AR009133A1 - Un procedimiento para preparar 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil- 1,2,3,4-tetrahidroisoquinolin-2-il)pirimidina, procedimientos para preparar una 4-halogeno-2-(4-fluorofenilamino)-5,6-dimetilpirimidina y un derivado de pirimidina util como intermediario - Google Patents

Un procedimiento para preparar 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil- 1,2,3,4-tetrahidroisoquinolin-2-il)pirimidina, procedimientos para preparar una 4-halogeno-2-(4-fluorofenilamino)-5,6-dimetilpirimidina y un derivado de pirimidina util como intermediario

Info

Publication number
AR009133A1
AR009133A1 ARP970104978A ARP970104978A AR009133A1 AR 009133 A1 AR009133 A1 AR 009133A1 AR P970104978 A ARP970104978 A AR P970104978A AR P970104978 A ARP970104978 A AR P970104978A AR 009133 A1 AR009133 A1 AR 009133A1
Authority
AR
Argentina
Prior art keywords
pirimidine
dimethyl
fluorophenylamine
preparing
methyl
Prior art date
Application number
ARP970104978A
Other languages
English (en)
Spanish (es)
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960049382A external-priority patent/KR100209587B1/ko
Priority claimed from KR1019960049380A external-priority patent/KR0185292B1/ko
Priority claimed from KR1019960049381A external-priority patent/KR100193080B1/ko
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of AR009133A1 publication Critical patent/AR009133A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ARP970104978A 1996-10-29 1997-10-28 Un procedimiento para preparar 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil- 1,2,3,4-tetrahidroisoquinolin-2-il)pirimidina, procedimientos para preparar una 4-halogeno-2-(4-fluorofenilamino)-5,6-dimetilpirimidina y un derivado de pirimidina util como intermediario AR009133A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019960049382A KR100209587B1 (ko) 1996-10-29 1996-10-29 피리미딘 유도체의 제조방법
KR1019960049380A KR0185292B1 (ko) 1996-10-29 1996-10-29 (s)-피리미딘 유도체의 제조방법
KR1019960049381A KR100193080B1 (ko) 1996-10-29 1996-10-29 (r)-피리미딘 유도체의 제조방법

Publications (1)

Publication Number Publication Date
AR009133A1 true AR009133A1 (es) 2000-03-08

Family

ID=27349413

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104978A AR009133A1 (es) 1996-10-29 1997-10-28 Un procedimiento para preparar 5,6-dimetil-2-(4-fluorofenilamino)-4-(1-metil- 1,2,3,4-tetrahidroisoquinolin-2-il)pirimidina, procedimientos para preparar una 4-halogeno-2-(4-fluorofenilamino)-5,6-dimetilpirimidina y un derivado de pirimidina util como intermediario

Country Status (5)

Country Link
AR (1) AR009133A1 (pt)
BR (1) BR9712392A (pt)
HU (1) HU226752B1 (pt)
TR (1) TR199900943T2 (pt)
WO (1) WO1998018784A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) * 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB0110338D0 (en) * 2001-04-27 2001-06-20 Sb Pharmco Inc Novel processes
JP4634144B2 (ja) 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
US7776873B2 (en) * 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
PL2007362T3 (pl) 2006-04-04 2019-02-28 Kg Acquisition Llc Doustne postacie leku obejmujące czynnik przeciwpłytkowy i inhibitor kwasu
CN102993173B (zh) * 2012-12-28 2014-09-03 山东大学 洛氟普啶的制备方法
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
CN105601611A (zh) * 2014-11-19 2016-05-25 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶多晶型物及其制备方法
CN107759562B (zh) * 2016-08-21 2020-10-23 常州四药制药有限公司 一种盐酸洛氟普啶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182584A (en) * 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
DE59010042D1 (de) * 1989-03-22 1996-02-22 Ciba Geigy Ag Schädlingsbekämpfungsmittel
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
DE69530989T2 (de) * 1994-08-13 2004-05-19 Yuhan Corp. Neue pyrimidinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
BR9712392A (pt) 2000-01-25
TR199900943T2 (xx) 1999-12-21
HUP9903520A1 (hu) 2000-05-28
HU226752B1 (en) 2009-09-28
HUP9903520A3 (en) 2002-01-28
WO1998018784A1 (en) 1998-05-07

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