AP2644A - Traditional chinese medicine preparation for cardiocerebral blood vessel diseases and its preparing method - Google Patents

Traditional chinese medicine preparation for cardiocerebral blood vessel diseases and its preparing method

Info

Publication number
AP2644A
AP2644A AP2006003788A AP2006003788A AP2644A AP 2644 A AP2644 A AP 2644A AP 2006003788 A AP2006003788 A AP 2006003788A AP 2006003788 A AP2006003788 A AP 2006003788A AP 2644 A AP2644 A AP 2644A
Authority
AP
ARIPO
Prior art keywords
cardiocerebral
chinese medicine
blood vessel
traditional chinese
medicine preparation
Prior art date
Application number
AP2006003788A
Other languages
English (en)
Other versions
AP2006003788A0 (en
Inventor
Yiyu Cheng
Zhengliang Ye
Haijiang Zhang
Original Assignee
Tianjin Tasly Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin Tasly Pharmaceutical filed Critical Tianjin Tasly Pharmaceutical
Publication of AP2006003788A0 publication Critical patent/AP2006003788A0/xx
Application granted granted Critical
Publication of AP2644A publication Critical patent/AP2644A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AP2006003788A 2004-03-17 2005-03-17 Traditional chinese medicine preparation for cardiocerebral blood vessel diseases and its preparing method AP2644A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2004100187584A CN100450501C (zh) 2004-03-17 2004-03-17 一种治疗心脑血管疾病的中药制剂及其制备方法
PCT/CN2005/000333 WO2005087242A1 (en) 2004-03-17 2005-03-17 Traditional chinese medicine preparation for cardio-cerebral blood vessel diseases and its preparing method

Publications (2)

Publication Number Publication Date
AP2006003788A0 AP2006003788A0 (en) 2006-10-31
AP2644A true AP2644A (en) 2013-04-17

Family

ID=34975326

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003788A AP2644A (en) 2004-03-17 2005-03-17 Traditional chinese medicine preparation for cardiocerebral blood vessel diseases and its preparing method

Country Status (21)

Country Link
US (1) US7396545B2 (ru)
EP (1) EP1741439B1 (ru)
JP (1) JP5567763B2 (ru)
KR (1) KR20070027532A (ru)
CN (1) CN100450501C (ru)
AP (1) AP2644A (ru)
AU (1) AU2005221260B2 (ru)
CA (1) CA2559826C (ru)
DK (1) DK1741439T3 (ru)
ES (1) ES2635869T3 (ru)
HU (1) HUE036016T2 (ru)
LT (1) LT1741439T (ru)
MX (1) MXPA06010597A (ru)
NO (1) NO345093B1 (ru)
NZ (1) NZ550335A (ru)
PL (1) PL1741439T3 (ru)
PT (1) PT1741439T (ru)
RU (1) RU2359692C2 (ru)
UA (1) UA88162C2 (ru)
WO (1) WO2005087242A1 (ru)
ZA (1) ZA200608606B (ru)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8486464B2 (en) * 2000-12-22 2013-07-16 Tasly Pharmaceutical Group Co. Ltd. Herbal composition for angina pectoris, method to prepare same and uses thereof
US20050037094A1 (en) * 2003-07-31 2005-02-17 Xijun Yan Composition for heart disease, its active ingredients, method to prepare same and uses thereof
CN100392400C (zh) * 2005-11-01 2008-06-04 上海中医药大学 生物体液中丹酚酸b浓度测定样品的预处理方法
CN100360931C (zh) * 2005-11-02 2008-01-09 中国药科大学 一种丹参和三七制剂的质量控制方法
CN100392399C (zh) * 2005-12-28 2008-06-04 劲牌有限公司 用指纹图谱技术检测中国劲酒质量的方法
CN101334386B (zh) 2007-04-27 2012-07-11 上海现代中医药股份有限公司 扶正化淤植物药血浆苦杏仁苷的测定方法
CN101078712A (zh) 2007-04-27 2007-11-28 上海现代中医药技术发展有限公司 扶正化瘀植物药血浆丹参素和丹酚酸b的测定方法
CN101042380A (zh) 2007-04-27 2007-09-26 上海现代中医药技术发展有限公司 扶正化淤植物药血浆五味子乙素的测定方法
CN101045092A (zh) 2007-04-29 2007-10-03 上海现代中医药技术发展有限公司 一种扶正化瘀植物药组合物的应用
CN101524352A (zh) 2008-03-04 2009-09-09 江苏先声药物研究有限公司 一种含有3-甲基-1-苯基-2-吡唑啉-5-酮的组合物
CN101244104B (zh) * 2008-03-24 2011-05-25 中国科学院长春应用化学研究所 一种增加人参总皂苷提取物中稀有皂苷含量的方法
US20120041062A1 (en) * 2009-03-30 2012-02-16 Tianjin Tasly Pharmaceutical Co., Ltd. Compound of salvianolic acid l, preparation method and use thereof
CN102100739B (zh) * 2009-12-17 2013-12-25 天士力制药集团股份有限公司 一种含有丹参素和三七皂苷r1的中药组合物及其应用
CN102293821A (zh) * 2010-06-28 2011-12-28 天津天士力制药股份有限公司 一种中药组合物在制备减轻急性心肌梗死后心绞痛发作的药物中的应用
ES2624285T3 (es) * 2010-08-06 2017-07-13 Tasly Pharmaceutical Group Co., Ltd. Uso de una composición de Salvia miltiorrhiza en la preparación de fármacos para la prevención secundaria de una enfermedad cardíaca coronaria
KR101445303B1 (ko) * 2011-06-30 2014-09-26 한국생명공학연구원 가공인삼의 원산지 또는 연령 판별용 표준 마커, 이의 확립방법 또는 이를 이용한 원산지 또는 연령 판별방법
CN102680626A (zh) * 2012-05-09 2012-09-19 正大青春宝药业有限公司 一种参麦注射液中特征性成分的定量检测方法
CN103424476B (zh) * 2012-05-25 2016-08-17 天津天士力之骄药业有限公司 同时测定丹参多酚酸中4种水溶性成分的方法
CA2878071A1 (en) * 2012-07-05 2014-01-09 Eden Shield Ltd. Novel pest repellents from plant extracts
KR101980183B1 (ko) 2013-03-01 2019-05-20 키무시코라이닌징 가부시키가이샤 진세노사이드 조성물
CN103235050B (zh) * 2013-04-12 2014-12-03 黑龙江珍宝岛药业股份有限公司 一种三七总皂苷注射剂的液相色谱检测方法
CN103245687B (zh) * 2013-05-07 2017-10-13 江苏省中医药研究院 一种丹参注射液的基于组分结构的质量控制检测方法
CA2916963C (en) * 2013-07-11 2022-11-08 Tasly Pharmaceutical Group Co., Ltd. Traditional chinese medicine composition, and preparation and application thereof
TWI621443B (zh) * 2013-07-11 2018-04-21 Tasly Pharmaceutical Group Co Ltd 中藥組合物及其用途、包含該中藥組合物之藥物製劑及複方丹參微滴丸劑、及該微滴丸劑的製備方法
HUE054609T2 (hu) 2013-07-11 2021-09-28 Tasly Pharmaceutical Group Co Elkészítési eljárás hagyományos kínai gyógyszer mikrocsepp pilulához, és a hagyományos kínai gyógyszer mikrocsepp pilula, amely ennek az eljárásnak az alkalmazásával van elkészítve
CN104418744B (zh) * 2013-08-29 2017-03-01 天士力制药集团股份有限公司 一种新的丹酚酸化合物t、其制备方法和用途
JP6372897B2 (ja) * 2013-08-29 2018-08-15 タスリー・ファーマシューティカル・グループ・カンパニー・リミテッドTasly Pharmaceutical Group Co., Ltd. 漢方薬組成物
RU2539133C1 (ru) * 2013-10-09 2015-01-10 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт общей патологии и патофизиологии" Иммунокорректирующее средство для терапии атеросклеротических заболеваний
KR101409848B1 (ko) * 2014-03-03 2014-06-19 한국생명공학연구원 가공인삼의 원산지 또는 연령 판별용 표준 마커, 이의 확립방법 또는 이를 이용한 원산지 또는 연령 판별방법
TWI535784B (zh) 2014-08-26 2016-06-01 財團法人工業技術研究院 剪切增稠配方、及包含其之複合材料
CN104374844A (zh) * 2014-11-13 2015-02-25 贵州信邦制药股份有限公司 丹参药材中水溶性成分的含量测定方法及其应用
CN104749280A (zh) * 2015-03-30 2015-07-01 神威药业集团有限公司 一种丹参注射液的质量控制方法
CN104749308A (zh) * 2015-03-30 2015-07-01 神威药业集团有限公司 一种丹参注射液的质量控制方法
CN106290677B (zh) * 2016-09-29 2018-01-02 国药集团冯了性(佛山)药业有限公司 冯了性风湿跌打药酒指纹图谱的建立方法及其指纹图谱
CN107315061B (zh) * 2017-06-15 2019-01-25 甘肃兰药药业有限公司 一种治疗妇女子宫出血的茜芷中药制剂的检测方法
CN110156863B (zh) * 2018-02-12 2022-12-13 吉林紫鑫参工堂生物科技有限公司 一种人参皂苷Rd自动控制分离纯化方法
CN109115904B (zh) * 2018-07-25 2021-02-02 山西广誉远国药有限公司 一种定坤丹uplc指纹图谱的构建方法及其应用
CN109633009A (zh) * 2018-12-28 2019-04-16 广西中医药大学 一种丹参及其提取物的质量控制方法
CN110907581B (zh) * 2019-12-23 2022-07-01 广州医药研究总院有限公司 复方丹参制剂七种成分血浆或组织浓度的质谱检测方法
CN111289648B (zh) * 2020-03-09 2021-12-17 四川省中医药科学院 一种中药复方制剂指纹图谱的建立方法及其指纹图谱
CN112843041A (zh) * 2021-01-08 2021-05-28 中国人民解放军空军军医大学 迷迭香酸或其衍生物作为新型trpc1拮抗剂的药用制备及其应用
CN113004364A (zh) * 2021-03-25 2021-06-22 杭州天草科技有限公司 一种高纯度人参皂苷Re的制备方法
CN113820405A (zh) * 2021-08-10 2021-12-21 劲牌有限公司 一种石韦配方颗粒质量控制方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002058625A2 (en) * 2000-12-22 2002-08-01 Tianjin Tasly Pharmaceutical Co., Ltd., China Herbal composition for angina pectoris, method to prepare same and uses thereof
WO2002085398A1 (en) * 2001-04-19 2002-10-31 Taipei-Veterans General Hospital Lithospermic acid-containing composition
CN1424096A (zh) * 2002-12-31 2003-06-18 北京采瑞医药有限公司 一种治疗心脑血管疾病的复方丹参微囊制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1072012C (zh) * 1999-06-30 2001-10-03 韩桂茹 丹参中丹参素及原儿茶醛的提取工艺
US8486464B2 (en) * 2000-12-22 2013-07-16 Tasly Pharmaceutical Group Co. Ltd. Herbal composition for angina pectoris, method to prepare same and uses thereof
FR2822701B1 (fr) * 2001-04-03 2005-03-18 Lvmh Rech Utilisation d'un extrait d'algue phaeodactylum comme agent cosmetique favorisant l'activite du proteasome des cellules de la peau et composition cosmetique le contenant
US6703053B2 (en) * 2001-10-24 2004-03-09 Tampa Bay Research Institute Anti-HSV agent for inhibiting replication of HSV-1 and HSV-2 and method of producing a substance having anti-HSV activity
JP3987733B2 (ja) * 2002-02-12 2007-10-10 共栄化学工業株式会社 線維芽細胞賦活剤及びこれを含む皮膚外用剤
CN1470255A (zh) * 2002-07-22 2004-01-28 王智民 自丹参三七中提取的制备物及其复方制备方法和医疗用途
US20050037094A1 (en) * 2003-07-31 2005-02-17 Xijun Yan Composition for heart disease, its active ingredients, method to prepare same and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002058625A2 (en) * 2000-12-22 2002-08-01 Tianjin Tasly Pharmaceutical Co., Ltd., China Herbal composition for angina pectoris, method to prepare same and uses thereof
WO2002085398A1 (en) * 2001-04-19 2002-10-31 Taipei-Veterans General Hospital Lithospermic acid-containing composition
CN1424096A (zh) * 2002-12-31 2003-06-18 北京采瑞医药有限公司 一种治疗心脑血管疾病的复方丹参微囊制剂及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HONG X. ET AL: 'Pharmacokinetic study of danshensu in compound danshen dropping pill.' NEW DRUG AND CLINICAL PHARMACOLOGY IN THE TRADITIONAL CHINESE MEDICINE. vol. 11, no. 5, September 2000, pages 286 - 288, XP008113303 *
WANG N. ET AL: 'LC/MS for the determination of reletive active ingredients of radix Salviae miltiorrhizae in biological sample after oral administration of danshen dropping pill.' NEW DRUG AND CLINICAL PHARMACOLOGY IN THE TRADITIONAL CHINESE MEDICINE. vol. 11, no. 3, May 2000, pages 141 - 142, XP008113304 *

Also Published As

Publication number Publication date
ES2635869T3 (es) 2017-10-05
CA2559826A1 (en) 2005-09-22
UA88162C2 (ru) 2009-09-25
ZA200608606B (en) 2008-06-25
WO2005087242A1 (en) 2005-09-22
RU2359692C2 (ru) 2009-06-27
JP5567763B2 (ja) 2014-08-06
JP2007529431A (ja) 2007-10-25
HUE036016T2 (hu) 2018-06-28
NO345093B1 (no) 2020-09-28
RU2006136529A (ru) 2008-04-27
AU2005221260A1 (en) 2005-09-22
AP2006003788A0 (en) 2006-10-31
PL1741439T3 (pl) 2017-10-31
CA2559826C (en) 2015-10-06
KR20070027532A (ko) 2007-03-09
PT1741439T (pt) 2017-08-23
CN100450501C (zh) 2009-01-14
DK1741439T3 (en) 2017-08-07
EP1741439B1 (en) 2017-05-31
LT1741439T (lt) 2017-08-25
US7396545B2 (en) 2008-07-08
MXPA06010597A (es) 2007-03-15
CN1669573A (zh) 2005-09-21
AU2005221260B2 (en) 2010-02-11
US20070071834A1 (en) 2007-03-29
EP1741439A4 (en) 2009-08-12
EP1741439A1 (en) 2007-01-10
NO20064572L (no) 2006-12-18
NZ550335A (en) 2008-12-24

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