AR035355A1 - Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-(2-(piperidin-1-il)etoxi]fenoxi) -2- (4-metoxifenil) benzo (b) tiofeno - Google Patents

Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-(2-(piperidin-1-il)etoxi]fenoxi) -2- (4-metoxifenil) benzo (b) tiofeno

Info

Publication number
AR035355A1
AR035355A1 ARP010104895A ARP010104895A AR035355A1 AR 035355 A1 AR035355 A1 AR 035355A1 AR P010104895 A ARP010104895 A AR P010104895A AR P010104895 A ARP010104895 A AR P010104895A AR 035355 A1 AR035355 A1 AR 035355A1
Authority
AR
Argentina
Prior art keywords
piperidin
benzo
cancer
phenoxi
etoxi
Prior art date
Application number
ARP010104895A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR035355A1 publication Critical patent/AR035355A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente se refiere a una nueva forma cristalina anhidra y no solvatada de clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1-il)etoxi]fenoxi)-2-(4-metoxifenil)benzo[b]tiofeno y a los usos de la misma, incluyendo la inhibición de estados de enfermedad asociados con la falta de estrógenos, incluyendo enfermedad cardiovascular, hiperlipidemia y osteoporosis; y a la inhibición de otros trastornos patológicos como endometriosis, fibrosis uterina, cáncer dependiente de estrógenos (incluyendo cáncer de mama y cáncer de útero), cáncer de próstata, hiperplasia prostática benigna, trastornos del SNC incluyendo la enfermedad de Alzheimer, prevención del cáncer de mama y regulación positiva de la ChAT.
ARP010104895A 2000-10-20 2001-10-18 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-(2-(piperidin-1-il)etoxi]fenoxi) -2- (4-metoxifenil) benzo (b) tiofeno AR035355A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24225200P 2000-10-20 2000-10-20

Publications (1)

Publication Number Publication Date
AR035355A1 true AR035355A1 (es) 2004-05-12

Family

ID=22914051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104895A AR035355A1 (es) 2000-10-20 2001-10-18 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-(2-(piperidin-1-il)etoxi]fenoxi) -2- (4-metoxifenil) benzo (b) tiofeno

Country Status (26)

Country Link
US (1) US20040014672A1 (es)
EP (1) EP1328521A2 (es)
JP (1) JP2004512333A (es)
KR (1) KR20030037690A (es)
CN (1) CN1268624C (es)
AR (1) AR035355A1 (es)
AU (1) AU2002214534A1 (es)
BR (1) BR0114792A (es)
CA (1) CA2426007A1 (es)
CZ (1) CZ20031098A3 (es)
EA (1) EA005116B1 (es)
EC (1) ECSP034560A (es)
HK (1) HK1061857A1 (es)
HR (1) HRP20030296A2 (es)
HU (1) HUP0301403A3 (es)
IL (1) IL155487A0 (es)
MX (1) MXPA03003432A (es)
MY (1) MY125009A (es)
NO (1) NO20031753L (es)
NZ (1) NZ525364A (es)
PE (1) PE20020588A1 (es)
PL (1) PL360946A1 (es)
SK (1) SK4902003A3 (es)
UA (1) UA76124C2 (es)
WO (1) WO2002034741A2 (es)
ZA (1) ZA200303061B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2371549T3 (es) * 2003-10-10 2012-01-05 Synthon B.V. Montelukast en estado sólido.
AU2005275185B2 (en) * 2004-07-22 2011-06-23 Eli Lilly And Company A crystalline variable hydrate of (S)-6-(4-(2-((3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)amino)-2-methylpropyl)phenoxy)-3-pyridinecarbox amide hemisuccinate salt
US20110251143A1 (en) * 2007-12-19 2011-10-13 Spectrum Pharmaceuticals, Inc. Stable elsamitrucin salt formulations
EP2305238B1 (en) 2009-09-25 2011-12-14 Iasomai aktiebolag N-acetyl-L-cysteine for the treatment of endometriosis
PL236889B1 (pl) * 2017-10-03 2021-02-22 Univ Warszawski Medyczny Nowa forma krystaliczna bezwodnego 17-β-estradiolu, sposób jej otrzymywania oraz kompozycja farmaceutyczna zawierająca nową formę krystaliczną bezwodnego 17-β-estradiolu i jej zastosowanie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT729956E (pt) * 1995-02-28 2002-03-28 Lilly Co Eli Compostos intermediarios formulacoes e metodos de benzotiofeno
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
ATE251151T1 (de) * 1999-07-29 2003-10-15 Lilly Co Eli Eine kristalline form von 6-hydroxy-3-(4-(2- (piperidin-1-yl)ethoxy)phenoxy)-2-(4- methoxyphenyl)benzo(b)thiophen-hydrochlorid

Also Published As

Publication number Publication date
EA200300491A1 (ru) 2003-08-28
JP2004512333A (ja) 2004-04-22
WO2002034741A3 (en) 2003-01-03
HRP20030296A2 (en) 2003-06-30
CZ20031098A3 (cs) 2003-08-13
IL155487A0 (en) 2003-11-23
KR20030037690A (ko) 2003-05-14
ECSP034560A (es) 2003-06-25
CN1469872A (zh) 2004-01-21
BR0114792A (pt) 2003-08-12
SK4902003A3 (en) 2003-10-07
NO20031753D0 (no) 2003-04-15
HK1061857A1 (en) 2004-10-08
PE20020588A1 (es) 2002-07-06
ZA200303061B (en) 2004-07-19
MY125009A (en) 2006-07-31
NZ525364A (en) 2005-09-30
NO20031753L (no) 2003-04-15
EP1328521A2 (en) 2003-07-23
UA76124C2 (en) 2006-07-17
WO2002034741A2 (en) 2002-05-02
EA005116B1 (ru) 2004-10-28
AU2002214534A1 (en) 2002-05-06
HUP0301403A3 (en) 2009-05-28
PL360946A1 (en) 2004-09-20
CN1268624C (zh) 2006-08-09
HUP0301403A2 (hu) 2003-10-28
CA2426007A1 (en) 2002-05-02
MXPA03003432A (es) 2003-08-07
US20040014672A1 (en) 2004-01-22

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