YU5396A - Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje - Google Patents

Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje

Info

Publication number
YU5396A
YU5396A YU5396A YU5396A YU5396A YU 5396 A YU5396 A YU 5396A YU 5396 A YU5396 A YU 5396A YU 5396 A YU5396 A YU 5396A YU 5396 A YU5396 A YU 5396A
Authority
YU
Yugoslavia
Prior art keywords
xaa
leu
ser
val
ile
Prior art date
Application number
YU5396A
Other languages
English (en)
Inventor
Richard Dimarchi
William Heath
Margaret Basinski
Brigitte Schoner
Original Assignee
Eli Lilly And Company, Lilly Corporate Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company, Lilly Corporate Center filed Critical Eli Lilly And Company, Lilly Corporate Center
Publication of YU5396A publication Critical patent/YU5396A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje - Opisani su novi biološki aktivni proteini formule (SEK ID NO: 1) 5 10 Val Pro Ile Xaa Lys Val Xaa Asp Asp Thr Lys Thr Leu Ile 15 20 25 Lys Thr Ile Val Thr Arg Ile Xaa Asp Ile Ser His Xaa Xaa 30 35 40 Ser Val Ser Ser Lys Xaa Lys Val Thr Gly Leu Asp Phe Ile 45 50 55 Pro Gly Leu His Pro Ile Leu Thr Leu Ser Lys Xaa Asp Xaa 60 65 70 Thr Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro Ser 75 80 Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg 85 90 95 Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu 100 105 110 Pro Xaa Ala Ser Gly Leu Glu Thr Leu Xaa Ser Leu Gly Gly 115 120 125 Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu 130 135 140 Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu 145 Asp Leu Ser Pro Gly Cys. Takodje su opisane farmaceutske smese koje kao aktivnu supstancu sadrže ove nove biološki aktivne proteine, kao i postupak za dobijanje tih proteina.
YU5396A 1995-01-31 1996-01-29 Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje YU5396A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38104895A 1995-01-31 1995-01-31
US38363895A 1995-02-06 1995-02-06

Publications (1)

Publication Number Publication Date
YU5396A true YU5396A (sh) 1998-08-14

Family

ID=27009220

Family Applications (1)

Application Number Title Priority Date Filing Date
YU5396A YU5396A (sh) 1995-01-31 1996-01-29 Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje

Country Status (10)

Country Link
EP (2) EP0725079A1 (sh)
JP (1) JPH10513450A (sh)
AR (1) AR002024A1 (sh)
AU (1) AU4766196A (sh)
CA (1) CA2211664A1 (sh)
CO (1) CO4480036A1 (sh)
PE (1) PE15297A1 (sh)
TR (1) TR199600084A2 (sh)
WO (2) WO1996023515A1 (sh)
YU (1) YU5396A (sh)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6357096A (ja) * 1986-08-29 1988-03-11 工業技術院長 紐体切断装置
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
EP0736599A3 (en) * 1995-04-03 1996-12-11 Takeda Chemical Industries Ltd The rat obesity gene, its gene product and its production
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
ZA963530B (en) * 1995-05-05 1996-11-05 Hoffmann La Roche Recombinant obese (ob) proteins
EP0741187A2 (en) * 1995-05-05 1996-11-06 F. Hoffmann-La Roche Ag Recombinant obese (Ob) proteins
YU29596A (sh) * 1995-05-19 1998-07-10 Eli Lilly And Company Genski proizvodi koji regulišu gojaznost
WO1996037517A1 (en) * 1995-05-26 1996-11-28 Eli Lilly And Company Rhesus ob protein and dna
ZA965346B (en) * 1995-06-30 1997-12-24 Lilly Co Eli Methods of treating neuropeptide Y-associated conditions.
EP0759441A3 (en) * 1995-06-30 1999-06-30 Eli Lilly And Company Methods of treating neuropeptide Y-associated conditions
EP0764722A2 (en) * 1995-09-19 1997-03-26 Eli Lilly And Company DNA encoding primate leptins as medicinal proteins
US6225446B1 (en) 1995-12-06 2001-05-01 Schering Corporation Mutational variants of mammalian proteins
WO1997020933A2 (en) * 1995-12-06 1997-06-12 Schering Corporation MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS
US6620413B1 (en) 1995-12-27 2003-09-16 Genentech, Inc. OB protein-polymer chimeras
US7074397B1 (en) 1996-01-08 2006-07-11 Genentech, Inc. Method for enhancing proliferation or differentiation of a cell using ob protein
US20050019325A1 (en) 1996-01-08 2005-01-27 Carter Paul J. WSX receptor agonist antibodies
US6541604B1 (en) 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
EP0786256A3 (en) * 1996-01-19 1999-08-18 Eli Lilly And Company Obesity protein formulations
JP2000505078A (ja) * 1996-01-19 2000-04-25 イーライ・リリー・アンド・カンパニー 肥満症タンパク質製剤
EP0784982A3 (en) * 1996-01-19 1999-08-18 Eli Lilly And Company Obesity protein formulations
EP0877627A1 (en) * 1996-01-25 1998-11-18 Eli Lilly And Company Obesity protein analog compounds and formulations thereof
AU1838797A (en) * 1996-02-06 1997-08-28 Eli Lilly And Company Obesity protein compounds and formulations thereof
HUP0000280A3 (en) * 1996-03-01 2002-09-30 Amgen Inc Thousand Oaks Canine ob protein compositions and methods
JP2000509018A (ja) * 1996-03-26 2000-07-18 イーライ・リリー・アンド・カンパニー 肥満タンパク質製剤
US6025324A (en) * 1996-05-15 2000-02-15 Hoffmann-La Roche Inc. Pegylated obese (ob) protein compositions
AU4160597A (en) * 1996-08-23 1998-03-06 Eli Lilly And Company Protein formulations
AU4582597A (en) * 1996-10-11 1998-05-11 Eli Lilly And Company Therapeutic proteins
WO1998024896A2 (en) * 1996-12-06 1998-06-11 F. Hoffmann-La Roche Ag Muteins of obese protein
AU5802898A (en) * 1996-12-20 1998-07-17 Eli Lilly And Company Anti-obesity proteins
EP0973535A1 (en) * 1996-12-20 2000-01-26 Eli Lilly And Company Protein crystals, their preparation and use
CA2217698A1 (en) * 1996-12-20 1998-06-20 Eli Lilly And Company Anti-obesity proteins
WO1998031390A1 (en) * 1997-01-17 1998-07-23 Eli Lilly And Company Obesity protein formulations
US5965521A (en) * 1997-02-25 1999-10-12 Eli Lilly Company Pulsatile delivery of leptin receptor ligands
EP0991420A1 (en) * 1997-02-25 2000-04-12 Eli Lilly And Company Modulation of the hypothalamic-pituitary-adrenal-adipose axis with leptin receptor ligands
AU1208599A (en) * 1997-10-31 1999-05-24 Eli Lilly And Company Glycosylated obesity protein analogs
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
WO2000024418A1 (en) * 1998-10-27 2000-05-04 Eli Lilly And Company Prevention of muscle mass loss with leptin receptor ligands
DE60237100D1 (de) 2001-10-22 2010-09-02 Amgen Inc Verwendung von leptin zur behandlung von lipoatropr prädisposition gegenüber der behandlung
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2005028438A1 (ja) 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. 新規ピペリジン誘導体
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
KR101397913B1 (ko) 2005-05-30 2014-05-26 엠에스디 가부시키가이샤 신규 피페리딘 유도체
WO2007018248A1 (ja) 2005-08-10 2007-02-15 Banyu Pharmaceutical Co., Ltd. ピリドン化合物
AU2006282260A1 (en) 2005-08-24 2007-03-01 Msd K.K. Phenylpyridone derivative
US8227408B2 (en) 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
AU2006288153A1 (en) 2005-09-07 2007-03-15 Msd K.K. Bicyclic aromatic substituted pyridone derivative
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
WO2007048027A2 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
US8163770B2 (en) 2005-10-27 2012-04-24 Msd. K. K. Benzoxathiin derivative
KR101318127B1 (ko) 2005-11-10 2013-10-16 엠에스디 가부시키가이샤 아자 치환된 스피로 유도체
WO2008039327A2 (en) 2006-09-22 2008-04-03 Merck & Co., Inc. Method of treatment using fatty acid synthesis inhibitors
EP2072519A4 (en) 2006-09-28 2009-10-21 Banyu Pharma Co Ltd DIARYLKETIMINDERIVAT
US8106086B2 (en) 2007-04-02 2012-01-31 Msd K.K. Indoledione derivative
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2714617A1 (en) 2008-03-06 2009-09-11 Banyu Pharmaceutical Co., Ltd. Alkylaminopyridine derivative
CN101981025A (zh) 2008-03-28 2011-02-23 万有制药株式会社 具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物
WO2009143380A2 (en) 2008-05-21 2009-11-26 Neurotez, Inc. Methods for treating progressive cognitive disorders related to neurofibrillary tangles
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JPWO2009154132A1 (ja) 2008-06-19 2011-12-01 Ｍｓｄ株式会社 スピロジアミン−ジアリールケトオキシム誘導体
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2319841A1 (en) 2008-07-30 2011-05-11 Msd K.K. (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
WO2010047982A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2352510A4 (en) 2008-11-04 2012-08-29 Neurotez Inc LEPTIN COMPOSITIONS AND METHODS OF TREATING PROGRESSIVE COGNITIVE DISORDERS DUE TO THE ASSEMBLY OF NEUROFIBRILLARY BUNNELS AND AMYLOID BETA
EP2379547A1 (en) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
JP2012523434A (ja) 2009-04-10 2012-10-04 アミリン・ファーマシューティカルズ，インコーポレイテッド エストロゲン欠乏哺乳類のためのアミリンアゴニスト化合物
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA032917B1 (ru) 2010-09-28 2019-08-30 Амилин Фармасьютикалс, Ллк Сконструированные полипептиды, характеризующиеся увеличенной продолжительностью действия
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
PT2729160T (pt) 2011-07-08 2019-07-08 Aegerion Pharmaceuticals Inc Polipéptidos modificados com uma maior duração da ação e uma imunogenicidade reduzida
DE102012106607B4 (de) 2012-07-20 2024-04-04 Heliatek Gmbh Verfahren zur Versiegelung von Modulen mit optoelektronischen Bauelementen
EP2880028B1 (en) 2012-08-02 2020-09-30 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CA2898482A1 (en) 2013-02-22 2014-08-28 Linda L. Brockunier Antidiabetic bicyclic compounds
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
SI3509624T1 (sl) 2016-09-12 2023-12-29 Amryt Pharmaceuticals, Inc., Postopki detektiranja nevtralizirajočih protiteles proti leptinu
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
EP3551176A4 (en) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. ANTIDIABETIC HETEROCYCLIC COMPOUNDS
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. ANTIDIABETIC SPIROCHROMAN COMPOUNDS
AU2019385644A1 (en) 2018-11-20 2021-06-03 Tes Pharma S.R.L. Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
CN115362165A (zh) * 2020-03-11 2022-11-18 安尼根有限公司 包含新型化合物的用于抗糖尿病和抗肥胖的组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626549A (en) * 1974-01-10 1986-12-02 Eli Lilly And Company Treatment of obesity with aryloxyphenylpropylamines
FI931701A (fi) * 1992-04-17 1993-10-18 Sankyo Co Derivat av faktor som inhiberar fettbildning, framstaellning och anvaendning
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Also Published As

Publication number Publication date
TR199600084A2 (tr) 1996-08-21
JPH10513450A (ja) 1998-12-22
PE15297A1 (es) 1997-05-22
WO1996023517A1 (en) 1996-08-08
CO4480036A1 (es) 1997-07-09
AU4766196A (en) 1996-08-21
WO1996023515A1 (en) 1996-08-08
AR002024A1 (es) 1998-01-07
CA2211664A1 (en) 1996-08-08
EP0725078A1 (en) 1996-08-07
EP0725079A1 (en) 1996-08-07

Similar Documents

Publication Publication Date Title
YU5396A (sh) Novi biološki aktivni proteini, njihove farmaceutske formulacije i postupak za njihovo dobijanje
DE69133354T2 (de) Interleukin 1-beta protease und ihre inhibitoren
DE59007517D1 (de) Neue proteine mit tnf-hemmender wirkung und ihre herstellung.
FR2770843B1 (fr) Association prolamines-lipides polaires vegetaux, son procede de preparation et ses applications
YU71395A (sh) Acilovani analozi insulina
HUP0003592A2 (hu) LH-RH peptid analógok, alkalmazásuk, és ezeket tartalmazó gyógyászati készítmények
AU6819294A (en) Oral drug delivery compositions and methods
MXPA02001340A (es) Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos.
RU94036773A (ru) Домен i ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена i
ZA952086B (en) Heterocyclic compounds their preparation and use
MD1652G2 (ro) Proteină cu activitate de tip citochină, ADN recombinant, codificator pentru această proteină, celule şi microorganisme transformate, vector de expresie, procedeu de obţinere a proteinei şi remediu care conţine această proteină
MX9710252A (es) Utilizacion de al menos un peptido en una composicion cosmetica o para la preparacion de un medicamento.
AU2003264708A1 (en) Use of aspartic proteases in cosmetics and therapeutics
YU394A (sh) Novi peptidi koji deluju kao antagonisti opijatskih receptora i postupci za njihovu izradu
AU7617796A (en) Variants of human recombinant interferon-gamma (rhu-ifn-gamma) having increased heat-stability
KR101870898B1 (ko) 갈릭산이 결합된 펩타이드 유도체 및 그를 포함하는 항노화 피부 외용제 조성물
YU29596A (sh) Genski proizvodi koji regulišu gojaznost
EP0277626A3 (en) Synthetic ghrh analogs
IL116436A0 (en) FCE-PE chimeric protein for targeted treatment of allergy responses a method for its production and pharmaceutical compositions containing the same
HUT58765A (en) Process for producing peptide compounds and pharmaceutical compositions containing them as active components
YU48997A (sh) Novi biološki aktivni proteini, njihove farmaceutske smeše i postupak za njihovo dobijanje
HUP0003357A2 (hu) Angiogén hatású ciklusos azapeptidek, ezeket hatóanyagként tartalmazó gyógyászati készítmények, eljárás ezek előállítására és alkalmazásuk
EP1908781A3 (en) Modulation of immune response and methods based thereon
FR2658190B1 (fr) Esters d'aminoacides de l'hydroquinone, leur procede de preparation et compositions pharmaceutiques ou cosmetiques les contenant.
JPH03284700A (ja) 機能性ポリペプチド