AR000111A1 - Un nuevo procedimiento para preparar sales de ácido clavulanico - Google Patents

Un nuevo procedimiento para preparar sales de ácido clavulanico

Info

Publication number
AR000111A1
AR000111A1 AR33419395A AR33419395A AR000111A1 AR 000111 A1 AR000111 A1 AR 000111A1 AR 33419395 A AR33419395 A AR 33419395A AR 33419395 A AR33419395 A AR 33419395A AR 000111 A1 AR000111 A1 AR 000111A1
Authority
AR
Argentina
Prior art keywords
clavulanic acid
alkali metal
metal salt
solvent
acid salts
Prior art date
Application number
AR33419395A
Other languages
English (en)
Inventor
Jung Woo Kim
Nam Hee Choi
Gang Sun Choi
Don Wha Lee
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of AR000111A1 publication Critical patent/AR000111A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

De acuerdo con la presente invención, se provee un procedimiento para preparar una sal de metal alcalino de ácido clavulánico en donde se extraeácido clavulánico impuro en solución acuosa por medio de una mezcla de solvente de cetona y acetatode alquilo bajo condiciones ácidas, tratado de una maneraconvencional, y se agrega una solución de sal de metal alcalino de ácido alcanoico disuelta en solvente de cetona o alcanol para obtener una sal demetal alcalino pura de ácido clavulánico. Como el procedimiento de acuerdo con la presente invención omite un paso de formación de sal de amina, se provee unmétodo simple y económico para preparar una sal de metal alcalino de ácido clavulánico con un alto rendimiento sin uso excesivo de solvente.
AR33419395A 1995-05-16 1995-11-10 Un nuevo procedimiento para preparar sales de ácido clavulanico AR000111A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950012068A KR100200242B1 (ko) 1995-05-16 1995-05-16 클라불란산염의 제조 방법

Publications (1)

Publication Number Publication Date
AR000111A1 true AR000111A1 (es) 1997-05-21

Family

ID=36955925

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33419395A AR000111A1 (es) 1995-05-16 1995-11-10 Un nuevo procedimiento para preparar sales de ácido clavulanico

Country Status (15)

Country Link
US (1) US5734048A (es)
EP (1) EP0827504B1 (es)
KR (1) KR100200242B1 (es)
CN (1) CN1064364C (es)
AR (1) AR000111A1 (es)
AU (1) AU3579195A (es)
ES (1) ES2147856T3 (es)
IL (1) IL115919A0 (es)
IN (1) IN183638B (es)
MX (1) MX9708774A (es)
SI (1) SI9520156A (es)
TR (1) TR199501453A2 (es)
TW (1) TW318849B (es)
WO (1) WO1995034194A2 (es)
ZA (1) ZA959443B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500074A (en) † 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
AU5551698A (en) * 1996-11-11 1998-06-03 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
KR100827898B1 (ko) 2000-05-13 2008-05-07 스미스클라인비이참피이엘시이 클라불란산의 염의 정제 방법
CN103304583B (zh) * 2013-07-09 2016-01-20 山东新时代药业有限公司 一种从克拉维酸胺盐结晶母液中回收克拉维酸的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
US4255332A (en) * 1977-09-01 1981-03-10 Beecham Group Limited Process for the preparation of potassium clavulanate from lithium clavulanate
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them

Also Published As

Publication number Publication date
TR199501453A2 (tr) 1996-12-21
IN183638B (es) 2000-03-11
EP0827504A2 (en) 1998-03-11
CN1064364C (zh) 2001-04-11
WO1995034194A3 (en) 1996-03-07
KR100200242B1 (ko) 1999-06-15
WO1995034194A2 (en) 1995-12-21
IL115919A0 (en) 1996-01-31
TW318849B (es) 1997-11-01
ES2147856T3 (es) 2000-10-01
AU3579195A (en) 1996-01-05
CN1185155A (zh) 1998-06-17
MX9708774A (es) 1998-02-28
SI9520156A (sl) 1998-06-30
US5734048A (en) 1998-03-31
KR960041182A (ko) 1996-12-19
EP0827504B1 (en) 2000-04-26
ZA959443B (en) 1996-05-29

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