ES2171445T3 - Nuevos oligopeptidos con afinidad para receptores opioides. - Google Patents

Nuevos oligopeptidos con afinidad para receptores opioides.

Info

Publication number
ES2171445T3
ES2171445T3 ES94901120T ES94901120T ES2171445T3 ES 2171445 T3 ES2171445 T3 ES 2171445T3 ES 94901120 T ES94901120 T ES 94901120T ES 94901120 T ES94901120 T ES 94901120T ES 2171445 T3 ES2171445 T3 ES 2171445T3
Authority
ES
Spain
Prior art keywords
amino acids
oligopeptides
opioid receptors
xyz
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94901120T
Other languages
English (en)
Inventor
Karin Ingeborg Fholenhag
Linda Fryklund
Bo Christer Larsson
Fred Jarl Nyberg
Gertrud Elisabe Westin-Sjodahl
Ronny Lundin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Application granted granted Critical
Publication of ES2171445T3 publication Critical patent/ES2171445T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REVELAN NUEVOS OLIGOPEPTIDOS CON AFINIDAD A LOS RECEPTORES DE OPIOIDE LOS CUALES SON PENTAPEPTIDOS RECTOS O CICLICOS CON LA COLUMNA VERTEBRAL DE SECUENCIA PRIMARIA TYR-X-PHE-LEU-Z, DONDE X Y Z DENOTAN AMINOACIDOS O DERIVADOS DE AMINOACIDOS Y/O ANALOGOS Y EN DONDE X Y Z PUEDEN SER COVALENTEMENTE ACOPLADOS PARA SUMINISTRAR UNA ESTRUCTURA HETEROCICLICA EN DONDE Z ES ELEGIDA ENTRE CIS, GLU, GLN O AMINO DERIVADOS DE GLU Y GLN, X SERA ELEGIDA ENTRE LOS AMINOACIDOS O LOS ANALOGOS DE AMINOACIDOS SER, GLI, PRO, AMCA, D-ALA, D- O L-ORNITINA, D- O L-2,4-ACIDO DIAMINOBUTIRICO, D- O L-CIS. TAMBIEN SE REVELAN PREPARADOS FARMACEUTICOS QUE COMPRENDEN DICHOS OLIGOPEPTIDOS, LOS CUALES SON POTENCIALMENTE UTILES COMO ANALGESICOS PARA ALIVIAR EL DOLOR, PARA EL TRATAMIENTO DE DEPRESIONES Y PARA INCREMENTAR EL BIENESTAR DE LOS INDIVIDUOS QUE PADECEN TENSION O CONMOCION EXTRAORDINARIA.
ES94901120T 1992-11-20 1993-11-18 Nuevos oligopeptidos con afinidad para receptores opioides. Expired - Lifetime ES2171445T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9203496A SE9203496D0 (sv) 1992-11-20 1992-11-20 New oligopeptides

Publications (1)

Publication Number Publication Date
ES2171445T3 true ES2171445T3 (es) 2002-09-16

Family

ID=20387887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94901120T Expired - Lifetime ES2171445T3 (es) 1992-11-20 1993-11-18 Nuevos oligopeptidos con afinidad para receptores opioides.

Country Status (16)

Country Link
US (1) US5872097A (es)
EP (1) EP0745093B1 (es)
JP (1) JP3470136B2 (es)
AT (1) ATE212357T1 (es)
AU (1) AU684481B2 (es)
CA (1) CA2149899A1 (es)
DE (1) DE69331499T2 (es)
DK (1) DK0745093T3 (es)
ES (1) ES2171445T3 (es)
FI (1) FI952455A0 (es)
NO (1) NO313098B1 (es)
NZ (1) NZ258260A (es)
PT (1) PT745093E (es)
RU (1) RU2131438C1 (es)
SE (1) SE9203496D0 (es)
WO (1) WO1994012532A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US7454406B2 (en) * 2005-04-29 2008-11-18 Adaptec, Inc. System and method of handling file metadata
PT2590992T (pt) 2010-07-09 2017-07-26 United States Dept Of Veterans Affairs Análogos agonistas do recetor de opioides mu das endomorfinas
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
US4254024A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Tetrapeptides and derivatives having opiate activity
US4699897A (en) * 1983-06-04 1987-10-13 Amgen Biologically active peptides structurally related to regions within growth hormones

Also Published As

Publication number Publication date
FI952455A (fi) 1995-05-19
EP0745093B1 (en) 2002-01-23
DK0745093T3 (da) 2002-05-13
DE69331499T2 (de) 2002-08-08
JPH08507748A (ja) 1996-08-20
DE69331499D1 (de) 2002-03-14
RU2131438C1 (ru) 1999-06-10
CA2149899A1 (en) 1994-06-09
SE9203496D0 (sv) 1992-11-20
ATE212357T1 (de) 2002-02-15
NO313098B1 (no) 2002-08-12
AU684481B2 (en) 1997-12-18
US5872097A (en) 1999-02-16
FI952455A0 (fi) 1995-05-19
PT745093E (pt) 2002-07-31
NO951990D0 (no) 1995-05-19
WO1994012532A1 (en) 1994-06-09
AU5581694A (en) 1994-06-22
NZ258260A (en) 1996-06-25
JP3470136B2 (ja) 2003-11-25
EP0745093A1 (en) 1996-12-04
NO951990L (no) 1995-05-19
RU95113498A (ru) 1997-03-20

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