SI0897386T1 - Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycle - Google Patents
Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycleInfo
- Publication number
- SI0897386T1 SI0897386T1 SI9730402T SI9730402T SI0897386T1 SI 0897386 T1 SI0897386 T1 SI 0897386T1 SI 9730402 T SI9730402 T SI 9730402T SI 9730402 T SI9730402 T SI 9730402T SI 0897386 T1 SI0897386 T1 SI 0897386T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparation
- magnesium salt
- substituted sulphinyl
- heterocycle
- sulphinyl heterocycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9601598A SE508669C2 (sv) | 1996-04-26 | 1996-04-26 | Nytt förfarande |
PCT/SE1997/000674 WO1997041114A1 (en) | 1996-04-26 | 1997-04-22 | Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycle |
EP97921045A EP0897386B1 (en) | 1996-04-26 | 1997-04-22 | Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycle |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0897386T1 true SI0897386T1 (en) | 2002-12-31 |
Family
ID=20402358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9730402T SI0897386T1 (en) | 1996-04-26 | 1997-04-22 | Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycle |
Country Status (40)
Country | Link |
---|---|
US (1) | US6124464A (xx) |
EP (1) | EP0897386B1 (xx) |
JP (1) | JP4233115B2 (xx) |
KR (1) | KR100468331B1 (xx) |
CN (1) | CN1100776C (xx) |
AR (1) | AR006640A1 (xx) |
AT (1) | ATE222904T1 (xx) |
BR (1) | BR9708829A (xx) |
CA (1) | CA2251636C (xx) |
CZ (1) | CZ295067B6 (xx) |
DE (1) | DE69714987T2 (xx) |
DK (1) | DK0897386T3 (xx) |
DZ (1) | DZ2209A1 (xx) |
EE (1) | EE03485B1 (xx) |
EG (1) | EG23874A (xx) |
ES (1) | ES2180981T3 (xx) |
HK (1) | HK1016978A1 (xx) |
HR (1) | HRP970210B1 (xx) |
HU (1) | HUP9901798A3 (xx) |
ID (1) | ID16685A (xx) |
IL (1) | IL126716A (xx) |
IS (1) | IS1984B (xx) |
MA (1) | MA24143A1 (xx) |
MY (1) | MY119011A (xx) |
NO (1) | NO318850B1 (xx) |
NZ (1) | NZ332154A (xx) |
PL (1) | PL188824B1 (xx) |
PT (1) | PT897386E (xx) |
RS (1) | RS49718B (xx) |
RU (1) | RU2163238C2 (xx) |
SA (1) | SA97170759B1 (xx) |
SE (1) | SE508669C2 (xx) |
SI (1) | SI0897386T1 (xx) |
SK (1) | SK282752B6 (xx) |
TN (1) | TNSN97068A1 (xx) |
TR (1) | TR199802156T2 (xx) |
TW (1) | TW420676B (xx) |
UA (1) | UA51699C2 (xx) |
WO (1) | WO1997041114A1 (xx) |
ZA (1) | ZA973153B (xx) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
US6875872B1 (en) * | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
DE19843413C1 (de) * | 1998-08-18 | 2000-03-30 | Byk Gulden Lomberg Chem Fab | Neue Salzform von Pantoprazol |
ATE271556T1 (de) * | 1998-11-18 | 2004-08-15 | Astrazeneca Ab | Verbesserter chemischer prozess und eine pharmazeutische zubereitung |
CA2290893C (en) | 1999-11-16 | 2007-05-01 | Bernard Charles Sherman | Magnesium omeprazole |
WO2002012225A1 (fr) * | 2000-08-04 | 2002-02-14 | Takeda Chemical Industries, Ltd. | Sels de composé à base de benzimidazole et leurs applications |
JP2005521662A (ja) * | 2002-01-25 | 2005-07-21 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤の経粘膜送達 |
ES2286408T3 (es) | 2002-03-05 | 2007-12-01 | Astrazeneca Ab | Sales de alquilamonio de omeprazol e esomeprazol. |
DE10234617B4 (de) * | 2002-07-29 | 2013-04-04 | Nycomed Gmbh | Neues Salz von (S)-Pantoprazol |
TW200410955A (en) | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
US20040235903A1 (en) * | 2002-10-22 | 2004-11-25 | Khanna Mahavir Singh | Amorphous form of esomeprazole salts |
US20040242642A1 (en) * | 2002-11-18 | 2004-12-02 | Dr. Reddy's Laboratories Limited | Crystalline esomeprazole compounds and process for the preparation thereof |
US7507829B2 (en) * | 2002-12-19 | 2009-03-24 | Teva Pharmaceuticals Industries, Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
CN1777598A (zh) * | 2003-02-28 | 2006-05-24 | 兰贝克赛实验室有限公司 | S-奥美拉唑的多晶型物 |
CL2004000983A1 (es) | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
PE20050150A1 (es) | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
WO2005012289A1 (en) * | 2003-07-17 | 2005-02-10 | Altana Pharma Ag | Novel salt of (r) - pantoprazole |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
SE0302382D0 (sv) * | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
ITMI20031813A1 (it) * | 2003-09-23 | 2005-03-24 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procedimento per la preparazione di pantoprazolo e suoi sali. |
WO2005082888A1 (en) * | 2004-03-01 | 2005-09-09 | Milen Merkez Ilac Endustrisi A.S. | Process for the preparation of magnesium salt of omeprazole |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
ES2246149B1 (es) | 2004-07-02 | 2007-06-01 | Esteve Quimica, S.A. | Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion. |
US8779175B2 (en) | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
US7799937B2 (en) | 2004-10-25 | 2010-09-21 | Synthonics, Inc. | Metal coordinated compositions |
US20060141054A1 (en) | 2004-10-25 | 2006-06-29 | Thomas Piccariello | Metal coordinated compositions |
EP1801110A1 (en) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Esomeprazole arginine salt |
US7553857B2 (en) * | 2005-12-23 | 2009-06-30 | Lek Pharmaceuticals D.D. | S-omeprazole magnesium |
US20080139623A1 (en) | 2006-06-12 | 2008-06-12 | Lilach Hedvati | Amorphous and crystalline forms of pantoprazole magnesium salt |
EP1947099A1 (en) * | 2007-01-18 | 2008-07-23 | LEK Pharmaceuticals D.D. | Process for solvent removal from omeprazole salts |
NZ579136A (en) | 2007-02-21 | 2012-05-25 | Cipla Ltd | Process for the preparation of esomeprazole magnesium dihydrate |
WO2009047775A2 (en) * | 2007-10-08 | 2009-04-16 | Hetero Drugs Limited | Polymorphs of esomeprazole salts |
EP2147918A1 (en) | 2008-07-21 | 2010-01-27 | LEK Pharmaceuticals D.D. | Process for the preparation of S-omeprazole magnesium in a stable form |
WO2010097583A1 (en) | 2009-02-24 | 2010-09-02 | Cipla Limited | Esomeprazole potassium polymorph and its preparation |
US20110207779A1 (en) * | 2010-02-25 | 2011-08-25 | Glenmark Generics Ltd | Process for the preparation of esomeprazole magnesium |
EP2426111A1 (en) | 2010-08-09 | 2012-03-07 | Laboratorios Del. Dr. Esteve, S.A. | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms |
CN103467453A (zh) * | 2013-09-13 | 2013-12-25 | 上海海虹实业(集团)巢湖今辰药业有限公司 | 一种奥美拉唑镁原料药制备方法 |
CN106397399A (zh) * | 2015-07-29 | 2017-02-15 | 陕西合成药业股份有限公司 | 一种泮托拉唑镁的精制方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
FI861772A (fi) * | 1985-05-07 | 1986-11-08 | Chemie Linz Ag | Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning. |
FI864138A (fi) * | 1985-10-16 | 1987-04-17 | Fisons Plc | Heterocykliska blandningar. |
NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
BR9506018A (pt) * | 1994-07-08 | 1997-09-02 | Astra Ab | Forma farmacêutica oral de múltipla dosagem unitária em tablete processos para a preparação da mesma para a inibição da secreção de ácido gástrico em mamiferos e no homem e para o tratamento das doenças inflamatórias gastrointestinais em mamiferos e no homem e embalagem de ampola de pressão transversal |
-
1996
- 1996-04-26 SE SE9601598A patent/SE508669C2/sv not_active IP Right Cessation
-
1997
- 1997-03-29 SA SA97170759A patent/SA97170759B1/ar unknown
- 1997-04-14 AR ARP970101488A patent/AR006640A1/es active IP Right Grant
- 1997-04-14 ZA ZA9703153A patent/ZA973153B/xx unknown
- 1997-04-14 TW TW086104766A patent/TW420676B/zh not_active IP Right Cessation
- 1997-04-15 TN TNTNSN97068A patent/TNSN97068A1/fr unknown
- 1997-04-17 MA MA24558A patent/MA24143A1/fr unknown
- 1997-04-20 DZ DZ970056A patent/DZ2209A1/fr active
- 1997-04-21 HR HR970210A patent/HRP970210B1/xx not_active IP Right Cessation
- 1997-04-22 CZ CZ19983398A patent/CZ295067B6/cs not_active IP Right Cessation
- 1997-04-22 IL IL12671697A patent/IL126716A/xx not_active IP Right Cessation
- 1997-04-22 NZ NZ332154A patent/NZ332154A/en unknown
- 1997-04-22 JP JP53879697A patent/JP4233115B2/ja not_active Expired - Fee Related
- 1997-04-22 EP EP97921045A patent/EP0897386B1/en not_active Expired - Lifetime
- 1997-04-22 US US08/860,825 patent/US6124464A/en not_active Expired - Lifetime
- 1997-04-22 ID IDP971342A patent/ID16685A/id unknown
- 1997-04-22 PT PT97921045T patent/PT897386E/pt unknown
- 1997-04-22 KR KR10-1998-0708556A patent/KR100468331B1/ko not_active IP Right Cessation
- 1997-04-22 CN CN97194114A patent/CN1100776C/zh not_active Expired - Fee Related
- 1997-04-22 BR BR9708829A patent/BR9708829A/pt not_active Application Discontinuation
- 1997-04-22 UA UA98105319A patent/UA51699C2/uk unknown
- 1997-04-22 RU RU98121016/04A patent/RU2163238C2/ru not_active IP Right Cessation
- 1997-04-22 CA CA002251636A patent/CA2251636C/en not_active Expired - Lifetime
- 1997-04-22 DK DK97921045T patent/DK0897386T3/da active
- 1997-04-22 HU HU9901798A patent/HUP9901798A3/hu unknown
- 1997-04-22 ES ES97921045T patent/ES2180981T3/es not_active Expired - Lifetime
- 1997-04-22 EG EG32297A patent/EG23874A/xx active
- 1997-04-22 EE EE9800363A patent/EE03485B1/xx not_active IP Right Cessation
- 1997-04-22 WO PCT/SE1997/000674 patent/WO1997041114A1/en active IP Right Grant
- 1997-04-22 TR TR1998/02156T patent/TR199802156T2/xx unknown
- 1997-04-22 PL PL97329683A patent/PL188824B1/pl not_active IP Right Cessation
- 1997-04-22 SK SK1407-98A patent/SK282752B6/sk not_active IP Right Cessation
- 1997-04-22 SI SI9730402T patent/SI0897386T1/xx unknown
- 1997-04-22 DE DE69714987T patent/DE69714987T2/de not_active Expired - Lifetime
- 1997-04-22 AT AT97921045T patent/ATE222904T1/de active
- 1997-04-23 MY MYPI97001748A patent/MY119011A/en unknown
-
1998
- 1998-10-14 RS YUP-448/98A patent/RS49718B/sr unknown
- 1998-10-19 IS IS4872A patent/IS1984B/is unknown
- 1998-10-21 NO NO19984903A patent/NO318850B1/no not_active IP Right Cessation
-
1999
- 1999-05-07 HK HK99102051A patent/HK1016978A1/xx not_active IP Right Cessation
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