AR006640A1 - Procedimiento para la preparacion de una sal de magnesio de un sulfinil-heterociclo substituido - Google Patents

Procedimiento para la preparacion de una sal de magnesio de un sulfinil-heterociclo substituido

Info

Publication number
AR006640A1
AR006640A1 ARP970101488A ARP970101488A AR006640A1 AR 006640 A1 AR006640 A1 AR 006640A1 AR P970101488 A ARP970101488 A AR P970101488A AR P970101488 A ARP970101488 A AR P970101488A AR 006640 A1 AR006640 A1 AR 006640A1
Authority
AR
Argentina
Prior art keywords
hydrogen
alkyl
substituted
halogen
alkoxy
Prior art date
Application number
ARP970101488A
Other languages
English (en)
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20402358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR006640(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR006640A1 publication Critical patent/AR006640A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP970101488A 1996-04-26 1997-04-14 Procedimiento para la preparacion de una sal de magnesio de un sulfinil-heterociclo substituido AR006640A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9601598A SE508669C2 (sv) 1996-04-26 1996-04-26 Nytt förfarande

Publications (1)

Publication Number Publication Date
AR006640A1 true AR006640A1 (es) 1999-09-08

Family

ID=20402358

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101488A AR006640A1 (es) 1996-04-26 1997-04-14 Procedimiento para la preparacion de una sal de magnesio de un sulfinil-heterociclo substituido

Country Status (39)

Country Link
US (1) US6124464A (enExample)
EP (1) EP0897386B1 (enExample)
JP (1) JP4233115B2 (enExample)
KR (1) KR100468331B1 (enExample)
CN (1) CN1100776C (enExample)
AR (1) AR006640A1 (enExample)
AT (1) ATE222904T1 (enExample)
BR (1) BR9708829A (enExample)
CA (1) CA2251636C (enExample)
CZ (1) CZ295067B6 (enExample)
DE (1) DE69714987T2 (enExample)
DK (1) DK0897386T3 (enExample)
DZ (1) DZ2209A1 (enExample)
EE (1) EE03485B1 (enExample)
EG (1) EG23874A (enExample)
ES (1) ES2180981T3 (enExample)
HR (1) HRP970210B1 (enExample)
HU (1) HUP9901798A3 (enExample)
ID (1) ID16685A (enExample)
IL (1) IL126716A (enExample)
IS (1) IS1984B (enExample)
MA (1) MA24143A1 (enExample)
MY (1) MY119011A (enExample)
NO (1) NO318850B1 (enExample)
NZ (1) NZ332154A (enExample)
PL (1) PL188824B1 (enExample)
PT (1) PT897386E (enExample)
RS (1) RS49718B (enExample)
RU (1) RU2163238C2 (enExample)
SA (1) SA97170759B1 (enExample)
SE (1) SE508669C2 (enExample)
SI (1) SI0897386T1 (enExample)
SK (1) SK282752B6 (enExample)
TN (1) TNSN97068A1 (enExample)
TR (1) TR199802156T2 (enExample)
TW (1) TW420676B (enExample)
UA (1) UA51699C2 (enExample)
WO (1) WO1997041114A1 (enExample)
ZA (1) ZA973153B (enExample)

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SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US6875872B1 (en) * 1993-05-28 2005-04-05 Astrazeneca Compounds
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
CN100503598C (zh) * 1998-11-18 2009-06-24 阿斯特拉曾尼卡有限公司 改进的化学方法和药物制剂
CA2290893C (en) 1999-11-16 2007-05-01 Bernard Charles Sherman Magnesium omeprazole
WO2002012225A1 (en) * 2000-08-04 2002-02-14 Takeda Chemical Industries, Ltd. Salts of benzimidazole compound and use thereof
EP1469839A2 (en) * 2002-01-25 2004-10-27 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
ES2286408T3 (es) * 2002-03-05 2007-12-01 Astrazeneca Ab Sales de alquilamonio de omeprazol e esomeprazol.
TW200410955A (en) * 2002-07-29 2004-07-01 Altana Pharma Ag Novel salt of (S)-PANTOPRAZOLE
DE10234617B4 (de) * 2002-07-29 2013-04-04 Nycomed Gmbh Neues Salz von (S)-Pantoprazol
EA200500673A1 (ru) * 2002-10-22 2005-12-29 Рэнбакси Лабораториз Лимитед Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
WO2004056804A2 (en) * 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
BRPI0407906A (pt) * 2003-02-28 2006-02-14 Ranbaxy Lab Ltd polimorfos de s-omeprazol
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
WO2005012289A1 (en) * 2003-07-17 2005-02-10 Altana Pharma Ag Novel salt of (r) - pantoprazole
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
SE0302382D0 (sv) * 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
ITMI20031813A1 (it) * 2003-09-23 2005-03-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di pantoprazolo e suoi sali.
WO2005082888A1 (en) * 2004-03-01 2005-09-09 Milen Merkez Ilac Endustrisi A.S. Process for the preparation of magnesium salt of omeprazole
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
US20060141054A1 (en) * 2004-10-25 2006-06-29 Thomas Piccariello Metal coordinated compositions
US7799937B2 (en) 2004-10-25 2010-09-21 Synthonics, Inc. Metal coordinated compositions
US8779175B2 (en) * 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
US20080139623A1 (en) 2006-06-12 2008-06-12 Lilach Hedvati Amorphous and crystalline forms of pantoprazole magnesium salt
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
AU2008217603C1 (en) 2007-02-21 2013-08-15 Cipla Limited Process for the preparation of esomeprazole magnesium dihydrate
WO2009047775A2 (en) * 2007-10-08 2009-04-16 Hetero Drugs Limited Polymorphs of esomeprazole salts
EP2147918A1 (en) 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Process for the preparation of S-omeprazole magnesium in a stable form
WO2010097583A1 (en) 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
US20110207779A1 (en) * 2010-02-25 2011-08-25 Glenmark Generics Ltd Process for the preparation of esomeprazole magnesium
EP2426111A1 (en) 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
CN103467453A (zh) * 2013-09-13 2013-12-25 上海海虹实业(集团)巢湖今辰药业有限公司 一种奥美拉唑镁原料药制备方法
CN106397399A (zh) * 2015-07-29 2017-02-15 陕西合成药业股份有限公司 一种泮托拉唑镁的精制方法

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Publication number Priority date Publication date Assignee Title
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
IL76837A0 (en) * 1984-10-31 1986-02-28 Byk Gulden Lomberg Chem Fab Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
FI861772A7 (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Uudet tieno(2,3)imidatsolijohdokset ja menetelmä niiden valmistamiseksi.
US4851419A (en) * 1985-10-16 1989-07-25 Fisons Plc Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
DD290192A5 (de) * 1986-11-13 1991-05-23 Eisai Co. Ltd,Jp Pyridinderivat mit antiulzeroeser wirkung
NZ234564A (en) * 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
WO1989000566A1 (fr) * 1987-07-21 1989-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyridine et leurs utilisations en medecine
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
KR950701921A (ko) * 1992-06-01 1995-05-17 고야 다다시 피리딘 화합물 및 이의 제약학적 용도(pyridine compound and medicinal use thereof)
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
US5374730A (en) * 1993-11-04 1994-12-20 Torcan Chemical Ltd. Preparation of omeprazole and lansoprazole
WO1996001623A1 (en) * 1994-07-08 1996-01-25 Astra Aktiebolag Multiple unit tableted dosage form i

Also Published As

Publication number Publication date
YU44898A (sh) 1999-07-28
KR100468331B1 (ko) 2005-03-16
NO984903D0 (no) 1998-10-21
JP2000509067A (ja) 2000-07-18
CN1100776C (zh) 2003-02-05
SK140798A3 (en) 1999-04-13
EP0897386A1 (en) 1999-02-24
HUP9901798A2 (hu) 2000-04-28
KR20000065018A (ko) 2000-11-06
SE9601598D0 (sv) 1996-04-26
AU711345B2 (en) 1999-10-14
SE508669C2 (sv) 1998-10-26
PT897386E (pt) 2002-12-31
PL188824B1 (pl) 2005-04-29
NO318850B1 (no) 2005-05-18
IL126716A (en) 2003-10-31
ID16685A (id) 1997-10-30
HK1016978A1 (en) 1999-11-12
EE9800363A (et) 1999-04-15
DK0897386T3 (da) 2002-10-28
CA2251636C (en) 2001-04-10
HUP9901798A3 (en) 2003-02-28
EE03485B1 (et) 2001-08-15
DZ2209A1 (fr) 2002-12-03
AU2719397A (en) 1997-11-19
IS4872A (is) 1998-10-19
UA51699C2 (uk) 2002-12-16
JP4233115B2 (ja) 2009-03-04
CZ295067B6 (cs) 2005-05-18
SE9601598L (sv) 1997-10-27
US6124464A (en) 2000-09-26
TR199802156T2 (xx) 1999-02-22
DE69714987T2 (de) 2003-04-30
NZ332154A (en) 2002-03-01
DE69714987D1 (de) 2002-10-02
RU2163238C2 (ru) 2001-02-20
SI0897386T1 (en) 2002-12-31
ATE222904T1 (de) 2002-09-15
PL329683A1 (en) 1999-04-12
EP0897386B1 (en) 2002-08-28
ZA973153B (en) 1997-10-27
MA24143A1 (fr) 1997-12-31
TNSN97068A1 (fr) 1999-12-31
ES2180981T3 (es) 2003-02-16
SA97170759B1 (ar) 2006-09-25
BR9708829A (pt) 1999-08-03
IL126716A0 (en) 1999-08-17
IS1984B (is) 2005-02-15
HRP970210B1 (en) 2002-06-30
HRP970210A2 (en) 1998-04-30
CN1216989A (zh) 1999-05-19
MY119011A (en) 2005-03-31
WO1997041114A1 (en) 1997-11-06
CA2251636A1 (en) 1997-11-06
CZ339898A3 (cs) 1999-03-17
NO984903L (no) 1998-10-21
EG23874A (en) 2007-11-27
SK282752B6 (sk) 2002-12-03
TW420676B (en) 2001-02-01
RS49718B (sr) 2007-12-31

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