ES2131913T3 - Derivados de camptotecina. - Google Patents
Derivados de camptotecina.Info
- Publication number
- ES2131913T3 ES2131913T3 ES96305579T ES96305579T ES2131913T3 ES 2131913 T3 ES2131913 T3 ES 2131913T3 ES 96305579 T ES96305579 T ES 96305579T ES 96305579 T ES96305579 T ES 96305579T ES 2131913 T3 ES2131913 T3 ES 2131913T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- group
- formula
- replaced
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 CARBOXYL GROUPS Chemical group 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN DERIVADO DE LA CAMPTOTECINA QUE COMPRENDE UN COMPUESTO DE LA FORMULA [1]: DONDE R{SUP,1} ES UN GRUPO ALQUILO INFERIOR SUSTITUIDO O NO SUSTITUIDO, X{SUP,1} ES UN GRUPO DE LA FORMULA: -NHR{SUP,2} (R{SUP,2} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR) O UN GRUPO DE -OH, Y ALK ES UN GRUPO ALQUILENO DE CADENA RECTA O RAMIFICADA QUE TIENE OPCIONALMENTE UN ATOMO DE OXIGENO EN SU CADENA, UNIDO A UN POLISACARIDO QUE TIENE GRUPOS CARBOXILOS A TRAVES DE UN AMINOACIDO O PEPTIDO, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. DICHOS DERIVADOS DE CAMPTOTECINA TIENEN UNA ACTIVIDAD ANTITUMORAL MEJORADA CON POCOS EFECTOS SECUNDARIOS A DIFERENCIA DE LOS AGENTES ANTICANCERIGENOS CONVENCIONALES, POR LO QUE ESTOS COMPUESTOS SON EXTREMADAMENTE UTILES COMO MEDICAMENTOS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19739195 | 1995-08-02 | ||
JP34061995 | 1995-12-27 | ||
JP17337296 | 1996-07-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2131913T3 true ES2131913T3 (es) | 1999-08-01 |
Family
ID=27323772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96305579T Expired - Lifetime ES2131913T3 (es) | 1995-08-02 | 1996-07-30 | Derivados de camptotecina. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5837673A (es) |
EP (1) | EP0757049B1 (es) |
KR (1) | KR100387191B1 (es) |
CN (2) | CN1075501C (es) |
AT (1) | ATE178067T1 (es) |
AU (1) | AU717653B2 (es) |
BG (1) | BG63342B1 (es) |
CA (1) | CA2182244C (es) |
DE (1) | DE69601841T2 (es) |
DK (1) | DK0757049T3 (es) |
ES (1) | ES2131913T3 (es) |
GR (1) | GR3029796T3 (es) |
HK (1) | HK1005545A1 (es) |
HU (1) | HUP9602122A3 (es) |
IL (1) | IL118957A (es) |
MY (1) | MY116665A (es) |
NO (1) | NO315469B1 (es) |
RU (1) | RU2138503C1 (es) |
SG (1) | SG50747A1 (es) |
TW (1) | TW466242B (es) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
WO1998014459A1 (de) * | 1996-09-30 | 1998-04-09 | Bayer Aktiengesellschaft | Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung) |
DE19640207A1 (de) * | 1996-09-30 | 1998-04-02 | Bayer Ag | Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung) |
SG116433A1 (en) | 1996-10-30 | 2005-11-28 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof. |
US6361938B1 (en) * | 1996-11-08 | 2002-03-26 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
ID23424A (id) * | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
US20030054977A1 (en) * | 1999-10-12 | 2003-03-20 | Cell Therapeutics, Inc. | Manufacture of polyglutamate-therapeutic agent conjugates |
US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
US20020077290A1 (en) * | 2000-03-17 | 2002-06-20 | Rama Bhatt | Polyglutamic acid-camptothecin conjugates and methods of preparation |
AU2001267831A1 (en) * | 2000-06-29 | 2002-01-08 | Daiichi Pharmaceutical Co., Ltd. | DDS compound and process for the preparation thereof |
PL363618A1 (en) | 2000-11-09 | 2004-11-29 | Neopharm, Inc. | Sn-38 lipid complexes and methods of use |
WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
WO2003033525A1 (en) * | 2001-10-12 | 2003-04-24 | Debio Recherche Pharmacuetique S.A. | Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
WO2004039869A1 (ja) * | 2002-10-31 | 2004-05-13 | Nippon Kayaku Kabushiki Kaisha | カンプトテシン類の高分子誘導体 |
WO2004092205A1 (en) * | 2003-04-16 | 2004-10-28 | Debio Recherche Pharmacuetique S.A. | Hydroxy-substituted-20-acyloxy-camptothecin polymer derivatives and use of the same for the manufacture of a medicament |
US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
CN1852740B (zh) | 2003-09-17 | 2011-05-11 | 耐科塔医药公司 | 多支链聚合物的药物前体 |
US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
JP4433918B2 (ja) * | 2004-07-15 | 2010-03-17 | コニカミノルタエムジー株式会社 | 画像形成方法 |
CN101023119B (zh) | 2004-09-22 | 2010-05-05 | 日本化药株式会社 | 新型嵌段共聚物,胶束制剂以及含胶束制剂为活性组分的抗癌剂 |
KR100651728B1 (ko) * | 2004-11-10 | 2006-12-06 | 한국전자통신연구원 | 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법 |
TWI375678B (en) | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
ITFI20050246A1 (it) * | 2005-12-02 | 2007-06-03 | Menarini Internat Operations Luxembourg Sa | Uso di un composto comprendente un derivato della camptotecina per la preparazione di formulazioni farmaceutiche utili nel trattamento del melanoma |
US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
KR20080106254A (ko) | 2006-03-28 | 2008-12-04 | 니폰 가야꾸 가부시끼가이샤 | 탁산류의 고분자 결합체 |
WO2007135910A1 (ja) | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | ポドフィロトキシン類の高分子結合体 |
WO2008056596A1 (en) | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
EP2090607B1 (en) | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
KR101441709B1 (ko) | 2006-11-30 | 2014-09-18 | 넥타르 테라퓨틱스 | 중합체 컨쥬게이트의 제조 방법 |
KR20090108082A (ko) | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
WO2009041570A1 (ja) | 2007-09-28 | 2009-04-02 | Nippon Kayaku Kabushiki Kaisha | ステロイド類の高分子結合体 |
CN101977631A (zh) | 2008-03-18 | 2011-02-16 | 日本化药株式会社 | 生理活性物质的高分子量偶联物 |
KR20230003298A (ko) | 2008-04-30 | 2023-01-05 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
CA2732508C (en) | 2008-08-11 | 2016-03-15 | Nektar Therapeutics | Multi-arm polymeric alkanoate conjugates |
PT2349346T (pt) | 2008-09-23 | 2019-10-24 | Nektar Therapeutics | Método de dosagem metronómica com profármacos de camptotecina (e.g. peg-irinotecano). |
US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
EP2641605B1 (en) | 2010-11-17 | 2018-03-07 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolism antagonist |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
JP5860480B2 (ja) | 2011-01-11 | 2016-02-16 | キャプシュゲル・ベルジウム・エヌ・ヴィ | プルランを含む新しい硬カプセル |
RU2623426C2 (ru) | 2011-09-11 | 2017-06-26 | Ниппон Каяку Кабусики Кайся | Способ получения блок-сополимера |
EP3632471A1 (en) | 2012-10-11 | 2020-04-08 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
EP2910573B1 (en) | 2012-10-19 | 2020-02-19 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
KR102535900B1 (ko) | 2013-12-25 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | 항 trop2 항체-약물 컨쥬게이트 |
SG10201800210TA (en) | 2014-01-31 | 2018-02-27 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugate |
KR102127623B1 (ko) | 2014-04-10 | 2020-06-29 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
ES2754348T3 (es) | 2014-04-10 | 2020-04-17 | Daiichi Sankyo Co Ltd | Conjugado de (anticuerpo anti-HER2)-fármaco |
EP4180455A1 (en) | 2015-06-29 | 2023-05-17 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
AU2017377233A1 (en) | 2016-12-12 | 2019-06-13 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
AU2018210081A1 (en) | 2017-01-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate |
US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
EP3610028A1 (en) | 2017-04-14 | 2020-02-19 | Capsugel Belgium NV | Process for making pullulan |
TW202330036A (zh) | 2017-05-15 | 2023-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
SG11202000997YA (en) | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Improved method for producing antibody-drug conjugate |
CN117838880A (zh) | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
DK3794042T3 (da) | 2018-05-18 | 2024-04-15 | Daiichi Sankyo Co Ltd | Anti-muc1-exatecet-antistof-lægemiddelkonjugat |
WO2024020734A1 (en) * | 2022-07-25 | 2024-02-01 | Immunogen, Inc. | Novel processes for preparing camptothecin derivatives |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3682874D1 (de) * | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US5049668A (en) * | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
JP2540357B2 (ja) * | 1987-06-24 | 1996-10-02 | 第一製薬株式会社 | 六環性化合物 |
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
NZ235329A (en) * | 1989-09-15 | 1992-01-29 | Res Triangle Inst | 20(s or rs)-camptothecin derivatives and pharmaceutical compositions |
US5140010A (en) * | 1989-09-28 | 1992-08-18 | Immunobiology Research Institute | Stabilized aqueous formulations of thymopentin |
WO1992003480A1 (fr) * | 1990-08-17 | 1992-03-05 | Drug Delivery System Institute, Ltd. | Derive de n-acetylcarboxymethylchitosan et procede de production |
DE69209969T2 (de) * | 1991-10-29 | 1996-09-12 | Glaxo Wellcome Inc | Wasserlösliche Camptothecinderivate |
JPH06228141A (ja) * | 1992-01-24 | 1994-08-16 | Takeda Chem Ind Ltd | 縮合複素環誘導体、その塩、その製造法および用途 |
CA2087898A1 (en) * | 1992-01-24 | 1993-07-25 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
AU3611093A (en) * | 1992-02-21 | 1993-09-13 | Smithkline Beecham Corporation | Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones |
JP3359955B2 (ja) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
DE69425464T2 (de) | 1993-02-26 | 2001-05-23 | Drug Delivery System Inst Ltd | Polysaccharidderivat und wirkstoffträger |
GB9320781D0 (en) | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
-
1996
- 1996-07-24 SG SG1996010359A patent/SG50747A1/en unknown
- 1996-07-25 AU AU60698/96A patent/AU717653B2/en not_active Ceased
- 1996-07-25 IL IL11895796A patent/IL118957A/xx not_active IP Right Cessation
- 1996-07-29 CA CA002182244A patent/CA2182244C/en not_active Expired - Fee Related
- 1996-07-30 AT AT96305579T patent/ATE178067T1/de not_active IP Right Cessation
- 1996-07-30 DK DK96305579T patent/DK0757049T3/da active
- 1996-07-30 US US08/689,018 patent/US5837673A/en not_active Expired - Lifetime
- 1996-07-30 EP EP96305579A patent/EP0757049B1/en not_active Expired - Lifetime
- 1996-07-30 DE DE69601841T patent/DE69601841T2/de not_active Expired - Fee Related
- 1996-07-30 ES ES96305579T patent/ES2131913T3/es not_active Expired - Lifetime
- 1996-07-31 BG BG100758A patent/BG63342B1/bg unknown
- 1996-08-01 MY MYPI96003153A patent/MY116665A/en unknown
- 1996-08-01 RU RU96115394A patent/RU2138503C1/ru not_active IP Right Cessation
- 1996-08-01 NO NO19963214A patent/NO315469B1/no not_active IP Right Cessation
- 1996-08-01 HU HU9602122A patent/HUP9602122A3/hu unknown
- 1996-08-02 TW TW085109331A patent/TW466242B/zh not_active IP Right Cessation
- 1996-08-02 KR KR1019960032296A patent/KR100387191B1/ko not_active IP Right Cessation
- 1996-08-02 CN CN96106979A patent/CN1075501C/zh not_active Expired - Fee Related
- 1996-08-02 CN CNB001326619A patent/CN1143859C/zh not_active Expired - Fee Related
-
1998
- 1998-05-29 HK HK98104671A patent/HK1005545A1/xx not_active IP Right Cessation
-
1999
- 1999-03-26 GR GR990400802T patent/GR3029796T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
SG50747A1 (en) | 1998-07-20 |
DE69601841T2 (de) | 1999-08-05 |
AU717653B2 (en) | 2000-03-30 |
CN1145365A (zh) | 1997-03-19 |
AU6069896A (en) | 1997-02-06 |
US5837673A (en) | 1998-11-17 |
HUP9602122A2 (en) | 1997-11-28 |
CN1308078A (zh) | 2001-08-15 |
CA2182244C (en) | 2004-02-03 |
KR100387191B1 (ko) | 2003-10-04 |
NO963214D0 (no) | 1996-08-01 |
BG63342B1 (bg) | 2001-10-31 |
KR19980013708A (ko) | 1998-05-15 |
HU9602122D0 (en) | 1996-09-30 |
GR3029796T3 (en) | 1999-06-30 |
BG100758A (bg) | 1997-02-28 |
TW466242B (en) | 2001-12-01 |
IL118957A0 (en) | 1996-10-31 |
ATE178067T1 (de) | 1999-04-15 |
CN1143859C (zh) | 2004-03-31 |
HK1005545A1 (en) | 1999-01-15 |
EP0757049A1 (en) | 1997-02-05 |
HUP9602122A3 (en) | 1998-07-28 |
CA2182244A1 (en) | 1997-02-03 |
RU2138503C1 (ru) | 1999-09-27 |
NO315469B1 (no) | 2003-09-08 |
NO963214L (no) | 1997-02-03 |
IL118957A (en) | 2000-11-21 |
EP0757049B1 (en) | 1999-03-24 |
DK0757049T3 (da) | 1999-06-23 |
DE69601841D1 (de) | 1999-04-29 |
CN1075501C (zh) | 2001-11-28 |
MY116665A (en) | 2004-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2131913T3 (es) | Derivados de camptotecina. | |
KR960007545A (ko) | 합성 흥분성 아미노산 | |
ID25979A (id) | TURUNAN-TURUNAN KOMTOTESIN (Pecahan dari P-963785) | |
KR930003912A (ko) | 울혈성 심장 마비 치료법 | |
KR890000494A (ko) | 메틸아미노 질소상에서 치환된 스타우로스포린 유도체 | |
EA200000391A1 (ru) | Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов | |
NO962073D0 (no) | Amfifiliske imidazoliniumderivater | |
EA200000871A1 (ru) | Ингибиторы фосфолипазных ферментов | |
ATE187641T1 (de) | Verfahren zum bekämpfen der pneumocystis carinii pneumonie und dafür verwendbare verbindungen | |
KR840005081A (ko) | Lhrh의 노나펩타이드 및 데카펩타이드 동족체 제조방법 | |
RU94045881A (ru) | Производные пептидов, способ получения, фармацевтическая композиция, способ лечения | |
CS202568B2 (en) | Process for preparing polypeptides | |
FR2649110B1 (fr) | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
GR1001597B (el) | Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών. | |
KR890014480A (ko) | 2-피리딜아세트산 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물 | |
IT1262921B (it) | Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono | |
EA199800155A1 (ru) | Новое соединение | |
ES2170956T3 (es) | Derivados 2-alquenilicos de acido ciclopentan(en)oico como agentes terapeuticos en el tratamiento de hipertension ocular. | |
TR200101083T2 (tr) | (7alfa,17alfa)-17-hidroksi- 7-metil-19-nor-17-pregn-5 (10)-en-20-in-3-on içeren yüksek saflıkta bileşim. | |
DK0823909T3 (da) | Hidtil ukendte heterocykliske forbindelser | |
KR910020023A (ko) | 헤테로사이클릭-nmda길항제 | |
ATE276272T1 (de) | Entzündungshemmende peptide | |
RU95102918A (ru) | Производные пролилтирозина, обладающие психотропной активностью | |
ES2144271T3 (es) | Sintesis de derivados de acido carboxilico. | |
AR004674A1 (es) | Derivado de camptotecina, compueso de camptotecina util como intermediario para obtenerlo, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso de dicho derivado para la preparacion de dicha composicion. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 757049 Country of ref document: ES |