AR002022A1 - Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, uso de los mismos para la manufactura de un medicamento y un procedimiento para preparar dichos compuestos. - Google Patents

Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, uso de los mismos para la manufactura de un medicamento y un procedimiento para preparar dichos compuestos.

Info

Publication number
AR002022A1
AR002022A1 ARP960101025A AR10102596A AR002022A1 AR 002022 A1 AR002022 A1 AR 002022A1 AR P960101025 A ARP960101025 A AR P960101025A AR 10102596 A AR10102596 A AR 10102596A AR 002022 A1 AR002022 A1 AR 002022A1
Authority
AR
Argentina
Prior art keywords
tricyclic
antagonists
benzacepine
vasopresin
preparing
Prior art date
Application number
ARP960101025A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AR002022A1 publication Critical patent/AR002022A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Antagonistas de vasopresina de benzacepina tricíclicos, de fórmula (I), en la cual Y es una cadena metilénica de 0 a 2 miembros o > CO; A-B es-(CH2)m-NR3- y -NR3-(CH2)m- en la cual n es un entero de 1 a 2 con la condición de que cuando Ye s -(CH2)n- y n es 2, m puede también ser cero ycuando n es cero, m puede ser también tres, con la condición asimismo de que cuando Y es -(CH2)n- y n es 2, m no puede ser dos; y el anillo Z es: (1) fenilosubstituido o nó con uno o dos alquilo,haló geno, amino, alcoxi inferior o alquilamino; (2) un anillo heterocíclico aromático (insaturado) de 5 ó 6miembros que tiene hasta dos heteroátomos de O, N o S; siendo uno al menos N. D, E y F son nitrógeno y carbono que pueden estarsubstituidos con halógeno,hidroxi, -COCl3, -COCF3, alcoxicarbonilo, alquilo sustituido o nó por amino, alcoxi, OH y heterociclos del N de 5 y 6 miembros; R3 es arilcarbonilo opiridilcarbonilo sustituidos en la parte cíclica por radicalesacíclicos y hete rocíclicos.
ARP960101025A 1995-01-17 1996-01-15 Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, uso de los mismos para la manufactura de un medicamento y un procedimiento para preparar dichos compuestos. AR002022A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,132 US5536718A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists

Publications (1)

Publication Number Publication Date
AR002022A1 true AR002022A1 (es) 1998-01-07

Family

ID=23471110

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101025A AR002022A1 (es) 1995-01-17 1996-01-15 Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, uso de los mismos para la manufactura de un medicamento y un procedimiento para preparar dichos compuestos.

Country Status (24)

Country Link
US (3) US5536718A (es)
EP (1) EP0804438B1 (es)
JP (2) JP4163252B2 (es)
KR (1) KR100443438B1 (es)
CN (1) CN1065244C (es)
AR (1) AR002022A1 (es)
AT (1) ATE320429T1 (es)
AU (1) AU707982B2 (es)
BR (1) BR9607182A (es)
CZ (1) CZ297797B6 (es)
DE (1) DE69635922T2 (es)
DK (1) DK0804438T3 (es)
EA (1) EA001143B1 (es)
ES (1) ES2258267T3 (es)
HK (1) HK1004132A1 (es)
HU (1) HUP9800646A3 (es)
IL (1) IL116775A (es)
MX (1) MX9705313A (es)
NZ (1) NZ302111A (es)
PT (1) PT804438E (es)
TW (1) TW403752B (es)
UA (1) UA54383C2 (es)
WO (1) WO1996022293A1 (es)
ZA (1) ZA96297B (es)

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Also Published As

Publication number Publication date
CZ224997A3 (en) 1997-12-17
ATE320429T1 (de) 2006-04-15
AU4769896A (en) 1996-08-07
BR9607182A (pt) 1997-11-11
JP4163252B2 (ja) 2008-10-08
IL116775A (en) 1999-08-17
TW403752B (en) 2000-09-01
US5610156A (en) 1997-03-11
KR100443438B1 (ko) 2004-10-14
US5612334A (en) 1997-03-18
CN1198746A (zh) 1998-11-11
CN1065244C (zh) 2001-05-02
HK1004132A1 (en) 1998-11-20
IL116775A0 (en) 1996-05-14
UA54383C2 (uk) 2003-03-17
DK0804438T3 (da) 2006-06-12
CZ297797B6 (cs) 2007-04-04
HUP9800646A2 (hu) 1998-08-28
AU707982B2 (en) 1999-07-22
EA001143B1 (ru) 2000-10-30
JPH11500106A (ja) 1999-01-06
ES2258267T3 (es) 2006-08-16
HUP9800646A3 (en) 1998-12-28
ZA96297B (en) 1997-07-15
DE69635922T2 (de) 2006-08-17
JP2008101012A (ja) 2008-05-01
EP0804438A1 (en) 1997-11-05
WO1996022293A1 (en) 1996-07-25
DE69635922D1 (de) 2006-05-11
US5536718A (en) 1996-07-16
EA199700117A1 (ru) 1997-12-30
EP0804438B1 (en) 2006-03-15
NZ302111A (en) 1999-04-29
PT804438E (pt) 2006-07-31
MX9705313A (es) 1998-07-31

Similar Documents

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