RU95113498A - Линейные или циклические олигопептиды, обладающие сродством к опиоидным рецепторам, фармацевтическая композиция, способ лечения - Google Patents
Линейные или циклические олигопептиды, обладающие сродством к опиоидным рецепторам, фармацевтическая композиция, способ леченияInfo
- Publication number
- RU95113498A RU95113498A RU95113498/04A RU95113498A RU95113498A RU 95113498 A RU95113498 A RU 95113498A RU 95113498/04 A RU95113498/04 A RU 95113498/04A RU 95113498 A RU95113498 A RU 95113498A RU 95113498 A RU95113498 A RU 95113498A
- Authority
- RU
- Russia
- Prior art keywords
- glu
- oligopeptides
- amino acids
- linear
- opioid receptors
- Prior art date
Links
- 102000015636 Oligopeptides Human genes 0.000 title claims abstract 6
- 108010038807 Oligopeptides Proteins 0.000 title claims abstract 6
- 102000003840 Opioid Receptors Human genes 0.000 title claims abstract 3
- 108090000137 Opioid Receptors Proteins 0.000 title claims abstract 3
- 125000004122 cyclic group Chemical group 0.000 title claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims abstract 5
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims abstract 4
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract 2
- OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 claims abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 2
- 229960003104 ornithine Drugs 0.000 claims abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- MXRPNYMMDLFYDL-YFKPBYRVSA-N AMCC Chemical compound CNC(=O)SC[C@@H](C(O)=O)NC(C)=O MXRPNYMMDLFYDL-YFKPBYRVSA-N 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000003862 amino acid derivatives Chemical class 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 2
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002635 electroconvulsive therapy Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Сущность изобретения: олигопептиды обладают сродством к опиоидным рецепторам, которые являются линейными или циклическими пентапептидами с первичной последовательностью аминокислот в скелете Тир-Х-Фен-Лей- Z, где Х и Z обозначают аминокислоты или производные аминокислот и/или аналоги и где Х и Z могут быть ковалентно связаны, образуя гетероциклическую структуру, в которой Z выбирают из Цис, Глу, Глн или аминокислотных производных Глу и Глн; Х выбирают из аминокислот или аминокислотных аналогов Сер, Глу, Про, АМЦК, D-Ала, D- или L-орнитина, D- или L-2,4-диаминомасляной кислоты, D- или L-Лиз и D- или L-Цис. Кроме того, фармацевтические препараты содержат вышеназванные олигопептиды, которые являются потенциально полезными в качестве анальгетиков для облегчения боли, для лечения депрессий и для повышения комфорта индивидуумов, страдающих от экстраординарного стресса или шока.
Claims (1)
- Сущность изобретения: олигопептиды обладают сродством к опиоидным рецепторам, которые являются линейными или циклическими пентапептидами с первичной последовательностью аминокислот в скелете Тир-Х-Фен-Лей- Z, где Х и Z обозначают аминокислоты или производные аминокислот и/или аналоги и где Х и Z могут быть ковалентно связаны, образуя гетероциклическую структуру, в которой Z выбирают из Цис, Глу, Глн или аминокислотных производных Глу и Глн; Х выбирают из аминокислот или аминокислотных аналогов Сер, Глу, Про, АМЦК, D-Ала, D- или L-орнитина, D- или L-2,4-диаминомасляной кислоты, D- или L-Лиз и D- или L-Цис. Кроме того, фармацевтические препараты содержат вышеназванные олигопептиды, которые являются потенциально полезными в качестве анальгетиков для облегчения боли, для лечения депрессий и для повышения комфорта индивидуумов, страдающих от экстраординарного стресса или шока.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9203496A SE9203496D0 (sv) | 1992-11-20 | 1992-11-20 | New oligopeptides |
| SE9203496-6 | 1992-11-20 | ||
| PCT/SE1993/000986 WO1994012532A1 (en) | 1992-11-20 | 1993-11-18 | New oligopeptides with affinity to opioid receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95113498A true RU95113498A (ru) | 1997-03-20 |
| RU2131438C1 RU2131438C1 (ru) | 1999-06-10 |
Family
ID=20387887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95113498A RU2131438C1 (ru) | 1992-11-20 | 1993-11-18 | Линейные или циклические олигопептиды, обладающие сродством к опиатным рецепторам, фармацевтическая композиция |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5872097A (ru) |
| EP (1) | EP0745093B1 (ru) |
| JP (1) | JP3470136B2 (ru) |
| AT (1) | ATE212357T1 (ru) |
| AU (1) | AU684481B2 (ru) |
| CA (1) | CA2149899A1 (ru) |
| DE (1) | DE69331499T2 (ru) |
| DK (1) | DK0745093T3 (ru) |
| ES (1) | ES2171445T3 (ru) |
| FI (1) | FI952455A (ru) |
| NO (1) | NO313098B1 (ru) |
| NZ (1) | NZ258260A (ru) |
| PT (1) | PT745093E (ru) |
| RU (1) | RU2131438C1 (ru) |
| SE (1) | SE9203496D0 (ru) |
| WO (1) | WO1994012532A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1623801A (en) * | 1999-11-19 | 2001-05-30 | Palatin Technologies, Inc. | Opioid metallopeptide compositions and methods |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| CN101065014A (zh) * | 2004-09-23 | 2007-10-31 | 亚历山大·米哈洛 | 通过诱导逆适应调节神经递质系统的方法 |
| US7454406B2 (en) * | 2005-04-29 | 2008-11-18 | Adaptec, Inc. | System and method of handling file metadata |
| RS56129B1 (sr) | 2010-07-09 | 2017-10-31 | The Administrators Of The Tulane Educational Fund | Analozi agonista receptora opioida mu endomorfina |
| US20160176930A1 (en) | 2010-07-09 | 2016-06-23 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8005121A (nl) * | 1979-09-20 | 1981-03-24 | Erba Farmitalia | Biologisch actieve peptiden. |
| US4254024A (en) * | 1979-10-16 | 1981-03-03 | Pennwalt Corporation | Tetrapeptides and derivatives having opiate activity |
| US4699897A (en) * | 1983-06-04 | 1987-10-13 | Amgen | Biologically active peptides structurally related to regions within growth hormones |
-
1992
- 1992-11-20 SE SE9203496A patent/SE9203496D0/xx unknown
-
1993
- 1993-11-08 US US08/433,401 patent/US5872097A/en not_active Expired - Fee Related
- 1993-11-18 RU RU95113498A patent/RU2131438C1/ru not_active IP Right Cessation
- 1993-11-18 AT AT94901120T patent/ATE212357T1/de not_active IP Right Cessation
- 1993-11-18 EP EP94901120A patent/EP0745093B1/en not_active Expired - Lifetime
- 1993-11-18 NZ NZ258260A patent/NZ258260A/en unknown
- 1993-11-18 AU AU55816/94A patent/AU684481B2/en not_active Ceased
- 1993-11-18 DK DK94901120T patent/DK0745093T3/da active
- 1993-11-18 PT PT94901120T patent/PT745093E/pt unknown
- 1993-11-18 ES ES94901120T patent/ES2171445T3/es not_active Expired - Lifetime
- 1993-11-18 CA CA002149899A patent/CA2149899A1/en not_active Abandoned
- 1993-11-18 JP JP51303594A patent/JP3470136B2/ja not_active Expired - Fee Related
- 1993-11-18 DE DE69331499T patent/DE69331499T2/de not_active Expired - Fee Related
- 1993-11-18 WO PCT/SE1993/000986 patent/WO1994012532A1/en active IP Right Grant
-
1995
- 1995-05-19 FI FI952455A patent/FI952455A/fi not_active IP Right Cessation
- 1995-05-19 NO NO19951990A patent/NO313098B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2131438C1 (ru) | 1999-06-10 |
| AU684481B2 (en) | 1997-12-18 |
| DE69331499T2 (de) | 2002-08-08 |
| ATE212357T1 (de) | 2002-02-15 |
| JPH08507748A (ja) | 1996-08-20 |
| WO1994012532A1 (en) | 1994-06-09 |
| ES2171445T3 (es) | 2002-09-16 |
| NO951990L (no) | 1995-05-19 |
| SE9203496D0 (sv) | 1992-11-20 |
| NO313098B1 (no) | 2002-08-12 |
| PT745093E (pt) | 2002-07-31 |
| NO951990D0 (no) | 1995-05-19 |
| AU5581694A (en) | 1994-06-22 |
| NZ258260A (en) | 1996-06-25 |
| DK0745093T3 (da) | 2002-05-13 |
| JP3470136B2 (ja) | 2003-11-25 |
| FI952455A0 (fi) | 1995-05-19 |
| US5872097A (en) | 1999-02-16 |
| EP0745093B1 (en) | 2002-01-23 |
| CA2149899A1 (en) | 1994-06-09 |
| FI952455A (fi) | 1995-05-19 |
| DE69331499D1 (de) | 2002-03-14 |
| EP0745093A1 (en) | 1996-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20051119 |