HUP0301655A2 - Peroxisom proliferátor aktivált receptor alfa agonista triazolszármazékok és ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

Peroxisom proliferátor aktivált receptor alfa agonista triazolszármazékok és ezeket tartalmazó gyógyászati készítmények és alkalmazásuk

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Publication number
HUP0301655A2
HUP0301655A2 HU0301655A HUP0301655A HUP0301655A2 HU P0301655 A2 HUP0301655 A2 HU P0301655A2 HU 0301655 A HU0301655 A HU 0301655A HU P0301655 A HUP0301655 A HU P0301655A HU P0301655 A2 HUP0301655 A2 HU P0301655A2
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Hungary
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alkyl
group
carbon atom
aryl
substituted
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HU0301655A
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English (en)
Inventor
David Scott Coffey
Ivan Collado Cano
Samuel James Dominianni
Garret Jay Etgen
Cristina Garcia-Paredes
Richard Duane Johnston
Michael Edward Letourneau
Nathan Bryan Mantlo
Michael John Martinelli
Daniel Ray Mayhugh
Ashraf Saeed
Christopher Randall Schmid
Richard Craig Thompson
Jeffrey Thomas Vicenzi
Xiadong Wang
Yanping Xu
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Eli Lilly And Co.
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Publication of HUP0301655A2 publication Critical patent/HUP0301655A2/hu

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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/22—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups further bound to nitrogen atoms, e.g. hydrazidines
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    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C07C281/04—Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract

A találmány tárgyát az (I) általános képletű vegyületek képezik, ezeka peroxisom proliferátor aktivált receptorokra agonista hatástfejtenek ki és mint ilyenek, eredményesen alkalmazhatók többek közöttdiabetes-mellitus, szív- és érrendszeri betegségek, elhízottság,gyulladásos bélbetegségek kezelésére és megelőzésére. A találmánytárgyához tartoznak az (I) általános képletű vegyületeket tartalmazógyógyászati készítmények is. Az (I) általános képletben aszubsztituensek jelentése igen sokféle, így például (a) R1 jelentésehidrogénatom, adott esetben szubsztituált csoport, amely választhatóalkil-, aril-(0-4 szénatomos alkil)-, heteroaril-(0-4 szénatomosalkil)-, (3-6 szénatomos cikloalkil)-aril-(0-2 szénatomos alkil)- és -fenilcsoport; (b) W jelentése O vagy S; (c) R2 jelentése hidrogénatomvagy adott esetben szubsztituált csoport, amely választható alkil-,allil-, aril-(0-4 szénatomos alkil)-, heteroaril-(0-4 szénatomosalkil)-, és 3-6 szénatomos cikloalkilcsoport közül; (d) X jelentéseadott esetben szubsztituált 1-5 szénatomos alkilén kapcsoló csoport,ahol a kapcsolócsoport egyik szénatomja helyett O, NH vagy S állhat;(e) Y jelentése C, O, S, NH vagy egyes vegyértékkötés; továbbá (f) Ejelentése hidrogénatom, C(R3)(R4)A, A, adott esetben szubsztituáltcsoport, amely választható (CH2)nCOOR19, alkil-, allil-, aril-(0-4szénatomos alkil)-, tio(1-4 szénatomos alkil)-, tioaril-, alkoxi-aril-, (1-4 szénatomos alkoxi)-(1-4 szénatomos alkil)-, amino-aril- ésamino-(1-4 szénatomos alkil)-csoport közül, ahol (i) n értéke 0, 1, 2vagy 3; (ii) A jelentése funkciós csoport, amely választhatókarboxil-, (1-3 szénatomos alkil)-nitril-, karboxamid-, szubsztituáltvagy szubsztituálatlan szulfonamid, szubsztituált vagyszubsztituálatlan acil-szulfonamid, valamint szubsztituált vagyszubsztituálatlan tetrazolilcsoport közül; (iii) R3 jelentésehidrogénatom, telített vagy telítetlen 1-5 szénatomos alkil-, 1-5szénatomos alkoxicsoport és (iv) R4 jelentése hidrogénatom,halogénatom, szubsztituált vagy szubsztituálatlan csoport, amelyválasztható alkil-, alkoxi-, 3-6 szénatomos cikloalkil-, aril-(0-4szénatomos alkil)- és fenilcsoport közül, vagy R3 és R4 együtt 3-4szénatomos cikloalkilcsoportot képezhetnek; Ó
HU0301655A 2000-11-10 2001-11-09 Peroxisom proliferátor aktivált receptor alfa agonista triazolszármazékok és ezeket tartalmazó gyógyászati készítmények és alkalmazásuk HUP0301655A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24731700P 2000-11-10 2000-11-10
PCT/US2001/042928 WO2002038553A2 (en) 2000-11-10 2001-11-09 Triazole derivatives and their use as peroxisome proliferator activated receptor alpha agonists

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HUP0301655A2 true HUP0301655A2 (hu) 2003-12-29

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EP (1) EP1335908B1 (hu)
JP (1) JP4243101B2 (hu)
KR (1) KR100839705B1 (hu)
CN (1) CN1479728A (hu)
AR (1) AR031305A1 (hu)
AT (1) ATE386026T1 (hu)
AU (3) AU2002228592B8 (hu)
BR (1) BR0114986A (hu)
CA (1) CA2421154A1 (hu)
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EC (1) ECSP034595A (hu)
ES (1) ES2300378T3 (hu)
HK (1) HK1058790A1 (hu)
HR (1) HRP20030365A2 (hu)
HU (1) HUP0301655A2 (hu)
IL (2) IL154840A0 (hu)
MX (1) MXPA03004141A (hu)
MY (1) MY157884A (hu)
NO (1) NO20032059L (hu)
NZ (1) NZ524569A (hu)
PE (1) PE20020693A1 (hu)
PL (1) PL362692A1 (hu)
PT (1) PT1335908E (hu)
SI (1) SI1335908T1 (hu)
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SV (1) SV2003000727A (hu)
TW (1) TW200716572A (hu)
UA (1) UA82048C2 (hu)
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