AR043120A1 - Acidos grasos de longitud de cadena mediana, gliceridos y analogos como estimuladores de la produccion de progenitores de eritrocitos - Google Patents
Acidos grasos de longitud de cadena mediana, gliceridos y analogos como estimuladores de la produccion de progenitores de eritrocitosInfo
- Publication number
- AR043120A1 AR043120A1 ARP040100385A ARP040100385A AR043120A1 AR 043120 A1 AR043120 A1 AR 043120A1 AR P040100385 A ARP040100385 A AR P040100385A AR P040100385 A ARP040100385 A AR P040100385A AR 043120 A1 AR043120 A1 AR 043120A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds described
- formula
- compounds
- stimulators
- glycerides
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title 1
- 210000003743 erythrocyte Anatomy 0.000 title 1
- 229930195729 fatty acid Natural products 0.000 title 1
- 239000000194 fatty acid Substances 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 230000010437 erythropoiesis Effects 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000004936 stimulating effect Effects 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 1
- 108090000394 Erythropoietin Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- FKYAWWVVKRUUFY-UHFFFAOYSA-L calcium;decanoate Chemical compound [Ca+2].CCCCCCCCCC([O-])=O.CCCCCCCCCC([O-])=O FKYAWWVVKRUUFY-UHFFFAOYSA-L 0.000 abstract 1
- NDWWLJQHOLSEHX-UHFFFAOYSA-L calcium;octanoate Chemical compound [Ca+2].CCCCCCCC([O-])=O.CCCCCCCC([O-])=O NDWWLJQHOLSEHX-UHFFFAOYSA-L 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- -1 oxy anion Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44545403P | 2003-02-07 | 2003-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043120A1 true AR043120A1 (es) | 2005-07-20 |
Family
ID=32850990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100385A AR043120A1 (es) | 2003-02-07 | 2004-02-06 | Acidos grasos de longitud de cadena mediana, gliceridos y analogos como estimuladores de la produccion de progenitores de eritrocitos |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9682054B2 (https=) |
| EP (1) | EP1592416B1 (https=) |
| JP (1) | JP5390070B2 (https=) |
| KR (1) | KR101120775B1 (https=) |
| CN (1) | CN100427081C (https=) |
| AP (1) | AP2005003367A0 (https=) |
| AR (1) | AR043120A1 (https=) |
| AT (1) | ATE419846T1 (https=) |
| AU (1) | AU2004210193B2 (https=) |
| BR (1) | BRPI0407276A (https=) |
| CA (1) | CA2515160C (https=) |
| CY (1) | CY1108963T1 (https=) |
| DE (2) | DE04708802T1 (https=) |
| DK (1) | DK1592416T3 (https=) |
| EA (1) | EA009939B1 (https=) |
| ES (1) | ES2255467T3 (https=) |
| IL (1) | IL170057A (https=) |
| JO (1) | JO2705B1 (https=) |
| MA (1) | MA27664A1 (https=) |
| MX (1) | MXPA05008382A (https=) |
| MY (1) | MY140913A (https=) |
| NO (1) | NO334085B1 (https=) |
| NZ (1) | NZ541593A (https=) |
| PT (1) | PT1592416E (https=) |
| SI (1) | SI1592416T1 (https=) |
| TN (1) | TNSN05189A1 (https=) |
| WO (1) | WO2004069237A1 (https=) |
| ZA (1) | ZA200506246B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5026655B2 (ja) | 2001-04-18 | 2012-09-12 | プロメティック、バイオサイエンシーズ、インコーポレーテッド | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
| CA2563533C (en) * | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ＡｃｔＲＩＩ受容体ポリペプチド、方法、および組成物 |
| MX2007002727A (es) * | 2004-09-03 | 2008-03-04 | Prometic Biosciences Inc | Derivados de purinilo sustituidos con actividad inmunomoduladora y quimioprotectora, y su uso solos o con acidos grasos de longitud de cadena media o gliceridos. |
| NZ554176A (en) * | 2004-10-01 | 2010-04-30 | Prometic Biosciences Inc | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
| US8071580B2 (en) * | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
| ES2649983T3 (es) | 2005-11-23 | 2018-01-16 | Acceleron Pharma, Inc. | Antagonistas de activina-ActRIIa en su uso para promover el crecimiento óseo |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| MX2009008222A (es) | 2007-02-01 | 2009-10-12 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| EA018221B1 (ru) | 2007-02-09 | 2013-06-28 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ |
| CN101861161B (zh) | 2007-09-18 | 2017-04-19 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
| PT2299998T (pt) * | 2007-11-02 | 2018-04-02 | Prometic Pharma Smt Ltd | Acidos gordos e glicerídeos de cadeia média como agentes nefroprotetores |
| CN101903028B (zh) * | 2007-12-19 | 2013-06-05 | 普罗米蒂克生物科学公司 | 与吉西他滨组合用于治疗胰腺癌的中等链长脂肪酸、盐类及三酸甘油酯 |
| TW201803586A (zh) | 2008-08-14 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 使用ｇｄｆ阱以增加紅血球水平 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| KR101814186B1 (ko) | 2008-09-17 | 2018-03-14 | 키아스마 인코포레이티드 | 약제학적 조성물 및 연관된 투여방법 |
| KR20120049214A (ko) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | 발열성 지방세포를 증가시키는 방법 |
| KR20180026795A (ko) | 2009-06-12 | 2018-03-13 | 악셀레론 파마 인코포레이티드 | 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 |
| AU2010282361B2 (en) * | 2009-08-13 | 2015-03-19 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
| EP3332796A1 (en) | 2009-11-17 | 2018-06-13 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| AU2011326586A1 (en) | 2010-11-08 | 2013-05-30 | Acceleron Pharma, Inc. | ActRIIA binding agents and uses thereof |
| TWI572352B (zh) * | 2012-03-01 | 2017-03-01 | 波麥堤克藥學Ｓｍｔ有限公司 | 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法 |
| US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| CN102973922B (zh) * | 2012-12-18 | 2016-02-03 | 华东理工大学 | 一种融合蛋白的应用 |
| CN114699529A (zh) | 2014-06-13 | 2022-07-05 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| JP2018501307A (ja) | 2014-12-03 | 2018-01-18 | セルジーン コーポレイション | アクチビン−ＡｃｔＲＩＩアンタゴニスト及び貧血を治療するための使用 |
| WO2016126830A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
| US20170021029A1 (en) * | 2015-04-15 | 2017-01-26 | Jeffrey Charles Raber | Topical formulations and uses |
| SG11202103011YA (en) | 2018-10-11 | 2021-04-29 | Basf As | Aromatic compounds and pharmaceutical uses thereof |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
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| US4871768A (en) * | 1984-07-12 | 1989-10-03 | New England Deaconess Hospital Corporation | Dietary supplement utilizing ω-3/medium chain trigylceride mixtures |
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| JP3249147B2 (ja) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| ATE147976T1 (de) * | 1991-01-15 | 1997-02-15 | Hemosphere Inc | Protein nanomatrizen und verfahren zur herstellung |
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| JP5026655B2 (ja) * | 2001-04-18 | 2012-09-12 | プロメティック、バイオサイエンシーズ、インコーポレーテッド | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
| US20040052836A1 (en) * | 2002-09-13 | 2004-03-18 | Li Luk Chiu | Pharmaceutical compositions containing at least one stable liposphere having an improved shelf life |
| US6725510B1 (en) * | 2003-04-25 | 2004-04-27 | Almetta Clyburn | Inclining coffin |
| PT1648851E (pt) | 2003-07-25 | 2007-05-31 | Prometic Biosciences Inc | Praparação de sais metálicos de ácidos gordos de cadeia média |
| MX2007002727A (es) * | 2004-09-03 | 2008-03-04 | Prometic Biosciences Inc | Derivados de purinilo sustituidos con actividad inmunomoduladora y quimioprotectora, y su uso solos o con acidos grasos de longitud de cadena media o gliceridos. |
| US8071580B2 (en) | 2004-10-01 | 2011-12-06 | Prometic Biosciences Inc. | Medium-chain length fatty alcohols as stimulators of hematopoiesis |
-
2004
- 2004-02-06 AT AT04708802T patent/ATE419846T1/de active
- 2004-02-06 DE DE04708802T patent/DE04708802T1/de active Pending
- 2004-02-06 US US10/544,350 patent/US9682054B2/en not_active Expired - Fee Related
- 2004-02-06 JP JP2006502243A patent/JP5390070B2/ja not_active Expired - Fee Related
- 2004-02-06 CA CA2515160A patent/CA2515160C/en not_active Expired - Fee Related
- 2004-02-06 AU AU2004210193A patent/AU2004210193B2/en not_active Ceased
- 2004-02-06 KR KR1020057014499A patent/KR101120775B1/ko not_active Expired - Fee Related
- 2004-02-06 AR ARP040100385A patent/AR043120A1/es not_active Application Discontinuation
- 2004-02-06 BR BR0407276-6A patent/BRPI0407276A/pt not_active Application Discontinuation
- 2004-02-06 DK DK04708802T patent/DK1592416T3/da active
- 2004-02-06 SI SI200431064T patent/SI1592416T1/sl unknown
- 2004-02-06 MX MXPA05008382A patent/MXPA05008382A/es active IP Right Grant
- 2004-02-06 NZ NZ541593A patent/NZ541593A/xx not_active IP Right Cessation
- 2004-02-06 PT PT04708802T patent/PT1592416E/pt unknown
- 2004-02-06 EP EP04708802A patent/EP1592416B1/en not_active Expired - Lifetime
- 2004-02-06 CN CNB200480004978XA patent/CN100427081C/zh not_active Expired - Fee Related
- 2004-02-06 AP AP2005003367A patent/AP2005003367A0/xx unknown
- 2004-02-06 ZA ZA200506246A patent/ZA200506246B/en unknown
- 2004-02-06 WO PCT/GB2004/000457 patent/WO2004069237A1/en not_active Ceased
- 2004-02-06 DE DE602004018902T patent/DE602004018902D1/de not_active Expired - Lifetime
- 2004-02-06 ES ES04708802T patent/ES2255467T3/es not_active Expired - Lifetime
- 2004-02-06 EA EA200501267A patent/EA009939B1/ru not_active IP Right Cessation
- 2004-02-07 MY MYPI20040371A patent/MY140913A/en unknown
- 2004-02-24 JO JOP/2004/0017A patent/JO2705B1/ar active
-
2005
- 2005-08-03 IL IL170057A patent/IL170057A/en active IP Right Grant
- 2005-08-03 TN TNP2005000189A patent/TNSN05189A1/en unknown
- 2005-08-26 NO NO20053994A patent/NO334085B1/no not_active IP Right Cessation
- 2005-09-05 MA MA28479A patent/MA27664A1/fr unknown
-
2009
- 2009-04-06 CY CY20091100397T patent/CY1108963T1/el unknown
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