ES2119990T3 - Procedimiento mejorado para la preparacion de derivados de cloruro de propargilamonio. - Google Patents

Procedimiento mejorado para la preparacion de derivados de cloruro de propargilamonio.

Info

Publication number
ES2119990T3
ES2119990T3 ES94890207T ES94890207T ES2119990T3 ES 2119990 T3 ES2119990 T3 ES 2119990T3 ES 94890207 T ES94890207 T ES 94890207T ES 94890207 T ES94890207 T ES 94890207T ES 2119990 T3 ES2119990 T3 ES 2119990T3
Authority
ES
Spain
Prior art keywords
general formula
isomero
amino
iii
general
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94890207T
Other languages
English (en)
Inventor
Zsuzsanna Nad
Tamas Kallay
Maria Sziladi
Tibor Montay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of ES2119990T3 publication Critical patent/ES2119990T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Steel In Its Molten State (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO PARA LA PREPARACION DE DERIVADOS DE L-ISOMERO DE CLORURO DE AMONIO DE PROPARGILO DE LA FORMULA GENERAL (I) MEDIANTE LA DESCOMPOSICION DE D-TARTARATO DE L-ISOMERO DEL AMINO DE LA FORMULA GENERAL (II) Y MEDIANTE LA REACCION DEL AMINO DE L-ISOMERO OBTENIDO DE LA FORMULA GENERAL (II) EN PRESENCIA DE UNA BASE CON UN HALURO DE LA FORMULA GENERAL (V), Y MEDIANTE LA REACCION DEL L-ISOMERO ASI OBTENIDO DE LA FORMULA GENERAL (III) CON CLORURO DE HIDROGENO EN UN DISOLVENTE ORGANICO, EN DONDE -X REPRESENTA UN ATOMO HALOGENO, -Y REPRESENTA UN ATOMO DE HIDROGENO O DE FLUOR QUE COMPRENDE LA LIBERACION DE LA BASE AMINA DEL D-TARTARATO DEL L-ISOMERO DEL AMINO DE LA FORMULA GENERAL (II), EN DONDE Y ES COMO SE MUESTRA ARRIBA, EN SOLUCION ACUOSA CON HIDROXIDO DE AMONIO O SAL ALCALINA BASICA Y/O SAL DE AMONIO, Y REACCIONANDO LA MISMA CON 1-1,5 MOL EQUIVALENTE A UN HALURO DE LA FORMULA GENERAL (V), EN DONDE -X ES COMO SE DEFINE ARRIBA A 0-50 (GRADOS) C EN UN SISTEMADE SEPARACION DEL PH DE 8-12 DIRECTAMENTE FORMADO EN EL CURSO DE LA LIBERACION DE LA BASE Y DESPUES DE LA SEPARACION DE LA CAPA ACUOSA EXTRAYENDO LA MEZCLA QUE CONTIENE AMINOS DE L-ISOMERO DE LAS FORMULAS GENERALES (II) Y (III) EN LA CAPA ORGANICA CON AGUA Y CON UNA MEZCLA DE HIDROXIDO DE AMONIO Y AGUA Y/O CON UNA SOLUCION DE SAL DE FOSFATO ACUOSO DE UN PH DE 5,5-7,5 Y DISOLVIENDO EL AMINO DE L-ISOMERO DE LA FORMULA GENERAL (II) O SALES DEL MISMO EN LA CAPA ACUOSA Y SEPARANDOLO SELECTIVAMENTE DEL AMINO DE L-ISOMERO DE LA FORMULA GENERAL (III) Y CONVIRTIENDO EL AMINO DE L-ISOMERO DE LA FORMULA GENERAL (III) DESPUES DE LA DESTILACION A SAL DE L-ISOMERO DE LA FORMULA GENERAL (I) MEDIANTE UN METODO CONOCIDO PER SE.
ES94890207T 1994-11-22 1994-12-09 Procedimiento mejorado para la preparacion de derivados de cloruro de propargilamonio. Expired - Lifetime ES2119990T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9403342A HU218927B (hu) 1994-11-22 1994-11-22 Eljárás propargil-ammónium-klorid-származékok előállítására

Publications (1)

Publication Number Publication Date
ES2119990T3 true ES2119990T3 (es) 1998-10-16

Family

ID=10985778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94890207T Expired - Lifetime ES2119990T3 (es) 1994-11-22 1994-12-09 Procedimiento mejorado para la preparacion de derivados de cloruro de propargilamonio.

Country Status (13)

Country Link
US (1) US5449828A (es)
EP (1) EP0713858B1 (es)
AT (1) ATE168987T1 (es)
CA (1) CA2137761C (es)
CZ (1) CZ289827B6 (es)
DE (1) DE69412101T2 (es)
DK (1) DK0713858T3 (es)
ES (1) ES2119990T3 (es)
GR (1) GR3027708T3 (es)
HU (1) HU218927B (es)
IL (1) IL113298A (es)
RU (1) RU2130450C1 (es)
UA (1) UA39938C2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006073547A1 (en) * 2005-01-06 2006-07-13 Mallinckrodt Inc. Process for preparing benzylated amines
CN102775317A (zh) * 2012-07-09 2012-11-14 盐城工学院 一种制备烯丙基二甲基脱氢枞基氯化铵的方法
CN102816074A (zh) * 2012-08-27 2012-12-12 万隆化工有限公司 一种对正丁基苯胺的合成方法
CN102850227B (zh) * 2012-09-19 2015-05-13 常州胜杰化工有限公司 前手性烯丙基胺类化合物及其合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121857A (en) * 1965-01-05 1968-07-31 Science Union & Cie New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
US3496195A (en) * 1966-05-11 1970-02-17 Chinoin Gyogyszer Es Vegyeszet D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts
HU187775B (en) * 1982-07-14 1986-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu New process for producing propargile-amines of pharmaceutical activity
HU207282B (en) * 1984-05-31 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69412101D1 (de) 1998-09-03
RU2130450C1 (ru) 1999-05-20
DK0713858T3 (da) 1998-11-16
IL113298A0 (en) 1995-07-31
CZ289827B6 (cs) 2002-04-17
CA2137761A1 (en) 1996-05-23
UA39938C2 (uk) 2001-07-16
RU94043796A (ru) 1996-10-10
GR3027708T3 (en) 1998-11-30
HUT74016A (en) 1996-10-28
US5449828A (en) 1995-09-12
EP0713858A1 (en) 1996-05-29
HU9403342D0 (en) 1995-02-28
CA2137761C (en) 1998-05-12
ATE168987T1 (de) 1998-08-15
HU218927B (hu) 2000-12-28
DE69412101T2 (de) 1999-01-14
EP0713858B1 (en) 1998-07-29
IL113298A (en) 1999-09-22
CZ309494A3 (en) 1996-06-12

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