AR009133A1 - A PROCEDURE FOR PREPARING 5,6-DIMETHYL-2- (4-FLUOROPHENYLAMINE) -4- (1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-2-IL) PIRIMIDINE, PROCEDURES FOR PREPARING A 4-HALOGEN-2 - (4-FLUOROPHENYLAMINE) -5,6-DIMETHYL PIRIMIDINE AND A DERIVATIVE OF PIRIMIDINE USEFUL AS AN INTERMEDIARY - Google Patents

A PROCEDURE FOR PREPARING 5,6-DIMETHYL-2- (4-FLUOROPHENYLAMINE) -4- (1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-2-IL) PIRIMIDINE, PROCEDURES FOR PREPARING A 4-HALOGEN-2 - (4-FLUOROPHENYLAMINE) -5,6-DIMETHYL PIRIMIDINE AND A DERIVATIVE OF PIRIMIDINE USEFUL AS AN INTERMEDIARY

Info

Publication number
AR009133A1
AR009133A1 ARP970104978A ARP970104978A AR009133A1 AR 009133 A1 AR009133 A1 AR 009133A1 AR P970104978 A ARP970104978 A AR P970104978A AR P970104978 A ARP970104978 A AR P970104978A AR 009133 A1 AR009133 A1 AR 009133A1
Authority
AR
Argentina
Prior art keywords
pirimidine
dimethyl
fluorophenylamine
preparing
methyl
Prior art date
Application number
ARP970104978A
Other languages
Spanish (es)
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019960049382A external-priority patent/KR100209587B1/en
Priority claimed from KR1019960049380A external-priority patent/KR0185292B1/en
Priority claimed from KR1019960049381A external-priority patent/KR100193080B1/en
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of AR009133A1 publication Critical patent/AR009133A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Un procedimiento para la preparacion de 5,6-dimetil-2-(4-fluofenilamino)- 4-(1-metil-1,2,3,4-tetrahidroisoquinolín-2-il)pirimidina representada por laformula (I) que se presenta a continuacion y sus sales de adicion ácidas; en segundo lugar, au n procedimiento para la preparacion de un intermediario conel fin de preparar el compuesto (I) y, en tercer lugar, a un compuesto intermediario novedoso. Más específicamente, en primer lugar, a unprocedimiento para la preparacion de 5,6-dime til-2- (4-fluofenilamino)-4-(1-metil-1,2,3,4-tetrahidroisoquinolin-2-il) pirimidina representada por laformula (I) que se presenta a continuacion y sus sales de adicion ácidas, al hacer reaccionar un derivado de pirimidina representado por lasiguienteformula (II-A), donde Hal representa un halogeno, con 1-metil-1,2,3,4- tetrahidroisoquinolina representada por la siguiente formula (III), en segundolugar, a un procedimiento para la preparacion del derivado de pirimidina de la for mula(III) y en tercer lugar, a un compuesto intermediario novedoso queincluye el derivado de piriminina de la formula (II-A)A process for the preparation of 5,6-dimethyl-2- (4-fluophenylamino) -4- (1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine represented by formula (I) which is Presented below and its acid addition salts; secondly, a process for the preparation of an intermediate to prepare compound (I) and, thirdly, to a novel intermediate compound. More specifically, first, to a process for the preparation of 5,6-dimethyl-2- (4-fluophenylamino) -4- (1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl) pyrimidine represented by the formula (I) below and its acid addition salts, by reacting a pyrimidine derivative represented by the following formula (II-A), where Hal represents a halogen, with 1-methyl-1,2,3 , 4- tetrahydroisoquinoline represented by the following formula (III), secondly, to a process for the preparation of the pyrimidine derivative of formula (III) and thirdly, to a novel intermediate compound that includes the pyriminine derivative of formula (II-A)

ARP970104978A 1996-10-29 1997-10-28 A PROCEDURE FOR PREPARING 5,6-DIMETHYL-2- (4-FLUOROPHENYLAMINE) -4- (1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-2-IL) PIRIMIDINE, PROCEDURES FOR PREPARING A 4-HALOGEN-2 - (4-FLUOROPHENYLAMINE) -5,6-DIMETHYL PIRIMIDINE AND A DERIVATIVE OF PIRIMIDINE USEFUL AS AN INTERMEDIARY AR009133A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019960049382A KR100209587B1 (en) 1996-10-29 1996-10-29 Process of the preparing pyrimidine derivatives
KR1019960049380A KR0185292B1 (en) 1996-10-29 1996-10-29 Process for preparation of (s)-pyrimidine derivatives
KR1019960049381A KR100193080B1 (en) 1996-10-29 1996-10-29 Method for preparing (R) -pyrimidine derivative

Publications (1)

Publication Number Publication Date
AR009133A1 true AR009133A1 (en) 2000-03-08

Family

ID=27349413

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104978A AR009133A1 (en) 1996-10-29 1997-10-28 A PROCEDURE FOR PREPARING 5,6-DIMETHYL-2- (4-FLUOROPHENYLAMINE) -4- (1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-2-IL) PIRIMIDINE, PROCEDURES FOR PREPARING A 4-HALOGEN-2 - (4-FLUOROPHENYLAMINE) -5,6-DIMETHYL PIRIMIDINE AND A DERIVATIVE OF PIRIMIDINE USEFUL AS AN INTERMEDIARY

Country Status (5)

Country Link
AR (1) AR009133A1 (en)
BR (1) BR9712392A (en)
HU (1) HU226752B1 (en)
TR (1) TR199900943T2 (en)
WO (1) WO1998018784A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (en) * 1998-11-17 2000-11-15 김선진 Novel pyrimidine derivatives and processes for the preparation thereof
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB0110338D0 (en) * 2001-04-27 2001-06-20 Sb Pharmco Inc Novel processes
JP4634144B2 (en) 2002-08-01 2011-02-16 ニコックス エスエー Nitrosated proton pump inhibitors, compositions and methods of use
US7776873B2 (en) * 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
PL2007362T3 (en) 2006-04-04 2019-02-28 Kg Acquisition Llc Oral dosage forms including an antiplatelet agent and an acid inhibitor
CN102993173B (en) * 2012-12-28 2014-09-03 山东大学 Preparation method of revaprzan hydrochloride
CN105669642B (en) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 Preparation method of loflupridine hydrochloride
CN105601611A (en) * 2014-11-19 2016-05-25 江苏天士力帝益药业有限公司 Revaprzan hydrochloride polymorphic substance and preparation method thereof
CN107759562B (en) * 2016-08-21 2020-10-23 常州四药制药有限公司 Preparation method of loflupridine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182584A (en) * 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
DE59010042D1 (en) * 1989-03-22 1996-02-22 Ciba Geigy Ag Pesticides
KR0144833B1 (en) * 1992-12-28 1998-07-15 김태훈 Novel quinazoline derivatives and their preparation
DE69530989T2 (en) * 1994-08-13 2004-05-19 Yuhan Corp. NEW PYRIMID DERIVATIVES AND METHOD FOR THEIR PRODUCTION

Also Published As

Publication number Publication date
BR9712392A (en) 2000-01-25
TR199900943T2 (en) 1999-12-21
HUP9903520A1 (en) 2000-05-28
HU226752B1 (en) 2009-09-28
HUP9903520A3 (en) 2002-01-28
WO1998018784A1 (en) 1998-05-07

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