AR051759A1 - Formulaciones de compuestos de acido boronico en liposomas - Google Patents
Formulaciones de compuestos de acido boronico en liposomasInfo
- Publication number
- AR051759A1 AR051759A1 ARP050104638A ARP050104638A AR051759A1 AR 051759 A1 AR051759 A1 AR 051759A1 AR P050104638 A ARP050104638 A AR P050104638A AR P050104638 A ARP050104638 A AR P050104638A AR 051759 A1 AR051759 A1 AR 051759A1
- Authority
- AR
- Argentina
- Prior art keywords
- liposomes
- boronic acid
- liposomas
- formulations
- trapped
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describe una composicion de liposomas compuesta por liposomas que tienen un compuesto peptídico de ácido boronico inhibidor el proteasoma atrapado en los liposomas. El compuesto de ácido boronico está atrapado en los liposomas en forma de éster de boronato, como consecuencia de la interaccion con un poliol atrapado en los liposomas. En una realizacion, los liposomas tienen un revestimiento externo de cadenas poliméricas hidrofilas y se los utiliza para tratar un tumor solido en un sujeto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62521604P | 2004-11-05 | 2004-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051759A1 true AR051759A1 (es) | 2007-02-07 |
Family
ID=35947260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104638A AR051759A1 (es) | 2004-11-05 | 2005-11-04 | Formulaciones de compuestos de acido boronico en liposomas |
Country Status (21)
Country | Link |
---|---|
US (2) | US20060153907A1 (es) |
EP (2) | EP1807053A1 (es) |
JP (2) | JP2008519041A (es) |
KR (2) | KR20070085642A (es) |
CN (2) | CN101094648A (es) |
AR (1) | AR051759A1 (es) |
AU (2) | AU2005304881A1 (es) |
BR (2) | BRPI0517061A (es) |
CA (2) | CA2586348A1 (es) |
CR (1) | CR9168A (es) |
EA (1) | EA200701005A1 (es) |
IL (1) | IL182967A0 (es) |
MX (2) | MX2007005499A (es) |
NI (1) | NI200700120A (es) |
NO (1) | NO20072830L (es) |
NZ (2) | NZ554950A (es) |
PE (1) | PE20061135A1 (es) |
TW (1) | TW200618820A (es) |
UY (1) | UY29191A1 (es) |
WO (2) | WO2006052733A1 (es) |
ZA (1) | ZA200705017B (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1932517A3 (en) * | 2006-12-11 | 2008-07-16 | Universiteit Utrecht Holding B.V. | Liposomes containing a polyphenol derivative such as caffeic acid and a method of post-loading thereof |
WO2009047639A2 (en) * | 2007-07-23 | 2009-04-16 | Keimyung University Industry Academic Cooperation Foundation | Epicatechin deficient green tea |
SG10201508712QA (en) * | 2007-08-06 | 2015-11-27 | Millenium Pharmaceuticals Inc | Proteasome inhibitors |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
CA2697044A1 (en) * | 2007-08-21 | 2009-02-26 | Alza Corporation | Liposome formulations of boronic acid compounds |
JP2010536874A (ja) * | 2007-08-21 | 2010-12-02 | アルザ・コーポレーシヨン | ボロン酸化合物をインビボ投与するためのリポソーム組成物 |
EP2733147A1 (en) | 2008-06-17 | 2014-05-21 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
KR100918776B1 (ko) * | 2009-04-20 | 2009-09-24 | 계명대학교 산학협력단 | 폴리에틸렌 글리콜과 갈레이트 카테킨을 이용한 혈당상승 억제 조성물 |
WO2010019718A2 (en) | 2008-08-13 | 2010-02-18 | California Institute Of Technology | Carrier nanoparticles and related compositions, methods and systems |
KR101530942B1 (ko) * | 2010-03-18 | 2015-06-23 | 이노파르마, 인코포레이티드 | 안정한 보르테조밉 포뮬레이션 |
US8263578B2 (en) | 2010-03-18 | 2012-09-11 | Innopharma, Inc. | Stable bortezomib formulations |
JP6266978B2 (ja) | 2010-08-10 | 2018-01-24 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | 環状ボロン酸エステル誘導体およびその治療的使用 |
IT1403157B1 (it) | 2010-12-01 | 2013-10-04 | Elbi Int Spa | Macchina lavatrice con rilevazione delle vibrazioni della vasca o camera di lavaggio. |
ES2913069T3 (es) * | 2011-03-02 | 2022-05-31 | Sensulin Llc | Composiciones de vesículas |
CN102784114B (zh) * | 2011-05-14 | 2016-03-02 | 山东新时代药业有限公司 | 一种硼替佐米冻干粉针及其制备方法 |
WO2014092858A1 (en) | 2012-12-12 | 2014-06-19 | Temple University - Of The Commonwealth System Of Higher Education | Compositions and methods for treatment of cancer |
US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CA2894891A1 (en) | 2013-01-04 | 2014-07-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9132097B2 (en) | 2013-03-01 | 2015-09-15 | California Institute Of Technology | Nanoparticles stabilized with nitrophenylboronic acid compositions |
US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
US20160129117A1 (en) | 2013-07-03 | 2016-05-12 | Nippon Kayaku Kabushiki Kaisha | Novel Boronic Acid Compound Preparation |
WO2015117136A1 (en) * | 2014-02-03 | 2015-08-06 | Ohio State Innovation Foundation | Boronic acid esters and pharmaceutical formulations thereof |
EP3139930A4 (en) | 2014-05-05 | 2018-01-17 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
RS59488B1 (sr) | 2014-05-05 | 2019-12-31 | Rempex Pharmaceuticals Inc | Sinteza boronatnih soli i njihove upotrebe |
MX2016015093A (es) | 2014-05-19 | 2017-03-27 | Rempex Pharmaceuticals Inc | Derivados de acido boronico y sus usos terapeuticos. |
WO2015179443A1 (en) | 2014-05-20 | 2015-11-26 | Millennium Pharmaceuticals. Inc. | Boron-containing proteasome inhibitors for use after primary cancer therapy |
EA201692301A1 (ru) * | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
MX2017014130A (es) * | 2015-05-04 | 2018-07-06 | Versantis AG | Metodo para preparar vesiculas con gradiente de ph de transmembrana. |
EP3310360B1 (en) * | 2015-06-19 | 2024-03-27 | Beijing Artivila BioPharma Co. Ltd. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
CN107922609B (zh) | 2015-07-01 | 2020-04-24 | 加州理工学院 | 基于阳离子粘酸聚合物的递送系统 |
CN104958768A (zh) * | 2015-07-17 | 2015-10-07 | 中国科学院长春应用化学研究所 | 一种葡聚糖-硼替佐米键合药及其制备方法 |
WO2017031084A1 (en) * | 2015-08-14 | 2017-02-23 | The Regents Of The University Of California | Poly(vinyl alcohol) nanocarriers |
BR112018077015B1 (pt) | 2016-06-30 | 2022-05-03 | Qpex Biopharma, Inc | Derivados de ácido borônico e usos terapêuticos dos mesmos |
US10583083B1 (en) * | 2016-08-10 | 2020-03-10 | Verily Life Sciences Llc | ROS-responsive multilamellar liposomal vesicles for targeting inflammatory macrophages |
US20200261596A1 (en) | 2016-10-20 | 2020-08-20 | Pfizer Inc. | Therapeutic Particles with Peptide Boronic Acid or Boronate Ester Compounds and Methods of Making and Using Same |
WO2019023092A1 (en) * | 2017-07-24 | 2019-01-31 | Pharmosa Biopharm Inc. | LIPOSOME COMPOSITIONS COMPRISING LOW ACID BASED MEDICAMENTS AND USES THEREOF |
BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
EP3781576B1 (en) | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN110540547A (zh) | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
WO2019241327A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles for crossing the blood brain barrier and methods of treatment using the same |
CN109045272A (zh) * | 2018-08-01 | 2018-12-21 | 厦门市壳聚糖生物科技有限公司 | 一种硼替佐米磷脂复合物及其制备方法与应用 |
US20220362268A1 (en) * | 2019-10-07 | 2022-11-17 | Cornell University | Antimicrobial and antiviral effects of c2-c7 alkyl boronic acids |
US20240173374A1 (en) * | 2021-02-25 | 2024-05-30 | Ohio State Innovation Foundation | Liposomal formulations of boronic acid containing active agents |
CN112915094A (zh) * | 2021-03-26 | 2021-06-08 | 东南大学 | 一种硼替佐米脂质体制剂的制备方法 |
WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
US5736155A (en) * | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
US5047245A (en) * | 1985-07-26 | 1991-09-10 | The Liposome Company, Inc. | Novel composition for targeting, storing and loading of liposomes |
US4885172A (en) * | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
US5252263A (en) * | 1986-06-16 | 1993-10-12 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US6132763A (en) * | 1988-10-20 | 2000-10-17 | Polymasc Pharmaceuticals Plc | Liposomes |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5620689A (en) * | 1989-10-20 | 1997-04-15 | Sequus Pharmaceuuticals, Inc. | Liposomes for treatment of B-cell and T-cell disorders |
DK0555229T3 (da) * | 1990-07-31 | 1996-08-19 | Liposome Co Inc | Akkumulation af aminosyrer og peptider i liposomer |
US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
US6180134B1 (en) * | 1993-03-23 | 2001-01-30 | Sequus Pharmaceuticals, Inc. | Enhanced ciruclation effector composition and method |
US6326353B1 (en) * | 1993-03-23 | 2001-12-04 | Sequus Pharmaceuticals, Inc. | Enhanced circulation effector composition and method |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US6214388B1 (en) * | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
US5972379A (en) * | 1995-02-14 | 1999-10-26 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering a quinolone |
WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
US6224903B1 (en) * | 1996-10-11 | 2001-05-01 | Sequus Pharmaceuticals, Inc. | Polymer-lipid conjugate for fusion of target membranes |
AU4907897A (en) * | 1996-10-11 | 1998-05-11 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method |
US6110491A (en) * | 1996-10-22 | 2000-08-29 | Hermes Biosciences, Inc. | Compound-loaded liposomes and methods for their preparation |
US6831057B2 (en) * | 1997-10-28 | 2004-12-14 | The University Of North Carolina At Chapel Hill | Use of NF-κB inhibition in combination therapy for cancer |
US6051251A (en) * | 1997-11-20 | 2000-04-18 | Alza Corporation | Liposome loading method using a boronic acid compound |
BR9914601A (pt) * | 1998-09-16 | 2001-10-23 | Alza Corp | Inibidor de topoisomerase capturado por lipossoma |
WO2001005873A1 (en) * | 1999-07-14 | 2001-01-25 | Alza Corporation | Neutral lipopolymer and liposomal compositions containing same |
AU1658401A (en) * | 1999-11-19 | 2001-05-30 | Topgene, Inc. | Boron compounds and complexes as anti-inflammatory agents |
DK1355910T3 (da) * | 2001-01-25 | 2011-06-27 | Us Of America Represented By The Secretary Dept Of Health And Human Services | Formulering af borsyreforbindelser |
US20060084592A1 (en) * | 2002-09-09 | 2006-04-20 | Trigen Limited | Peptide boronic acid inhibitors |
WO2004043374A2 (en) * | 2002-11-06 | 2004-05-27 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for treating cancer using proteasome inhibitors |
-
2005
- 2005-10-25 TW TW094137236A patent/TW200618820A/zh unknown
- 2005-11-02 PE PE2005001284A patent/PE20061135A1/es not_active Application Discontinuation
- 2005-11-04 MX MX2007005499A patent/MX2007005499A/es unknown
- 2005-11-04 JP JP2007540071A patent/JP2008519041A/ja not_active Withdrawn
- 2005-11-04 CN CNA2005800457552A patent/CN101094648A/zh active Pending
- 2005-11-04 JP JP2007540070A patent/JP2008519040A/ja not_active Withdrawn
- 2005-11-04 CA CA002586348A patent/CA2586348A1/en not_active Abandoned
- 2005-11-04 KR KR1020077012432A patent/KR20070085642A/ko not_active Application Discontinuation
- 2005-11-04 AU AU2005304881A patent/AU2005304881A1/en not_active Abandoned
- 2005-11-04 MX MX2007005497A patent/MX2007005497A/es unknown
- 2005-11-04 EP EP05824137A patent/EP1807053A1/en not_active Withdrawn
- 2005-11-04 UY UY29191A patent/UY29191A1/es unknown
- 2005-11-04 CA CA002586354A patent/CA2586354A1/en not_active Abandoned
- 2005-11-04 NZ NZ554950A patent/NZ554950A/en not_active IP Right Cessation
- 2005-11-04 EP EP05821699A patent/EP1807052A1/en not_active Withdrawn
- 2005-11-04 US US11/267,794 patent/US20060153907A1/en not_active Abandoned
- 2005-11-04 WO PCT/US2005/039972 patent/WO2006052733A1/en active Application Filing
- 2005-11-04 KR KR1020077012434A patent/KR20070085644A/ko not_active Application Discontinuation
- 2005-11-04 AU AU2005304880A patent/AU2005304880A1/en not_active Abandoned
- 2005-11-04 BR BRPI0517061-3A patent/BRPI0517061A/pt not_active IP Right Cessation
- 2005-11-04 EA EA200701005A patent/EA200701005A1/ru unknown
- 2005-11-04 CN CNA2005800457618A patent/CN101094649A/zh active Pending
- 2005-11-04 BR BRPI0517668-9A patent/BRPI0517668A/pt not_active IP Right Cessation
- 2005-11-04 NZ NZ554951A patent/NZ554951A/en not_active IP Right Cessation
- 2005-11-04 WO PCT/US2005/039973 patent/WO2006052734A1/en active Application Filing
- 2005-11-04 US US11/267,076 patent/US20060159736A1/en not_active Abandoned
- 2005-11-04 AR ARP050104638A patent/AR051759A1/es unknown
-
2007
- 2007-05-03 IL IL182967A patent/IL182967A0/en unknown
- 2007-05-04 NI NI200700120A patent/NI200700120A/es unknown
- 2007-06-04 ZA ZA200705017A patent/ZA200705017B/xx unknown
- 2007-06-04 NO NO20072830A patent/NO20072830L/no not_active Application Discontinuation
- 2007-06-05 CR CR9168A patent/CR9168A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX2007005499A (es) | 2007-09-21 |
CR9168A (es) | 2008-11-24 |
BRPI0517668A (pt) | 2008-10-14 |
IL182967A0 (en) | 2007-08-19 |
US20060153907A1 (en) | 2006-07-13 |
PE20061135A1 (es) | 2006-10-20 |
MX2007005497A (es) | 2007-09-21 |
NO20072830L (no) | 2007-07-24 |
UY29191A1 (es) | 2006-01-31 |
KR20070085644A (ko) | 2007-08-27 |
WO2006052733A1 (en) | 2006-05-18 |
CA2586348A1 (en) | 2006-05-18 |
ZA200705017B (en) | 2008-09-25 |
CN101094649A (zh) | 2007-12-26 |
NZ554951A (en) | 2010-12-24 |
NZ554950A (en) | 2010-12-24 |
EA200701005A1 (ru) | 2007-10-26 |
JP2008519040A (ja) | 2008-06-05 |
BRPI0517061A (pt) | 2008-09-30 |
EP1807052A1 (en) | 2007-07-18 |
EP1807053A1 (en) | 2007-07-18 |
US20060159736A1 (en) | 2006-07-20 |
KR20070085642A (ko) | 2007-08-27 |
AU2005304881A1 (en) | 2006-05-18 |
TW200618820A (en) | 2006-06-16 |
JP2008519041A (ja) | 2008-06-05 |
NI200700120A (es) | 2008-05-15 |
WO2006052734A1 (en) | 2006-05-18 |
CA2586354A1 (en) | 2006-05-18 |
CN101094648A (zh) | 2007-12-26 |
AU2005304880A1 (en) | 2006-05-18 |
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