AR038956A1 - Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto - Google Patents
Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujetoInfo
- Publication number
- AR038956A1 AR038956A1 ARP020101893A ARP020101893A AR038956A1 AR 038956 A1 AR038956 A1 AR 038956A1 AR P020101893 A ARP020101893 A AR P020101893A AR P020101893 A ARP020101893 A AR P020101893A AR 038956 A1 AR038956 A1 AR 038956A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- group
- alkyl
- independently selected
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 238000004519 manufacturing process Methods 0.000 title 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 2
- 108090000765 processed proteins & peptides Proteins 0.000 title 2
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 26
- 125000003118 aryl group Chemical group 0.000 abstract 21
- 229910052739 hydrogen Inorganic materials 0.000 abstract 15
- 239000001257 hydrogen Substances 0.000 abstract 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 125000001424 substituent group Chemical group 0.000 abstract 11
- 150000002431 hydrogen Chemical class 0.000 abstract 9
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000012453 solvate Substances 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000001072 heteroaryl group Chemical class 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004104 aryloxy group Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29365101P | 2001-05-25 | 2001-05-25 | |
| US32391101P | 2001-09-21 | 2001-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038956A1 true AR038956A1 (es) | 2005-02-02 |
Family
ID=26968071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101893A AR038956A1 (es) | 2001-05-25 | 2002-05-22 | Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20030013699A1 (enExample) |
| EP (1) | EP1392287B8 (enExample) |
| JP (1) | JP2004532868A (enExample) |
| AR (1) | AR038956A1 (enExample) |
| AT (1) | ATE345792T1 (enExample) |
| AU (1) | AU2002308778A1 (enExample) |
| CA (1) | CA2447884A1 (enExample) |
| CY (1) | CY1105922T1 (enExample) |
| DE (1) | DE60216275T2 (enExample) |
| DK (1) | DK1392287T3 (enExample) |
| ES (1) | ES2275007T3 (enExample) |
| MX (1) | MXPA03010843A (enExample) |
| PT (1) | PT1392287E (enExample) |
| WO (1) | WO2002096415A2 (enExample) |
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| AU2003270909A1 (en) * | 2002-09-27 | 2004-04-19 | Martek Biosciences Corporation | Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation |
| AU2003291719A1 (en) | 2002-11-06 | 2004-06-03 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| CA2517573C (en) | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| ES2311806T3 (es) * | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| WO2004110350A2 (en) * | 2003-05-14 | 2004-12-23 | Torreypines Therapeutics, Inc. | Compouds and uses thereof in modulating amyloid beta |
| ATE437641T1 (de) | 2003-05-15 | 2009-08-15 | Roskamp Res Llc | Verfahren zur herstellung von medikamenten zur verringerung der amyloid-abscheidung, amyloid- neurotoxizität und mikrogliosis |
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| ATE485267T1 (de) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
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| GB0708507D0 (en) * | 2007-05-02 | 2007-06-13 | Queen Mary & Westfield College | Substituted phosphonates and their use |
| RU2490014C2 (ru) | 2007-10-05 | 2013-08-20 | Альцгеймер'С Инститьют Оф Америка, Инк. | Способ уменьшения отложения амилоида, амилоидной нейротоксичности и микроглиоза с помощью (-)-энантиомера нилвадипина |
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-
2002
- 2002-05-22 PT PT02774113T patent/PT1392287E/pt unknown
- 2002-05-22 CA CA002447884A patent/CA2447884A1/en not_active Abandoned
- 2002-05-22 AU AU2002308778A patent/AU2002308778A1/en not_active Abandoned
- 2002-05-22 DE DE60216275T patent/DE60216275T2/de not_active Expired - Fee Related
- 2002-05-22 JP JP2002592925A patent/JP2004532868A/ja active Pending
- 2002-05-22 WO PCT/US2002/016306 patent/WO2002096415A2/en not_active Ceased
- 2002-05-22 AR ARP020101893A patent/AR038956A1/es unknown
- 2002-05-22 MX MXPA03010843A patent/MXPA03010843A/es active IP Right Grant
- 2002-05-22 EP EP02774113A patent/EP1392287B8/en not_active Expired - Lifetime
- 2002-05-22 ES ES02774113T patent/ES2275007T3/es not_active Expired - Lifetime
- 2002-05-22 DK DK02774113T patent/DK1392287T3/da active
- 2002-05-22 AT AT02774113T patent/ATE345792T1/de not_active IP Right Cessation
- 2002-05-22 US US10/154,106 patent/US20030013699A1/en not_active Abandoned
-
2007
- 2007-01-15 CY CY20071100048T patent/CY1105922T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1392287A2 (en) | 2004-03-03 |
| DE60216275T2 (de) | 2007-06-21 |
| PT1392287E (pt) | 2007-02-28 |
| DK1392287T3 (da) | 2007-03-19 |
| CA2447884A1 (en) | 2002-12-05 |
| CY1105922T1 (el) | 2011-04-06 |
| WO2002096415A2 (en) | 2002-12-05 |
| EP1392287B8 (en) | 2007-01-10 |
| WO2002096415A3 (en) | 2003-01-16 |
| ES2275007T3 (es) | 2007-06-01 |
| ATE345792T1 (de) | 2006-12-15 |
| US20030013699A1 (en) | 2003-01-16 |
| AU2002308778A1 (en) | 2002-12-09 |
| MXPA03010843A (es) | 2004-02-17 |
| EP1392287B1 (en) | 2006-11-22 |
| JP2004532868A (ja) | 2004-10-28 |
| DE60216275D1 (de) | 2007-01-04 |
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