AR005659A1 - Tableta farmaceutica que comprende un nucleo comprimido interno y un recubrimiento de azucar que contiene un esteroide hormonal con liberacion controlada de dicho esteroide desde el recubrimiento de azucar - Google Patents

Tableta farmaceutica que comprende un nucleo comprimido interno y un recubrimiento de azucar que contiene un esteroide hormonal con liberacion controlada de dicho esteroide desde el recubrimiento de azucar

Info

Publication number
AR005659A1
AR005659A1 ARP970100205A ARP970100205A AR005659A1 AR 005659 A1 AR005659 A1 AR 005659A1 AR P970100205 A ARP970100205 A AR P970100205A AR P970100205 A ARP970100205 A AR P970100205A AR 005659 A1 AR005659 A1 AR 005659A1
Authority
AR
Argentina
Prior art keywords
sugar coating
steroid
compressed core
hormonal
pharmaceutical tablet
Prior art date
Application number
ARP970100205A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24554700&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR005659(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR005659A1 publication Critical patent/AR005659A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una tableta farmacéutica que conprende un núcleo comprimido inteno y un recubrimiento externo de azúcar en la cual dicho núcleo comprimidoopcionalmente no contiene agente farmacológicamente activo alguno o bien contiene uno o más agentesn o esteroides, farmacológicamente activos que seadministran convencionalmente en forma conjunta con un esteroide hormonal. Dicha tableta comprende, incorporados en dicho recubrimiento de azúcar, unesteroide hormonal y una cantidad de celulosamic rocristalina que controla el régimen de liberación de esteroides hormonales.
ARP970100205A 1996-04-24 1997-01-17 Tableta farmaceutica que comprende un nucleo comprimido interno y un recubrimiento de azucar que contiene un esteroide hormonal con liberacion controlada de dicho esteroide desde el recubrimiento de azucar AR005659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/637,139 US5759577A (en) 1995-01-17 1996-04-24 Controlled release of steroids from sugar coatings

Publications (1)

Publication Number Publication Date
AR005659A1 true AR005659A1 (es) 1999-07-14

Family

ID=24554700

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100205A AR005659A1 (es) 1996-04-24 1997-01-17 Tableta farmaceutica que comprende un nucleo comprimido interno y un recubrimiento de azucar que contiene un esteroide hormonal con liberacion controlada de dicho esteroide desde el recubrimiento de azucar

Country Status (36)

Country Link
US (1) US5759577A (es)
EP (1) EP0803250B1 (es)
JP (1) JP4112648B2 (es)
KR (1) KR100482913B1 (es)
CN (1) CN1149982C (es)
AR (1) AR005659A1 (es)
AT (1) ATE218326T1 (es)
AU (1) AU722188B2 (es)
BR (1) BR9701904A (es)
CA (1) CA2194428A1 (es)
CO (1) CO4780019A1 (es)
CY (1) CY2302B1 (es)
CZ (1) CZ289762B6 (es)
DE (1) DE69621588T2 (es)
DK (1) DK0803250T3 (es)
EG (1) EG23911A (es)
ES (1) ES2179165T3 (es)
HK (1) HK1003870A1 (es)
HU (1) HU226397B1 (es)
ID (1) ID16611A (es)
IL (1) IL119976A (es)
IS (1) IS1886B (es)
MY (1) MY115223A (es)
NO (1) NO315354B1 (es)
NZ (1) NZ299823A (es)
PL (1) PL187255B1 (es)
PT (1) PT803250E (es)
RU (1) RU2181586C2 (es)
SG (1) SG64407A1 (es)
SI (1) SI0803250T1 (es)
SK (1) SK282484B6 (es)
TR (1) TR199700052A3 (es)
TW (1) TW487583B (es)
UA (1) UA59333C2 (es)
UY (1) UY24527A1 (es)
ZA (1) ZA9610424B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
ES2152671T3 (es) * 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
CN1236435A (zh) * 1996-11-07 1999-11-24 奥索·麦克尼尔药品公司 一种固体甾族药物制剂的溶解测试方法
US5985325A (en) * 1997-06-13 1999-11-16 American Home Products Corporation Rapamycin formulations for oral administration
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
US6432448B1 (en) 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6500462B1 (en) 1999-10-29 2002-12-31 Fmc Corporation Edible MCC/PGA coating composition
FR2801218B1 (fr) * 1999-11-23 2001-12-28 Hoechst Marion Roussel Inc Compositions pharmaceutiques comprenant de la trimegestone, leurs procedes de preparation ainsi que le conditionnement primaire les renfermant
AT500063A1 (de) 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
US6399591B1 (en) * 2000-01-19 2002-06-04 Yung-Shin Pharmaceutical Ind. Co., Ltd. Chargeable pharmaceutical tablets
US7989436B2 (en) 2003-07-23 2011-08-02 Duramed Pharmaceuticals, Inc. Estrogenic compounds and pharmaceutical formulations comprising the same
US6855703B1 (en) 2000-03-10 2005-02-15 Endeavor Pharmaceuticals Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds
US6660726B2 (en) 2000-03-10 2003-12-09 Endeavor Pharmaceuticals Estrogenic compounds, pharmaceutical compositions thereof, and methods of using same
US7459445B2 (en) * 2000-03-10 2008-12-02 Duramed Pharmaceuticals, Inc. Estrogenic compounds and topical pharmaceutical formulations of the same
US20010034340A1 (en) * 2000-03-20 2001-10-25 American Home Products Corporation Hormone replacement therapy
IL155959A0 (en) 2000-11-28 2003-12-23 Fmc Corp Edible pga (propylene glycol alginate) coating composition
JP4969747B2 (ja) * 2001-01-19 2012-07-04 武田薬品工業株式会社 錠剤フィルムコーティング用組成物
EA200301022A1 (ru) * 2001-03-16 2004-02-26 Уайт Гормональная заместительная терапия
TW200306196A (en) * 2002-04-03 2003-11-16 Wyeth Corp Hormone replacement therapy
TW200306846A (en) * 2002-04-03 2003-12-01 Wyeth Corp Hormone replacement therapy
TW200306851A (en) * 2002-04-29 2003-12-01 Wyeth Corp Hormone replacement therapy
TW200400040A (en) * 2002-05-17 2004-01-01 Wyeth Corp Hormone replacement therapy
US20060111577A1 (en) * 2003-02-28 2006-05-25 Kim Hyun K Method for preparing 17 alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates
US6992075B2 (en) * 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
CA2521471A1 (en) * 2003-04-11 2004-10-28 Barr Laboratories, Inc. Methods of administering estrogens and progestins
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
ES2933479T3 (es) * 2003-09-29 2023-02-09 Novo Nordisk Healthcare Ag Estabilidad mejorada de formulaciones de progestágenos
US20050271724A1 (en) * 2004-06-07 2005-12-08 Wyeth Sugar coatings and methods therefor
US8394409B2 (en) * 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US20060127451A1 (en) * 2004-09-23 2006-06-15 Michael Augello Coating composition
WO2006084082A1 (en) * 2005-02-03 2006-08-10 Duramed Pharmaceuticals, Inc. Compositions of unconjugated estrogens and methods for their use
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
TW200738283A (en) * 2005-06-29 2007-10-16 Wyeth Corp Formulations of conjugated estrogens and bazedoxifene
WO2007058645A1 (en) * 2005-11-15 2007-05-24 Wm. Wrigley Jr. Company Tablets comprising a core and a medicament-containing coating for buccal release
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CA2648280C (en) * 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
JP2010509350A (ja) * 2006-11-07 2010-03-25 ワイス エルエルシー 糖コーティングおよびその方法
JP2010511062A (ja) * 2006-11-29 2010-04-08 ワイス エルエルシー エストロゲン／ｓｅｒｍおよびエストロゲン／プロゲスチン二層錠剤
US8512745B2 (en) * 2008-12-08 2013-08-20 Laboratoire Hra Pharma Ulipristal acetate tablets
FR2997628B1 (fr) * 2012-11-08 2015-01-16 Hra Pharma Lab Produit de co-micronisation comprenant un modulateur selectif des recepteurs a la progesterone
KR102221846B1 (ko) * 2014-04-07 2021-02-26 영진약품 주식회사 안정성이 개선된 프레가발린을 함유하는 약제학적 조성물 및 이의 제조방법
US20170196816A1 (en) * 2014-06-02 2017-07-13 Nipro Corporation Laser-printable tablet, and method for manufacturing the same
MX2017005163A (es) 2014-11-17 2018-01-18 Arno Therapeutics Inc Composiciones de liberación prolongada de onapristona y métodos.
BR112018005999A2 (pt) 2015-09-25 2019-01-08 Context Biopharma Inc métodos para a produção de intermediários de onapristona
CN108883067B (zh) 2015-12-15 2021-03-09 康特斯生物制药公司 非晶奥那司酮组合物及其制备方法
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154820A (en) * 1976-02-23 1979-05-15 Akzona Incorporated Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers
US4191741A (en) * 1978-09-22 1980-03-04 Eli Lilly And Company Removable drug implant
US4248856A (en) * 1979-07-10 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
US4309405A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4309404A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4425339A (en) * 1981-04-09 1984-01-10 Syntex (U.S.A.) Inc. Treatment of menopausal symptoms
US4390531A (en) * 1981-08-10 1983-06-28 Syntex Pharmaceuticals International Ltd. Method of contraception using peak progestogen dosage
US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
GB8403360D0 (en) * 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
US4755386A (en) * 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5208225A (en) * 1986-02-27 1993-05-04 Warner-Lambert Company Compositions containing fixed combinations
US4927816A (en) * 1987-08-20 1990-05-22 Ester George C Formulae and methods for sublingual ingestion of natural progesterone
US5108995A (en) * 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
US5073374A (en) * 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
DK469989D0 (da) * 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
JP2542122B2 (ja) * 1990-04-18 1996-10-09 旭化成工業株式会社 球状核、球形顆粒およびその製造方法
US5223268A (en) * 1991-05-16 1993-06-29 Sterling Drug, Inc. Low solubility drug-coated bead compositions
WO1994009762A1 (en) * 1992-11-05 1994-05-11 Merck & Co., Inc. Drug delivery device
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings

Also Published As

Publication number Publication date
CN1163103A (zh) 1997-10-29
ATE218326T1 (de) 2002-06-15
KR100482913B1 (ko) 2005-08-05
CN1149982C (zh) 2004-05-19
HK1003870A1 (en) 1998-11-13
RU2181586C2 (ru) 2002-04-27
MX9700515A (es) 1997-10-31
PT803250E (pt) 2002-09-30
AU7181996A (en) 1997-10-30
IL119976A0 (en) 1997-04-15
KR970069031A (ko) 1997-11-07
NZ299823A (en) 1998-09-24
EG23911A (en) 2007-12-30
UA59333C2 (uk) 2003-09-15
DE69621588D1 (de) 2002-07-11
SG64407A1 (en) 1999-04-27
CZ6897A3 (en) 1997-11-12
HUP9603151A3 (en) 1998-11-30
NO970094L (no) 1997-10-27
ES2179165T3 (es) 2003-01-16
SK5597A3 (en) 1997-11-05
US5759577A (en) 1998-06-02
NO970094D0 (no) 1997-01-09
TW487583B (en) 2002-05-21
PL187255B1 (pl) 2004-06-30
EP0803250A1 (en) 1997-10-29
DK0803250T3 (da) 2002-09-09
JPH09291027A (ja) 1997-11-11
IL119976A (en) 2000-10-31
SI0803250T1 (en) 2002-10-31
EP0803250B1 (en) 2002-06-05
HU9603151D0 (en) 1997-01-28
NO315354B1 (no) 2003-08-25
JP4112648B2 (ja) 2008-07-02
PL317923A1 (en) 1997-10-27
CZ289762B6 (cs) 2002-04-17
CO4780019A1 (es) 1999-05-26
BR9701904A (pt) 1998-11-10
AU722188B2 (en) 2000-07-27
HU226397B1 (en) 2008-11-28
CY2302B1 (en) 2003-07-04
TR199700052A2 (xx) 1997-11-21
HUP9603151A2 (en) 1997-12-29
CA2194428A1 (en) 1997-10-25
ZA9610424B (en) 1998-06-11
ID16611A (id) 1997-10-23
TR199700052A3 (tr) 1997-11-21
MY115223A (en) 2003-04-30
DE69621588T2 (de) 2003-01-30
UY24527A1 (es) 2000-09-29
IS4385A (is) 1997-10-25
IS1886B (is) 2003-09-01
SK282484B6 (sk) 2002-02-05

Similar Documents

Publication Publication Date Title
AR005659A1 (es) Tableta farmaceutica que comprende un nucleo comprimido interno y un recubrimiento de azucar que contiene un esteroide hormonal con liberacion controlada de dicho esteroide desde el recubrimiento de azucar
AU2002224926A1 (en) Novel medicament compositions based on anticholinesterase drugs and on a steroid
ATE269709T1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
TR200200562T2 (tr) Vücutta kontrollü şekilde salgılanabilen ve nahoş tadı önleyebilen ağızdan alınmaya mahsus farmasötik bileşimler
PT1238658E (pt) Administracao controlada de um agente activo que utiliza um sistema implantavel
ZA995839B (en) Orally administered controlled drug delivery system providing temporal and spatial control.
GT199900151A (es) Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial.
WO2000025753A3 (en) Controlled delivery of active agents
CA2069483A1 (en) Steroid sulphatase inhibitors
UY27532A1 (es) Forma de dosificación de liberación controlada dual.
BR0014929A (pt) Dispositivo para distribuição de medicamento, e, processo para distribuir um agente farmaceuticamente ativo para um tecido alvo dentro de um corpo
HU9602283D0 (en) Sexual steroid-containing transdermal therapeutic systems
WO2003028660A3 (en) Drug delivery devices and methods
NO20003159L (no) Dobbelkapsel til administrering av aktive prinsipp ved multippel terapier
ZA200102441B (en) Cntrolled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues.
EP1357870A4 (en) BIOADHESIVE FOAM FILTER WITH FIXED RELEASE
UA86404C2 (ru) Рентгеноконтрастное средство снабжения лекарства
WO2004082715A8 (ja) 炎症性腸疾患治療剤としての併用医薬
HK1032010A1 (en) Medicament formulation with a controlled release of an active agent.
EE05415B1 (et) Ravimi manustamise vahend, eriti androgeenide manustamiseks
WO2002011724A3 (en) Neuroprotective 2-pyridinamine compositions and related methods
SI1227814T1 (en) Hormonal composition based on nomegestrol acetate and an oestrogen and use thereof
PL348202A1 (en) Pharmaceutically active composition and dispensing device
DE69923988D1 (de) Gedächnissverbesserung durch verabreichung von delta-5-androsten-3-beta-ol-7,17-dion und 3-beta-estern desselben
ECSP971998A (es) Desprendimiento controlado de esteroides del recubrimiento de azucar

Legal Events

Date Code Title Description
FG Grant, registration