AR055012A1 - Derivados de tetralina y de indano y usos de los mismos - Google Patents

Derivados de tetralina y de indano y usos de los mismos

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Publication number
AR055012A1
AR055012A1 ARP050105401A ARP050105401A AR055012A1 AR 055012 A1 AR055012 A1 AR 055012A1 AR P050105401 A ARP050105401 A AR P050105401A AR P050105401 A ARP050105401 A AR P050105401A AR 055012 A1 AR055012 A1 AR 055012A1
Authority
AR
Argentina
Prior art keywords
alkyl
carbonyl
hydrogen
alkoxy
optionally substituted
Prior art date
Application number
ARP050105401A
Other languages
English (en)
Inventor
Robert Greenhouse
Ralph New Harris Iii
Saul Jaime-Figueroa
James M Kress
David Bruce Repke
Russell Stephen Stabler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR055012A1 publication Critical patent/AR055012A1/es

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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P25/16—Anti-Parkinson drugs
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un compuesto de la formula (1), o una sal farmacéuticamente aceptable del mismo, en la que: m es de un numero 0 a 3; p es de 1 a 3; q es 0, 1 o 2; Ar es arilo opcionalmente sustituido o heteroarilo de 5 o 6 eslabones opcionalmente sustituido; ôla línea de puntoö es un enlace opcional; cada R1 con independencia de su aparicion es halogeno, alquilo C1-12, haloalquilo C1-12, alcoxi C1-12, hidroxi, heteroalquilo C1-12, ciano, -S(O)t-Ra, -C(=O)-NRbRc, -SO2-NRbRc, -N(Rd)-C(=O)-Re, o -C(=O)-Re, en el que t es un numero de 0 a 2, Ra, Rb, Rc, Rd y Re con independencia entre sí son hidrogeno, alquilo C1-12, alcoxi C1-12 o hidroxi; R2 es una formula (2), n es de un numero 1 a 3; R3 y R4 con independencia entre sí son hidrogeno o alquilo C1-12 o R3 y R4 juntos pueden formar =O o =NRf, en el que Rf es hidrogeno o alquilo C1-12; y uno de R5 y R6 es hidrogeno o alquilo C1-12 y el otro es: hidrogeno; alquilo C1-12; amidinilo; aminocarbonilo; (alquilC1-7)carbonilo; (alcoxiC1-12)carbonilo; aminocarbonilo-alquiloC1-12; amino-(alquilC1-12)carbonilo; (alcoxiC1-12)carbonil-alquiloC1-12; imidazolonilo; imidazolilcarbonilo; pirrolilcarbonilo; pirrolidinilcarbonilo; N-cianoamidinilo; alquilsulfonilo C1-12; hidroxi-(alquilC1-12)carbonilo; aminosulfonilo; hidroxi-alquiloC1-12; alcoxiC1-12alquiloC1-12; (alquilC1-12)sulfonil-alquiloC1-12; o heteroarilo de 5 o 6 eslabones opcionalmente sustituido; o R5 y R6 junto con el nitrogeno al que están unidos pueden formar un grupo amidinilo, un grupo urea, un grupo guanidinilo o un heteroarilo de 5 o 6 eslabones o anillo heterociclilo de 5 o 6 eslabones que está opcionalmente sustituido y que incluye opcionalmente un heteroátomo adicional, elegido entre O, N y S; o uno de R5 y R6 y uno de R3 y R4 junto con los átomos a los que están unidos pueden formar un anillo de 5 o 6 eslabones que incluye opcionalmente un heteroátomo adicional, elegido entre O, N y S.
ARP050105401A 2004-12-21 2005-12-21 Derivados de tetralina y de indano y usos de los mismos AR055012A1 (es)

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