EA200701005A1 - Липосомальный препарат бортезомиба (ps-341) - Google Patents

Липосомальный препарат бортезомиба (ps-341)

Info

Publication number
EA200701005A1
EA200701005A1 EA200701005A EA200701005A EA200701005A1 EA 200701005 A1 EA200701005 A1 EA 200701005A1 EA 200701005 A EA200701005 A EA 200701005A EA 200701005 A EA200701005 A EA 200701005A EA 200701005 A1 EA200701005 A1 EA 200701005A1
Authority
EA
Eurasian Patent Office
Prior art keywords
liposomes
captured
borthesomib
liposomal
drug
Prior art date
Application number
EA200701005A
Other languages
English (en)
Inventor
Сэмьюэл Залипски
Франсис Мартин
Original Assignee
Алза Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алза Корпорейшн filed Critical Алза Корпорейшн
Publication of EA200701005A1 publication Critical patent/EA200701005A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описана липосомная композиция, состоящая из липосом, содержащих ингибитор протеасомы, соединение пептидобороновой кислоты бортезомиб, захваченный в липосомы. Соединение бороновой кислоты захвачено в липосомы в форме боронатного сложного эфира после взаимодействия с захваченным липосомой полиолом. В одном варианте осуществления липосомы имеют внешние покрывающие цепи гидрофильного полимера и используются для лечения солидных опухолей у субъекта.
EA200701005A 2004-11-05 2005-11-04 Липосомальный препарат бортезомиба (ps-341) EA200701005A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62521604P 2004-11-05 2004-11-05
PCT/US2005/039972 WO2006052733A1 (en) 2004-11-05 2005-11-04 Liposomal formulation of bortezomib (ps-341)

Publications (1)

Publication Number Publication Date
EA200701005A1 true EA200701005A1 (ru) 2007-10-26

Family

ID=35947260

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701005A EA200701005A1 (ru) 2004-11-05 2005-11-04 Липосомальный препарат бортезомиба (ps-341)

Country Status (21)

Country Link
US (2) US20060159736A1 (ru)
EP (2) EP1807053A1 (ru)
JP (2) JP2008519040A (ru)
KR (2) KR20070085644A (ru)
CN (2) CN101094648A (ru)
AR (1) AR051759A1 (ru)
AU (2) AU2005304880A1 (ru)
BR (2) BRPI0517061A (ru)
CA (2) CA2586348A1 (ru)
CR (1) CR9168A (ru)
EA (1) EA200701005A1 (ru)
IL (1) IL182967A0 (ru)
MX (2) MX2007005497A (ru)
NI (1) NI200700120A (ru)
NO (1) NO20072830L (ru)
NZ (2) NZ554950A (ru)
PE (1) PE20061135A1 (ru)
TW (1) TW200618820A (ru)
UY (1) UY29191A1 (ru)
WO (2) WO2006052734A1 (ru)
ZA (1) ZA200705017B (ru)

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Also Published As

Publication number Publication date
MX2007005499A (es) 2007-09-21
JP2008519041A (ja) 2008-06-05
US20060159736A1 (en) 2006-07-20
AR051759A1 (es) 2007-02-07
EP1807053A1 (en) 2007-07-18
CR9168A (es) 2008-11-24
BRPI0517061A (pt) 2008-09-30
CN101094648A (zh) 2007-12-26
NZ554951A (en) 2010-12-24
EP1807052A1 (en) 2007-07-18
NO20072830L (no) 2007-07-24
TW200618820A (en) 2006-06-16
UY29191A1 (es) 2006-01-31
AU2005304881A1 (en) 2006-05-18
CN101094649A (zh) 2007-12-26
NZ554950A (en) 2010-12-24
CA2586348A1 (en) 2006-05-18
US20060153907A1 (en) 2006-07-13
AU2005304880A1 (en) 2006-05-18
ZA200705017B (en) 2008-09-25
KR20070085642A (ko) 2007-08-27
WO2006052733A1 (en) 2006-05-18
BRPI0517668A (pt) 2008-10-14
IL182967A0 (en) 2007-08-19
JP2008519040A (ja) 2008-06-05
CA2586354A1 (en) 2006-05-18
WO2006052734A1 (en) 2006-05-18
PE20061135A1 (es) 2006-10-20
NI200700120A (es) 2008-05-15
MX2007005497A (es) 2007-09-21
KR20070085644A (ko) 2007-08-27

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