ES2144271T3 - Sintesis de derivados de acido carboxilico. - Google Patents

Sintesis de derivados de acido carboxilico.

Info

Publication number
ES2144271T3
ES2144271T3 ES96938374T ES96938374T ES2144271T3 ES 2144271 T3 ES2144271 T3 ES 2144271T3 ES 96938374 T ES96938374 T ES 96938374T ES 96938374 T ES96938374 T ES 96938374T ES 2144271 T3 ES2144271 T3 ES 2144271T3
Authority
ES
Spain
Prior art keywords
synthesis
acid derivatives
carboxyl acid
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938374T
Other languages
English (en)
Inventor
Maxwell Reeve
Stephen Arthur Bowles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2144271T3 publication Critical patent/ES2144271T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPUESTOS CON LA FORMULA (I) DONDE R 1 , R 2 , R3 , R 4 Y X SON GRUPOS DEFINIDOS EN LA ESPECIFICACION QUE SE PREPARAN MEDIANTE LA ELIMINACION DE UNO DE LOS GRUPOS X 1 Y X 2 DE UN COMPUESTO CON LA FORMULA (II) DONDE X 1 Y X 2 REPRESENTAN DE MANERA INDEPENDIENTE UN GRUPO ACIDO CARBOXILICO O UNA SAL DEL MISMO, O UN GRUPO ACIDO CARBOXILICO PROTEGIDO, DONDE EL GRUPO X 1 O X 2 NO ELIM INADO CORRESPONDE AL GRUPO X DEL COMPUESTO DESEADO DE LA FORMULA (I).
ES96938374T 1995-11-18 1996-11-18 Sintesis de derivados de acido carboxilico. Expired - Lifetime ES2144271T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9523637.8A GB9523637D0 (en) 1995-11-18 1995-11-18 Synthesis of carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
ES2144271T3 true ES2144271T3 (es) 2000-06-01

Family

ID=10784104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938374T Expired - Lifetime ES2144271T3 (es) 1995-11-18 1996-11-18 Sintesis de derivados de acido carboxilico.

Country Status (9)

Country Link
US (1) US5986132A (es)
EP (1) EP0861226B1 (es)
JP (1) JP2000500759A (es)
AT (1) ATE189886T1 (es)
AU (1) AU7582396A (es)
DE (1) DE69606776T2 (es)
ES (1) ES2144271T3 (es)
GB (2) GB9523637D0 (es)
WO (1) WO1997019050A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
US20100226922A1 (en) * 2006-06-08 2010-09-09 Dorothea Maetzel Specific protease inhibitors and their use in cancer therapy
BR112021006407A8 (pt) 2018-10-04 2022-12-06 Inst Nat Sante Rech Med uso de inibidores do egfr para ceratodermas

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds

Also Published As

Publication number Publication date
DE69606776T2 (de) 2000-08-10
EP0861226A1 (en) 1998-09-02
EP0861226B1 (en) 2000-02-23
DE69606776D1 (en) 2000-03-30
AU7582396A (en) 1997-06-11
ATE189886T1 (de) 2000-03-15
WO1997019050A1 (en) 1997-05-29
GB9806358D0 (en) 1998-05-20
JP2000500759A (ja) 2000-01-25
GB9523637D0 (en) 1996-01-17
GB2321459A (en) 1998-07-29
US5986132A (en) 1999-11-16

Similar Documents

Publication Publication Date Title
ES2194986T3 (es) Compuestos de carbonil-piperazinilo y piperidinilo que inhiben la farnesil-protein-transferasa.
ATE167476T1 (de) Substituierte 2-phenyl-3-methocypropensäurenester als fungizide mittel.
ITMI932113A1 (it) Oligopeptidi ad attivita' fungicida
DE69325262T2 (de) Vinylen-azaindolderivate und verfahren zu ihrer herstellung
ES2131913T3 (es) Derivados de camptotecina.
ATE128985T1 (de) Hydantoinderivate.
EA200200510A1 (ru) 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
RU94028888A (ru) Производные 1,3-замещенного циклоалкана и циклоалкена, смесь их изомеров или индивидуальные изомеры, их гидраты и соли, способ их получения и фармацевтическая композиция
IT1252227B (it) Composti tetrametilpiperidinici atti all'impiego come stabilizzanti per materiali organici
KR950008468A (ko) 방향족 카복실산 유도체
JPS5699485A (en) 66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids
ZA945007B (en) Heterocyclic derivatives
ES2174113T3 (es) Nuevos derivados de ((3-alcoxi-fenoxi)-etil)-dialquilamina y su utilizacion como anestesicos locales.
ATE225774T1 (de) Imidazolidinonderivate als korrosionsinhibitoren
NO980643L (no) Propylendopeptidase inhibitorer
ES2144271T3 (es) Sintesis de derivados de acido carboxilico.
DE69403541D1 (de) Lacton-Verbindung und Verfahren zu ihrer Herstellung
FI923841A (fi) Substituerade mandelsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
TW344743B (en) Therapeutic nucleosides
CO4410199A1 (es) Procedimiento estereoselectivo para producir derivados de dihidro-2,3-benzodiacepina
NZ503880A (en) Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
RU95108600A (ru) Способ получения промежуточных соединений замещенных производных имидазола
MX9301810A (es) Productos de reaccion que contienen epoxido-acido fosforoso y su uso en composiciones de revestimiento.
GR1001566B (el) Μέ?οδος παρασκευής νέων παραγώγων βενζοφουρανυλιμιδαζόλης.
ES2157345T3 (es) Compuestos de gamma-dicetona con actividad inhibidora contra la agregacion de plaquetas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 861226

Country of ref document: ES