AR036741A1 - Combinaciones para el tratamiento de los trastornos inmunoinflamatorios - Google Patents
Combinaciones para el tratamiento de los trastornos inmunoinflamatoriosInfo
- Publication number
- AR036741A1 AR036741A1 ARP020103758A ARP020103758A AR036741A1 AR 036741 A1 AR036741 A1 AR 036741A1 AR P020103758 A ARP020103758 A AR P020103758A AR P020103758 A ARP020103758 A AR P020103758A AR 036741 A1 AR036741 A1 AR 036741A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- independently
- combination
- immunoinflammatory disorder
- patient suffering
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un método para tratar a un paciente que padece un trastorno inmunoinflamatorio, para lo cual se administra al paciente: (i) una pirimidopirimidina tetra-sustituida, y (ii) un corticosteroide de forma simultánea o dentro de los 14 días el uno del otro en cantidades suficientes para reducir o inhibir la inmunoinflamación, usos, composición y equipo transportable. Reivindicación 1: El uso de: (a) un corticosteroide; y (b) un compuesto de la fórmula (1), en la cual cada uno de los Z y cada uno de los Z' es, independientemente de los demás, N, O, C, SO2, -(CH2)1-3-P(O)-, -(CH2), -P(:O)(O)2-. Cuando Z ó Z' es O ó SO2 entonces p = 1; cuando Z ó Z' es N, -(CH2)1-3-P(O)-, -(CH2), -P(:O)(O)2-, entonces p = 2; y cuando Z ó Z' es C, entonces p = 3, cada uno de los R1 es, independientemente de los demás, X, OH, N-alquilo, un grupo alquilo ramificado o no ramificado C1-20, un heterociclo, ó, cuando p > 1, dos grupos R1 de un átomo Z ó Z' en común, en combinación el uno con el otro, representan -(CY2)k-, siendo k un número entero entre 4 y 6, inclusive; cada uno de los X es, independientemente de los demás, Y, CY3, C(CY3)3, CY2CY3, (CY2)1-5OY, CnY2n-1; en donde n = 3-7 inclusive; y cada uno de los Y, es independientemente de los demás: H, F, Cl, Br ó I, siendo dicho compuesto y dicho corticosteroide, administrados simultáneamente o dentro de los 14 días el uno del otro, en cantidades y durante un tiempo suficiente para tratar dicho paciente, para la manufactura de un medicamento para tratar a un paciente que padece un trastorno inmunoinflamatorio o que se encuentra bajo riesgo de desarrollar un trastorno inmunoinflamatorio. Reivindicación 32: Un método para identificar combinaciones de compuestos útiles para el tratamiento de un paciente que padece un trastorno inmunoinflamatorio, comprendiendo dicho método los siguientes pasos: (a) poner en contacto células inmunes in vitro con: (i) un primer compuesto seleccionado de entre el grupo consistente en el dipyridamole, fludrocortisone y predinisolone; y (ii) un compuesto candidato; y (b) determinar si la combinación de dicho primer compuesto y dicho compuesto candidato reduce los niveles de TNFa de dichas células inmunes con respecto a las células inmunes puestas en contacto con dicho primer compuesto pero que no han sido puestas en contacto con dicho compuesto candidato, o células mononucleares de sangre periférica puestas en contacto con dicho compuesto candidato pero no con dicho primer compuesto, en lo cual una reducción de dicho niveles de TNFa identifica a dicha combinación como una combinación que es útil para el tratamiento de un paciente que padece un trastorno inmunoinflamatorio.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32767401P | 2001-10-05 | 2001-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR036741A1 true AR036741A1 (es) | 2004-09-29 |
Family
ID=23277540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103758A AR036741A1 (es) | 2001-10-05 | 2002-10-04 | Combinaciones para el tratamiento de los trastornos inmunoinflamatorios |
Country Status (27)
Country | Link |
---|---|
US (3) | US7253155B2 (es) |
EP (2) | EP1448205B1 (es) |
JP (1) | JP2005508346A (es) |
KR (2) | KR100824491B1 (es) |
CN (1) | CN100400044C (es) |
AR (1) | AR036741A1 (es) |
AT (1) | ATE502642T1 (es) |
AU (1) | AU2002334870B2 (es) |
BR (1) | BR0213100A (es) |
CA (1) | CA2461946C (es) |
DE (1) | DE60239558D1 (es) |
DK (1) | DK1448205T3 (es) |
ES (1) | ES2363334T3 (es) |
HK (1) | HK1076387A1 (es) |
HR (1) | HRP20040388A2 (es) |
IL (1) | IL161267A0 (es) |
IS (1) | IS7202A (es) |
MX (1) | MXPA04003266A (es) |
NO (1) | NO20041386L (es) |
NZ (1) | NZ532310A (es) |
PL (1) | PL370764A1 (es) |
PT (1) | PT1448205E (es) |
RU (1) | RU2322984C2 (es) |
SI (1) | SI1448205T1 (es) |
TW (1) | TWI247605B (es) |
WO (1) | WO2003030823A2 (es) |
ZA (1) | ZA200402955B (es) |
Families Citing this family (24)
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CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
EP1448205B1 (en) * | 2001-10-05 | 2011-03-23 | Zalicus Inc. | Combinations for the treatment of immunoinflammatory disorders |
WO2004088272A2 (en) | 2003-03-26 | 2004-10-14 | Synergy Biosystems Ltd. | Methods to identify biologically active agents and synergistic combinations |
US20050112199A1 (en) * | 2003-09-24 | 2005-05-26 | Mahesh Padval | Therapeutic regimens for administering drug combinations |
TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
AU2005235369B2 (en) * | 2004-04-22 | 2010-11-11 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
US20070196452A1 (en) * | 2004-06-07 | 2007-08-23 | Jie Zhang | Flux-enabling compositions and methods for dermal delivery of drugs |
US7799331B2 (en) | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
MX2008014828A (es) * | 2006-05-22 | 2009-02-06 | Combinatorx Inc | Metodos y composiciones para el tratamiento de enfermedades o condiciones asociadas con niveles incrementados de proteina c-reactiva, interleucina-6 o interferon-gamma. |
US20070299017A1 (en) * | 2006-06-23 | 2007-12-27 | Kanter Mitchell M | Compositions for lowering blood serum cholesterol and use in foods, beverages, and health supplements |
US20100112590A1 (en) | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
FI2557517T3 (fi) | 2007-07-23 | 2022-11-30 | Nukleiinihapposekvenssiepätasapainon määrittäminen | |
EP2203174A4 (en) * | 2007-09-19 | 2010-09-29 | Combinatorx Inc | THERAPEUTIC REGIMES FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS |
MX2010006724A (es) * | 2007-12-17 | 2010-09-07 | Combinatorx Inc | Regimenes terapeuticos para el tratamiento de desordenes inmunoinflamatorios. |
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BR112012028267A2 (pt) * | 2010-05-06 | 2016-11-01 | Nuvo Res Inc | formulações de acetonida de triancinolona para tratamento dermatite e psoríase |
MD480Z5 (ro) * | 2011-07-07 | 2012-09-30 | Эльвира АНДОН | Metodă de tratament al colitei ulceroase nespecifice acute |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
US20180289708A1 (en) * | 2015-10-15 | 2018-10-11 | Moshe Rogosnitzky | Low dose oral dipyridamole compositions and uses thereof |
CN111346228B (zh) * | 2018-12-21 | 2022-01-14 | 广州市妇女儿童医疗中心 | 胃肠道疾病的免疫机制及治疗药物 |
CN114432451B (zh) * | 2018-12-21 | 2024-02-09 | 广州市妇女儿童医疗中心 | 胃肠道疾病的免疫机制及治疗药物 |
CN113456618A (zh) * | 2020-03-31 | 2021-10-01 | 天津金耀集团有限公司 | 一种复方双嘧达莫的吸入制剂及其制备方法 |
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