AR040031A1 - Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR040031A1 AR040031A1 ARP030101712A ARP030101712A AR040031A1 AR 040031 A1 AR040031 A1 AR 040031A1 AR P030101712 A ARP030101712 A AR P030101712A AR P030101712 A ARP030101712 A AR P030101712A AR 040031 A1 AR040031 A1 AR 040031A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- substituted
- heterocycle
- hydroxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- -1 hydroxy, methoxy Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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-
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38201402P | 2002-05-20 | 2002-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040031A1 true AR040031A1 (es) | 2005-03-09 |
Family
ID=29584346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101712A AR040031A1 (es) | 2002-05-20 | 2003-05-16 | Compuestos de pirazol-pirimidina anilina utiles como inhibidores de cinasa y composiciones farmaceuticas que los contienen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6962915B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1507780B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005531584A (cg-RX-API-DMAC7.html) |
| AR (1) | AR040031A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003241561A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2391948T3 (cg-RX-API-DMAC7.html) |
| IS (1) | IS7534A (cg-RX-API-DMAC7.html) |
| MY (1) | MY135309A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20044866L (cg-RX-API-DMAC7.html) |
| PE (1) | PE20040512A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL374218A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200400034A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003099820A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| CA2483164C (en) | 2002-04-23 | 2011-06-07 | Bristol-Myers Squibb Company | Pyrrolo-triazine aniline compounds useful as kinase inhibitors |
| AU2003221753A1 (en) | 2002-04-23 | 2003-11-10 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
| TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
| TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
| EP1543009A4 (en) * | 2002-08-02 | 2007-08-08 | Bristol Myers Squibb Co | Pyrrolotriazine KINASE INHIBITORS |
| TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| AU2004212435A1 (en) | 2003-02-05 | 2004-08-26 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine kinase inhibitors |
| US7419978B2 (en) * | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
| JP2007517052A (ja) * | 2003-12-23 | 2007-06-28 | ノバルティス アクチエンゲゼルシャフト | 二環式ヘテロ環式p−38キナーゼ阻害剤 |
| CA2557268A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Indazole derivatives and pharmaceutical compositions containing them |
| MXPA06009462A (es) | 2004-02-27 | 2007-03-15 | Hoffmann La Roche | Derivados pirazolo heteroaril fusionados. |
| AU2005219525B2 (en) | 2004-02-27 | 2011-08-18 | F. Hoffmann-La Roche Ag | Fused derivatives of pyrazole |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
| TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
| US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
| US7148348B2 (en) | 2004-08-12 | 2006-12-12 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
| ATE517901T1 (de) | 2004-09-06 | 2011-08-15 | Bayer Schering Pharma Ag | Pyrazolopyrimidine als hemmer der proteinkinase b (akt) |
| GB0425035D0 (en) * | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
| GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| CA2594422A1 (en) | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as cell cycle kinase inhibitors |
| AU2006205851A1 (en) | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
| US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| GB0507575D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| US20060264431A1 (en) * | 2005-05-11 | 2006-11-23 | Array Biopharma Inc. | P38 inhibitors and methods of use thereof |
| AU2006283935A1 (en) | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | Fused pyrazole as p38 MAP kinase inhibitors |
| EP1919913A2 (en) * | 2005-08-25 | 2008-05-14 | F.Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
| MX2008002588A (es) | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Inhibidores de p38-map-cinasa y los metodos para utilizarlos. |
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-
2003
- 2003-05-14 TW TW092113120A patent/TW200400034A/zh unknown
- 2003-05-16 JP JP2004507477A patent/JP2005531584A/ja not_active Withdrawn
- 2003-05-16 MY MYPI20031804A patent/MY135309A/en unknown
- 2003-05-16 EP EP03731307A patent/EP1507780B1/en not_active Expired - Lifetime
- 2003-05-16 AU AU2003241561A patent/AU2003241561A1/en not_active Abandoned
- 2003-05-16 WO PCT/US2003/016072 patent/WO2003099820A1/en not_active Ceased
- 2003-05-16 AR ARP030101712A patent/AR040031A1/es unknown
- 2003-05-16 PL PL03374218A patent/PL374218A1/xx not_active Application Discontinuation
- 2003-05-16 ES ES03731307T patent/ES2391948T3/es not_active Expired - Lifetime
- 2003-05-19 US US10/440,864 patent/US6962915B2/en not_active Expired - Lifetime
- 2003-05-20 PE PE2003000490A patent/PE20040512A1/es not_active Application Discontinuation
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2004
- 2004-11-09 NO NO20044866A patent/NO20044866L/no not_active Application Discontinuation
- 2004-11-16 IS IS7534A patent/IS7534A/is unknown
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| NO20044866L (no) | 2004-12-17 |
| EP1507780A1 (en) | 2005-02-23 |
| AU2003241561A1 (en) | 2003-12-12 |
| PE20040512A1 (es) | 2004-08-25 |
| ES2391948T3 (es) | 2012-12-03 |
| EP1507780B1 (en) | 2012-08-22 |
| US6962915B2 (en) | 2005-11-08 |
| WO2003099820A1 (en) | 2003-12-04 |
| MY135309A (en) | 2008-03-31 |
| EP1507780A4 (en) | 2006-08-02 |
| JP2005531584A (ja) | 2005-10-20 |
| US20040023992A1 (en) | 2004-02-05 |
| TW200400034A (en) | 2004-01-01 |
| PL374218A1 (en) | 2005-10-03 |
| IS7534A (is) | 2004-11-16 |
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