AR069326A1 - Derivados bis-(sulfonilamino), proceso de preparacion, composiciones farmaceuticas que los contienen y su uso en terapia. - Google Patents

Derivados bis-(sulfonilamino), proceso de preparacion, composiciones farmaceuticas que los contienen y su uso en terapia.

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Publication number
AR069326A1
AR069326A1 ARP080104977A ARP080104977A AR069326A1 AR 069326 A1 AR069326 A1 AR 069326A1 AR P080104977 A ARP080104977 A AR P080104977A AR P080104977 A ARP080104977 A AR P080104977A AR 069326 A1 AR069326 A1 AR 069326A1
Authority
AR
Argentina
Prior art keywords
phenyl
alkoxy
heteroaryl
carbocyclyl
alkyl
Prior art date
Application number
ARP080104977A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40638954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069326(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR069326A1 publication Critical patent/AR069326A1/es

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

Compuestos, Isomeros opticos, racematos y tautomeros de los mismos, y sales farmacéuticamente aceptables de los mismos; junto con procesos para su preparacion, composiciones farmacéuticas que las contienen y su uso en terapia. Los compuestos son inhibidores de la prostaglandina E sintasa-l microsomal. Reivindicacion 1: Un compuesto de formula (1) o una sal farmacéuticamente aceptable del mismo donde: A es seleccionado de una mitad fenil o heteroaril de 5 o 6 miembros; estando dicha mitad fenil o heteroaril de 5 o 6 miembros fusionada con un fenil, un heteroaril de 5 o 6 miembros, o con un anillo carbociclil C5-6 o heterociclil C5-6; R1 es independientemente seleccionado de halogeno, nitro, SF5, OH, CHO, CO2R4, CONR5R6, alquil C1-4, alcoxi C1-4, G3, OG3 o OCH2G3, estando dicho alquil C1-4 o alcoxi C1-4 opcionalmente sustituido con OH, o con uno o más átomos F; m representa un numero entero 0, 1 o 2; R3 es hidrogeno; L1 representa un enlace directo,.alquileno C1-4, alquenileno C2-4 o alquinileno C2-4; L2 representa un enlace directo, -O- , -OCH2-, alquileno C1-2 o -C:::C-; G1 representa fenil, heteroaril de 5 o 6 miembros, carbociclil C3-10 o heterociclil C5-8; G2 representa H, alquil C1-6, alquenil C1-6, fenil, heteroaril de 5 o 6 miembros, carbociclil C3-10 o heterociclil C5-8; estando dicho alquil C1-6 opcionalmente sustituido adicionalmente con uno o más grupos seleccionados de OH, alcoxi C1-6 y halogeno; estando las mitades fenil, heteroaril, carbociclil o heterociclil en G1 y G2 opcionalmente fusionadas con uno o dos anillos adicionales independientemente seleccionados de fenil, un heteroaril de 5 o 6 miembros, o un anillo carbociclil C5-6 o heterociclil C5-6; estando cualquier mitad fenil, heteroaril, carbociclil o heterociclil en G1 y G2 opcionalmente sustituida con uno o más sustituyentes independientemente seleccionados de halogeno, OH, CN, NO2, CO2R9, alquil C1-6, alcoxi C1-6, tioalcoxi C1-4, SO2NR10R11, NR12R13, -O(CH2)2O(CH2)2-alcoxi C1-6, -NHCOC(OH)(CH3)CF3, -CH2OCH2CF2CHF2 o -CH2OCH2CH2CF3, estando dicho alquil C1-6 o alcoxi C1-6 opcionalmente sustituido con OH, alcoxi C1-6, fenil, o con uno o más átomos F; G3 representa fenil o heteroaril de 5 o 6 miembros; y cada R4, R5, R6, R9, R10, R11, R12 y R13 es independientemente seleccionado de H o alquil C1-4, siempre que los compuestos: 1,2-Bencenodisulfonamida, N1-[[(4,6-dimetil-2-pirimidinil)amino]carbonil]; 1,2-Bencenodisulfonamida, N1-[[(4,6-dimetoxi-1,3,5-triazin-2-il)amino]carbonil]; 1,2-Bencenodisulfonamida, N1-[[(4-metoxi-6-metil-2-pirimidinil)amino]carbonil]; 1,2-Bencenodisulfonamida, N1-[[(4,6-dimetoxi-2-pirimidinil)amino]carbonil] estén excluidos.
ARP080104977A 2007-11-15 2008-11-14 Derivados bis-(sulfonilamino), proceso de preparacion, composiciones farmaceuticas que los contienen y su uso en terapia. AR069326A1 (es)

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