AR014915A1 - Cromanos sustituidos con sulfonamida, su utilizacion como medicamentos y preparados farmaceuticos que los contienen - Google Patents
Cromanos sustituidos con sulfonamida, su utilizacion como medicamentos y preparados farmaceuticos que los contienenInfo
- Publication number
- AR014915A1 AR014915A1 ARP980104775A ARP980104775A AR014915A1 AR 014915 A1 AR014915 A1 AR 014915A1 AR P980104775 A ARP980104775 A AR P980104775A AR P980104775 A ARP980104775 A AR P980104775A AR 014915 A1 AR014915 A1 AR 014915A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- hydrogen
- group
- methyl
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Cromanos sustituidos con sulfonamidas que comprenden la formula (I) en la que significan: R(1) y R(2) independientemente uno de otro, hidrogeno, CF3, C2F5,C3F7, alquilo con 1, 2, 3, 4, 5 o 6 átomos de C o fenilo, que está sin sustituir o sustituidoc on 1 o 2 sustituyentes, seleccionados entre el grupo que constade F, Cl, Br, I, CF3, NO2, CN, NH2, OH, metilo, etilo, metoxi, dimetilamino, sulfamoílo, metilsulfonilo y metilsulfonilamino; R(1) y R(2) en comun, una cadenade alquileno con 2, 3, 4,5, 6, 7, 8, 9 o 10 átomos de C; R(3) R(10)-CnH2n- pudiendo un grupo CH2 en los grupos CnH2n estar reemplazado por -O-, -CO-, -S-,-SO-, -SO2- o -NR(12a)-; R(12a) hidrogeno, metilo o etilo; R(10) hidrogeno, metilo cicloalquilo con 3, 4, 5, 6, 7 u 8átomos de C, CF3, C2F5 o C3F7; n cero, 1,2, 3, 4, 5, 6, 7, 8, 9 o 10; R(11) hidrogeno o alquilo con 1, 2, 3, 4, 5 o 6 átomos de C; o R(10) y R(11) en comun un enlace, siempre y cuando n no se menorque 3; o R(3) en comun con R(4) una cadena dealquileno con 3, 4, 5, 6, 7 u 8 átomos de C, pudiendo un grupo CH2 de la cadena de alquileno estar reemplazadopor -O-, -CO-, -S-, -SO-, -SO2- o -NR(12a)-; R(12a) hidrogeno, metilo o etilo; R(4) R(13) -CrH2r, pudiendo un grupo CH2 del grupo CrH2restar reemplazad o por-O-, -CH=CH-, -C=C-, -CO-, -CO-O-, -O-CO-, -S-, -SO-, -SO2-, -nr(14) o -CONR(14)-; R(14) hidrogeno, alquilo con 1, 2 o 3 átomos de C; -CyH2y-OR(12b),CyH2y-NR(12b)2; R(12b) hidrogeno, metilo o etilo y 2 o 3; R(13) H, CF3, C2F5,C3F7, cicloalquilo con 3, 4, 5, 6, 7 u 8 átomos de C, -NR(15)R(16, -OR(17),-COOR(17), fenilo o un heterociclo que contiene N con 1, 2, 3, 4, 5, 6, 7, 8 o 9 átomos de C estando el fenilo y el heterociclo que contiene N sin sustituir osutituidos con 1o 2 sustituyentes, seleccionados entre el grupo que consta de F, Cl, Br, I, CF2, NO2, CH, NH2, OH, metilo, etilo, metoxi, dimetilamino,sulfamoílo, metilsulfonilo, aminosulfonilo y metilsulfonilamino; R(15 y R(16) independientemente uno de otro,hidrogeno, alquilo con 1, 2, 3, o 4 átomos de C;o R(15) y R(16) en comun una cadena de 4 o 5 grupos de metileno, delos cuales un grupo CH2, puede estar reemplazado por -O-, -S-, -NH-, -N(CH2) - o -N-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742508A DE19742508A1 (de) | 1997-09-26 | 1997-09-26 | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014915A1 true AR014915A1 (es) | 2001-04-11 |
Family
ID=7843708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104775A AR014915A1 (es) | 1997-09-26 | 1998-09-24 | Cromanos sustituidos con sulfonamida, su utilizacion como medicamentos y preparados farmaceuticos que los contienen |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6177449B1 (es) |
| EP (1) | EP0906911B1 (es) |
| JP (1) | JP4422222B2 (es) |
| KR (1) | KR19990030120A (es) |
| CN (1) | CN1216763A (es) |
| AR (1) | AR014915A1 (es) |
| AT (1) | ATE265445T1 (es) |
| AU (1) | AU755735B2 (es) |
| BR (1) | BR9803367A (es) |
| CA (1) | CA2248300C (es) |
| CZ (1) | CZ307198A3 (es) |
| DE (2) | DE19742508A1 (es) |
| ES (1) | ES2221107T3 (es) |
| HR (1) | HRP980528A2 (es) |
| HU (1) | HUP9802155A3 (es) |
| ID (1) | ID20967A (es) |
| IL (1) | IL126280A (es) |
| NO (1) | NO984476L (es) |
| NZ (1) | NZ332030A (es) |
| PL (1) | PL328854A1 (es) |
| RU (1) | RU2220965C2 (es) |
| SK (1) | SK131898A3 (es) |
| TR (1) | TR199801903A2 (es) |
| TW (1) | TW565559B (es) |
| ZA (1) | ZA988788B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19748469A1 (de) * | 1997-11-03 | 1999-05-06 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE19858253A1 (de) | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| TW589305B (en) * | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| FI20011507A0 (fi) * | 2001-07-10 | 2001-07-10 | Orion Corp | Uusia yhdisteitä |
| US7001660B2 (en) | 2001-07-16 | 2006-02-21 | Gilbert Garitano | Images in solids surfaces |
| FI20030030A0 (fi) * | 2003-01-09 | 2003-01-09 | Orion Corp | Uusia yhdisteitä |
| US7368582B2 (en) | 2003-10-17 | 2008-05-06 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| ZA200707473B (en) * | 2005-04-12 | 2008-12-31 | Solvay Pharm Gmbh | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3 , 4-dihydro-2H-cromen-6-yl derivatives and their use as potassium channel blockers |
| US7714150B2 (en) | 2005-04-12 | 2010-05-11 | Solvay Pharmaceuticals Gmbh | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives |
| WO2010018867A1 (ja) * | 2008-08-14 | 2010-02-18 | 日産化学工業株式会社 | ジ置換ベンゾピラン化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820834A (en) | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| FR2639349B1 (fr) | 1988-11-23 | 1991-02-22 | Sanofi Sa | Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant |
| US5104890A (en) * | 1989-03-28 | 1992-04-14 | Fujisawa Pharmaceutical Company, Ltd. | Benzopyran derivatives and processes for preparation thereof |
| US5428031A (en) | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| SK283837B6 (sk) * | 1996-05-15 | 2004-03-02 | Hoechst Aktiengesellschaft | Chrómany, spôsob ich prípravy, liečivá, ktoré ich obsahujú, a ich použitie |
| DE19706675A1 (de) * | 1997-02-20 | 1998-08-27 | Hoechst Ag | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19742509A1 (de) * | 1997-09-26 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
-
1997
- 1997-09-26 DE DE19742508A patent/DE19742508A1/de not_active Withdrawn
-
1998
- 1998-09-17 IL IL12628098A patent/IL126280A/xx not_active IP Right Cessation
- 1998-09-19 DE DE59811267T patent/DE59811267D1/de not_active Expired - Lifetime
- 1998-09-19 EP EP98117810A patent/EP0906911B1/de not_active Expired - Lifetime
- 1998-09-19 ES ES98117810T patent/ES2221107T3/es not_active Expired - Lifetime
- 1998-09-19 AT AT98117810T patent/ATE265445T1/de not_active IP Right Cessation
- 1998-09-22 CN CN98119539A patent/CN1216763A/zh active Pending
- 1998-09-22 CA CA002248300A patent/CA2248300C/en not_active Expired - Fee Related
- 1998-09-24 AR ARP980104775A patent/AR014915A1/es not_active Application Discontinuation
- 1998-09-24 SK SK1318-98A patent/SK131898A3/sk unknown
- 1998-09-24 NZ NZ332030A patent/NZ332030A/xx unknown
- 1998-09-24 TR TR1998/01903A patent/TR199801903A2/xx unknown
- 1998-09-24 RU RU98117567/04A patent/RU2220965C2/ru not_active IP Right Cessation
- 1998-09-24 ID IDP981279A patent/ID20967A/id unknown
- 1998-09-24 CZ CZ983071A patent/CZ307198A3/cs unknown
- 1998-09-25 HR HR19742508.9A patent/HRP980528A2/hr not_active Application Discontinuation
- 1998-09-25 JP JP27216898A patent/JP4422222B2/ja not_active Expired - Fee Related
- 1998-09-25 PL PL98328854A patent/PL328854A1/xx unknown
- 1998-09-25 AU AU87082/98A patent/AU755735B2/en not_active Ceased
- 1998-09-25 HU HU9802155A patent/HUP9802155A3/hu unknown
- 1998-09-25 KR KR1019980039836A patent/KR19990030120A/ko not_active Application Discontinuation
- 1998-09-25 ZA ZA988788A patent/ZA988788B/xx unknown
- 1998-09-25 BR BR9803367-0A patent/BR9803367A/pt not_active IP Right Cessation
- 1998-09-25 NO NO984476A patent/NO984476L/no not_active Application Discontinuation
- 1998-10-22 TW TW087115865A patent/TW565559B/zh active
-
1999
- 1999-10-20 US US09/421,277 patent/US6177449B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL328854A1 (en) | 1999-03-29 |
| DE19742508A1 (de) | 1999-04-01 |
| EP0906911B1 (de) | 2004-04-28 |
| ES2221107T3 (es) | 2004-12-16 |
| TR199801903A3 (tr) | 1999-04-21 |
| ATE265445T1 (de) | 2004-05-15 |
| CA2248300A1 (en) | 1999-03-26 |
| EP0906911A1 (de) | 1999-04-07 |
| IL126280A0 (en) | 1999-05-09 |
| AU8708298A (en) | 1999-04-15 |
| SK131898A3 (en) | 1999-06-11 |
| HUP9802155A2 (hu) | 1999-09-28 |
| JP4422222B2 (ja) | 2010-02-24 |
| JPH11158171A (ja) | 1999-06-15 |
| KR19990030120A (ko) | 1999-04-26 |
| TR199801903A2 (xx) | 1999-04-21 |
| BR9803367A (pt) | 2000-05-09 |
| US6177449B1 (en) | 2001-01-23 |
| IL126280A (en) | 2003-10-31 |
| CN1216763A (zh) | 1999-05-19 |
| RU2220965C2 (ru) | 2004-01-10 |
| CA2248300C (en) | 2008-12-02 |
| TW565559B (en) | 2003-12-11 |
| ID20967A (id) | 1999-04-01 |
| AU755735B2 (en) | 2002-12-19 |
| DE59811267D1 (de) | 2004-06-03 |
| ZA988788B (en) | 1999-03-26 |
| HUP9802155A3 (en) | 2002-04-29 |
| HU9802155D0 (en) | 1998-11-30 |
| NO984476L (no) | 1999-03-29 |
| NZ332030A (en) | 2000-04-28 |
| NO984476D0 (no) | 1998-09-25 |
| CZ307198A3 (cs) | 1999-04-14 |
| HRP980528A2 (en) | 1999-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |