DE69018099D1 - Polyamin-Derivate als antineoplastische Mittel. - Google Patents

Polyamin-Derivate als antineoplastische Mittel.

Info

Publication number
DE69018099D1
DE69018099D1 DE69018099T DE69018099T DE69018099D1 DE 69018099 D1 DE69018099 D1 DE 69018099D1 DE 69018099 T DE69018099 T DE 69018099T DE 69018099 T DE69018099 T DE 69018099T DE 69018099 D1 DE69018099 D1 DE 69018099D1
Authority
DE
Germany
Prior art keywords
antineoplastic agents
polyamine derivatives
compounds
formula
polyamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69018099T
Other languages
English (en)
Other versions
DE69018099T2 (de
Inventor
David M Stemerick
Michael L Edwards
Nellikunja J Prakash
Alan J Bitonti
Peter P Mccann
Albert Sjoerdsma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69018099D1 publication Critical patent/DE69018099D1/de
Application granted granted Critical
Publication of DE69018099T2 publication Critical patent/DE69018099T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
DE69018099T 1989-01-10 1990-01-08 Polyamin-Derivate als antineoplastische Mittel. Expired - Fee Related DE69018099T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29561789A 1989-01-10 1989-01-10
US29572189A 1989-01-10 1989-01-10

Publications (2)

Publication Number Publication Date
DE69018099D1 true DE69018099D1 (de) 1995-05-04
DE69018099T2 DE69018099T2 (de) 1995-08-03

Family

ID=26969226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018099T Expired - Fee Related DE69018099T2 (de) 1989-01-10 1990-01-08 Polyamin-Derivate als antineoplastische Mittel.

Country Status (4)

Country Link
EP (1) EP0378146B1 (de)
AT (1) ATE120447T1 (de)
DE (1) DE69018099T2 (de)
DK (1) DK0378146T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5719193A (en) * 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
AU648846B2 (en) * 1990-12-13 1994-05-05 Merrell Dow Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N-bis(3-(ethylamino)propyl)-1,7-heptanediamine and a cytotoxic agent
US5561136A (en) * 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
KR100311851B1 (ko) * 1993-02-23 2002-04-24 슈테펜엘.네스비트 방사선보호제로서의폴리아민유도체
MXPA00009705A (es) * 1998-04-03 2003-07-14 Univ Manitoba Uso de poliaminas en el tratamiento de sintomas dermatologicos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305425C (en) * 1986-12-02 1992-07-21 Raymond J. Bergeron Anti-neoplastic spermine derivative
NZ223340A (en) * 1987-02-03 1991-03-26 Merrell Dow Pharma Polyamine derivatives and pharmaceutical compositions
ZA887410B (en) * 1987-10-08 1989-06-28 Merrell Dow Pharma Polyamine derivatives as antineoplastic agents

Also Published As

Publication number Publication date
EP0378146B1 (de) 1995-03-29
DK0378146T3 (da) 1995-05-01
ATE120447T1 (de) 1995-04-15
EP0378146A3 (de) 1991-04-24
DE69018099T2 (de) 1995-08-03
EP0378146A2 (de) 1990-07-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERRELL PHARMACEUTICALS INC., CINCINNATI, OHIO, US

8339 Ceased/non-payment of the annual fee