CA2617980A1 - Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof - Google Patents

Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof Download PDF

Info

Publication number
CA2617980A1
CA2617980A1 CA002617980A CA2617980A CA2617980A1 CA 2617980 A1 CA2617980 A1 CA 2617980A1 CA 002617980 A CA002617980 A CA 002617980A CA 2617980 A CA2617980 A CA 2617980A CA 2617980 A1 CA2617980 A1 CA 2617980A1
Authority
CA
Canada
Prior art keywords
4alkyl
formula
compound
short
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002617980A
Other languages
English (en)
French (fr)
Inventor
Gary T. Emmons
Sathapana Kongsamut
Craig N. Karson
Corrine M. Legoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2617980A1 publication Critical patent/CA2617980A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CA002617980A 2005-08-19 2006-08-16 Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof Abandoned CA2617980A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70965505P 2005-08-19 2005-08-19
US60/709,655 2005-08-19
PCT/US2006/032027 WO2007024600A2 (en) 2005-08-19 2006-08-16 Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof

Publications (1)

Publication Number Publication Date
CA2617980A1 true CA2617980A1 (en) 2007-03-01

Family

ID=37772166

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002617980A Abandoned CA2617980A1 (en) 2005-08-19 2006-08-16 Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof

Country Status (17)

Country Link
US (1) US7618650B2 (enExample)
EP (1) EP1928442B1 (enExample)
JP (1) JP2009504761A (enExample)
KR (1) KR20080038416A (enExample)
CN (1) CN101242819A (enExample)
AR (1) AR055609A1 (enExample)
AT (1) ATE447400T1 (enExample)
AU (1) AU2006283703A1 (enExample)
BR (1) BRPI0614943A2 (enExample)
CA (1) CA2617980A1 (enExample)
DE (1) DE602006010219D1 (enExample)
ES (1) ES2336142T3 (enExample)
MX (1) MX2008001778A (enExample)
RU (1) RU2008110498A (enExample)
SG (1) SG140147A1 (enExample)
TW (1) TW200815009A (enExample)
WO (1) WO2007024600A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889811B1 (fr) * 2005-08-19 2009-10-09 Sanofi Aventis Sa Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique.
US8231902B2 (en) * 2005-11-18 2012-07-31 Accu-Break Technologies, Inc. Segmented pharmaceutical dosage forms
US8338367B2 (en) 2008-10-15 2012-12-25 Boehringer Ingelheim International Gmbh Fused heteroaryl diamide compounds useful as MMP-13 inhibitors
EP2340243B1 (en) 2008-10-17 2014-10-08 Boehringer Ingelheim International GmbH Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
CN102018681A (zh) * 2010-12-10 2011-04-20 荣港生技医药科技（北京）有限公司 一种美乐托宁缓释剂、其制备方法及其应用
US20130060052A1 (en) * 2011-01-17 2013-03-07 Takeda Pharmaceutical Company Limited Orally dispersible tablet
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EA030481B1 (ru) 2013-03-14 2018-08-31 Эпизим, Инк. Ингибиторы аргининметилтрансферазы и их применения
CN116715633B (zh) * 2022-04-27 2025-08-12 杭州新元素药业股份有限公司 可用于降尿酸的化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ127299A3 (cs) * 1996-10-21 1999-09-15 Neurosearch A/S 1-Fenyl-benzimidazolové sloučeniny a jejich použití jako modulátorů GABAA receptorů
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
PL358548A1 (en) * 2000-04-24 2004-08-09 Teva Pharmaceutical Industries Ltd. Zolpidem hemitartrate
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a

Also Published As

Publication number Publication date
KR20080038416A (ko) 2008-05-06
AU2006283703A1 (en) 2007-03-01
WO2007024600A2 (en) 2007-03-01
ES2336142T3 (es) 2010-04-08
AR055609A1 (es) 2007-08-29
SG140147A1 (en) 2008-03-28
ATE447400T1 (de) 2009-11-15
BRPI0614943A2 (pt) 2011-04-26
DE602006010219D1 (de) 2009-12-17
CN101242819A (zh) 2008-08-13
EP1928442A2 (en) 2008-06-11
RU2008110498A (ru) 2009-09-27
TW200815009A (en) 2008-04-01
US20080138413A1 (en) 2008-06-12
US7618650B2 (en) 2009-11-17
WO2007024600A3 (en) 2007-05-24
EP1928442B1 (en) 2009-11-04
MX2008001778A (es) 2008-04-07
JP2009504761A (ja) 2009-02-05

Similar Documents

Publication Publication Date Title
US7618650B2 (en) Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
US7625889B2 (en) Substituted bis aryl and heteroaryl compounds as selective 5HT2A antagonists
EP2455370A1 (en) Pharmaceutical product containing lactam or benzene sulfonamide compound
TW200808310A (en) Amide derivative or salt thereof
EA006604B1 (ru) Сочетание агониста (5-ht2) и антагониста (5-ht6) серотонина в качестве фармацевтической композиции
CN105829301A (zh) 作为离子通道调节剂的稠合杂环化合物
US20200190075A1 (en) Synthesis, pharmacology and use of new and selective fms-like tyrosine kinase 3 (flt3) flt3 inhibitors
KR20100057433A (ko) 신규 피라졸로[4,3-ｂ]피리딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물
CN111542529B (zh) 对蛋白激酶具有抑制活性的噻吩并[3,2-d]嘧啶化合物
EP1871364A1 (en) Methods for treating or preventing acute myelogenous leukemia
US20080139615A1 (en) Combination of a hypnotic agent and r (+)-alpha-(2,3-dimethoxy-phenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and therapeutic application thereof
HK1121673A (en) Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
EP4389223A1 (en) Synthesis, pharmacology and use of new water-soluble and selective fms-like tyrosine kinase 3 (flt3) inhibitors
ES2360763T3 (es) Derivados de piridina para el tratamiento de desórdenes metabólicos relacionados con la resistencia a la insulina o hiperglucemia.
CN117616022A (zh) 晶形
HK1123500A (en) Comination of a hypnotic agent and r(+)-alpha-(2,3-dimethoxy-phenyl)-1-[2-(4-fluorophenl)ethyl]-4-piperidinemethanol and therapeutic application thereof

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued