ECSP109981A - Composiciones de liposomas para administración in vivo de compuestos de ácido borónico - Google Patents

Composiciones de liposomas para administración in vivo de compuestos de ácido borónico

Info

Publication number
ECSP109981A
ECSP109981A EC2010009981A ECSP109981A ECSP109981A EC SP109981 A ECSP109981 A EC SP109981A EC 2010009981 A EC2010009981 A EC 2010009981A EC SP109981 A ECSP109981 A EC SP109981A EC SP109981 A ECSP109981 A EC SP109981A
Authority
EC
Ecuador
Prior art keywords
boronic acid
liposomes
compositions
acid compounds
vivo administration
Prior art date
Application number
EC2010009981A
Other languages
English (en)
Inventor
Anthony Huang
Bing Luo
Jinkang Wang
Yuanpeng Zhang
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of ECSP109981A publication Critical patent/ECSP109981A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen formulaciones de liposomas para la administración de un compuesto de ácido borónico. Los liposomas comprenden un fosfolípido que tiene dos cadenas de acilo con 20 a 22 átomos de carbono en cada cadena y un compuesto de ácido borónico atrapado en los liposomas. En una modalidad preferida, el compuesto de ácido borónico se presenta en forma de un complejo con meglumina.
EC2010009981A 2007-08-21 2010-02-22 Composiciones de liposomas para administración in vivo de compuestos de ácido borónico ECSP109981A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95704507P 2007-08-21 2007-08-21

Publications (1)

Publication Number Publication Date
ECSP109981A true ECSP109981A (es) 2010-04-30

Family

ID=39772942

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010009981A ECSP109981A (es) 2007-08-21 2010-02-22 Composiciones de liposomas para administración in vivo de compuestos de ácido borónico

Country Status (13)

Country Link
US (1) US20090092661A1 (es)
EP (1) EP2190411A2 (es)
JP (1) JP2010536874A (es)
KR (1) KR20100095507A (es)
CN (1) CN101795671A (es)
AU (1) AU2008288917A1 (es)
BR (1) BRPI0815613A2 (es)
CA (1) CA2697042A1 (es)
CO (1) CO6260056A2 (es)
EA (1) EA201070296A1 (es)
EC (1) ECSP109981A (es)
MX (1) MX2010002100A (es)
WO (1) WO2009026427A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201170921A1 (ru) 2009-01-09 2012-01-30 Сан Фарма Адвансед Ресёрч Компани Лимитед Фармацевтическая композиция
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
NZ602392A (en) * 2010-03-18 2014-03-28 Innopharma Inc Stable bortezomib formulations
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
GB201020860D0 (en) * 2010-12-09 2011-01-26 Univ Wolverhampton Disulfiram formulation and uses thereof
EP2787977A4 (en) * 2011-12-09 2015-05-06 Univ California LIPOSOMAL ACTIVE INVERTING
AU2013227219A1 (en) * 2012-03-02 2014-10-23 Dr. Reddy's Laboratories Limited Pharmaceutical compositions comprising boronic acid compounds
MX363455B (es) * 2012-07-18 2019-03-25 Onyx Therapeutics Inc Composiciones liposómicas de inhibidores de proteasoma basadas en epoxicetona.
ES2877084T3 (es) * 2013-02-01 2021-11-16 Zoneone Pharma Inc Carga remota de fármacos poco solubles en agua en liposomas
CN103142509B (zh) * 2013-03-06 2018-01-02 石药集团中奇制药技术（石家庄）有限公司 一种注射用硼替佐米药物组合物
CN105407878A (zh) 2013-05-30 2016-03-16 纳米生物技术公司 药物组合物、制备及其用途
US10167311B2 (en) 2014-02-03 2019-01-01 Ohio State Innovation Foundation Boronic acid esters and pharmaceutical formulations thereof
EP3177269A4 (en) 2014-08-04 2018-02-28 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into lipid vesicles
US11304902B2 (en) 2014-11-25 2022-04-19 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
TW201628656A (zh) * 2014-11-25 2016-08-16 奈諾生技公司 醫藥組合物、其製備與用途
EP3229776B1 (en) 2014-11-25 2023-06-28 Curadigm Sas Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof
WO2016171446A1 (ko) * 2015-04-20 2016-10-27 동아에스티 주식회사 펩타이드 붕소산 화합물을 함유하는 안정화 약학 제제
WO2016189125A1 (en) 2015-05-28 2016-12-01 Nanobiotix Nanoparticles for use as a therapeutic vaccine
CN106265536B (zh) * 2016-08-24 2019-01-11 江苏豪森药业集团有限公司 硼替佐米药物组合物及其制备方法
CN109045272A (zh) * 2018-08-01 2018-12-21 厦门市壳聚糖生物科技有限公司 一种硼替佐米磷脂复合物及其制备方法与应用
CN112915094A (zh) * 2021-03-26 2021-06-08 东南大学 一种硼替佐米脂质体制剂的制备方法
TW202416936A (zh) * 2022-09-30 2024-05-01 大陸商上海濟煜醫藥科技有限公司 脂質體及其製備方法和用途
WO2024067849A1 (zh) * 2022-09-30 2024-04-04 上海济煜医药科技有限公司 一种脂质体药物组合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
WO1996032930A1 (en) * 1995-04-18 1996-10-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US7351427B2 (en) * 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
WO2001085131A2 (en) * 2000-05-11 2001-11-15 Celator Technologies Inc. Lipid carrier compositions for improved drug retention
MXPA05002661A (es) * 2002-09-09 2005-08-19 Trigen Ltd Sales de acido boronico y su uso en el tratamiento de trombosis.
TW200618820A (en) * 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds

Also Published As

Publication number Publication date
WO2009026427A2 (en) 2009-02-26
BRPI0815613A2 (pt) 2015-03-24
EP2190411A2 (en) 2010-06-02
KR20100095507A (ko) 2010-08-31
JP2010536874A (ja) 2010-12-02
MX2010002100A (es) 2010-03-26
US20090092661A1 (en) 2009-04-09
AU2008288917A1 (en) 2009-02-26
WO2009026427A3 (en) 2009-09-24
CO6260056A2 (es) 2011-03-22
CN101795671A (zh) 2010-08-04
CA2697042A1 (en) 2009-02-26
EA201070296A1 (ru) 2010-08-30

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