AR050272A1 - Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa - Google Patents

Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa

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Publication number
AR050272A1
AR050272A1 ARP050103118A AR050272A1 AR 050272 A1 AR050272 A1 AR 050272A1 AR P050103118 A ARP050103118 A AR P050103118A AR 050272 A1 AR050272 A1 AR 050272A1
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AR
Argentina
Prior art keywords
alkyl
hydrogen
amino
desacetilasa
histona
Prior art date
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English (en)
Original Assignee
Janssen Pharmaceutica Nv
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34979048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR050272(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR050272A1 publication Critical patent/AR050272A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula 1, las formas N-oxido, las sales de adicion aceptables para uso farmacéutico y las fornas estereoquímicamente isoméricas del mismo, en el cual cada n es un numero entero con valor 0, 1 o 2 y cuando n es 0 entonces se quiere significar un enlace directo; cada m es un numero entero con valor 1 o 2; cada X es independientemente N o CH; cada Y es independientemente O, S o NR4; donde cada R4 es hidrogeno, alquilo C1-6, alquiloxi C1-6-alquilo C1-6, cicloalquilo C3-6, cicloalquilmetilo C3-6, fenilalquilo C1-6,-C(=O)-CHR5R6 o -S(=O)2-N(CH3)2, dondecada R5 y R6 es independientemente hidrogeno, amino, alquilo C1-6 o aminoalquilo C1-6; y cuando Y es NR4 y R2 está en la oposicion 7 del indolilo, entonces R2 y R4 juntos pueden formar el radical bivalente -(CH2)2-, (a-1), o -(CH2)3-, (a-2); R1 es hidrogeno, alquilo C1-6, hidroalquilo C1-6, alquilsulfonilo C1-6, alquil C1-6 carbonilo o mono- o di(alquil C1-6)aminosulfonilo; R2 es hidrogeno, hidroxi, amino, halo, alquilo C1-6, ciano, alquenilo C2-6, polihalolaquilo C1-6, nitro, fenilo, alquil C1-6, nitro, fenilo, alquil C1-6 carbonilo, hidroxicarbonilo, alquil C1-6-carbonilamino, alquiloxi C1-6 o mono- o di(alquil C1-6)amino; R3 es hidrogeno, alquilo C1-6 o alquiloxi C1-6; y cuando R2 y R3 son átomos de carbono adyacentes , pueden formar el radical bivalente-O-CH2-O.
ARP050103118 2004-07-28 2005-07-27 Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa AR050272A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04077172 2004-07-28
US59218204P 2004-07-29 2004-07-29

Publications (1)

Publication Number Publication Date
AR050272A1 true AR050272A1 (es) 2006-10-11

Family

ID=34979048

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050103118 AR050272A1 (es) 2004-07-28 2005-07-27 Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa
ARP130103204A AR092490A2 (es) 2004-07-28 2013-09-09 Indolil alquil amino derivados sustituidos como inhibidores de la histona desacetilasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP130103204A AR092490A2 (es) 2004-07-28 2013-09-09 Indolil alquil amino derivados sustituidos como inhibidores de la histona desacetilasa

Country Status (23)

Country Link
US (6) US8193205B2 (es)
EP (1) EP1781639B1 (es)
JP (1) JP4948403B2 (es)
KR (1) KR101261305B1 (es)
AP (1) AP2336A (es)
AR (2) AR050272A1 (es)
AU (1) AU2005266312C1 (es)
BR (1) BRPI0512676B8 (es)
CA (1) CA2572833C (es)
CY (1) CY1112914T1 (es)
EA (1) EA010652B1 (es)
EC (1) ECSP20027480A (es)
HK (1) HK1106234A1 (es)
HR (1) HRP20120327T1 (es)
IL (1) IL180960A0 (es)
MX (1) MX2007001120A (es)
MY (1) MY147316A (es)
NO (1) NO338503B1 (es)
NZ (1) NZ552865A (es)
PL (1) PL1781639T3 (es)
SG (1) SG156687A1 (es)
TW (1) TWI372622B (es)
WO (1) WO2006010750A1 (es)

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