AR015997A1 - Derivados de benzopiranos sustituidos con sulfonamida, procedimientos para su preparacion y su utilizacion en calidad de medicamentos, asi como preparadosfarmaceuticos que los contienen - Google Patents
Derivados de benzopiranos sustituidos con sulfonamida, procedimientos para su preparacion y su utilizacion en calidad de medicamentos, asi como preparadosfarmaceuticos que los contienenInfo
- Publication number
- AR015997A1 AR015997A1 ARP980105473A ARP980105473A AR015997A1 AR 015997 A1 AR015997 A1 AR 015997A1 AR P980105473 A ARP980105473 A AR P980105473A AR P980105473 A ARP980105473 A AR P980105473A AR 015997 A1 AR015997 A1 AR 015997A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- methyl
- hydrogen
- substituted
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de benzopiranos sustituidos con sulfonamida de la formula (I) en la que R5 está enlazado con una de las posiciones 5 a 8, y en las que significanR1 y R2 independientemente uno del otro, hidrogeno, CF3, C2F5, C3F7, alquilo C1-6 o fenilo,que está sin sustituir o sustituido con 1 o 2 sustituyentes,seleccionados entre el grupo que consta de F, Cl, Br, I, CF3, NO2, CN, NH2, OH, metilo, etilo, metoxi, dimetilamino, sulfamoílo, metilsulfonilo ymetilsulfonilamino; o R1 y R2 en comun, unacade na de alquileno C2-10; R3 es R10-CnH2n-NR11- o R10-CnH2n-, pudiendo un grupo CH2 en los grupos CnH2n estarreemplazado por -O-, -CO-, -S-, -SO-, -SO2- o -NR12a-; R12a es hidrogeno, metilo o etilo; R10 puede ser hidrogeno, metilo, cicloalquilo C3-8, CF 3, C2F5 o C3F7;n puede ser de 0 a 10; R11 es hidrogeno o alquilo C1-6; o R10 y R11 en comun, un enlace, siempre y cuando que n no sea menor que 3; o R3 en comun con R4 unacadena de alquileno C3-8, pudiendo un grupo CH2 de la cadena dealquileno estar reemplazado por -O-, -CO-, -S-, -SO-, -SO2- o -NR12a; R12a es hidrogeno, metiloo etilo; R4 es R13-CrH2r, pudiendo un grupo CH2 del grupo CrH2r estar reemplazado por -O-, -CH=CH-, -C:::C-, -CO-, -CO-O-, -O-CO-, -S-, -SO-, -SO2- o -NR14-;siendo R14 hi drogeno o alquilo C1-3; R13 puede ser CH3, CF3, C2F5, C3F7, cicloalquilo C3-8, NR15R16, fenilo o un heterociclo que contiene N C1-9, estando elfenilo y el heterociclo que contiene N sin sustituir o sustituido con 1 o 2sustituyentes, seleccionados en tre el grupo que consta de F, Cl, Br, I, CF3, NO2,CN, NH2, OH, metilo, etilo, metoxi, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R15 y R16 en comun, forman una cadena de 4 o 5 grupos demetileno, delos cuales un grupo CH2 puede es tar reemplazado por -O-, -S-, -NH-, -N(metilo)- o -N(bencilo)-; r puede ser de 0 a 20; R5 es -Y-CsH2s-R18 ofenilo, que está sin sustituir o sustituido con 1 o 2 sustituyentes seleccionados entre el grupo que constade F, Cl, Br, I, CF3, NO2, CN, NH2, OH, metilo,etilo, metoxi, dimetilamino, sulfamoílo, metilsulfonilo o metilsulfonilamino; Y puede ser -O-, -S- o -NR10c; R10c es hidrogeno o alquilo C1-3; s es de 1 a 8;
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19748469A DE19748469A1 (de) | 1997-11-03 | 1997-11-03 | Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015997A1 true AR015997A1 (es) | 2001-05-30 |
Family
ID=7847428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105473A AR015997A1 (es) | 1997-11-03 | 1998-10-30 | Derivados de benzopiranos sustituidos con sulfonamida, procedimientos para su preparacion y su utilizacion en calidad de medicamentos, asi como preparadosfarmaceuticos que los contienen |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6008245A (es) |
| EP (1) | EP0913396B1 (es) |
| JP (1) | JP4430749B2 (es) |
| KR (1) | KR19990044961A (es) |
| CN (1) | CN1218050A (es) |
| AR (1) | AR015997A1 (es) |
| AT (1) | ATE250051T1 (es) |
| AU (1) | AU740814B2 (es) |
| BR (1) | BR9805088A (es) |
| CA (1) | CA2252733A1 (es) |
| CZ (1) | CZ293913B6 (es) |
| DE (2) | DE19748469A1 (es) |
| DK (1) | DK0913396T3 (es) |
| ES (1) | ES2203867T3 (es) |
| HR (1) | HRP980576B1 (es) |
| HU (1) | HUP9802518A3 (es) |
| ID (1) | ID21209A (es) |
| IL (1) | IL126855A (es) |
| MY (1) | MY118262A (es) |
| NO (1) | NO985023L (es) |
| NZ (1) | NZ332575A (es) |
| PL (1) | PL329437A1 (es) |
| PT (1) | PT913396E (es) |
| RU (1) | RU2225403C2 (es) |
| SI (1) | SI0913396T1 (es) |
| SK (1) | SK284859B6 (es) |
| TR (1) | TR199802200A2 (es) |
| TW (1) | TW593307B (es) |
| ZA (1) | ZA989982B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5408940A (en) * | 1992-06-25 | 1995-04-25 | Winchell; Paul W. | Adjustable height work surface wtih rack and pinion arrangements |
| DE19858253A1 (de) | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| KR100512486B1 (ko) * | 2003-05-28 | 2005-09-06 | 동부한농화학 주식회사 | 싸이옥소벤즈옥사졸 유도체로 치환된 벤조피란 유도체또는 약학적으로 허용되는 염, 이의 제조방법 및 이를포함하는 약학적 조성물 |
| KR100545780B1 (ko) * | 2003-05-28 | 2006-01-24 | 동부한농화학 주식회사 | 벤즈이미다졸 유도체로 치환된 벤조피란 유도체 또는약학적으로 허용되는 그의 염, 이의 제조 방법 및 이를포함하는 약학적 조성물 |
| DE602006016420D1 (de) * | 2005-04-12 | 2010-10-07 | Abbott Products Gmbh | Aminoalkylamidomethylsubstituierte 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2h-cromen-6-yl derivate und ihre verwendung als kaliumkanalblocker |
| WO2012012473A1 (en) | 2010-07-19 | 2012-01-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of delta tocopherol for the treatment of lysosomal storage disorders |
| WO2014078573A2 (en) | 2012-11-16 | 2014-05-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders |
| US9573921B2 (en) * | 2013-09-30 | 2017-02-21 | Polfarmex S.A. | Substituted N, N-dimethylaminoalkyl ethers of isoflavanone oximes as H1-receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3737195A1 (de) * | 1987-11-03 | 1989-05-18 | Bayer Ag | Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| GB8808069D0 (en) * | 1988-04-07 | 1988-05-11 | Fujisawa Pharmaceutical Co | Benzopyran derivatives & processes for preparation thereof |
| US5104890A (en) * | 1989-03-28 | 1992-04-14 | Fujisawa Pharmaceutical Company, Ltd. | Benzopyran derivatives and processes for preparation thereof |
| ES2218617T3 (es) * | 1996-05-15 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | Cromanos sustituidos con sulfonamida, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico, asi como medicamentos que los contienen. |
| DE19706675A1 (de) * | 1997-02-20 | 1998-08-27 | Hoechst Ag | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19742509A1 (de) * | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19742508A1 (de) * | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
-
1997
- 1997-11-03 DE DE19748469A patent/DE19748469A1/de not_active Withdrawn
-
1998
- 1998-10-28 AT AT98120379T patent/ATE250051T1/de not_active IP Right Cessation
- 1998-10-28 DE DE59809628T patent/DE59809628D1/de not_active Expired - Lifetime
- 1998-10-28 NO NO985023A patent/NO985023L/no not_active Application Discontinuation
- 1998-10-28 PT PT98120379T patent/PT913396E/pt unknown
- 1998-10-28 EP EP98120379A patent/EP0913396B1/de not_active Expired - Lifetime
- 1998-10-28 DK DK98120379T patent/DK0913396T3/da active
- 1998-10-28 SI SI9830559T patent/SI0913396T1/xx unknown
- 1998-10-28 ES ES98120379T patent/ES2203867T3/es not_active Expired - Lifetime
- 1998-10-30 SK SK1494-98A patent/SK284859B6/sk unknown
- 1998-10-30 AU AU90437/98A patent/AU740814B2/en not_active Ceased
- 1998-10-30 ID IDP981433A patent/ID21209A/id unknown
- 1998-10-30 TW TW087118010A patent/TW593307B/zh not_active IP Right Cessation
- 1998-10-30 AR ARP980105473A patent/AR015997A1/es unknown
- 1998-10-30 NZ NZ332575A patent/NZ332575A/xx unknown
- 1998-10-30 PL PL98329437A patent/PL329437A1/xx not_active Application Discontinuation
- 1998-10-30 TR TR1998/02200A patent/TR199802200A2/xx unknown
- 1998-11-02 MY MYPI98004981A patent/MY118262A/en unknown
- 1998-11-02 HU HU9802518A patent/HUP9802518A3/hu unknown
- 1998-11-02 RU RU98119955/04A patent/RU2225403C2/ru not_active IP Right Cessation
- 1998-11-02 HR HR980576A patent/HRP980576B1/xx not_active IP Right Cessation
- 1998-11-02 IL IL12685598A patent/IL126855A/xx not_active IP Right Cessation
- 1998-11-02 ZA ZA989982A patent/ZA989982B/xx unknown
- 1998-11-02 JP JP31194798A patent/JP4430749B2/ja not_active Expired - Fee Related
- 1998-11-02 US US09/184,110 patent/US6008245A/en not_active Expired - Lifetime
- 1998-11-02 CZ CZ19983508A patent/CZ293913B6/cs not_active IP Right Cessation
- 1998-11-03 CN CN98123865A patent/CN1218050A/zh active Pending
- 1998-11-03 CA CA002252733A patent/CA2252733A1/en not_active Abandoned
- 1998-11-03 KR KR1019980046904A patent/KR19990044961A/ko not_active Application Discontinuation
- 1998-11-03 BR BR9805088A patent/BR9805088A/pt not_active Application Discontinuation
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |