| RU (1) | RU2008110498A (enExample) |
| SG (1) | SG140147A1 (enExample) |
| TW (1) | TW200815009A (enExample) |
| WO (1) | WO2007024600A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2889811B1 (fr) * | 2005-08-19 | 2009-10-09 | Sanofi Aventis Sa | Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique. |
| CA2630154C (en) * | 2005-11-18 | 2015-06-16 | Lawrence Solomon | Segmented pharmaceutical dosage forms |
| EP2344480A1 (en) | 2008-10-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| CN102018681A (zh) * | 2010-12-10 | 2011-04-20 | 荣港生技医药科技（北京）有限公司 | 一种美乐托宁缓释剂、其制备方法及其应用 |
| US20130060052A1 (en) * | 2011-01-17 | 2013-03-07 | Takeda Pharmaceutical Company Limited | Orally dispersible tablet |
| AU2014236146B2 (en) | 2013-03-14 | 2018-05-17 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP4516781A1 (en) * | 2022-04-27 | 2025-03-05 | Atom Therapeutics Co., Ltd. | Compound for reducing uric acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE454375T1 (de) * | 1996-10-21 | 2010-01-15 | Neurosearch As | 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors |
| US20040258750A1 (en) * | 1999-06-28 | 2004-12-23 | Gerard Alaux | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| PT1473036E (pt) * | 2000-04-24 | 2006-10-31 | Teva Pharma | Solvato de hemitartarato de zolpidem |
| GT200600042A (es) * | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
-
2006
- 2006-08-16 CA CA002617980A patent/CA2617980A1/en not_active Abandoned
- 2006-08-16 MX MX2008001778A patent/MX2008001778A/es not_active Application Discontinuation
- 2006-08-16 CN CNA2006800296536A patent/CN101242819A/zh active Pending
- 2006-08-16 WO PCT/US2006/032027 patent/WO2007024600A2/en not_active Ceased
- 2006-08-16 SG SG200801326A patent/SG140147A1/en unknown
- 2006-08-16 RU RU2008110498/04A patent/RU2008110498A/ru not_active Application Discontinuation
- 2006-08-16 AT AT06789813T patent/ATE447400T1/de not_active IP Right Cessation
- 2006-08-16 ES ES06789813T patent/ES2336142T3/es active Active
- 2006-08-16 EP EP06789813A patent/EP1928442B1/en active Active
- 2006-08-16 AU AU2006283703A patent/AU2006283703A1/en not_active Abandoned
- 2006-08-16 JP JP2008527115A patent/JP2009504761A/ja active Pending
- 2006-08-16 BR BRPI0614943-0A patent/BRPI0614943A2/pt not_active IP Right Cessation
- 2006-08-16 DE DE602006010219T patent/DE602006010219D1/de active Active
- 2006-08-16 KR KR1020087006619A patent/KR20080038416A/ko not_active Withdrawn
- 2006-08-17 AR ARP060103594A patent/AR055609A1/es unknown
- 2006-08-18 TW TW095130323A patent/TW200815009A/zh unknown
-
2008
- 2008-02-06 US US12/027,022 patent/US7618650B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE447400T1 (de) | 2009-11-15 |
| EP1928442A2 (en) | 2008-06-11 |
| AU2006283703A1 (en) | 2007-03-01 |
| ES2336142T3 (es) | 2010-04-08 |
| EP1928442B1 (en) | 2009-11-04 |
| BRPI0614943A2 (pt) | 2011-04-26 |
| CA2617980A1 (en) | 2007-03-01 |
| DE602006010219D1 (de) | 2009-12-17 |
| WO2007024600A2 (en) | 2007-03-01 |
| CN101242819A (zh) | 2008-08-13 |
| RU2008110498A (ru) | 2009-09-27 |
| MX2008001778A (es) | 2008-04-07 |
| WO2007024600A3 (en) | 2007-05-24 |
| US20080138413A1 (en) | 2008-06-12 |
| TW200815009A (en) | 2008-04-01 |
| US7618650B2 (en) | 2009-11-17 |
| SG140147A1 (en) | 2008-03-28 |
| JP2009504761A (ja) | 2009-02-05 |
| KR20080038416A (ko) | 2008-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR052903A1 (es) | Compuestos de bis arilo y heteroarilo sustituidos como antagonistas selectivos de 5ht2a, composiciones farmaceuticas que los contienen y su empleo en el tratamiento de trastornos del sueno. | |
| AR054799A1 (es) | Derivados de oxindol | |
| AR037489A1 (es) | Quinolinas sustituidas y proceso para su preparacion | |
| AR048346A1 (es) | Piridonas sustituidas como inhibidores de poli(adp-ribosa)-polimerasa (parp), composiciones farmaceuticas que las contienen y el uso de las mismas para el tratamiento de trastornos cardiovasculares y del sistema nervioso central. | |
| AR092108A1 (es) | Piridazina 1,4 disustituida, analogos de la misma y metodos para tratar las enfermedades relacionadas con deficiencia del smn | |
| AR072227A1 (es) | Derivados de triazinona sustituidos | |
| AR035260A1 (es) | Derivados de piperidina amino sustituidas, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de medicamentos como inhibidores de la gama secretasa, y para el tratamiento de la enfermedad de alzheimer | |
| AR076076A1 (es) | Compuestos biciclicos y heterociclicos fusionados,composiciones farmaceuticas que los contienen, procedimiento para prepararlos y uso de los mismos en el tratamiento de enfermedades inflamatorias y/o autoinmunes | |
| AR064471A1 (es) | Macrociclos inhibidores selectivos del factor de coagulacion viia, composiciones farmaceuticas que los comprenden y uso de los mismos como agentes anticoagulantes. | |
| CO5660268A2 (es) | Derivados de malonamida que bloquean la actividad de la gama-secretasa | |
| AR052156A1 (es) | Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos | |
| AR057131A1 (es) | Derivados de purina como inmunomodulador | |
| AR082886A1 (es) | Compuestos y composiciones farmaceuticas que los contienen | |
| AR035234A1 (es) | Aril y biaril-piperidinas con actividad moduladora mch, metodo para preparar dichos compuestos, composiciones farmaceuticas, metodo para preparar las composiciones farmaceuticas y el uso de dichos compuestos para la manufactura de un medicamento | |
| AR078163A1 (es) | Utilizacion de aminodihidrotiazinas para el tratamiento o prevencion de la diabetes | |
| AR052887A1 (es) | Derivados de tiazol, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para tratar enfermedades mediadas por la inhibicion de la protein quinasa | |
| AR044909A1 (es) | Derivados de tiazolilpiperidina, procesos para su preparacion, composiciones farmaceuticas que los comprenden y aplicaciones de dichos derivados en el tratamiento de hipertrigliceridemia , hipercolesterolemia y dislipidemia | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| AR069326A1 (es) | Derivados bis-(sulfonilamino), proceso de preparacion, composiciones farmaceuticas que los contienen y su uso en terapia. | |
| AR054035A1 (es) | Derivados benzodioxano y benzodioxolano y uso de los mismos | |
| AR037503A1 (es) | Compuestos derivados de 1,8-naftiridina, una composicion farmaceutica y su uso para la fabricacion de un medicamento para el tratamiento de la diabetes y trastornos relacionados | |
| AR061515A1 (es) | Benzoxazoles sustituidos con heteroarilo. composiciones farmaceuticas. | |
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| AR049521A1 (es) | Derivados de pirrazol - pirimidina | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |