AR003475A1 - Nuevos peptidos opiaceos, composiciones farmaceuticas que los contienen, el uso de los mismos en la preparacion de formulaciones y un metodo para su preparacion. - Google Patents
Nuevos peptidos opiaceos, composiciones farmaceuticas que los contienen, el uso de los mismos en la preparacion de formulaciones y un metodo para su preparacion.Info
- Publication number
- AR003475A1 AR003475A1 ARP960103900A AR10390096A AR003475A1 AR 003475 A1 AR003475 A1 AR 003475A1 AR P960103900 A ARP960103900 A AR P960103900A AR 10390096 A AR10390096 A AR 10390096A AR 003475 A1 AR003475 A1 AR 003475A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptides
- preparation
- new
- phe
- formulations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a nuevos péptidos opiáceos (I), y sales, derivados y sus análogos en los que, R1 es Tyr ó 2,6-dimetiltirosina, o unanálogo o su derivado;R2 es D-Ala ó D-Arg;R3 es Phe(p-F); R4 es Phe ó Phe(p-F); X es H o C1-6-alquil o; y Y y Z son independientemente H, aralquilo;ó -C1-6alquilo;tratamiento del dolor así como también al método para su preparación y a las composiciones farmacéuticamente aceptables que comprenden a estospéptidos.La invención también serefiere al u so de estos compuestos en la preparación de las formulaciones efectivas para el tratamiento del dolor. Lospéptidos de esta invención tienen un grado alto de selectividad para el receptor opiáceo (mu).Asimismo péptidos dela presente inv ención sonparticularmente analgésicos que actúan substancialmente sobre los receptores periféricos opiáceos my. Debido a que estos péptidos actúan periféricamente,evitan substancialmente los efectos colaterales normalmenteasociados con la acci ón analgésica central.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9502877A SE9502877D0 (sv) | 1995-08-18 | 1995-08-18 | Novel opioid peptides |
| SE9503924A SE9503924D0 (sv) | 1995-08-18 | 1995-11-07 | Novel opioid peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003475A1 true AR003475A1 (es) | 1998-08-05 |
Family
ID=26662362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103900A AR003475A1 (es) | 1995-08-18 | 1996-08-06 | Nuevos peptidos opiaceos, composiciones farmaceuticas que los contienen, el uso de los mismos en la preparacion de formulaciones y un metodo para su preparacion. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6337319B1 (es) |
| EP (1) | EP0845003B1 (es) |
| JP (1) | JPH11512086A (es) |
| KR (1) | KR19990037677A (es) |
| CN (1) | CN1200127A (es) |
| AR (1) | AR003475A1 (es) |
| AT (1) | ATE210148T1 (es) |
| AU (1) | AU711862B2 (es) |
| BR (1) | BR9610248A (es) |
| CA (1) | CA2229797A1 (es) |
| CZ (1) | CZ287299B6 (es) |
| DE (1) | DE69617699T2 (es) |
| DK (1) | DK0845003T3 (es) |
| EE (1) | EE9800048A (es) |
| ES (1) | ES2171224T3 (es) |
| HU (1) | HUP9901209A3 (es) |
| IL (1) | IL123258A (es) |
| IS (1) | IS4664A (es) |
| NO (1) | NO980592D0 (es) |
| NZ (1) | NZ315809A (es) |
| PL (1) | PL325113A1 (es) |
| RU (1) | RU2165432C2 (es) |
| SE (1) | SE9503924D0 (es) |
| SK (1) | SK282469B6 (es) |
| TR (1) | TR199800258T1 (es) |
| TW (1) | TW424095B (es) |
| WO (1) | WO1997007130A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032774A1 (en) * | 1994-02-21 | 2003-02-13 | Astrazeneca Ab | Novel opioid peptides for the treatment of pain |
| US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| SE9701718D0 (sv) * | 1997-05-07 | 1997-05-07 | Astra Ab | Analgesic peptidomimetic compounds |
| SE9800865D0 (sv) * | 1998-03-16 | 1998-03-16 | Astra Ab | New Process |
| WO2001013938A1 (fr) * | 1999-08-25 | 2001-03-01 | Daiichi Fine Chemical Co., Ltd. | Composition therapeutique pouvant etre administree par voie percutanee ou par les muqueuses |
| WO2001036006A1 (en) | 1999-11-19 | 2001-05-25 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
| US7498297B2 (en) | 2000-07-18 | 2009-03-03 | Cornell Research Foundation | Medicinal uses of mu-opioid receptor agonists |
| JP2002069059A (ja) * | 2000-08-28 | 2002-03-08 | Teikoku Seiyaku Co Ltd | ピラジノン環を含む新規なオピオイドペプチド誘導体 |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) * | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| AU2005286733B2 (en) * | 2004-09-23 | 2009-11-05 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| WO2006132925A2 (en) * | 2005-06-01 | 2006-12-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| EP1782819A1 (en) | 2005-11-03 | 2007-05-09 | Cognis IP Management GmbH | Oligopeptides and their use |
| NZ577107A (en) | 2006-11-10 | 2012-01-12 | Cara Therapeutics Inc | Synthetic peptide amide ligands of the kappa opiod receptor |
| US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
| US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
| WO2009092601A1 (en) | 2008-01-25 | 2009-07-30 | Grünenthal GmbH | Pharmaceutical dosage form |
| MX2010012039A (es) * | 2008-05-09 | 2010-11-30 | Gruenenthal Gmbh | Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio. |
| BR112012001547A2 (pt) | 2009-07-22 | 2016-03-08 | Gruenenthal Gmbh | forma de dosagem farmacêutica extrusada por fusão a quente |
| RU2567723C2 (ru) | 2009-07-22 | 2015-11-10 | Грюненталь Гмбх | Стабильная при окислении, прочная на излом лекарственная форма |
| ES2606227T3 (es) * | 2010-02-03 | 2017-03-23 | Grünenthal GmbH | Preparación de una composición farmacéutica en polvo mediante una extrusora |
| US20160176930A1 (en) | 2010-07-09 | 2016-06-23 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
| PE20131126A1 (es) | 2010-09-02 | 2013-10-21 | Gruenenthal Chemie | Forma de dosificacion resistente a alteracion que comprende un polimero anionico |
| DK2736497T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel. |
| CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| WO2013156453A1 (en) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| CN102964279B (zh) * | 2012-12-12 | 2014-05-07 | 中国药科大学 | 一类具有外周镇痛作用的κ阿片受体激动剂 |
| AR096438A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso |
| CA2907950A1 (en) | 2013-05-29 | 2014-12-04 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
| AU2014289187B2 (en) | 2013-07-12 | 2019-07-11 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| MX371372B (es) | 2013-11-26 | 2020-01-28 | Gruenenthal Gmbh | Preparacion de una composicion farmaceutica en polvo por medio de criomolienda. |
| EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| JP2017516789A (ja) | 2014-05-26 | 2017-06-22 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エタノール過量放出に対して防護されている多粒子 |
| KR20170139158A (ko) | 2015-04-24 | 2017-12-18 | 그뤼넨탈 게엠베하 | 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태 |
| CA2998259A1 (en) | 2015-09-10 | 2017-03-16 | Grunenthal Gmbh | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68926269T2 (de) * | 1988-06-30 | 1996-08-14 | Astra Ab | Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge |
| IS4261A (is) | 1994-02-21 | 1995-08-22 | Astra Aktiebolag | Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra |
-
1995
- 1995-11-07 SE SE9503924A patent/SE9503924D0/xx unknown
-
1996
- 1996-08-06 AR ARP960103900A patent/AR003475A1/es active IP Right Grant
- 1996-08-14 ES ES96927978T patent/ES2171224T3/es not_active Expired - Lifetime
- 1996-08-14 DK DK96927978T patent/DK0845003T3/da active
- 1996-08-14 WO PCT/SE1996/001011 patent/WO1997007130A1/en not_active Application Discontinuation
- 1996-08-14 BR BR9610248A patent/BR9610248A/pt unknown
- 1996-08-14 CA CA002229797A patent/CA2229797A1/en not_active Abandoned
- 1996-08-14 CN CN96197625A patent/CN1200127A/zh active Pending
- 1996-08-14 NZ NZ315809A patent/NZ315809A/xx unknown
- 1996-08-14 RU RU98104253/04A patent/RU2165432C2/ru active
- 1996-08-14 AU AU67600/96A patent/AU711862B2/en not_active Ceased
- 1996-08-14 EE EE9800048A patent/EE9800048A/xx unknown
- 1996-08-14 PL PL96325113A patent/PL325113A1/xx unknown
- 1996-08-14 US US08/718,585 patent/US6337319B1/en not_active Expired - Fee Related
- 1996-08-14 JP JP9509209A patent/JPH11512086A/ja active Pending
- 1996-08-14 IL IL12325896A patent/IL123258A/xx not_active IP Right Cessation
- 1996-08-14 AT AT96927978T patent/ATE210148T1/de not_active IP Right Cessation
- 1996-08-14 DE DE69617699T patent/DE69617699T2/de not_active Expired - Fee Related
- 1996-08-14 SK SK203-98A patent/SK282469B6/sk unknown
- 1996-08-14 HU HU9901209A patent/HUP9901209A3/hu unknown
- 1996-08-14 CZ CZ1998401A patent/CZ287299B6/cs not_active IP Right Cessation
- 1996-08-14 EP EP96927978A patent/EP0845003B1/en not_active Expired - Lifetime
- 1996-08-14 TR TR1998/00258T patent/TR199800258T1/xx unknown
- 1996-08-14 KR KR1019980701156A patent/KR19990037677A/ko not_active Application Discontinuation
- 1996-08-15 TW TW085109918A patent/TW424095B/zh not_active IP Right Cessation
-
1998
- 1998-02-04 IS IS4664A patent/IS4664A/is unknown
- 1998-02-11 NO NO980592A patent/NO980592D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL123258A (en) | 2003-03-12 |
| DE69617699T2 (de) | 2003-08-07 |
| CN1200127A (zh) | 1998-11-25 |
| IS4664A (is) | 1998-02-04 |
| SK20398A3 (en) | 1998-12-02 |
| DE69617699D1 (de) | 2002-01-17 |
| EE9800048A (et) | 1998-08-17 |
| KR19990037677A (ko) | 1999-05-25 |
| JPH11512086A (ja) | 1999-10-19 |
| HUP9901209A2 (hu) | 1999-08-30 |
| AU6760096A (en) | 1997-03-12 |
| DK0845003T3 (da) | 2002-07-15 |
| SK282469B6 (sk) | 2002-02-05 |
| PL325113A1 (en) | 1998-07-06 |
| IL123258A0 (en) | 1998-09-24 |
| BR9610248A (pt) | 1999-07-06 |
| EP0845003B1 (en) | 2001-12-05 |
| EP0845003A1 (en) | 1998-06-03 |
| RU2165432C2 (ru) | 2001-04-20 |
| WO1997007130A1 (en) | 1997-02-27 |
| CZ287299B6 (en) | 2000-10-11 |
| NO980592L (no) | 1998-02-11 |
| ATE210148T1 (de) | 2001-12-15 |
| NO980592D0 (no) | 1998-02-11 |
| HUP9901209A3 (en) | 2000-12-28 |
| US6337319B1 (en) | 2002-01-08 |
| ES2171224T3 (es) | 2002-09-01 |
| TW424095B (en) | 2001-03-01 |
| CZ40198A3 (cs) | 1998-08-12 |
| CA2229797A1 (en) | 1997-02-27 |
| SE9503924D0 (sv) | 1995-11-07 |
| NZ315809A (en) | 1999-05-28 |
| AU711862B2 (en) | 1999-10-21 |
| TR199800258T1 (xx) | 1998-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |