AP783A - Composition of L-oddC Compound derivatives and methods of use as antineoplastic agents. - Google Patents
Composition of L-oddC Compound derivatives and methods of use as antineoplastic agents. Download PDFInfo
- Publication number
- AP783A AP783A APAP/P/1997/000939A AP9700939A AP783A AP 783 A AP783 A AP 783A AP 9700939 A AP9700939 A AP 9700939A AP 783 A AP783 A AP 783A
- Authority
- AP
- ARIPO
- Prior art keywords
- composition
- tumor
- cancer
- pharmaceutically acceptable
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/301,298 US5817667A (en) | 1991-04-17 | 1994-09-06 | Compounds and methods for the treatment of cancer |
| US39063395A | 1995-02-17 | 1995-02-17 | |
| PCT/US1995/011464 WO1996007413A1 (en) | 1994-09-06 | 1995-09-05 | Compounds and methods for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9700939A0 AP9700939A0 (en) | 1997-04-30 |
| AP783A true AP783A (en) | 1999-11-17 |
Family
ID=26972285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1997/000939A AP783A (en) | 1994-09-06 | 1995-09-05 | Composition of L-oddC Compound derivatives and methods of use as antineoplastic agents. |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US6063787A (is) |
| EP (2) | EP1468687A1 (is) |
| JP (1) | JP3979662B2 (is) |
| KR (1) | KR100374477B1 (is) |
| CN (3) | CN1827108A (is) |
| AP (1) | AP783A (is) |
| AT (1) | ATE267015T1 (is) |
| AU (1) | AU704977B2 (is) |
| BG (1) | BG63122B1 (is) |
| BR (1) | BR9508886A (is) |
| CA (1) | CA2199117C (is) |
| CZ (1) | CZ297873B6 (is) |
| DE (1) | DE69533066T2 (is) |
| DK (1) | DK0781136T3 (is) |
| ES (1) | ES2219666T3 (is) |
| FI (1) | FI970918L (is) |
| HU (1) | HUT77172A (is) |
| IL (1) | IL115156A (is) |
| IS (1) | IS2011B (is) |
| MY (1) | MY121548A (is) |
| NO (1) | NO313268B1 (is) |
| NZ (1) | NZ335013A (is) |
| OA (1) | OA10473A (is) |
| PL (2) | PL188359B1 (is) |
| PT (1) | PT781136E (is) |
| RO (1) | RO118748B1 (is) |
| RU (1) | RU2168995C2 (is) |
| SI (1) | SI0781136T1 (is) |
| SK (1) | SK284564B6 (is) |
| WO (1) | WO1996007413A1 (is) |
| ZA (1) | ZA957483B (is) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
| US6069252A (en) | 1990-02-01 | 2000-05-30 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
| IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
| US6022876A (en) * | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
| ATE413881T1 (de) | 1997-08-08 | 2008-11-15 | Celmed Oncology Usa Inc | Verfahren und zubereitungen um resistenz gegen biologische oder chemische therapien zu überwinden |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| ES2172303T3 (es) | 1998-01-23 | 2002-09-16 | Newbiotics Inc | Agentes terapeuticos obtenidos por catalisis enzimatica. |
| EA200700564A1 (ru) | 1998-02-25 | 2007-08-31 | Эмори Юниверсити | 2`-фторнуклеозиды |
| AU2004201676B2 (en) * | 1999-03-29 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | Methods of treating leukemia |
| DE60042921D1 (de) * | 1999-03-29 | 2009-10-22 | Shire Canada Inc | Verwendung von cytidinderivaten zur behandlung von leukämie |
| US6653318B1 (en) | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| WO2001022950A2 (en) | 1999-09-24 | 2001-04-05 | Shire Biochem Inc. | Diosolane nucleoside analogs for the treatment or prevention of viral infection |
| CA2389745C (en) | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| EP1600452A3 (en) | 1999-11-12 | 2008-09-10 | Pharmasset, Inc. | Synthesis of 2'-deoxy-L-nucleosides |
| CN100376570C (zh) * | 2000-10-13 | 2008-03-26 | 希拉生物化学股份有限公司 | 改善胞间传输的二氧戊环类似物 |
| WO2002056832A2 (en) | 2001-01-19 | 2002-07-25 | Newbiotics, Inc. | Methods to treat autoimmune and inflammatory conditions |
| ATE450265T1 (de) * | 2001-03-23 | 2009-12-15 | Shire Canada Inc | Pharmazeutische mischung zur behandlung von krebs,die dioxolan nukleosidanalogen enthält |
| CN1744902B (zh) * | 2001-03-23 | 2010-05-26 | 希拉加拿大股份有限公司 | 治疗癌症的药物组合 |
| AU2002242561A1 (en) * | 2001-03-30 | 2002-10-15 | Shire Biochem Inc. | Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine |
| CA2465682A1 (en) * | 2001-11-02 | 2003-05-08 | Shire Biochem Inc. | Methods of treating leukemia |
| EP2055300B1 (de) * | 2001-11-19 | 2016-01-27 | Medigene AG | Arzneimittel enthaltend Isopropylmyristat und ein Catechin |
| CN1556988B (zh) | 2002-06-21 | 2011-09-14 | Lg电子株式会社 | 具有用于管理记录在其上面的视频数据的再现的数据结构的记录介质 |
| CA2465105C (en) | 2002-06-21 | 2012-08-28 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of video data recorded thereon |
| WO2004001750A1 (en) | 2002-06-24 | 2003-12-31 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple reproduction path video data recorded thereon and recording and reproducing methods and apparatuses |
| KR20040000290A (ko) | 2002-06-24 | 2004-01-03 | 엘지전자 주식회사 | 고밀도 광디스크의 멀티 경로 데이터 스트림 관리방법 |
| EP1518240B1 (en) | 2002-06-28 | 2014-05-07 | LG Electronics, Inc. | Recording medium having data structure for managing recording and reproduction of multiple path data recorded thereon and recording and reproducing methods and apparatus |
| CN100372535C (zh) * | 2002-09-24 | 2008-03-05 | 诺瓦提斯公司 | 4-吡啶基甲基-酞嗪衍生物在制备治疗骨髓增生异常综合征的药物中的用途 |
| EP1552519A4 (en) | 2002-10-14 | 2006-08-16 | Lg Electronics Inc | RECORDING MEDIA WITH A DATA STRUCTURE FOR MANAGING THE PLAYBACK OF SEVERAL AUDIO TONES RECORDED AND RECORDING AND PLAYING METHOD AND DEVICES |
| WO2004036578A1 (en) | 2002-10-15 | 2004-04-29 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple graphics streams recorded thereon and recording and reproducing methods and apparatuses |
| RU2313139C2 (ru) | 2002-11-12 | 2007-12-20 | Эл Джи Электроникс Инк. | Носитель записи со структурой данных для управления воспроизведением записанных на нем видеоданных нескольких каналов воспроизведения и способы и устройства записи и воспроизведения |
| US7720356B2 (en) | 2002-11-12 | 2010-05-18 | Lg Electronics Inc | Recording medium having data structure for managing reproduction of multiple reproduction path video data recorded thereon and recording and reproducing methods and apparatuses |
| US7664372B2 (en) | 2002-11-20 | 2010-02-16 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of multiple component data recorded thereon and recording and reproducing methods and apparatuses |
| US7606463B2 (en) | 2003-02-24 | 2009-10-20 | Lg Electronics, Inc. | Recording medium having data structure for managing playback control and recording and reproducing methods and apparatuses |
| US7693394B2 (en) | 2003-02-26 | 2010-04-06 | Lg Electronics Inc. | Recording medium having data structure for managing reproduction of data streams recorded thereon and recording and reproducing methods and apparatuses |
| US7809775B2 (en) | 2003-02-27 | 2010-10-05 | Lg Electronics, Inc. | Recording medium having data structure for managing playback control recorded thereon and recording and reproducing methods and apparatuses |
| CN100397882C (zh) | 2003-02-28 | 2008-06-25 | Lg电子株式会社 | 具有用于管理记录其上的视频数据的随机/洗牌重现的数据结构的记录媒体以及记录和重现的方法和装置 |
| US7620301B2 (en) | 2003-04-04 | 2009-11-17 | Lg Electronics Inc. | System and method for resuming playback |
| WO2005037300A1 (en) | 2003-10-09 | 2005-04-28 | Medigene Ag | The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin |
| BRPI0613796A2 (pt) * | 2005-06-07 | 2011-02-15 | Univ Yale | composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt) |
| CN101511375B (zh) * | 2005-12-02 | 2012-09-05 | 耶鲁大学 | L-胞嘧啶核苷类似物在制备用于治疗癌症和其它病症或疾病状态的药物中的应用 |
| NO324263B1 (no) * | 2005-12-08 | 2007-09-17 | Clavis Pharma Asa | Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser |
| WO2008030373A2 (en) * | 2006-09-01 | 2008-03-13 | University Of Georgia Research Foundation, Inc. | L- oddc prodrugs for cancer |
| RU2322243C1 (ru) * | 2006-10-20 | 2008-04-20 | Наталья Юрьевна Костюкова | Фармацевтическая композиция для лечения поражений роговицы |
| CN103720693A (zh) * | 2011-11-15 | 2014-04-16 | 张始状 | 人体五种正常碱基在制备治疗肿瘤药物中的应用 |
| CN102406649A (zh) * | 2011-11-15 | 2012-04-11 | 张始状 | 人体五种正常碱基在制备治疗肿瘤药物中的应用 |
| SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
| CA3045228C (en) * | 2016-12-28 | 2024-01-02 | Transgene Sa | Oncolytic viruses and therapeutic molecules |
| SG10201708886RA (en) * | 2017-10-30 | 2019-05-30 | Xylonix Ip Holdings Pte Ltd | α-PGA-ZINC COMPOSITIONS AND METHODS FOR TREATING CANCER |
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|---|---|---|---|---|
| US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
| EP0337713A2 (en) * | 1988-04-11 | 1989-10-18 | Biochem Pharma Inc | 2-Substituted-4-Substituted-1,3-Dioxolanes, Synthesis and use thereof |
| US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5668674A (en) * | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
| PT82580B (pt) * | 1985-05-15 | 1989-01-17 | Wellcome Found | Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem |
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| WO1987001284A1 (en) * | 1985-08-26 | 1987-03-12 | United States Of America, Represented By The Unite | Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine |
| DK167377B1 (da) * | 1985-09-17 | 1993-10-25 | Wellcome Found | 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion |
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| FR2601385B1 (fr) * | 1986-07-09 | 1989-09-29 | Sucre Rech & Dev | Procede de preparation a partir de saccharose d'un melange de sucres a haute teneur en isomaltose par voie enzymatique et produits obtenus |
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-
1995
- 1995-09-04 IL IL11515695A patent/IL115156A/xx not_active IP Right Cessation
- 1995-09-05 DK DK95933071T patent/DK0781136T3/da active
- 1995-09-05 US US08/809,007 patent/US6063787A/en not_active Expired - Fee Related
- 1995-09-05 CN CNA2006100549917A patent/CN1827108A/zh active Pending
- 1995-09-05 ES ES95933071T patent/ES2219666T3/es not_active Expired - Lifetime
- 1995-09-05 AP APAP/P/1997/000939A patent/AP783A/en active
- 1995-09-05 PL PL95318971A patent/PL188359B1/pl not_active IP Right Cessation
- 1995-09-05 WO PCT/US1995/011464 patent/WO1996007413A1/en not_active Ceased
- 1995-09-05 CA CA002199117A patent/CA2199117C/en not_active Expired - Fee Related
- 1995-09-05 EP EP04003357A patent/EP1468687A1/en not_active Withdrawn
- 1995-09-05 RU RU97105381/04A patent/RU2168995C2/ru not_active IP Right Cessation
- 1995-09-05 CZ CZ0063397A patent/CZ297873B6/cs not_active IP Right Cessation
- 1995-09-05 CN CN95195621A patent/CN1111409C/zh not_active Expired - Lifetime
- 1995-09-05 EP EP95933071A patent/EP0781136B1/en not_active Expired - Lifetime
- 1995-09-05 BR BR9508886A patent/BR9508886A/pt not_active Application Discontinuation
- 1995-09-05 AU AU35862/95A patent/AU704977B2/en not_active Ceased
- 1995-09-05 HU HU9701687A patent/HUT77172A/hu unknown
- 1995-09-05 SK SK281-97A patent/SK284564B6/sk not_active IP Right Cessation
- 1995-09-05 FI FI970918A patent/FI970918L/fi unknown
- 1995-09-05 JP JP50970596A patent/JP3979662B2/ja not_active Expired - Lifetime
- 1995-09-05 AT AT95933071T patent/ATE267015T1/de not_active IP Right Cessation
- 1995-09-05 DE DE69533066T patent/DE69533066T2/de not_active Expired - Lifetime
- 1995-09-05 PT PT95933071T patent/PT781136E/pt unknown
- 1995-09-05 KR KR1019970701464A patent/KR100374477B1/ko not_active Expired - Lifetime
- 1995-09-05 SI SI9530703T patent/SI0781136T1/xx unknown
- 1995-09-05 RO RO97-00419A patent/RO118748B1/ro unknown
- 1995-09-05 PL PL95358979A patent/PL189288B1/pl not_active IP Right Cessation
- 1995-09-06 MY MYPI95002637A patent/MY121548A/en unknown
- 1995-09-06 ZA ZA957483A patent/ZA957483B/xx unknown
-
1997
- 1997-03-03 OA OA60972A patent/OA10473A/en unknown
- 1997-03-04 IS IS4434A patent/IS2011B/is unknown
- 1997-03-05 BG BG101284A patent/BG63122B1/xx unknown
- 1997-03-05 NO NO19971015A patent/NO313268B1/no not_active IP Right Cessation
-
1999
- 1999-04-01 NZ NZ335013A patent/NZ335013A/xx not_active IP Right Cessation
-
2003
- 2003-04-18 CN CNB031106706A patent/CN1251680C/zh not_active Expired - Lifetime
- 2003-08-22 US US10/646,980 patent/US7262213B2/en not_active Expired - Lifetime
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2007
- 2007-03-05 US US11/713,975 patent/US8076347B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
| EP0337713A2 (en) * | 1988-04-11 | 1989-10-18 | Biochem Pharma Inc | 2-Substituted-4-Substituted-1,3-Dioxolanes, Synthesis and use thereof |
| US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
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