AP370A - Process for the preparation of substituted steroidal dienes. - Google Patents

Process for the preparation of substituted steroidal dienes. Download PDF

Info

Publication number
AP370A
AP370A APAP/P/1993/000473A AP9300473A AP370A AP 370 A AP370 A AP 370A AP 9300473 A AP9300473 A AP 9300473A AP 370 A AP370 A AP 370A
Authority
AP
ARIPO
Prior art keywords
reagent
process according
chloride
vilsmeier reagent
source
Prior art date
Application number
APAP/P/1993/000473A
Other languages
English (en)
Other versions
AP9300473A0 (en
Inventor
Neil Howard Baine
Donald Nathaniel Kline
Richard Eric Mewshaw
Franklin Owings
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9300473A0 publication Critical patent/AP9300473A0/xx
Application granted granted Critical
Publication of AP370A publication Critical patent/AP370A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1993/000473A 1992-01-06 1993-01-05 Process for the preparation of substituted steroidal dienes. AP370A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81717992A 1992-01-06 1992-01-06
US94134892A 1992-09-04 1992-09-04

Publications (2)

Publication Number Publication Date
AP9300473A0 AP9300473A0 (en) 1993-01-31
AP370A true AP370A (en) 1994-11-10

Family

ID=27124147

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000473A AP370A (en) 1992-01-06 1993-01-05 Process for the preparation of substituted steroidal dienes.

Country Status (23)

Country Link
EP (1) EP0643723A4 (fr)
JP (1) JPH07505138A (fr)
KR (1) KR940703849A (fr)
CN (1) CN1077201A (fr)
AP (1) AP370A (fr)
AU (1) AU666167B2 (fr)
BG (1) BG98887A (fr)
BR (1) BR9305786A (fr)
CA (1) CA2127272A1 (fr)
CZ (1) CZ161994A3 (fr)
FI (1) FI943214A (fr)
HU (1) HUT68273A (fr)
IL (1) IL104302A (fr)
MA (1) MA22761A1 (fr)
MX (1) MX9300025A (fr)
NO (1) NO942535D0 (fr)
NZ (1) NZ246788A (fr)
OA (1) OA09961A (fr)
RU (1) RU94038223A (fr)
SI (1) SI9300006A (fr)
SK (1) SK80094A3 (fr)
TW (1) TW300226B (fr)
WO (1) WO1993014106A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US8143428B2 (en) 2004-06-08 2012-03-27 Temple University-Of The Commonwealth System Of Higher Education Heteroaryl sulfones and sulfonamides and therapeutic uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017568A (en) * 1987-04-29 1991-05-21 Smithkline Beecham Corporation Steriod 5-alpha-reductase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017568A (en) * 1987-04-29 1991-05-21 Smithkline Beecham Corporation Steriod 5-alpha-reductase inhibitors

Also Published As

Publication number Publication date
BR9305786A (pt) 1997-02-18
MX9300025A (es) 1994-01-31
EP0643723A4 (fr) 1995-05-10
WO1993014106A1 (fr) 1993-07-22
EP0643723A1 (fr) 1995-03-22
HU9402030D0 (en) 1994-09-28
IL104302A0 (en) 1993-05-13
JPH07505138A (ja) 1995-06-08
AU3434893A (en) 1993-08-03
AU666167B2 (en) 1996-02-01
CA2127272A1 (fr) 1993-07-22
NO942535L (no) 1994-07-05
IL104302A (en) 1998-02-22
CN1077201A (zh) 1993-10-13
FI943214A0 (fi) 1994-07-05
CZ161994A3 (en) 1995-03-15
OA09961A (en) 1995-12-11
RU94038223A (ru) 1997-04-20
FI943214A (fi) 1994-07-05
HUT68273A (en) 1995-06-28
NO942535D0 (no) 1994-07-05
MA22761A1 (fr) 1993-10-01
AP9300473A0 (en) 1993-01-31
KR940703849A (ko) 1994-12-12
TW300226B (fr) 1997-03-11
SK80094A3 (en) 1994-12-07
NZ246788A (en) 1996-11-26
BG98887A (bg) 1995-05-31
SI9300006A (en) 1993-09-30

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