AR031305A1 - Agonistas del receptor alfa activado del proliferador de peroxisomas - Google Patents

Agonistas del receptor alfa activado del proliferador de peroxisomas

Info

Publication number
AR031305A1
AR031305A1 ARP010105214A ARP010105214A AR031305A1 AR 031305 A1 AR031305 A1 AR 031305A1 AR P010105214 A ARP010105214 A AR P010105214A AR P010105214 A ARP010105214 A AR P010105214A AR 031305 A1 AR031305 A1 AR 031305A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
cycloalkyl
peroxisom
prolifer
Prior art date
Application number
ARP010105214A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR031305A1 publication Critical patent/AR031305A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06Compounds containing any of the groups, e.g. semicarbazides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/22Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups further bound to nitrogen atoms, e.g. hydrazidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • C07C281/04Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cultivation Of Plants (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

La presente se refiere a acompuestos representados por la formula estructural (1) y a sales, solvatos e hidratos farmacéuticamente aceptables de los mismos, en la que R1 es un grupo sustituido o no sustituido seleccionado entre alquilo C1-8, aril-alquilo C0-2, heteroaril-alquilo C0-2, cicloalquil C3-6-arilalquilo C0-2 o fenilo. W es O o S. R2 es H o un grupo sustituido o no sustituido seleccionado entre alquilo C1-6, cicloalquilo C3-6. X es un engarce alquileno C2-5 en el que un átomo de carbono del engarce puede estar reemplazado con O, NH o S. Y es C, O, S, NH o un enlace sencillo. Además, E es (CH2)nCOOH, siendo n 0, 1, 2 o 3, o C(R3)(R4)A, siendo A un grupo funcional ácido tal como carboxilo, carboxamida, sulfonamida sustituida o no sustituida o tetrazol sustituido o no sustituido. R3 es H, alcoxi C1-5 o alquilo C1-5 saturado o insaturado. Además, R4 es H, halo, un grupo sustituido o no sustituido seleccionado entre alquilo C1-5, alcoxi C1-5, cicloalquilo C3-6 y fenilo, o R3 y R4 se combinan para formar un cicloalquilo C3-4.
ARP010105214A 2000-11-10 2001-11-07 Agonistas del receptor alfa activado del proliferador de peroxisomas AR031305A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24731700P 2000-11-10 2000-11-10

Publications (1)

Publication Number Publication Date
AR031305A1 true AR031305A1 (es) 2003-09-17

Family

ID=22934453

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105214A AR031305A1 (es) 2000-11-10 2001-11-07 Agonistas del receptor alfa activado del proliferador de peroxisomas

Country Status (35)

Country Link
US (3) US7304062B2 (es)
EP (1) EP1335908B1 (es)
JP (1) JP4243101B2 (es)
KR (1) KR100839705B1 (es)
CN (1) CN1479728A (es)
AR (1) AR031305A1 (es)
AT (1) ATE386026T1 (es)
AU (3) AU2859202A (es)
BR (1) BR0114986A (es)
CA (1) CA2421154A1 (es)
CY (1) CY1107388T1 (es)
CZ (1) CZ20031283A3 (es)
DE (1) DE60132799T2 (es)
DK (1) DK1335908T3 (es)
EA (1) EA006920B1 (es)
EC (1) ECSP034595A (es)
ES (1) ES2300378T3 (es)
HK (1) HK1058790A1 (es)
HR (1) HRP20030365A2 (es)
HU (1) HUP0301655A2 (es)
IL (2) IL154840A0 (es)
MX (1) MXPA03004141A (es)
MY (1) MY157884A (es)
NO (1) NO20032059L (es)
NZ (1) NZ524569A (es)
PE (1) PE20020693A1 (es)
PL (1) PL362692A1 (es)
PT (1) PT1335908E (es)
SI (1) SI1335908T1 (es)
SK (1) SK5412003A3 (es)
SV (1) SV2003000727A (es)
TW (1) TW200716572A (es)
UA (1) UA82048C2 (es)
WO (1) WO2002038553A2 (es)
ZA (1) ZA200302517B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205321B2 (en) 2001-11-15 2007-04-17 Eli Lilly And Company Peroxisome proliferator activated receptor alpha agonists
GB0314079D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
EP1517882A1 (en) 2002-06-19 2005-03-30 Eli Lilly And Company Amide linker peroxisome proliferator activated receptor modulators
TW200505441A (en) 2003-03-24 2005-02-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitorsⅠ
FR2866339B1 (fr) * 2004-02-18 2006-05-05 Pf Medicament Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
CN1993332B (zh) * 2004-07-27 2011-04-06 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的苄基三唑酮化合物
KR100803481B1 (ko) * 2004-07-27 2008-02-14 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역전사효소 억제제로서의벤질트라이아졸론 화합물
EP1780210A4 (en) * 2004-08-11 2009-06-10 Kyorin Seiyaku Kk NEW CYCLIC AMINOBENOIC ACID DERIVATIVE
WO2006068199A1 (ja) * 2004-12-22 2006-06-29 Mochida Pharmaceutical Co., Ltd. 代謝的に安定な3-オキシ-1,2,4-トリアゾール誘導体
TW200640453A (en) * 2005-01-28 2006-12-01 Lilly Co Eli Formulations and dosing regimen for PPAR-α modulators
FR2882750B1 (fr) 2005-03-03 2007-05-11 Pierre Fabre Medicament Sa Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine
EP1862464A4 (en) * 2005-03-23 2010-08-25 Kyorin Seiyaku Kk NEW CYCLIC AMINOPHENYL ALKANIC ACID DERIVATIVE
WO2006099978A1 (en) * 2005-03-24 2006-09-28 F.Hoffmann-La Roche Ag 1,2,4-triazole-5-one compounds as heterocyclic reverse transcriptase inhibitors
WO2007126043A1 (ja) * 2006-04-27 2007-11-08 Mitsubishi Tanabe Pharma Corporation チアゾール環を含むカルボン酸誘導体の医薬用途
JP2010519308A (ja) * 2007-02-23 2010-06-03 イーライ リリー アンド カンパニー ペルオキシソーム増殖剤活性化受容体修飾因子
AU2008233929A1 (en) 2007-03-29 2008-10-09 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
US8323360B2 (en) * 2008-06-30 2012-12-04 3M Innovative Properties Company Method of crystallization
CN101643451B (zh) * 2008-08-07 2013-03-06 浙江海正药业股份有限公司 过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法
US8497382B2 (en) 2008-12-01 2013-07-30 Mitsubishi Tanabe Pharma Corporation Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof
US8575430B2 (en) * 2010-03-02 2013-11-05 Nunhems, B.V. Hybrid artichoke variety NUN 4006 AR
US20110167512A1 (en) * 2009-03-02 2011-07-07 Nunhems B.V. Hybrid artichoke variety nun 4006 ar
DE102010001064A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
US20100245582A1 (en) * 2009-03-25 2010-09-30 Syclipse Technologies, Inc. System and method of remote surveillance and applications therefor
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US8648233B2 (en) * 2010-09-20 2014-02-11 Nunhems B.V. Hybrid artichoke variety NUN 4021 AR
US8669420B2 (en) 2012-02-29 2014-03-11 Nunhems B.V. Hybrid artichoke variety NUN 4060 AR
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
AU2013363398B2 (en) * 2012-12-20 2017-06-01 Tempest Therapeutics, Inc. Triazolone compounds and uses thereof
EA201690230A1 (ru) * 2013-09-06 2016-07-29 Инсепшн 2, Инк. Соединения триазолона и их применения
RU177130U1 (ru) * 2017-11-29 2018-02-09 Владимир Алексеевич Коннов Плита изоляционная облицовочная
JPWO2021205803A1 (es) 2020-04-10 2021-10-14
CN112774869B (zh) * 2020-12-25 2022-09-16 厦门紫金矿冶技术有限公司 黄铁矿抑制剂及其制备和在铜铅锌多金属硫化矿中的应用
CN114853686B (zh) * 2021-08-23 2023-06-20 中国药科大学 三氮唑酮类化合物及其医药用途
CN115894379A (zh) * 2022-01-20 2023-04-04 中国药科大学 海因类化合物及其医药用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2090283A1 (en) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Phenoxyacetic acid derivatives
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
DE19517505A1 (de) 1995-05-12 1996-11-14 Bayer Ag Sulfonylamino(thio)carbonyltriazolin(thi)one mit Aryloxy- oder Arylthio-Substituenten
CA2229617A1 (en) 1995-10-20 1997-05-01 Dr. Karl Thomae Gmbh 5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation
DE69823858T2 (de) 1997-10-17 2005-04-28 Yamanouchi Pharmaceutical Co., Ltd. Amidderivate oder deren salze
WO1999008501A2 (en) 1998-04-23 1999-02-25 Dr. Reddy's Research Foundation New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
PE20011010A1 (es) 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
US6573287B2 (en) 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
USPP14578P2 (en) * 2002-09-23 2004-03-09 Plant Sciences, Inc. Artichoke plant named ‘PS-MSC0003’

Also Published As

Publication number Publication date
NZ524569A (en) 2006-05-26
US20040102500A1 (en) 2004-05-27
MXPA03004141A (es) 2003-08-19
EP1335908A2 (en) 2003-08-20
DE60132799T2 (de) 2009-03-19
AU2002228592B2 (en) 2006-04-27
PT1335908E (pt) 2008-05-08
NO20032059L (no) 2003-06-24
PL362692A1 (en) 2004-11-02
BR0114986A (pt) 2003-09-23
TW200716572A (en) 2007-05-01
AU2002228592B8 (en) 2006-08-24
ES2300378T3 (es) 2008-06-16
UA82048C2 (uk) 2008-03-11
PE20020693A1 (es) 2002-08-05
KR100839705B1 (ko) 2008-06-19
SK5412003A3 (en) 2004-01-08
US20090062358A1 (en) 2009-03-05
US20090044299A1 (en) 2009-02-12
CZ20031283A3 (cs) 2003-09-17
DE60132799D1 (de) 2008-03-27
US7304062B2 (en) 2007-12-04
JP2004513166A (ja) 2004-04-30
SV2003000727A (es) 2003-01-13
ECSP034595A (es) 2003-06-25
EP1335908B1 (en) 2008-02-13
SI1335908T1 (sl) 2008-08-31
ATE386026T1 (de) 2008-03-15
AU2859202A (en) 2002-05-21
HRP20030365A2 (en) 2003-08-31
EA200300558A1 (ru) 2004-02-26
WO2002038553A3 (en) 2003-05-01
NO20032059D0 (no) 2003-05-08
EA006920B1 (ru) 2006-04-28
DK1335908T3 (da) 2008-06-02
CN1479728A (zh) 2004-03-03
IL154840A (en) 2009-09-22
HUP0301655A2 (hu) 2003-12-29
CA2421154A1 (en) 2002-05-16
WO2002038553A2 (en) 2002-05-16
US7868225B2 (en) 2011-01-11
AU2006202811A1 (en) 2006-07-20
KR20030048133A (ko) 2003-06-18
MY157884A (en) 2016-08-01
JP4243101B2 (ja) 2009-03-25
CY1107388T1 (el) 2012-12-19
IL154840A0 (en) 2003-10-31
ZA200302517B (en) 2004-06-30
HK1058790A1 (en) 2004-06-04

Similar Documents

Publication Publication Date Title
AR031305A1 (es) Agonistas del receptor alfa activado del proliferador de peroxisomas
AR066348A1 (es) Inhibidores de las iap
DE60324898D1 (de) Modulatoren von peroxisome proliferator-aktivierten rezeptoren
AR062224A1 (es) Tetrazolilos macrociclicos como inhibidores de serina proteasa ns3 del virus de hepatitis c y composiciones farmaceuticas que los comprenden.
AR047591A1 (es) Composiciones antiincrustantes que comprenden un polimero con grupos de estructura de tipo sal
TW200621786A (en) Condensed pyrazole derivatives, their preparation and application in therapeutics
RS20090104A (en) Pyrudo (2,3-d)pyrimidinone compounds and their use as p13 inhibitors
CO6160296A2 (es) Derivados de acido benzoazepin-oxi-acetico como agonistas de receptores activados por proliferador de peroxisona delta usados para incrementar la lipoproteina de alta densidad-colesterol-colesterol reducir la lipoproteina de baja densidad-colesterol
PE20050948A1 (es) Compuestos de carbamoil-amina como inhibidores de la dipeptidil peptidasa iv
ES2396613T3 (es) Imidazopirazinas e imidazotriazinas sustituidas
NO20071476L (no) Antidiuretiske midler.
ATE506354T1 (de) Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
CO6160234A2 (es) Nuevos compuestos ciclicos fusionados que presentan una accion moduladora de la funcion del recptor gpr40
AR038536A1 (es) N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
ES2557477T3 (es) Nuevos compuestos peptídicos cíclicos
AR052915A1 (es) Derivados de pirrolidin y piperidin acetileno
AR057408A1 (es) Agonistas del receptor de niacina composiciones que contienen tales compuestos y procedimientos para tratamiento
HRP20120108T1 (en) Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
AR059621A1 (es) Acidos 4- fenil- tiazol-5- carboxilicos y amidas de acidos 4- fenil- tiazol5 carboxilicos como inhibidores de la plk1
MY148953A (en) Substituted biphenyl carboxylic acids and derivatives thereof
CO5640129A2 (es) Agonistas del receptor activado por proliferador de peroxisoma
CO5570696A2 (es) 1-amino-alquilciclohexanos insaturados como antagonistas de los receptores nmda, 5ht3 y nicotinico neuronal
AR050032A1 (es) Derivados de acido benzoico como inhibidores no nucleosidos de la transcriptasa inversa
ECSP045121A (es) Agonistas del receptor activado por proliferador de peroxisoma
PE20090602A1 (es) Nuevos compuestos

Legal Events

Date Code Title Description
FB Suspension of granting procedure